Cited by 688Skin and Cellular Biology ResearchHereditary Neurological DisordersMultiple Sclerosis Research Studies

The DOI matches its Crossref record; 136 of the 136 references it cites were found in a registry or an index.

Neurofilament phosphoforms: Surrogate markers for axonal injury, degeneration and loss

Open access

Petzold, Axel·2005·Journal of the Neurological Sciences

DOI 10.1016/j.jns.2005.03.015

Open this paper in CoChat — free account Open PDF

Abstract

This review on the role of neurofilaments as surrogate markers for axonal degeneration in neurological diseases provides a brief background to protein synthesis, assembly, function and degeneration. Methodological techniques for quantification are described and a protein nomenclature is proposed. The relevance for recognising anti-neurofilament autoantibodies is noted. Pathological implications are discussed in view of immunocytochemical, cell-culture and genetic findings. With reference to the present symposium on multiple sclerosis, the current literature on body fluid levels of neurofilaments in demyelinating disease is summarised.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Integrity signals

Registry

Crossref · 10.1016/j.jns.2005.03.015

Cites

136 of 136 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Axonal transection in the lesions of multiple sclerosis
Trapp, B. D., Peterson, J., Ransohoff, R. M., Rudick, R., Mörk, S., & Bö, L. (1998) · New England Journal of Medicine · doi:10.1056/nejm199801293380502 · Cited by 4,029
The cell: a molecular approach
(1997) · Choice Reviews Online · doi:10.5860/choice.35-0264 · Cited by 1,465
Monoclonal antibodies distinguish phosphorylated and nonphosphorylated forms of neurofilaments in situ.
Sternberger, L. A., & Sternberger, N. H. (1983) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.80.19.6126 · Cited by 1,158
A Structural Scaffolding of Intermediate Filaments in Health and Disease
Fuchs, E. V., & Cleveland, D. W. (1998) · Science · doi:10.1126/science.279.5350.514 · Cited by 1,013
The slow component of axonal transport. Identification of major structural polypeptides of the axon and their generality among mammalian neurons.
Hoffman, P. N., & Lasek, R. J. (1975) · The Journal of Cell Biology · doi:10.1083/jcb.66.2.351 · Cited by 941
Local modulation of neurofilament phosphorylation, axonal caliber, and slow axonal transport by myelinating Schwann cells
de Waegh, S. M., Lee, V. M. ‐., & Brady, S. T. (1992) · Cell · doi:10.1016/0092-8674(92)90183-d · Cited by 743
Neurofilament gene expression: a major determinant of axonal caliber.
Hoffman, P. N., Cleveland, D. W., Griffin, J. W., Landes, P. W., Cowan, N. J., & Price, D. L. (1987) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.84.10.3472 · Cited by 719
A Mechanistic Analysis of Nondisruptive Axonal Injury: A Review
Maxwell, W. L., Povlishock, J. T., & Graham, D. I. (1997) · Journal of Neurotrauma · doi:10.1089/neu.1997.14.419 · Cited by 564
Increased expression of neurofilament subunit NF-L produces morphological alterations that resemble the pathology of human motor neuron disease
Xu, Z. (1993) · Cell · doi:10.1016/0092-8674(93)90157-l · Cited by 543
Minocycline Provides Neuroprotection Against N -Methyl- d -aspartate Neurotoxicity by Inhibiting Microglia
Tikka, T., & Koıstınaho, J. (2001) · The Journal of Immunology · doi:10.4049/jimmunol.166.12.7527 · Cited by 539

Flagged first, then by citations

Show all 135 references

Research works printed but not linked: 2

Bö L, Grey matter pathology in early MS. In: Miller, DH, Filipi M, A.J. Thompson, editors. MAGNIMS Clinically Isolated Syndrome Workshop, The National Hospital for Neurology and Neurosurgery, Queen Square, London, WC1N 3BG, 22.–23. Jan. MS NMR Research, Unit, Department of Neuroinflammation; 2004.
Julien, 1999, Neurofilament functions in health and disease, Curr Opin Neurobiol, 9, 554, 10.1016/S0959-4388(99)00004-5 · DOI

