Cited by 688Skin and Cellular Biology ResearchHereditary Neurological DisordersMultiple Sclerosis Research Studies

The DOI matches its Crossref record; 136 of the 136 references it cites were found in a registry or an index.

Neurofilament phosphoforms: Surrogate markers for axonal injury, degeneration and loss

Open access

Petzold, Axel·2005·Journal of the Neurological Sciences

DOI 10.1016/j.jns.2005.03.015

Open this paper in CoChat — free account Open PDF

Abstract

This review on the role of neurofilaments as surrogate markers for axonal degeneration in neurological diseases provides a brief background to protein synthesis, assembly, function and degeneration. Methodological techniques for quantification are described and a protein nomenclature is proposed. The relevance for recognising anti-neurofilament autoantibodies is noted. Pathological implications are discussed in view of immunocytochemical, cell-culture and genetic findings. With reference to the present symposium on multiple sclerosis, the current literature on body fluid levels of neurofilaments in demyelinating disease is summarised.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Integrity signals

Registry

Crossref · 10.1016/j.jns.2005.03.015

Cites

136 of 136 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Axonal transection in the lesions of multiple sclerosis
Trapp, B. D., Peterson, J., Ransohoff, R. M., Rudick, R., Mörk, S., & Bö, L. (1998) · New England Journal of Medicine · doi:10.1056/nejm199801293380502 · Cited by 4,029
The cell: a molecular approach
(1997) · Choice Reviews Online · doi:10.5860/choice.35-0264 · Cited by 1,465
Monoclonal antibodies distinguish phosphorylated and nonphosphorylated forms of neurofilaments in situ.
Sternberger, L. A., & Sternberger, N. H. (1983) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.80.19.6126 · Cited by 1,158
A Structural Scaffolding of Intermediate Filaments in Health and Disease
Fuchs, E. V., & Cleveland, D. W. (1998) · Science · doi:10.1126/science.279.5350.514 · Cited by 1,013
The slow component of axonal transport. Identification of major structural polypeptides of the axon and their generality among mammalian neurons.
Hoffman, P. N., & Lasek, R. J. (1975) · The Journal of Cell Biology · doi:10.1083/jcb.66.2.351 · Cited by 941
Local modulation of neurofilament phosphorylation, axonal caliber, and slow axonal transport by myelinating Schwann cells
de Waegh, S. M., Lee, V. M. ‐., & Brady, S. T. (1992) · Cell · doi:10.1016/0092-8674(92)90183-d · Cited by 743
Neurofilament gene expression: a major determinant of axonal caliber.
Hoffman, P. N., Cleveland, D. W., Griffin, J. W., Landes, P. W., Cowan, N. J., & Price, D. L. (1987) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.84.10.3472 · Cited by 719
A Mechanistic Analysis of Nondisruptive Axonal Injury: A Review
Maxwell, W. L., Povlishock, J. T., & Graham, D. I. (1997) · Journal of Neurotrauma · doi:10.1089/neu.1997.14.419 · Cited by 564
Increased expression of neurofilament subunit NF-L produces morphological alterations that resemble the pathology of human motor neuron disease
Xu, Z. (1993) · Cell · doi:10.1016/0092-8674(93)90157-l · Cited by 543
Minocycline Provides Neuroprotection Against N -Methyl- d -aspartate Neurotoxicity by Inhibiting Microglia
Tikka, T., & Koıstınaho, J. (2001) · The Journal of Immunology · doi:10.4049/jimmunol.166.12.7527 · Cited by 539

Flagged first, then by citations

Show all 135 references

Research works printed but not linked: 2

Bö L, Grey matter pathology in early MS. In: Miller, DH, Filipi M, A.J. Thompson, editors. MAGNIMS Clinically Isolated Syndrome Workshop, The National Hospital for Neurology and Neurosurgery, Queen Square, London, WC1N 3BG, 22.–23. Jan. MS NMR Research, Unit, Department of Neuroinflammation; 2004.
Julien, 1999, Neurofilament functions in health and disease, Curr Opin Neurobiol, 9, 554, 10.1016/S0959-4388(99)00004-5 · DOI

