The effect of proinflammatory cytokines in Cognitive Behavioral Therapy
Open accessAbstract
Major depressive disorder (MDD) is a debilitating disorder and its pathophysiology is associated with deregulation of the immune system. We investigated the changes in circulating levels of proinflammatory cytokines (specifically IL-6 and TNF-α) measured by the ELISA kit in two psychotherapeutic interventions for MDD: Narrative Cognitive Therapy (NCT) and Cognitive Behavioral Therapy (CBT). This is a randomized clinical trial including 97 individuals (18 to 29years-old) with MDD. In CBT there was a significant difference in serum levels of IL-6 and TNF-α, therefore indicating that CBT was more effective than NCT on serum levels proinflammatory cytokines.
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Cognitive-behavioral therapies were able to reduce inflammatory markers in short-term psychological trials for depressive symptoms.
“On the other hand, cognitive-behavioral therapies were able to reduce inflammatory markers in short-term psychological trials for depressive symptoms (Moreira et al., 2015; Ma et al., 2022).”
From Inflammatory markers changes following acceptance-based behavioral psychotherapy in generalized anxiety disorder patients: Evidence from a randomized controlled trial (2024) · cites this paper as Moreira et al., 2015
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ASSOCIAÇÃO ENTRE TRANSTORNOS PSIQUIÁTRICOS E DOENÇAS INFLAMATÓRIAS
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Intensity and exposure proximity as determinants of differential stress-related health outcomes
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- Authors
- Moreira, F. P., Cardoso, T. D. A., Mondin, T. C., Souza, L. D. D. M., Silva, R., Jansen, K., Oses, J. P., & Wiener, C. D.
- Affiliations
- Universidade Católica de Pelotas (BR)
- Corresponding author
- Wiener, Carolina David
- ORCID
- Venue
- Journal of Neuroimmunology
- Publisher
- Elsevier BV
- Published
- 2015-08
- Volume
- 285
- Pages
- 143-146
- ISSN
- 0165-5728 (ISSN-L)
- OpenAlex
- W1716888447
- Cited by
- 77
- References
- 32
- Citations by year
- 2026: 2 · 2025: 3 · 2024: 7 · 2023: 6 · 2022: 14 · 2021: 12 · 2020: 10 · 2019: 9 · 2018: 5 · 2017: 6 · 2016: 3
- FWCI
- 1.57
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Journal of Neuroimmunology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Fundação de Apoio à Pesquisa do Estado do Rio Grande do Sul (FAPERGS) (10/0055-0)
- Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES) (23038.001671/2012-16)
- Topics
- Life Sciences › Neuroscience › Biological Psychiatry › Tryptophan and brain disorders
- Health Sciences › Medicine › Pharmacology › Treatment of Major Depression
- Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
- Keywords
- major depressive disorder, inflammatory cytokines, interleukin-6, TNF-α, cognitive behavioral therapy, psychotherapy, serum cytokine levels, young adults
- MeSH terms
- Adolescent, Adult, Major Depressive Disorder, Double-Blind Method, Female, Humans, Male, Biomarkers, Cognitive Behavioral Therapy, Cytokines, Inflammation Mediators, Young Adult
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