Sorted by citations

Items 201–300 of 686

Serum phosphorylated neurofilament-heavy chain levels in multiple sclerosis patients
Gresle, M. M., Liu, Y., Dagley, L. F., Haartsen, J., Pearson, F., Purcell, A. W., Laverick, L., Petzold, A., Lucas, R. M., van der Walt, A., et al. (2014) · Journal of Neurology Neurosurgery & Psychiatry · doi:10.1136/jnnp-2013-306789 · Cited by 48
Self-citation
Amyloid-beta modulates the association between neurofilament light chain and brain atrophy in Alzheimer’s disease
Kang, M. S., Aliaga, A., Shin, M., Mathotaarachchi, S. S., Benedet, A. L., Pascoal, T. A., Therriault, J., Chamoun, M., Savard, M., Devenyi, G. A., et al. (2020) · Molecular Psychiatry · doi:10.1038/s41380-020-0818-1 · Cited by 47
MSC p43 required for axonal development in motor neurons
Zhu, X., Liu, Y., Yin, Y., Shao, A., Zhang, B., Kim, S., & Zhou, J. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0901872106 · Cited by 48
Evidence that a Panel of Neurodegeneration Biomarkers Predicts Vasospasm, Infarction, and Outcome in Aneurysmal Subarachnoid Hemorrhage
Siman, R. G., Giovannone, N., Toraskar, N., Frangos, S. G., Stein, S. C., Levine, J. M., & Kumar, M. A. (2011) · PLoS ONE · doi:10.1371/journal.pone.0028938 · Cited by 47
Patients with chronic insomnia disorder have increased serum levels of neurofilaments, neuron-specific enolase and S100B: does organic brain damage exist?
Zhang, P., Tan, C.-W., Chen, G.-H., Ge, Y.-J., Xu, J., Xia, L., Wang, F., Li, X., & Kong, X.-Y. (2018) · Sleep Medicine · doi:10.1016/j.sleep.2017.12.012 · Cited by 47
Microfluidics-Based Systems in Diagnosis of Alzheimer’s Disease and Biomimetic Modeling
Li, Y., Li, D., Zhao, P., Nandakumar, K., Wang, L., & Song, Y. (2020) · Micromachines · doi:10.3390/mi11090787 · Cited by 45
Advanced Overview of Biomarkers and Techniques for Early Diagnosis of Alzheimer’s Disease
Rani, S., Dhar, S. B., Khajuria, A., Gupta, D., Jaiswal, P. K., Singla, N., Kaur, M., Singh, G., & Barnwal, R. P. (2023) · Cellular and Molecular Neurobiology · doi:10.1007/s10571-023-01330-y · Cited by 48
Associations of sNfL with clinico‐radiological measures in a large MS population
Sotirchos, E. S., Fitzgerald, K. C., Singh, C. M., Smith, M. D., Reyes-Mantilla, M. I., Hersh, C. M., Hyland, M. H., Canissario, R., Simmons, S. B., Arrambide, G., et al. (2022) · Annals of Clinical and Translational Neurology · doi:10.1002/acn3.51704 · Cited by 46
Neurofilament heavy chain and heat shock protein 70 as markers of seizure‐related brain injury
Rejdak, K., Kühle, J., Rüegg, S. J., Lindberg, R. L. P., Petzold, A., Sulejczak, D., Papuć, E., Ręjdak, R., Stelmasiak, Z., & Grieb, P. (2012) · Epilepsia · doi:10.1111/j.1528-1167.2012.03459.x · Cited by 47
Self-citation
Soluble Beta-Amyloid Precursor Protein Is Related to Disease Progression in Amyotrophic Lateral Sclerosis
Steinacker, P., Fang, L., Kühle, J., Petzold, A., Tumani, H., Ludolph, A. C., Otto, M., & Brettschneider, J. (2011) · PLoS ONE · doi:10.1371/journal.pone.0023600 · Cited by 44
Self-citation
Antibodies against light neurofilaments in multiple sclerosis patients
Bartoš, A., Fialová, L., Soukupová, J., Kukal, J., Malbohan, I. M., & ha, J. P. (2007) · Acta Neurologica Scandinavica · doi:10.1111/j.1600-0404.2006.00794.x · Cited by 45
Neurochemical features of boar lumbosacral dorsal root ganglion neurons and characterization of sensory neurons innervating the urinary bladder trigone
Russo, D., Clavenzani, P., Sorteni, C., Minelli, L. B., Botti, M., Gazza, F., Panu, R., Ragionieri, L., & Chiocchetti, R. (2012) · The Journal of Comparative Neurology · doi:10.1002/cne.23177 · Cited by 45
Neurofilament Proteins as Body Fluid Biomarkers of Neurodegeneration in Multiple Sclerosis
Gresle, M., Butzkueven, H., & Shaw, G. (2011) · Multiple Sclerosis International · doi:10.1155/2011/315406 · Cited by 49
Repeated mild traumatic brain injuries induce persistent changes in plasma protein and magnetic resonance imaging biomarkers in the rat
Wright, D. K., Brady, R. D., Kamnaksh, A., Trezise, J., Sun, M., McDonald, S. J., Mychasiuk, R., Kolbe, S., Law, M., Johnston, L. A., et al. (2019) · Scientific Reports · doi:10.1038/s41598-019-51267-w · Cited by 46
PD-L1 Improves Motor Function and Alleviates Neuropathic Pain in Male Mice After Spinal Cord Injury by Inhibiting MAPK Pathway
Kong, F., Sun, K., Zhu, J., Li, F., Lin, F., Sun, X., Luo, X., Ren, C., Lu, L., Zhao, S., et al. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.670646 · Cited by 45
Exceptional preservation of a prehistoric human brain from Heslington, Yorkshire, UK
O’Connor, S., Ali, E. M. A., Al-Sabah, S., Anwar, D., Bergström, E., Brown, K. A., Buckberry, J., Buckley, S., Collins, M. J., Denton, J., et al. (2011) · Journal of Archaeological Science · doi:10.1016/j.jas.2011.02.030 · Cited by 44
