Cited by 275Neuroscience and Neuropharmacology ResearchMemory and Neural MechanismsTreatment of Major Depression

The impact of postsynaptic calcium on synaptic transmission — its role in long-term potentiation

Malenka, R.C., Kauer, J.A., Perkel, D.J., Nicoll, R.A.·1989·Trends in Neurosciences

Abstract

Recent studies have gone a long way to explain the steps involved in generating long-term potentiation (LTP). This review focuses on the triggering role of postsynaptic calcium, the sequence of events which might be initiated by calcium, and where the persistent change may ultimately occur during LTP.

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Crossref · 10.1016/0166-2236(89)90094-5

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69 of 69 references verified0 citation errors · 0 not checkable

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  • Depolarization in the absence of synaptic stimulation fails to induce LTP.

    “Importantly, this same depolarization in the absence of synaptic stimulation fails to induce LTP.”

    From Synaptic memory and CaMKII (2023) · cites this paper as [41]

  • LTP can be induced by depolarizing the postsynaptic cell with current through the recording electrode combined with low-frequency synaptic stimulation.

    “However, it is now known that LTP can be induced by just depolarizing the postsynaptic cell with current through the recording electrode combined with low-frequency synaptic stimulation (40, 41).”

    From Synaptic memory and CaMKII (2023) · cites this paper as [41]

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Authors
Malenka, R. C., Kauer, J. A., Perkel, D. J., & Nicoll, R. A.
Affiliations
  • University of California, San Francisco (US)
  • Stanford University (US)
Corresponding author
Nicoll, R.A.
Venue
Trends in Neurosciences
Publisher
Elsevier BV
Published
1989-01
Volume
12
Issue
11
Pages
444-450
ISSN
0166-2236 (ISSN-L)
OpenAlex
W2072731296
Cited by
275
References
69
Citations by year
2026: 1 · 2025: 1 · 2024: 4 · 2023: 2 · 2022: 1 · 2021: 2 · 2020: 1 · 2019: 4 · 2018: 1 · 2017: 3 · 2016: 2 · 2015: 3 · 2014: 1 · 2013: 4 · 2012: 5
FWCI
3.53
Type
journal article
Language
en
Open access
closed
Locations
  • Trends in Neurosciences (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • National Institutes of Health
  • U.S. Public Health Service (N524205)
  • National Institute of Mental Health (MH00437)
Topics
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
  • Health Sciences › Medicine › Pharmacology › Treatment of Major Depression
Keywords
postsynaptic calcium, synaptic transmission, long-term potentiation, synaptic plasticity
MeSH terms
Animals, Calcium, Synaptic Transmission, Synapses, Synaptic Membranes, Time Factors, Receptors, N-Methyl-D-Aspartate, Receptors, Neurotransmitter

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