Sorted by citations

Items 401–500 of 686

Role of plasma phosphorylated neurofilament heavy chain (pNfH) in amyotrophic lateral sclerosis
Zecca, C., Dell’Abate, M. T., Pasculli, G., Capozzo, R., Barone, R., Arima, S., Pollice, A., Brescia, V., Tortelli, R., & Logroscino, G. (2022) · Journal of Cellular and Molecular Medicine · doi:10.1111/jcmm.17232 · Cited by 15
Neurofilament isoform alterations in the rat cerebellum following cytosine arabinoside administration
Koros, C., & Kitraki, E. (2009) · Toxicology Letters · doi:10.1016/j.toxlet.2009.05.024 · Cited by 15
Ultrasensitive immunoassay allows measurement of serum neurofilament heavy in multiple sclerosis
Verberk, I. M. W., Simmelink, M. J. A., Twaalfhoven, H. A. M., Vrenken, H., Korth, C., Killestein, J., Teunissen, C. E., & Bridel, C. (2021) · Multiple Sclerosis and Related Disorders · doi:10.1016/j.msard.2021.102840 · Cited by 13
A novel biomarker for retinal degeneration: vitreous body neurofilament proteins
Petzold, A., Jünemann, A. G. M., Rejdak, K., Żarnowski, T., Thaler, S., Grieb, P., Kruse, F. E., Zrenner, E., & Ręjdak, R. (2009) · Journal of Neural Transmission · doi:10.1007/s00702-009-0316-8 · Cited by 14
Self-citation
Analysis of neurofilament concentration in healthy adult horses and utility in the diagnosis of equine protozoal myeloencephalitis and equine motor neuron disease
Gomez, A. M. M., Zhu, S., Palmer, S. E., Olsen, E., Ness, S. L., Divers, T. J., Bischoff, K. L., & Mohammed, H. O. (2019) · Research in Veterinary Science · doi:10.1016/j.rvsc.2019.04.018 · Cited by 14
Welche Biomarker zu Diagnosestellung und Steuerung der antiinfektiven Therapie bei Sepsis?
Ehler, J., Busjahn, C., & Schürholz, T. (2021) · Der Anaesthesist · doi:10.1007/s00101-021-01067-7 · Cited by 13
Concentration of Serum Biomarkers of Brain Injury in Neonates With a Low Cord pH With or Without Mild Hypoxic-Ischemic Encephalopathy
Gaulee, P., Yang, Z., Sura, L., Xu, H., Rossignol, C., Weiss, M. D., & Bliznyuk, N. (2022) · Frontiers in Neurology · doi:10.3389/fneur.2022.934755 · Cited by 15
Neurofilaments – Small proteins of physiological significance and predictive power for future neurodegeneration and cognitive decline across the life span
Elmers, J., Colzato, L. S., Akgün, K., Ziemssen, T., & Beste, C. (2023) · Ageing Research Reviews · doi:10.1016/j.arr.2023.102037 · Cited by 15
Role of circulating biomarkers in spinal muscular atrophy: insights from a new treatment era
Querin, G., de la Banda, M. G. G., & Smeriglio, P. (2023) · Frontiers in Neurology · doi:10.3389/fneur.2023.1226969 · Cited by 15
Potential role of blood pressure variability and plasma neurofilament light in the mechanism of comorbidity between Alzheimer's disease and cerebral small vessel disease
Li, Q., Su, S., Feng, Y., Jia, M., Zhan, J., Liao, Z., Li, J., Li, X., & Initiative, A. D. N. (2024) · Alzheimer s & Dementia · doi:10.1002/alz.14056 · Cited by 13
Sectoral variations in the distribution of axonal cytoskeleton proteins in the human optic nerve head
Kang, M. H., Law-Davis, S., Balaratnasingam, C., & Yu, D. (2014) · Experimental Eye Research · doi:10.1016/j.exer.2014.10.006 · Cited by 13
Vitreal IgM Autoantibodies Target Neurofilament Medium in a Spontaneous Model of Autoimmune Uveitis
Swadzba, M. E., Hirmer, S., Amann, B., Hauck, S. M., & Deeg, C. A. (2011) · Investigative Ophthalmology & Visual Science · doi:10.1167/iovs.11-8734 · Cited by 13
HTLV-1 encephalitis
King‐Robson, J., Hampton, T., Rosadas, C., Taylor, G. P., & Stanton, B. R. (2021) · Practical Neurology · doi:10.1136/practneurol-2021-003053 · Cited by 13
Urinary biomarkers for amyotrophic lateral sclerosis: candidates, opportunities and considerations
Rogers, M., Schultz, D. W., Karnaros, V., & Shepheard, S. R. (2023) · Brain Communications · doi:10.1093/braincomms/fcad287 · Cited by 13
Neuroproteomics and microRNAs studies in multiple sclerosis: transforming research and clinical knowledge in biomarker research
Fawaz, C. N., Makki, I., Kazan, J. M., Gebara, N. Y., Andary, F. S., Itani, M. M., El-Sayyed, M., Zeidan, A., Quartarone, A., Darwish, H., et al. (2015) · Expert Review of Proteomics · doi:10.1586/14789450.2015.1099435 · Cited by 13
Neurofilament Light Chain Determination from Peripheral Blood Samples
Limberg, M., Disanto, G., Barro, C., & Kühle, J. (2015) · Methods in molecular biology · doi:10.1007/7651_2015_206 · Cited by 13
CSF neurofilament and soluble TNF receptor 1 levels in subacute sclerosing panencephalitis
Matsushige, T., Ichiyama, T., Anlar, B., Tohyama, J., Nomura, K. T., Yamashita, Y., & Furukawa, S. (2008) · Journal of Neuroimmunology · doi:10.1016/j.jneuroim.2008.09.011 · Cited by 13
Oligodendrocyte Loss During the Disease Course in a Canine Model of the Lysosomal Storage Disease Fucosidosis