Self-citation
Integrative proteomic analysis of the nucleus accumbens in rhesus monkeys following cocaine self-administration
Tannu, N. S., Howell, L. L., & Hemby, S. E. (2008) · Molecular Psychiatry · doi:10.1038/mp.2008.53 · Cited by 43
Neuronal and glial cerebrospinal fluid protein biomarkers are elevated after West Nile Virus infection
Petzold, A., Groves, M., Leis, A. A., Scaravilli, F., & Stokić, D. S. (2009) · Muscle & Nerve · doi:10.1002/mus.21448 · Cited by 43
Self-citation
Cytokines and Tissue Damage Biomarkers in First-Onset Neuromyelitis Optica Spectrum Disorders: Significance of Interleukin-6
Wei, Y., Chang, H., Li, X., Wang, H., Du, L., Zhou, H., Xu, W., Ma, Y., Yin, L., & Zhang, X. (2018) · NeuroImmunoModulation · doi:10.1159/000494976 · Cited by 43
A case series on the value of tau and neurofilament protein levels to predict and detect delirium in cardiac surgery patients
Saller, T., Petzold, A., Zetterberg, H., Kühle, J., Chappell, D., von Dossow, V., Klawitter, F., Schürholz, T., Hagl, C. M., Reuter, D. A., et al. (2019) · Biomedical Papers · doi:10.5507/bp.2019.043 · Cited by 43
Self-citation
The Identification of Novel Biomarkers Is Required to Improve Adult SMA Patient Stratification, Diagnosis and Treatment
Smeriglio, P., Langard, P., Querin, G., & Biferi, M. G. (2020) · Journal of Personalized Medicine · doi:10.3390/jpm10030075 · Cited by 47
Serum neurofilament light chain
Aktaş, O., Renner, A., Huss, A. M., Filser, M., Baetge, S. J., Stute, N., Gasis, M., Lepka, K., Goebels, N., Şenel, M., et al. (2020) · Neurology Neuroimmunology & Neuroinflammation · doi:10.1212/nxi.0000000000000885 · Cited by 43
Hyperacute Detection of Neurofilament Heavy Chain in Serum Following Stroke: A Transient Sign
Sellner, J., Patel, A. P., Dassan, P., Brown, M. M., & Petzold, A. (2011) · Neurochemical Research · doi:10.1007/s11064-011-0553-8 · Cited by 43
Self-citation
Epigenetic silencing of neurofilament genes promotes an aggressive phenotype in breast cancer
Calmon, M. F., Jeschke, J., Zhang, W., Dhir, M., Siebenkäs, C., Herrera, A., Tsai, H.-C., O’Hagan, H. M., Pappou, E. P., Hooker, C. M., et al. (2015) · Epigenetics · doi:10.1080/15592294.2015.1050173 · Cited by 42
Serial soluble neurofilament heavy chain in plasma as a marker of brain injury after cardiac arrest
Rundgren, M., Friberg, H., Cronberg, T., Romner, B., & Petzold, A. (2012) · Critical Care · doi:10.1186/cc11244 · Cited by 42
Self-citation
N-acetylcysteine attenuates the maternal and fetal proinflammatory response to intrauterine LPS injection in an animal model for preterm birth and brain injury
Chang, E., Zhang, J., SULLIVAN, S. A., Newman, R., & Singh, I. (2011) · The Journal of Maternal-Fetal & Neonatal Medicine · doi:10.3109/14767058.2010.528089 · Cited by 42
Circulating Neurofilament Light Chain Is Associated With Survival After Pediatric Cardiac Arrest*
Kirschen, M. P., Yehya, N., Graham, K., Kilbaugh, T. J., Berg, R. A., Topjian, A., & Diaz-Arrastia, R. R. (2020) · Pediatric Critical Care Medicine · doi:10.1097/pcc.0000000000002294 · Cited by 42
CSF Neurofilament Proteins Levels are Elevated in Sporadic Creutzfeldt-Jakob Disease
van Eijk, J. J. J., Everbroeck, B. V., Abdo, W. F., Kremer, B. P. H., & Verbeek, M. M. (2010) · Journal of Alzheimer s Disease · doi:10.3233/jad-2010-090649 · Cited by 41
Correlations between serum and CSF pNfH levels in ALS, FTD and controls: a comparison of three analytical approaches
Wilke, C., Pujol-Calderón, F., Barro, C., Stransky, E., Blennow, K., Michalak, Z., Deuschle, C., Jeromin, A., Zetterberg, H., Schüle, R., et al. (2019) · Clinical Chemistry and Laboratory Medicine (CCLM) · doi:10.1515/cclm-2019-0015 · Cited by 41
Longitudinal Development of Peripapillary Hyper‐Reflective Ovoid Masslike Structures Suggests a Novel Pathological Pathway in Multiple Sclerosis
Petzold, A., Coric, D., Balk, L. J., Hamann, S., Uitdehaag, B. M. J., Denniston, A. K., Keane, P. A., & Crabb, D. P. (2020) · Annals of Neurology · doi:10.1002/ana.25782 · Cited by 41
Self-citation
Bridging the Gap Between Fluid Biomarkers for Alzheimer’s Disease, Model Systems, and Patients
Bjorkli, C., Sandvig, A., & Sandvig, I. (2020) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2020.00272 · Cited by 41
Spatio‐Temporal Development of Axonopathy in Canine Intervertebral Disc Disease as a Translational Large Animal Model for Nonexperimental Spinal Cord Injury
Bock, P., Spitzbarth, I., Haist, V., Stein, V. M., Tipold, A., Puff, C., Beineke, A., & Baumgärtner, W. (2012) · Brain Pathology · doi:10.1111/j.1750-3639.2012.00617.x · Cited by 40
High-Fidelity Simulation of Primary Blast: Direct Effects on the Head
