Cited by 77Tryptophan and brain disordersTreatment of Major DepressionStress Responses and Cortisol

The effect of proinflammatory cytokines in Cognitive Behavioral Therapy

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Moreira, Fernanda Pedrotti, Cardoso, Taiane de Azevedo, Mondin, Thaíse Campos, Souza, Luciano Dias de Mattos, Silva, Ricardo, Jansen, Karen, Oses, Jean Pierre, Wiener, Carolina David·2015·Journal of Neuroimmunology

Abstract

Major depressive disorder (MDD) is a debilitating disorder and its pathophysiology is associated with deregulation of the immune system. We investigated the changes in circulating levels of proinflammatory cytokines (specifically IL-6 and TNF-α) measured by the ELISA kit in two psychotherapeutic interventions for MDD: Narrative Cognitive Therapy (NCT) and Cognitive Behavioral Therapy (CBT). This is a randomized clinical trial including 97 individuals (18 to 29years-old) with MDD. In CBT there was a significant difference in serum levels of IL-6 and TNF-α, therefore indicating that CBT was more effective than NCT on serum levels proinflammatory cytokines.

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Crossref · 10.1016/j.jneuroim.2015.06.004

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Authors
Moreira, F. P., Cardoso, T. D. A., Mondin, T. C., Souza, L. D. D. M., Silva, R., Jansen, K., Oses, J. P., & Wiener, C. D.
Affiliations
Universidade Católica de Pelotas (BR)
Corresponding author
Wiener, Carolina David
Venue
Journal of Neuroimmunology
Publisher
Elsevier BV
Published
2015-08
Volume
285
Pages
143-146
ISSN
0165-5728 (ISSN-L)
OpenAlex
W1716888447
Cited by
77
References
32
Citations by year
2026: 2 · 2025: 3 · 2024: 7 · 2023: 6 · 2022: 14 · 2021: 12 · 2020: 10 · 2019: 9 · 2018: 5 · 2017: 6 · 2016: 3
FWCI
1.57
Type
journal article
Language
en
Open access
Locations
  • Journal of Neuroimmunology (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • Fundação de Apoio à Pesquisa do Estado do Rio Grande do Sul (FAPERGS) (10/0055-0)
  • Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES) (23038.001671/2012-16)
Topics
  • Life Sciences › Neuroscience › Biological Psychiatry › Tryptophan and brain disorders
  • Health Sciences › Medicine › Pharmacology › Treatment of Major Depression
  • Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
Keywords
major depressive disorder, inflammatory cytokines, interleukin-6, TNF-α, cognitive behavioral therapy, psychotherapy, serum cytokine levels, young adults
MeSH terms
Adolescent, Adult, Major Depressive Disorder, Double-Blind Method, Female, Humans, Male, Biomarkers, Cognitive Behavioral Therapy, Cytokines, Inflammation Mediators, Young Adult

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