The impact of postsynaptic calcium on synaptic transmission — its role in long-term potentiation
Abstract
Recent studies have gone a long way to explain the steps involved in generating long-term potentiation (LTP). This review focuses on the triggering role of postsynaptic calcium, the sequence of events which might be initiated by calcium, and where the persistent change may ultimately occur during LTP.
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Depolarization in the absence of synaptic stimulation fails to induce LTP.
“Importantly, this same depolarization in the absence of synaptic stimulation fails to induce LTP.”
From Synaptic memory and CaMKII (2023) · cites this paper as [41]
LTP can be induced by depolarizing the postsynaptic cell with current through the recording electrode combined with low-frequency synaptic stimulation.
“However, it is now known that LTP can be induced by just depolarizing the postsynaptic cell with current through the recording electrode combined with low-frequency synaptic stimulation (40, 41).”
From Synaptic memory and CaMKII (2023) · cites this paper as [41]
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- Authors
- Malenka, R. C., Kauer, J. A., Perkel, D. J., & Nicoll, R. A.
- Affiliations
- University of California, San Francisco (US)
- Stanford University (US)
- Corresponding author
- Nicoll, R.A.
- Venue
- Trends in Neurosciences
- Publisher
- Elsevier BV
- Published
- 1989-01
- Volume
- 12
- Issue
- 11
- Pages
- 444-450
- ISSN
- 0166-2236 (ISSN-L)
- OpenAlex
- W2072731296
- Cited by
- 275
- References
- 69
- Citations by year
- 2026: 1 · 2025: 1 · 2024: 4 · 2023: 2 · 2022: 1 · 2021: 2 · 2020: 1 · 2019: 4 · 2018: 1 · 2017: 3 · 2016: 2 · 2015: 3 · 2014: 1 · 2013: 4 · 2012: 5
- FWCI
- 3.53
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Trends in Neurosciences (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health
- U.S. Public Health Service (N524205)
- National Institute of Mental Health (MH00437)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Health Sciences › Medicine › Pharmacology › Treatment of Major Depression
- Keywords
- postsynaptic calcium, synaptic transmission, long-term potentiation, synaptic plasticity
- MeSH terms
- Animals, Calcium, Synaptic Transmission, Synapses, Synaptic Membranes, Time Factors, Receptors, N-Methyl-D-Aspartate, Receptors, Neurotransmitter
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