Sawyer, T. W., Wang, Y., Ritzel, D. V., Josey, T., Villanueva, M., Shei, Y., Nelson, P., Hennes, G., Weiss, T., Vair, C., et al. (2015) · Journal of Neurotrauma · doi:10.1089/neu.2015.3914 · Cited by 41
Elevated α-synuclein and NfL levels in tear fluids and decreased retinal microvascular densities in patients with Parkinson’s disease
Lin, C.-W., Lai, T.-T., Chen, S., & Lin, C. (2022) · GeroScience · doi:10.1007/s11357-022-00576-6 · Cited by 40
Neurofilament levels in patients with neurological diseases: A comparison of neurofilament light and heavy chain levels
Kušnierová, P., Zeman, D., Hradílek, P., Čábal, M., & Zapletalová, O. (2019) · Journal of Clinical Laboratory Analysis · doi:10.1002/jcla.22948 · Cited by 39
Comparison of different MRI-based morphometric estimates for defining neurodegeneration across the Alzheimer's disease continuum
Allison, S. L., Koscik, R. L., Cary, R. P., Jonaitis, E. M., Rowley, H. A., Chin, N. A., Zetterberg, H., Blennow, K., Carlsson, C. M., Asthana, S., et al. (2019) · NeuroImage Clinical · doi:10.1016/j.nicl.2019.101895 · Cited by 41
Early plasma biomarker dynamic profiles are associated with acute ischemic stroke outcomes
Correia, M. A., da Silva, I. C. B., Gabriel, D., Simrén, J., Carneiro, Â., Ribeiro, S., Dória, H. M., Varela, R., Aires, A., Minta, K., et al. (2022) · European Journal of Neurology · doi:10.1111/ene.15273 · Cited by 38
Neuronal apoptosis, axon damage and synapse loss occur synchronously in acute ocular hypertension
Zhou, L., Chen, W., Lin, D., Hu, W., & Tang, Z. (2018) · Experimental Eye Research · doi:10.1016/j.exer.2018.12.006 · Cited by 38
Toward development of clinically translatable diagnostic and prognostic metrics of traumatic brain injury using animal models: A review and a look forward
Hajiaghamemar, M., Seidi, M., Oeur, A., & Margulies, S. S. (2019) · Experimental Neurology · doi:10.1016/j.expneurol.2019.04.019 · Cited by 37
Cerebrospinal fluid light and heavy neurofilament level increased in anti‐N‐methyl‐ d ‐aspartate receptor encephalitis
Li, J., Gu, Y., An, H., Zhou, Z., Dong, Z., Wang, Z., Wen, Z., Shen, H., Wang, Q., & Wang, H. (2019) · Brain and Behavior · doi:10.1002/brb3.1354 · Cited by 38
Cerebrospinal Fluid Neurofilament Light Chain (NfL) Predicts Disease Aggressiveness in Amyotrophic Lateral Sclerosis: An Application of the D50 Disease Progression Model
Dreger, M., Steinbach, R., Gaur, N., Metzner, K., Stubendorff, B., Witte, O. W., & Großkreutz, J. (2021) · Frontiers in Neuroscience · doi:10.3389/fnins.2021.651651 · Cited by 37
Plasma neurofilament light in Huntington's disease: A marker for disease onset, but not symptom progression
Parkin, G. M., Corey‐Bloom, J., Snell, C. M., Castleton, J., & Thomas, E. A. (2021) · Parkinsonism & Related Disorders · doi:10.1016/j.parkreldis.2021.04.017 · Cited by 36
A longitudinal and cross‐sectional study of plasma neurofilament light chain concentration in Charcot‐Marie‐Tooth disease
Rossor, A. M., Kapoor, M., Wellington, H., Spaulding, E. L., Sleigh, J. N., Burgess, R. W., Laurá, M., Zetterberg, H., Bacha, A., Wu, X., et al. (2021) · Journal of the Peripheral Nervous System · doi:10.1111/jns.12477 · Cited by 38
Elevated CSF and plasma complement proteins in genetic frontotemporal dementia: results from the GENFI study
van der Ende, E. L., Heller, C., Sogorb‐Esteve, A., Swift, I. J., McFall, D. J., Peakman, G., Bouzigues, A., Poos, J. M., Jiskoot, L. C., Panman, J. L., et al. (2022) · Journal of Neuroinflammation · doi:10.1186/s12974-022-02573-0 · Cited by 40
High CSF neurofilament heavy chain levels in neuromyelitis optica
Miyazawa, I., Nakashima, I., Petzold, A., Fujihara, K., Sato, S., & Itoyama, Y. (2007) · Neurology · doi:10.1212/01.wnl.0000256820.26489.17 · Cited by 38
Self-citation
Up-regulation of neurofilament light chains is associated with diminished immunoreactivities for MAP2 and tau after ischemic stroke in rodents and in a human case
Härtig, W., Krueger, M., Hofmann, S., Preißler, H., Märkel, M., Frydrychowicz, C., Mueller, W. C., Bechmann, I., & Michalski, D. (2016) · Journal of Chemical Neuroanatomy · doi:10.1016/j.jchemneu.2016.09.004 · Cited by 37
Serum neurofilament light chain in pediatric MS and other acquired demyelinating syndromes
Wong, Y. Y. M., Bruijstens, A. L., Barro, C., Michalak, Z., Melief, M., Wierenga‐Wolf, A. F., van Pelt, E. D., Neuteboom, R. F., Kühle, J., & Hintzen, R. Q. (2019) · Neurology · doi:10.1212/wnl.0000000000008057 · Cited by 37
Spinal Muscular Atrophy
Nance, J. (2020) · CONTINUUM Lifelong Learning in Neurology · doi:10.1212/con.0000000000000918 · Cited by 39
The Potential of Neurofilament Light as a Biomarker in Alzheimer’s Disease
Xiong, Y.-L., Meng, T., Luo, J., & Zhang, H. (2021) · European Neurology · doi:10.1159/000513008 · Cited by 37
The new Global Multiple Sclerosis Severity Score (MSSS) correlates with axonal but not glial biomarkers
