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Sex differences in experimental autoimmune encephalomyelitis in multiple murine strains
Abstract
Multiple sclerosis (MS) is more prevalent in women than men. We evaluated seven different mouse strains commonly used in the study of autoimmune diseases, for sex differences in the disease course of experimental autoimmune encephalomyelitis (EAE). Greater severity of EAE was observed in the female SJL immunized with two different peptides of myelin proteolipid protein (PLP) and myelin oligodendrocyte glycoprotein (MOG) as well as in the female ASW relative to males. Female NZW mice showed a greater incidence of EAE than males. However, male B10.PL and PL/J mice showed more severe disease than females. No sex differences were noted in the C57BL/6 or NOD strains.
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“A comprehensive comparison of EAE clinical disease scores in several mouse strains revealed that female SJL and ASW have more severe EAE than males when induced by active immunization (44).”
From SJL Mice Exposed to Cuprizone Intoxication Reveal Strain and Gender Pattern Differences in Demyelination (2009) · cites this paper as [44]
In the citing paper
“In the experimental autoimmune encephalomyelitis (EAE) animal model for demyelinating disease, several strains of rodents display gender differences in disease incidence and severity 3, 4, 44, 53.”
From SJL Mice Exposed to Cuprizone Intoxication Reveal Strain and Gender Pattern Differences in Demyelination (2009) · cites this paper as [44]
In the citing paper
“Nevertheless, these findings of gender differences are in contrast to those in the EAE model, in which female SJL mice are both more susceptible to disease induction and exhibit more severe neurological deficits 3, 44, 53.”
From SJL Mice Exposed to Cuprizone Intoxication Reveal Strain and Gender Pattern Differences in Demyelination (2009) · cites this paper as [44]
In the citing paper
“Interestingly, it has been shown that male and female mice present with similar disease courses, but that females often have increased infiltration of immune cells to the spinal cord accompanied by increased demyelination compared to males [152, 153].”
From Insights and challenges on animal models for progressive multiple sclerosis (2026) · cites this paper as [152]
In the citing paper
“The A.SW-EAE model offers a unique representation of both PPMS and SPMS, with disease courses that include both PMS phenotypes.”
From Insights and challenges on animal models for progressive multiple sclerosis (2026) · cites this paper as [152]
In the citing paper
“The model can be induced in both males and females, but females tend to present with increased severity compared to males [152].”
From Insights and challenges on animal models for progressive multiple sclerosis (2026) · cites this paper as [152]
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Metadata
- Authors
- Papenfuss, T. L., Rogers, C. J., Gienapp, I., Yurrita, M., McClain, M., Damico, N., Valo, J., Song, F., & Whitacre, C. C.
- Affiliations
- The Ohio State University (US)
- Corresponding author
- Papenfuss, Tracey L.
- Venue
- Journal of Neuroimmunology
- Publisher
- Elsevier BV
- Published
- 2004-05
- Volume
- 150
- Issue
- 1-2
- Pages
- 59-69
- ISSN
- 0165-5728 (ISSN-L)
- OpenAlex
- W2048700200
- Cited by
- 152
- References
- 50
- Citations by year
- 2026: 5 · 2025: 5 · 2024: 5 · 2023: 4 · 2022: 9 · 2021: 9 · 2020: 7 · 2019: 14 · 2018: 8 · 2017: 8 · 2016: 11 · 2015: 11 · 2014: 7 · 2013: 4 · 2012: 4
- FWCI
- 3.82
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of Neuroimmunology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Multiple Sclerosis Society
- National Institutes of Health
- National Institute of Allergy and Infectious Diseases (R01AI043376, AI43376)
- Topics
- Health Sciences › Medicine › Clinical Neurology › Multiple Sclerosis Research Studies
- Health Sciences › Medicine › Rheumatology › Systemic Lupus Erythematosus Research
- Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
- Keywords
- experimental autoimmune encephalomyelitis, sex differences, multiple sclerosis, mouse strains, myelin proteolipid protein, myelin oligodendrocyte glycoprotein, SJL mice, NZW mice, disease severity, autoimmune disease susceptibility
- MeSH terms
- Amino Acid Sequence, Animals, Castration, Encephalomyelitis, Autoimmune, Experimental, Female, Male, Mice, Inbred C57BL, Mice, Inbred NZB, Mice, Inbred Strains, Molecular Sequence Data, Ovariectomy, Severity of Illness Index, Sex Characteristics, Species Specificity, Incidence, Mice, Inbred NOD, Mice
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