Fletcher, J. L., Kondagari, G. S., Vite, C. H., Williamson, P., & Taylor, R. M. (2014) · Journal of Neuropathology & Experimental Neurology · doi:10.1097/nen.0000000000000075 · Cited by 13
Effect of amitriptyline treatment on neurofilament-H protein in an experimental model of depression
Sanna, M. D., Ghelardini, C., & Galeotti, N. (2016) · Brain Research Bulletin · doi:10.1016/j.brainresbull.2016.11.001 · Cited by 13
Serum neurofilament light chain levels are associated with depression among US adults: a cross-sectional analysis among US adults, 2013–2014
Song, Y., Jiao, H., Weng, Q., Liu, H., & Li, Y. (2024) · BMC Psychiatry · doi:10.1186/s12888-024-05964-0 · Cited by 12
Associations between cerebrospinal fluid markers and cognition in ageing and dementia: A systematic review
Saunders, T. S., Gadd, D. A., Spires‐Jones, T. L., King, D., Ritchie, C. W., & Terrera, G. M. (2022) · European Journal of Neuroscience · doi:10.1111/ejn.15656 · Cited by 12
Urinary di-(2-ethylhexyl) phthalate metabolites are independently related to serum neurofilament light chain, a biomarker of neurological diseases, in adults: results from NHANES 2013–2014
Yang, A., Lai, T., Lin, Y., Wang, C., & Lin, C. (2023) · Environmental Science and Pollution Research · doi:10.1007/s11356-023-26943-0 · Cited by 11
Cerebrospinal fluid in the differential diagnosis of Alzheimer’s disease: an update of the literature
Milos, T., Vuić, B., Balic, N., Farkaš, V., Erjavec, G. N., Štrac, D. Š., Perković, M. N., & Pivac, N. (2024) · Expert Review of Neurotherapeutics · doi:10.1080/14737175.2024.2400683 · Cited by 11
Neurofilament dot blot assays: Novel means of assessing axon viability in culture
Hares, K. M., Kemp, K. C., Gray, E., Scolding, N. J., & Wilkins, A. (2011) · Journal of Neuroscience Methods · doi:10.1016/j.jneumeth.2011.03.025 · Cited by 11
A Pilot Cross-Sectional Study to Investigate the Biomarker Potential of Phosphorylated Neurofilament-H and Immune Mediators of Disability in Patients With 5 Year Relapsing-Remitting Multiple Sclerosis
Herrera, M. I., Kölliker-Frers, R. A., Losada, M. E. O., Perez‐Lloret, S., Filippo, M., Tau, J., Capani, F., & Villa, A. M. (2019) · Frontiers in Neurology · doi:10.3389/fneur.2019.01046 · Cited by 11
Elevated serum neurofilament levels in young first-episode and medication-naïve major depressive disorder patients with alterative white matter integrity
Jiang, L., Shen, Z., Cheng, Y., Lü, J., He, B., Xu, J., Jiang, H., Liu, F., Li, N., Lü, Y., et al. (2021) · Psychiatry Research Neuroimaging · doi:10.1016/j.pscychresns.2021.111351 · Cited by 12
Assessing Plasma Levels of α-Synuclein and Neurofilament Light Chain by Different Blood Preparation Methods
Chang, K., Liu, K., Lai, C., Yang, S., & Chen, C. (2021) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2021.759182 · Cited by 11
Novel CSF Biomarkers Tracking Autoimmune Inflammatory and Neurodegenerative Aspects of CNS Diseases
Kapaki, E. N., Vakrakou, A. G., & Boufidou, F. (2022) · Diagnostics · doi:10.3390/diagnostics13010073 · Cited by 11
Distribution pattern of axonal cytoskeleton proteins in the human optic nerve head
Yu, D., & Kang, M. (2015) · Neural Regeneration Research · doi:10.4103/1673-5374.162691 · Cited by 11
Perihematomal Pathological Changes in Neurons and Astrocytes Following Acute Cerebral Hemorrhage
Li, H., Wang, S., Wang, L.-K., Chen, X., Zhao, C.-J., Duan, S., Liu, N., & Wang, D. (2010) · International Journal of Neuroscience · doi:10.3109/00207454.2010.513460 · Cited by 11
Role of Phosphorylated Neurofilament H as a diagnostic and prognostic marker in traumatic brain injury
Ghonemi, M. O., Rabah, A. A., Saber, H. M., & Radwan, W. A. (2013) · The Egyptian Journal of Critical Care Medicine · doi:10.1016/j.ejccm.2013.03.002 · Cited by 11
The Use and Potential of pNF-H as a General Blood Biomarker of Axonal Loss: An Immediate Application for CNS Injury
Kobeissy, F. H. (2015) · CRC Press eBooks · doi:10.1201/b18126-28 · Cited by 11
Fluid Biomarkers of Frontotemporal Lobar Degeneration
van der Ende, E. L., & Swieten, J. C. V. (2021) · Advances in experimental medicine and biology · doi:10.1007/978-3-030-51140-1_9 · Cited by 11
Neurofilament Light Chain Levels in Frontotemporal Dementia and Progressive Supranuclear Palsy: A Systematic Review
Bendstrup, N., Hejl, A., & Salvesen, L. (2022) · Journal of Alzheimer s Disease · doi:10.3233/jad-215616 · Cited by 11
Relationship between cerebrospinal fluid neurodegeneration biomarkers and temporal brain atrophy in cognitively healthy older adults
Dídac Vidal-piñeiro, A., Sørensen, Ø., Blennow, K., Capogna, E., Halaas, N. B., Idland, A., Mowinckel, A. M., Pereira, J. B., Watne, L. O., Zetterberg, H., et al. (2022) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2022.04.010 · Cited by 11
Plasma neurofilament pNF‐H concentration is not increased in acute equine grass sickness
Stratford, C. H., Pemberton, A. D., CAMERON, L., & McGorum, B. C. (2012) · Equine Veterinary Journal · doi:10.1111/j.2042-3306.2012.00603.x · Cited by 11
Hyperhomocysteinemia selectively alters expression and stoichiometry of intermediate filament and induces glutamate‐ and calcium‐mediated mechanisms in rat brain during development
Loureiro, S. O., Heimfarth, L., Pelaez, P. D. L., Lacerda, B. A., Vidal, L. F., Soska, Â. K., dos Santos, N. G., Andrade, C. M. B., Tagliari, B., Scherer, E. B. S., et al. (2009) · International Journal of Developmental Neuroscience · doi:10.1016/j.ijdevneu.2009.10.002 · Cited by 11
Immunohistochemical evaluation of akabane virus infection in aborted and new-born calves
Halıgür, M., Hasırcıoğlu, S., Özmen, Ö., Kale, M., & Aydoğan, A. (2014) · Veterinární Medicína · doi:10.17221/7516-vetmed · Cited by 11
Blood neurofilament light chain and thrombospondin-1 levels of patients with autism spectrum disorder
Paketçi, C., ERMİŞ, Ç., ŞİŞMAN, A., Hız, S., Baykara, B., & Yiş, U. (2022) · TURKISH JOURNAL OF MEDICAL SCIENCES · doi:10.55730/1300-0144.5406 · Cited by 10
Early blood neurofilament light chain and myelin oligodendrocyte glycoprotein antibody levels associate with different disease courses of myelin oligodendrocyte glycoprotein-associated disease in children
Horellou, P., Flet‐Berliac, L., Leroy, C., Giorgi, L., Joly, C., Desjardins, D., Chrétien, P., Hacein‐Bey‐Abina, S., Grand, R. L., & Deiva, K. (2023) · Brain Communications · doi:10.1093/braincomms/fcad063 · Cited by 10
Late Blood Levels of Neurofilament Light Correlate With Outcome in Patients With Traumatic Brain Injury
Tuure, J., Mohammadian, M., Tenovuo, O. S., Blennow, K., Hossain, I., Hutchinson, P. J., Maanpää, H.-R., Menon, D. K., Newcombe, V., Takala, R. S. K., et al. (2023) · Journal of Neurotrauma · doi:10.1089/neu.2023.0207 · Cited by 10
Associations of sleep disorders with serum neurofilament light chain levels in Parkinson’s disease
Qi, W.-Y., Sun, Y., Guo, Y., & Tan, L. (2024) · BMC Neurology · doi:10.1186/s12883-024-03642-y · Cited by 12
Advancing personalized spinal muscular atrophy care: matching the right biomarker to the right patient at the right time
Corti, S. P., Ottoboni, L., & Sansone, V. (2025) · Journal of Neurology · doi:10.1007/s00415-025-13314-7 · Cited by 14
Update on Multiple Sclerosis Molecular Biomarkers to Monitor Treatment Effects
Nociti, V., Romozzi, M., & Massimiliano Mirabella, A. (2022) · Journal of Personalized Medicine · doi:10.3390/jpm12040549 · Cited by 13
Association between neurofilament light chain concentration and lesion size in dogs with meningoencephalitis of unknown origin
Yun, T., Koo, Y., Chae, Y., Lee, D., Kim, H., Yang, M., & Kang, B. (2023) · Veterinary Medicine and Science · doi:10.1002/vms3.1155 · Cited by 10
Novel therapeutic for multiple sclerosis protects white matter function in EAE mouse model
Zerimech, S., Nguyen, H., Vandenbark, A. A., Offner, H., & Baltan, S. (2023) · Frontiers in Molecular Medicine · doi:10.3389/fmmed.2023.1237078 · Cited by 10
Alteration of LARGE1 abundance in patients and a mouse model of 5q-associated spinal muscular atrophy
Roos, A., Schmitt, L.-I., Hansmann, C., Hezel, S., Salmanian, S., Hentschel, A., Meyer, N., Marina, A. D., Kölbel, H., Kleinschnitz, C., et al. (2024) · Acta Neuropathologica · doi:10.1007/s00401-024-02709-x · Cited by 10
Transient degradation of myelin basic protein in the rat hippocampus following acute carbon monoxide poisoning
Watanabe, S., Matsuo, H., Kobayashi, Y., Satoh, Y., Fujita, M., Nakayama, A., Aizawa, Y., Shinomiya, N., & Suzuki, S. (2010) · Neuroscience Research · doi:10.1016/j.neures.2010.07.2029 · Cited by 10
Cerebrospinal fluid neurofilament light chain as a biomarker of neurodegeneration in the Tg4510 and MitoPark mouse models
Clement, A., Mitchelmore, C., Andersson, D. R., & Asuni, A. A. (2017) · Neuroscience · doi:10.1016/j.neuroscience.2017.04.030 · Cited by 10
Blood-based Biomarkers for Amyotrophic Lateral Sclerosis
Wilkins, H., Dimachkie, M. M., & Aǵbaş, A. (2021) · Exon Publications eBooks · doi:10.36255/exonpublications.amyotrophiclateralsclerosis.biomarkers.2021 · Cited by 11
Discrepancy of synaptic and microtubular protein phosphorylation in the hippocampus of APP/PS1 and MAPT×P301S transgenic mice at the early stage of Alzheimer’s disease
Wang, Q., Xia, C., Zhu, A., Bao, Y., Lu, J., Chen, Y., Xu, J., Wang, B., Naman, C. B., Li, L., et al. (2023) · Metabolic Brain Disease · doi:10.1007/s11011-023-01209-3 · Cited by 12
Serum Neurofilament Light in Patients with Frontotemporal Dementia Caused by CHMP2B Mutation