Petzold, A., Eikelenboom, M. J., Keir, G., Polman, C. H., Uitdehaag, B. M. J., Thompson, E. J., & Giovannoni, G. (2006) · Multiple Sclerosis Journal · doi:10.1191/135248505ms1277oa · Cited by 37
Self-citation
Neurofilament Light Protein Predicts Disease Progression in Idiopathic REM Sleep Behavior Disorder
Zhang, X., Ma, L., Liang, D., Song, B., Chen, J., Huang, Y., Xu, L., Zhao, P., Wu, W., Zhang, N., et al. (2023) · Journal of Parkinson s Disease · doi:10.3233/jpd-223519 · Cited by 35
Protecting axons in multiple sclerosis
Wilkins, A., & Scolding, N. J. (2008) · Multiple Sclerosis Journal · doi:10.1177/1352458508091370 · Cited by 36
Harpagide inhibits neuronal apoptosis and promotes axonal regeneration after spinal cord injury in rats by activating the Wnt/β-catenin signaling pathway
Rong, Y., Liu, W., Zhou, Z., Gong, F., Bai, J., Fan, J., Li, L., Luo, Y., Zhou, Z., & Cai, W. (2019) · Brain Research Bulletin · doi:10.1016/j.brainresbull.2019.03.014 · Cited by 36
Cerebrospinal fluid analysis
Giovannoni, G. (2014) · Handbook of clinical neurology · doi:10.1016/b978-0-444-52001-2.00029-7 · Cited by 38
Temporal trajectory of biofluid markers in Parkinson’s disease
Baek, M. S., Lee, M. J., Kim, H., & Lyoo, C. H. (2021) · Scientific Reports · doi:10.1038/s41598-021-94345-8 · Cited by 35
Immunoglobulin M Deposition in Cutaneous Nerves of Anti-Myelin-Associated Glycoprotein Polyneuropathy Patients Correlates With Axonal Degeneration
Stalder, A. K., Erne, B., Reimann, R., Renaud, S., Fuhr, P., Thomann, S., Arnold, A., Probst, A., Schaeren‐Wiemers, N., & Steck, A. J. (2009) · Journal of Neuropathology & Experimental Neurology · doi:10.1097/nen.0b013e3181958187 · Cited by 35
Proteomic studies in the discovery of cerebrospinal fluid biomarkers for amyotrophic lateral sclerosis
Barschke, P., Oeckl, P., Steinacker, P., Ludolph, A. C., & Otto, M. (2017) · Expert Review of Proteomics · doi:10.1080/14789450.2017.1365602 · Cited by 38
Neurofilament light chain is increased in the parahippocampal cortex and associates with pathological hallmarks in Parkinson’s disease dementia
Frigerio, I., Laansma, M. A., Lin, C., Hermans, E. J. M., Bouwman, M. M. A., Bol, J. G. J. M., Graaf, Y. G.-D., Hepp, D. H., Rozemüller, A. J. M., Barkhof, F., et al. (2023) · Translational Neurodegeneration · doi:10.1186/s40035-022-00328-8 · Cited by 35
Neuroprotection in multiple sclerosis: therapeutic strategies and clinical trial design
Kapoor, R. (2006) · Current Opinion in Neurology · doi:10.1097/01.wco.0000227034.85576.16 · Cited by 35
Protein Biomarkers for Traumatic and Ischemic Brain Injury: From Bench to Bedside
Zhang, Z.-Q., Mondello, S., Kobeissy, F., Rubenstein, R., Streeter, J., Hayes, R., & Wang, K. K. W. (2011) · Translational Stroke Research · doi:10.1007/s12975-011-0137-6 · Cited by 32
Patterns of retrograde axonal degeneration in the visual system
de Vries-Knoppert, W. A. E. J., Baaijen, J. C., & Petzold, A. (2019) · Brain · doi:10.1093/brain/awz221 · Cited by 36
Self-citation
Case for a new corticosteroid treatment trial in optic neuritis: review of updated evidence
Petzold, A., Braithwaite, T., van Oosten, B. W., Balk, L. J., Martínez‐Lapiscina, E. H., Wheeler, R., Wiegerinck, N., Waters, C., & Plant, G. T. (2019) · Journal of Neurology Neurosurgery & Psychiatry · doi:10.1136/jnnp-2019-321653 · Cited by 35
Self-citation
In Search of a Cure: The Development of Therapeutics to Alter the Progression of Spinal Muscular Atrophy
Ojala, K. S., Reedich, E. J., DiDonato, C. J., & Meriney, S. D. (2021) · Brain Sciences · doi:10.3390/brainsci11020194 · Cited by 37
Polydopamine-Decorated Microcomposites Promote Functional Recovery of an Injured Spinal Cord by Inhibiting Neuroinflammation
Wei, G., Jiang, D., Hu, S. P., Yang, Z., Zhang, Z., Li, W., Cai, W., & Liu, D. (2021) · ACS Applied Materials & Interfaces · doi:10.1021/acsami.1c11772 · Cited by 34
E.U. paediatric MOG consortium consensus: Part 3 – Biomarkers of paediatric myelin oligodendrocyte glycoprotein antibody-associated disorders
Armangué, T., Capobianco, M. A. N., de Chalus, A., Giorgi, L., Deiva, K., Bruijstens, A. L., Wendel, E., Lechner, C., Bartels, F., Finke, C., et al. (2020) · European Journal of Paediatric Neurology · doi:10.1016/j.ejpn.2020.11.001 · Cited by 37
Cerebrospinal Fluid Protein Biomarker Panel for Assessment of Neurotoxicity Induced by Kainic Acid in Rats
Glushakova, O. Y., Jeromin, A., Martinez, J., Johnson, D., Denslow, N. D., Streeter, J., Hayes, R. L., & Mondello, S. (2012) · Toxicological Sciences · doi:10.1093/toxsci/kfs224 · Cited by 34
The prognostic value of CSF neurofilaments in multiple sclerosis at 15-year follow-up
Petzold, A. (2015) · Journal of Neurology Neurosurgery & Psychiatry · doi:10.1136/jnnp-2014-309827 · Cited by 33
Self-citation
The role of blood and CSF biomarkers in the evaluation of new treatments against multiple sclerosis
Lycke, J., & Zetterberg, H. (2017) · Expert Review of Clinical Immunology · doi:10.1080/1744666x.2017.1400380 · Cited by 33
Raised Plasma Neurofilament Light Protein Levels Are Associated with Abnormal MRI Outcomes in Newborns Undergoing Therapeutic Hypothermia
Shah, D. K., Ponnusamy, V., Evanson, J., Kapellou, O., Ekitzidou, G., Gupta, N., Clarke, P., Michael-Titus, A. T., & Yip, P. K. (2018) · Frontiers in Neurology · doi:10.3389/fneur.2018.00086 · Cited by 33
A motor neuron strategy to save time and energy in neurodegeneration: adaptive protein stoichiometry
Zucchi, E., Lu, C., Cho, Y., Chang, R., Adiutori, R., Zubiri, I., Ceroni, M., Cereda, C., Pansarasa, O., Greensmith, L., et al. (2018) · Journal of Neurochemistry · doi:10.1111/jnc.14542 · Cited by 33
Self-citation
Following the Clues: Usefulness of Biomarkers of Neuroinflammation and Neurodegeneration in the Investigation of HTLV-1-Associated Myelopathy Progression
Souza, F. D. S., Freitas, N. L., Gomes, Y. C. P., Torres, R. C., Echevarria‐Lima, J., da Silva-Filho, I. L., Leite, A. C. C. B., Lima, M. A., Silva, M. T. T., Araújo, A., et al. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.737941 · Cited by 32
Serum neurofilament light chain: a promising early diagnostic biomarker for hereditary transthyretin amyloidosis?
Romano, Â., Primiano, G., Antonini, G., Ceccanti, M., Fenu, S., Forcina, F., Gentile, L., Inghilleri, M., Leonardi, L., Manganelli, F., et al. (2023) · European Journal of Neurology · doi:10.1111/ene.16070 · Cited by 32
Effects of AraC treatment on motor coordination and cerebellar cytoarchitecture in the adult rat
Koros, C., Papalexi, E., Anastasopoulos, D., Kittas, C. N., & Kitraki, E. (2006) · NeuroToxicology · doi:10.1016/j.neuro.2006.07.016 · Cited by 32
Serum neurofilament concentrations in children with prolonged febrile seizures
Matsushige, T., Inoue, H., Fukunaga, S., Hasegawa, S., Okuda, M., & Ichiyama, T. (2012) · Journal of the Neurological Sciences · doi:10.1016/j.jns.2012.07.043 · Cited by 32
Cerebrospinal Fluid and Blood Biomarkers of Neuroaxonal Damage in Multiple Sclerosis
Dujmović, I. (2011) · Multiple Sclerosis International · doi:10.1155/2011/767083 · Cited by 34
Predictive value of phosphorylated axonal neurofilament subunit H for clinical outcome in patients with acute intracerebral hemorrhage
Cai, J., Lü, C., Chen, M., Ba, H., Chen, X.-D., Lin, J.-H., & Sun, J. (2013) · Clinica Chimica Acta · doi:10.1016/j.cca.2013.06.019 · Cited by 32
Phosphorylated neurofilament heavy chain levels in paired plasma and CSF of amyotrophic lateral sclerosis
Li, S., Ren, Y., Zhu, W., Yang, F., Zhang, X., & Huang, X. (2016) · Journal of the Neurological Sciences · doi:10.1016/j.jns.2016.05.062 · Cited by 32
Fluid biomarkers of the neurovascular unit in cerebrovascular disease and vascular cognitive disorders: A systematic review and meta-analysis
Hansra, G. K., Jayasena, T., Hosoki, S., Poljak, A., Lam, B. C. P., Rust, R., Sagare, A. P., Zloković, B. V., Thalamuthu, A., & Sachdev, P. S. (2024) · Cerebral Circulation - Cognition and Behavior · doi:10.1016/j.cccb.2024.100216 · Cited by 34
Bone marrow mesenchymal stem cells repair spinal cord ischemia/reperfusion injury by promoting axonal growth and anti-autophagy
Yin, F., Meng, C., Lu, R., Lu, R., Zhang, Y., Chen, H., Qin, Y., & Guo, L. (2014) · Neural Regeneration Research · doi:10.4103/1673-5374.141801 · Cited by 31
Neurofilaments in CSF As Diagnostic Biomarkers in Motor Neuron Disease: A Meta-Analysis
Li, D., Shen, D., Tai, H., & Cui, L. (2016) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2016.00290 · Cited by 31
TAF1 Transcripts and Neurofilament Light Chain as Biomarkers for X‐linked Dystonia‐Parkinsonism
Ali, J. A., Vaine, C. A., Shah, S., Campion, L. N., Hakoum, A., Supnet, M. L., Acuña, P. J., Aldykiewicz, G., Multhaupt‐Buell, T., Ganza-Bautista, N. G., et al. (2020) · Movement Disorders · doi:10.1002/mds.28305 · Cited by 28
Differences in Alzheimer’s Disease and Related Dementias Pathology Among African American and Hispanic Women: A Qualitative Literature Review of Biomarker Studies
Royse, S. K., Cohen, A. D., Snitz, B. E., & Rosano, C. (2021) · Frontiers in Systems Neuroscience · doi:10.3389/fnsys.2021.685957 · Cited by 31
Role of Blood Neurofilaments in the Prognosis of Amyotrophic Lateral Sclerosis: A Meta-Analysis
Zhou, Y., Chen, Y.-H., Dong, S.-Q., Yang, W., Qian, T., Liu, X.-N., Cheng, Q. H., Wang, J., & Chen, X. (2021) · Frontiers in Neurology · doi:10.3389/fneur.2021.712245 · Cited by 31
Neuroserpin gene therapy inhibits retinal ganglion cell apoptosis and promotes functional preservation in glaucoma
Chitranshi, N., Rajput, R., Godinez, A., Pushpitha, K., Mirzaei, M., Basavarajappa, D. K., Gupta, V. B., Sharma, S., You, Y., Galliciotti, G., et al. (2023) · Molecular Therapy · doi:10.1016/j.ymthe.2023.03.008 · Cited by 32
Extensive structural remodeling of the injured spinal cord revealed by phosphorylated MAP1B in sprouting axons and degenerating neurons
Soares, S., Barnat, M., Salim, C., von Boxberg, Y., Ravaille‐Veron, M., & Nothias, F. (2007) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2007.05794.x · Cited by 31
Effect of the Histone Deacetylase Inhibitor FRM-0334 on Progranulin Levels in Patients With Progranulin Gene Haploinsufficiency: A Randomized Clinical Trial
Ljubenkov, P. A., Edwards, L., Iaccarino, L., La Joie, R., Rojas, J. C., Koestler, M., Harris, B., Boeve, B. F., Borroni, B., van Swieten, J. C., et al. (2021) · JAMA Network Open · doi:10.1001/jamanetworkopen.2021.25584 · Cited by 30
Neurochemical biomarkers in the diagnosis of frontotemporal lobar degeneration: an update
Oeckl, P., Steinacker, P., Feneberg, E., & Otto, M. (2016) · Journal of Neurochemistry · doi:10.1111/jnc.13669 · Cited by 30
Brain network decoupling with increased serum neurofilament and reduced cognitive function in Alzheimer’s disease
Wheelock, M. D., Strain, J. F., Mansfield, P. K., Tu, J. C., Tanenbaum, A., Preische, O., Chhatwal, J. P., Cash, D. M., Cruchaga, C., Fagan, A. M., et al. (2023) · Brain · doi:10.1093/brain/awac498 · Cited by 31
Biofluid Biomarkers in Huntington’s Disease
Rodrigues, F. B., Byrne, L. M., & Wild, E. J. (2018) · Methods in molecular biology · doi:10.1007/978-1-4939-7825-0_17 · Cited by 30
Phosphorylated neurofilament heavy chain is a marker of neurodegeneration in Leber hereditary optic neuropathy (LHON).
Guy, J. R., Shaw, G., Ross‐Cisneros, F. N., Quirós, P. A., Salomão, S. R., Berezovsky, A., Carelli, V., Feuer, W. J., & Sadun, A. A. (2008) · PubMed Central · Cited by 30
Differential effects of neurodegeneration biomarkers on subclinical cognitive decline
Merluzzi, A. P., Vogt, N. M., Norton, D., Jonaitis, E. M., Clark, L. R., Carlsson, C. M., Johnson, S. C., Asthana, S., Blennow, K., Zetterberg, H., et al. (2019) · Alzheimer s & Dementia Translational Research & Clinical Interventions · doi:10.1016/j.trci.2019.02.004 · Cited by 28
Autoantibodies targeting neuronal proteins as biomarkers for neurodegenerative diseases
Kocurova, G., Říčný, J., & Ovsepian, S. V. (2022) · Theranostics · doi:10.7150/thno.72126 · Cited by 29
Post-Translational Modifications in the Rat Lumbar Spinal Cord in Experimental Autoimmune Encephalomyelitis
Grant, J. E., Hu, J., Liu, T., Jain, M. R., Elkabes, S., & Hong Li, A. (2007) · Journal of Proteome Research · doi:10.1021/pr070013c · Cited by 29
CHP1-Mediated NHE1 Biosynthetic Maturation Is Required for Purkinje Cell Axon Homeostasis
Liu, Y., Zaun, H. C., Orlowski, J., & Ackerman, S. L. (2013) · Journal of Neuroscience · doi:10.1523/jneurosci.0406-13.2013 · Cited by 29
CSF Neurofilament Light Chain Levels in Primary Progressive MS: Signs of Axonal Neurodegeneration
Pawlitzki, M., Schreiber, S., Bittner, D., Kreipe, J., Leypoldt, F., Rupprecht, K., Carare, R. O., Meuth, S. G., Vielhaber, S., & Körtvélyessy, P. (2018) · Frontiers in Neurology · doi:10.3389/fneur.2018.01037 · Cited by 28
APOE Genotype Specific Effects on the Early Neurodegenerative Sequelae Following Chronic Repeated Mild Traumatic Brain Injury
Muza, P. M., Bachmeier, C. J., Mouzon, B., Algamal, M., Rafi, N. G., Lungmus, C., Abdullah, L. I., Evans, J. E., Ferguson, S., MULLAN, M. J., et al. (2019) · Neuroscience · doi:10.1016/j.neuroscience.2019.01.049 · Cited by 28
Necroptosis inhibition counteracts neurodegeneration, memory decline, and key hallmarks of aging, promoting brain rejuvenation
Arrázola, M. S., Lira, M., Quiroz, G., Véliz‐Valverde, F., Iqbal, S., Eaton, S. L., Kline, R., Lamont, D. J., Huerta, H., Ureta, G., et al. (2023) · Aging Cell · doi:10.1111/acel.13814 · Cited by 32
Neurofilaments as a plasma biomarker for ICU-acquired weakness: an observational pilot study
Wieske, L., Witteveen, E., Petzold, A., Verhamme, C., Schultz, M. J., van Schaik, I. N., & Horn, J. (2014) · Critical Care · doi:10.1186/cc13699 · Cited by 28
Self-citation
Axonal damage in the making: Neurofilament phosphorylation, proton mobility and magnetisation transfer in multiple sclerosis normal appearing white matter
Petzold, A., Tozer, D., & Schmierer, K. (2011) · Experimental Neurology · doi:10.1016/j.expneurol.2011.09.011 · Cited by 31
Self-citation
Neurofilament light chain in the assessment of patients with multiple sclerosis
Domingues, R. B., Fernandes, G. B. P., Leite, F. B. V. D. M., & Senne, C. (2019) · Arquivos de Neuro-Psiquiatria · doi:10.1590/0004-282x20190060 · Cited by 27

Authors: Petzold, A.
Affiliations: UCL Queen Square Institute of Neurology (GB)
Corresponding author: Petzold, Axel
ORCID: Petzold, Axel
Venue: Journal of the Neurological Sciences
Publisher: Elsevier BV
Published: 2005-06
Volume: 233
Issue: 1-2
Pages: 183-198
ISSN: 0022-510X (ISSN-L)
DOI: 10.1016/j.jns.2005.03.015
OpenAlex: W2133652987
Cited by: 688
References: 135
Citations by year: 2026: 26 · 2025: 44 · 2024: 40 · 2023: 49 · 2022: 46 · 2021: 65 · 2020: 42 · 2019: 54 · 2018: 38 · 2017: 27 · 2016: 24 · 2015: 23 · 2014: 38 · 2013: 27 · 2012: 24
FWCI: 1.17
Type: journal article
Language: en
Open access: green
discovery.ucl.ac.uk
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Journal of the Neurological Sciences (publishedVersion)
PubMed (publishedVersion)
UCL Discovery (University College London) (submittedVersion)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Skin and Cellular Biology Research
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Hereditary Neurological Disorders
Health Sciences › Medicine › Clinical Neurology › Multiple Sclerosis Research Studies
Keywords: neurofilaments, axonal injury, axonal degeneration, surrogate markers, neurofilament assembly, multiple sclerosis, demyelinating disease, neurodegeneration
MeSH terms: Animals, Axons, Enzyme-Linked Immunosorbent Assay, Glycosylation, Humans, Immunohistochemistry, Models, Biological, Nerve Degeneration, Phosphorylation, