Acute exposure to CXC chemokine ligand 10, but not its chronic astroglial production, alters synaptic plasticity in mouse hippocampal slices

Vlkolinský, Roman; Siggins, George R.; Campbell, Iain L.; Krucker, Thomas

doi:10.1016/j.jneuroim.2004.01.011

Cited by 57Neuroscience and Neuropharmacology ResearchNeuroinflammation and Neurodegeneration MechanismsChemokine receptors and signaling

Acute exposure to CXC chemokine ligand 10, but not its chronic astroglial production, alters synaptic plasticity in mouse hippocampal slices

Vlkolinský, Roman, Siggins, George R., Campbell, Iain L., Krucker, Thomas·2004·Journal of Neuroimmunology

DOI 10.1016/j.jneuroim.2004.01.011

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Abstract

Brain levels of CXC chemokine ligand 10 (CXCL10) are elevated in a number of neuropathological conditions. To determine its impact on neuronal function, we measured synaptic transmission and plasticity in hippocampal slices prepared from transgenic (TG) mice with chronic astroglial production of CXCL10. We also tested the acute effect of recombinant CXCL10 applied to slices from normal C57Bl/6J mice, CXCL10 TG mice and CXCR3 knock out (KO) mice. Chronic production of CXCL10 did not alter synaptic plasticity. By contrast, exogenous CXCL10 (10 ng/ml) significantly inhibited long-term potentiation (LTP) in slices from normal C57Bl/6J mice and CXCL10 TG. The effect was probably receptor-mediated because CXCL10-induced inhibition of LTP was not observed in CXCR3 KO mice. Our findings suggest that acute exposure to CXCL10 alters synaptic plasticity via CXCR3 in mouse hippocampus.

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Both CXCL10 and CCL3 were shown to impair synaptic functions.
“Moreover, both cytokines were shown to impair synaptic functions (58, 59).”
From The effect of Abi3 locus deletion on the progression of Alzheimer’s disease-related pathologies (2023) · cites this paper as [58]
Both CXCL10 and CCL3 have been shown to impair LTP and synaptic function.
“Both CXCL10 and CCL3 have been shown to impair LTP and synaptic function (61, 62).”
From Deletion of <i>Abi3</i> gene locus exacerbates neuropathological features of Alzheimer’s disease in a mouse model of Aβ amyloidosis (2021) · cites this paper as [61]

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The Inflammatory Chemokine CXCL10 Modulates Synaptic Plasticity and Neuronal Activity in the Hippocampus
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CX3CL1 is up-regulated in the rat hippocampus during memory-associated synaptic plasticity
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Authors: Vlkolinský, R., Siggins, G. R., Campbell, I. L., & Krucker, T.
Corresponding author: Krucker, Thomas
ORCID: Vlkolinský, Roman
Campbell, Iain L.
Venue: Journal of Neuroimmunology
Publisher: Elsevier BV
Published: 2004-05
Volume: 150
Issue: 1-2
Pages: 37-47
ISSN: 0165-5728 (ISSN-L)
DOI: 10.1016/j.jneuroim.2004.01.011
OpenAlex: W2069356387
Cited by: 57
References: 82
Citations by year: 2026: 1 · 2025: 3 · 2024: 4 · 2023: 4 · 2022: 1 · 2021: 2 · 2020: 2 · 2019: 1 · 2018: 2 · 2017: 5 · 2016: 4 · 2015: 3 · 2013: 1 · 2012: 7
FWCI: 0.94
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Journal of Neuroimmunology (publishedVersion)
PubMed (publishedVersion)
Funders: National Institutes of Health
National Institute of Mental Health (MH 62261, P30MH062261, MH 62231, R01MH062231)
National Institute on Drug Abuse (DA 12444, P01DA012444)
Topics: Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
Health Sciences › Medicine › Oncology › Chemokine receptors and signaling
Keywords: CXCL10, chemokines, CXCR3, synaptic plasticity, long-term potentiation, hippocampus, synaptic transmission, neuroinflammation, transgenic mice
MeSH terms: Animals, Astrocytes, Male, Mice, Inbred C57BL, Mice, Transgenic, Neural Inhibition, Neuronal Plasticity, Recombinant Proteins, Synapses, Time Factors, Long-Term Potentiation, Mice, Knockout, Excitatory Postsynaptic Potentials, Receptors, Chemokine, Chemokines, CXC, Mice, Chemokine CXCL10, Receptors, CXCR3, In Vitro Techniques

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Acute exposure to CXC chemokine ligand 10, but not its chronic astroglial production, alters synaptic plasticity in mouse hippocampal slices

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