Toft, A. D., Roos, P., Jääskeläinen, O., Musaeus, C. S., Henriksen, E. E., Johannsen, P., Nielsen, T. T., Herukka, S., Simonsen, A. H., & Nielsen, J. E. (2020) · Dementia and Geriatric Cognitive Disorders · doi:10.1159/000513877 · Cited by 10
Intermediate filament proteins are reliable immunohistological biomarkers to help diagnose multiple tissue‐specific diseases
Doğanyiğit, Z., Eroğlu, E., & Okan, A. (2023) · Anatomia Histologia Embryologia · doi:10.1111/ahe.12937 · Cited by 9
Ataxia with giant axonopathy in Acbd5 -deficient mice halted by adeno-associated virus gene therapy
Granadeiro, L., Zarralanga, V. E., Rosa, R., Franquinho, F., Lamas, S., & Brites, P. (2024) · Brain · doi:10.1093/brain/awad407 · Cited by 9
Elevated plasma and CSF neurofilament light chain concentrations are stabilized in response to mutant huntingtin lowering in the brains of Huntington’s disease mice
Caron, N. S., Byrne, L. M., Lemarié, F. L., Bone, J. N., Aly, A. E.-E., Ko, S., Anderson, C., Casal, L. L., Hill, A. M., Hawellek, D. J., et al. (2024) · Translational Neurodegeneration · doi:10.1186/s40035-024-00443-8 · Cited by 10
Factors associated with mortality in early stages of parkinsonism
van Rumund, A., Esselink, R. A. J., Aerts, M. B., Otto, M., Bloem, B. R., & Verbeek, M. M. (2022) · npj Parkinson s Disease · doi:10.1038/s41531-022-00329-4 · Cited by 8
Determination of the phosphorylated neurofilament subunit NF-H (pNF-H) in cerebro-spinal fluid as biomarker in acute traumatic spinal cord injuries / Dozarea neurofilamentelor fosforilate (subunitatea pNF-H) ȋn LCR ca biomarker ȋn traumatismul vertebro-medular acut
Ungureanu, D. A., Iencean, Ş. M., Dimitriu, C., Iencean, A. Ş., & Tascu, A. (2014) · Revista română de medicină de laborator · doi:10.2478/rrlm-2014-0029 · Cited by 9
Characterization of a novel rat model of X-linked hydrocephalus by CRISPR-mediated mutation in L1cam
Emmert, A. S., Vuong, S. M., Shula, C., Lindquist, D. M., Yuan, W., Hu, Y., Mangano, F. T., & Goto, J. (2019) · Journal of neurosurgery · doi:10.3171/2018.10.jns181015 · Cited by 9
Adverse Vascular Risk Relates to Cerebrospinal Fluid Biomarker Evidence of Axonal Injury in the Presence of Alzheimer’s Disease Pathology
Osborn, K. E., Alverio, J., Dumitrescu, L. C., Pechman, K. R., Initiative, A. D. N., Gifford, K. A., Hohman, T. J., Blennow, K., Zetterberg, H., & Jefferson, A. L. (2019) · Journal of Alzheimer s Disease · doi:10.3233/jad-190077 · Cited by 9
In vitro assay of neurofilament light chain self-assembly using truncated mutants
Kim, S.-K., Cho, S.-M., Lee, I.-B., Lee, Y. H., Kang, J. H., Choi, J. H., Suh, P., & Chang, J. (2006) · Journal of Neuroscience Methods · doi:10.1016/j.jneumeth.2006.10.022 · Cited by 9
Blood biomarkers in neurology: “a call to arms” for laboratory professionals
Musso, G., & Plebani, M. (2019) · Clinical Chemistry and Laboratory Medicine (CCLM) · doi:10.1515/cclm-2019-0680 · Cited by 9
The utility of serum neurofilament light chain in MOGAD: Current insights and future directions
Labib, M., Thebault, S., Booth, R. A., Brooks, J., Rush, C., MacLean, H. J., Bose, G., Freedman, M. S., & Fadda, G. (2025) · Multiple Sclerosis and Related Disorders · doi:10.1016/j.msard.2025.106410 · Cited by 8
Evaluating Glial Fibrillary Acidic Protein and Neurofilament Light as Potential Biomarkers for Spinocerebellar Ataxia 7
Al‐Shaikh, R. H., Jansen‐West, K. R., Strongosky, A. J., Parrales, Z., Dunmore, J. A., Song, Y., Gendron, T. F., Guevara, J. C., Teive, H. A. G., Dulski, J., et al. (2025) · International Journal of Molecular Sciences · doi:10.3390/ijms26115070 · Cited by 9
Plasma Neurofilament Light Chain Levels Are Elevated in Children and Young Adults With Wolfram Syndrome
Eisenstein, S. A., Boodram, R. S., Sutphen, C. L., Lugar, H. M., Gordon, B. A., Marshall, B. A., Urano, F., Fagan, A. M., & Hershey, T. G. (2022) · Frontiers in Neuroscience · doi:10.3389/fnins.2022.795317 · Cited by 8
Changes in pNFH Levels in Cerebrospinal Fluid and Motor Evolution after the Loading Dose with Nusinersen in Different Types of Spinal Muscular Atrophy
Badina, M., Bejan, G. C., Sporea, C., Pădure, L., Mirea, A., Leanca, M. C., Axente, M., Grigoras, F. P., Bejan, M., Shelby, E.-S., et al. (2023) · Medicina · doi:10.3390/medicina59071244 · Cited by 8
Plasma and cerebrospinal fluid concentrations of neurofilament light protein correlate in patients with idiopathic normal pressure hydrocephalus
Jeppsson, A., Sandelius, Å., Zettergren, A., Kern, S., Skoog, I. G., Blennow, K., Zetterberg, H., Wikkelsø, C., Hellström, P., & Tullberg, M. (2023) · Fluids and Barriers of the CNS · doi:10.1186/s12987-023-00455-y · Cited by 8
Cerebrospinal fluid neurofilament light chains predicts early disease-activity in Multiple Sclerosis
Toscano, S., Oteri, V., Chisari, C. G., Finocchiaro, C., Fermo, S. L., Valentino, P., Bertolotto, A., Zappia, M., & Patti, F. (2023) · Multiple Sclerosis and Related Disorders · doi:10.1016/j.msard.2023.105131 · Cited by 8
Exposure of young rats to diphenyl ditelluride during lactation affects the homeostasis of the cytoskeleton in neural cells from striatum and cerebellum
Heimfarth, L., Reis, K. P., Loureiro, S. O., de Lima, B. O., da Rocha, J. B. T., & Pessoa‐Pureur, R. (2012) · NeuroToxicology · doi:10.1016/j.neuro.2012.06.003 · Cited by 8
Traumatic white matter injury and toxic leukoencephalopathies
al-Hasani, O. H., & Smith, C. (2011) · Expert Review of Neurotherapeutics · doi:10.1586/ern.11.119 · Cited by 8
Prominence of nestin-expressing Schwann cells in bone marrow of patients with myelodysplastic syndromes with severe fibrosis
Cao-Sy, L., Obara, N., Sakamoto, T., Kato, T., Hattori, K., Sakashita, S., Nannya, Y., Ogawa, S., Harada, H., Sakata‐Yanagimoto, M., et al. (2019) · International Journal of Hematology · doi:10.1007/s12185-018-02576-9 · Cited by 8
Plasma neurofilament light as a longitudinal biomarker of neurodegeneration in Alzheimer’s disease
Ou, Y., Hu, H., Wang, Z.-T., Xu, W., Tan, L., Yu, J., & Initiative, A. D. N. (2019) · Brain Science Advances · doi:10.1177/2096595820902582 · Cited by 10
Phosphorylated Neurofilament Heavy Chain in the Cerebrospinal Fluid Is a Suitable Biomarker of Acute and Chronic Blast-Induced Traumatic Brain Injury
Arun, P., Rossetti, F., Eken, O., Wilder, D. M., Wang, Y., & Long, J. B. (2021) · Journal of Neurotrauma · doi:10.1089/neu.2021.0144 · Cited by 8
Recent Advances in the Application Peptide and Peptoid in Diagnosis Biomarkers of Alzheimer’s Disease in Blood
Guo, Y., Hu, Z., & Wang, Z. (2021) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2021.778955 · Cited by 8
Microfluidic Systems: Recent Advances in Chronic Disease Diagnosis and Their Therapeutic Management
Pandey, S., Gupta, S. K., Bharadwaj, A., & Rastogi, A. (2024) · Indian Journal of Microbiology · doi:10.1007/s12088-024-01296-5 · Cited by 8
Neurodegeneration and Multiple Sclerosis
Petzold, A. (2014) · Springer eBooks · doi:10.1007/978-1-4471-6380-0_14 · Cited by 8
Self-citation
What makes a prognostic biomarker in CNS diseases: strategies for targeted biomarker discovery? Part 2: chronic progressive and relapsing disease
Kühle, J., & Petzold, A. (2011) · Expert Opinion on Medical Diagnostics · doi:10.1517/17530059.2011.592184 · Cited by 8
Self-citation
Neurofilament heavy phosphorylated epitopes as biomarkers in ageing and neurodegenerative disease
Paoli, L. F. D., Kirkcaldie, M., King, A. E., & Collins, J. M. (2024) · Journal of Neurochemistry · doi:10.1111/jnc.16261 · Cited by 7
Serum neurofilament light chain as a diagnostic and prognostic biomarker in multiple system atrophy: a prospective cohort study
Liu, M., Cai, Y., Pan, J., Wang, T., Li, Y., Yu, Q., Mao, W., & Chan, P. (2024) · Journal of Neurology · doi:10.1007/s00415-024-12784-5 · Cited by 7
Neurofilament Light Protein as a Biomarker in Severe Mental Disorders: A Systematic Review
Squitti, R., Fiorenza, A., Martinelli, A., Brembati, V., Crescenti, D., Rongioletti, M. C. A., & Ghidoni, R. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms26010061 · Cited by 7
Comparisons of neurodegenerative disease biomarkers across different biological fluids from patients with Huntington’s disease
Bamford, A. R., Parkin, G. M., Corey‐Bloom, J., & Thomas, E. A. (2025) · Journal of Neurology · doi:10.1007/s00415-024-12785-4 · Cited by 8
Alteration of neurofilament heavy chain and its phosphoforms reveals early subcellular damage beyond the optic nerve head in glaucoma
Zhou, L., Lin, D., Xu, G., Wang, X., Chen, Z., Wang, D., & Fan, H. (2023) · Frontiers in Neurology · doi:10.3389/fneur.2023.1091697 · Cited by 7
Research Trends in the Comorbidity Between Periodontitis and Neurodegenerative Diseases
Han, J., Liu, Y., Guo, X., Gao, G., & Wu, Q. (2024) · International Dental Journal · doi:10.1016/j.identj.2024.07.1212 · Cited by 7
A turn-on fluorescent immunosensor for neurodegenerative disease related neurofilament light chain protein
Song, Q., Zhang, H., Kong, J., Wong, M. S., & Li, H. (2025) · Microchimica Acta · doi:10.1007/s00604-025-06995-4 · Cited by 6
Cerebellar Contributions to Motor Impairments in People with Multiple Sclerosis
Fietsam, A. C., Darling, W. G., Sosnoff, J. J., Workman, C. D., Kamholz, J. A., & Rudroff, T. (2021) · The Cerebellum · doi:10.1007/s12311-021-01336-6 · Cited by 7
Cerebrospinal fluid neurofilament light chains and CXCL13 as predictive factors for clinical course of multiple sclerosis
Hradílek, P., Revendová, K. Ž., Horakova, J., Bunganic, R., Pelíšek, O., Zeman, D., Hanzlíková, P., & Kušnierová, P. (2023) · Biomedical Papers · doi:10.5507/bp.2023.002 · Cited by 7
Biomarkers in Alzheimer’s Disease: Are Olfactory Neuronal Precursors Useful for Antemortem Biomarker Research?
Santillán-Morales, V., Rodríguez-Espinosa, N., Muñoz‐Estrada, J., Alarcón-Elizalde, S., Acebes, Á., & Benítez‐King, G. (2024) · Brain Sciences · doi:10.3390/brainsci14010046 · Cited by 8
Combination of serum phosphorylated neurofilament heavy subunit and hyperintensity of intramedullary T2W on magnetic resonance imaging provides better prognostic value of canine thoracolumbar intervertebral disc herniation
Mashita, T., Kamishina, H., NAKAMOTO, Y., Akagi, Y., NAKANISHI, A., Harasaki, Y., OZAWA, T., UEMURA, T., Kobatake, Y., SHIMAMURA, S., et al. (2014) · Journal of Veterinary Medical Science · doi:10.1292/jvms.14-0582 · Cited by 7
Elevated levels of phosphorylated neurofilament heavy subunit in the cerebrospinal fluid of patients with lumbar spinal stenosis: preliminary findings
Ohya, J., Chikuda, H., Kato, S., Hayakawa, K., Oka, H., Takeshita, K., Tanaka, S., & Ogata, T. (2015) · The Spine Journal · doi:10.1016/j.spinee.2015.03.013 · Cited by 7
Subclinical Neuroaxonal Damage in Patients With Clinically Mild Encephalitis/Encephalopathy With a Reversible Splenial Lesion
Motobayashi, M., Fukuyama, T., Okuno-Yuguchi, J., Tsukahara, K., Nagaharu, S., Hagimoto, R., Kinoshita, T., Nakazawa, Y., & Inaba, Y. (2017) · Pediatric Neurology · doi:10.1016/j.pediatrneurol.2017.05.026 · Cited by 7
Phosphorylation‐dependent dimerization and subcellular localization of islet‐brain 1/c‐Jun N‐terminal kinase‐interacting protein 1
Borsello, T., Centeno, C., Riederer, I. M., Haefliger, J., & Riederer, B. M. (2007) · Journal of Neuroscience Research · doi:10.1002/jnr.21435 · Cited by 7
BDNF Val66Met polymorphism moderates associations between physical activity and neurocognitive outcomes in older adults
Cadwallader, C. J., VandeBunte, A. M., Fischer, D. L., Chen, C., Diaz, V. E., Lee, S. Y., Chan, B., Lario‐Lago, A., Rojas, J. C., Ramos, E. M., et al. (2025) · Alzheimer s & Dementia Translational Research & Clinical Interventions · doi:10.1002/trc2.70106 · Cited by 8
Cerebrospinal fluid neurofilament light and cerebral atrophy in younger‐onset dementia and primary psychiatric disorders
Walia, N., Eratne, D., Loi, S. M., Farrand, S., Li, Q., Malpas, C. B., Varghese, S., Walterfang, M., Evans, A. H., Parker, S., et al. (2023) · Internal Medicine Journal · doi:10.1111/imj.15956 · Cited by 6
Mechanisms of Disease Progression
Wilkins, A. (2017) · Springer eBooks · doi:10.1007/978-3-319-65921-3_4 · Cited by 6
Immunolabelling of non‐phosphorylated neurofilament indicates damage of spinal cord axons in TSE‐infected goats
Nadeem, M., Spitzbarth, I., Haist, V., Rohn, K., Tauscher, K., Rohn, K., Bossers, A., Langeveld, J., Papasavva-Stylianou, P., Groschup, M. H., et al. (2016) · Veterinary Record · doi:10.1136/vr.103425 · Cited by 6
Investigating the Risk of Equine Motor Neuron Disease in a Brazilian Stable and Successful Intervention
Banfield, J., Lisak, R., Omar, A., Domingos, W., Fiaschitello, A., Morales-Gomez, A., Divers, T. J., & Mohammed, H. O. (2019) · Journal of Equine Veterinary Science · doi:10.1016/j.jevs.2019.02.024 · Cited by 6
Sulphur mustard induces progressive toxicity and demyelination in brain cell aggregate culture
Sawyer, T. W., Wang, Y., Song, Y., Villanueva, M., & Jimenez, A. (2021) · NeuroToxicology · doi:10.1016/j.neuro.2021.03.004 · Cited by 6
Serum phosphorylated neurofilament heavy chain as a diagnostic biomarker for progressive myelomalacia in dogs with thoracolumbar intervertebral disc herniation
Murthy, V. D., Li, C., Hicks, J. A., Kroll, J., Giuffrida, M. A., Dickinson, P. J., & Toedebusch, C. M. (2021) · Journal of Veterinary Internal Medicine · doi:10.1111/jvim.16251 · Cited by 6
Cerebrospinal fluid neurofilament light predicts the rate of executive function decline in younger-onset dementia
Walia, N., Eratne, D., Loi, S. M., Li, Q.-X., Varghese, S., Malpas, C. B., Walterfang, M., Evans, A. H., Parker, S., Collins, S. J., et al. (2021) · Journal of the Neurological Sciences · doi:10.1016/j.jns.2021.120088 · Cited by 6
A translational MRI approach to validate acute axonal damage detection as an early event in multiple sclerosis
Cerdá, A. C., Toschi, N., Treaba, C. A., Barletta, V. T., Herranz, E., Mehndiratta, A., Gomez-Sanchez, J. A., Mainero, C., & Santis, S. D. (2023) · eLife · doi:10.7554/elife.79169 · Cited by 6
Impact of Nusinersen on Neurofilament, Creatinine Levels, and Motor Function in Pediatric Spinal Muscular Atrophy Rehabilitation: A Biomarker Analysis
Badina, M., Sporea, C., Bejan, G. C., Mirea, A., & Ion, D. A. (2024) · Balneo and PRM Research Journal · doi:10.12680/balneo.2024.681 · Cited by 6

Authors: Petzold, A.
Affiliations: UCL Queen Square Institute of Neurology (GB)
Corresponding author: Petzold, Axel
ORCID: Petzold, Axel
Venue: Journal of the Neurological Sciences
Publisher: Elsevier BV
Published: 2005-06
Volume: 233
Issue: 1-2
Pages: 183-198
ISSN: 0022-510X (ISSN-L)
DOI: 10.1016/j.jns.2005.03.015
OpenAlex: W2133652987
Cited by: 688
References: 135
Citations by year: 2026: 26 · 2025: 44 · 2024: 40 · 2023: 49 · 2022: 46 · 2021: 65 · 2020: 42 · 2019: 54 · 2018: 38 · 2017: 27 · 2016: 24 · 2015: 23 · 2014: 38 · 2013: 27 · 2012: 24
FWCI: 1.17
Type: journal article
Language: en
Open access: green
discovery.ucl.ac.uk
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Journal of the Neurological Sciences (publishedVersion)
PubMed (publishedVersion)
UCL Discovery (University College London) (submittedVersion)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Skin and Cellular Biology Research
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Hereditary Neurological Disorders
Health Sciences › Medicine › Clinical Neurology › Multiple Sclerosis Research Studies
Keywords: neurofilaments, axonal injury, axonal degeneration, surrogate markers, neurofilament assembly, multiple sclerosis, demyelinating disease, neurodegeneration
MeSH terms: Animals, Axons, Enzyme-Linked Immunosorbent Assay, Glycosylation, Humans, Immunohistochemistry, Models, Biological, Nerve Degeneration, Phosphorylation, Blotting, Western, Biomarkers, Neurofilament Proteins, Protein Isoforms

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Neurofilament phosphoforms: Surrogate markers for axonal injury, degeneration and loss

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Self-check

Citations

Cites

Cited by

Related

Metadata

Record

About these checks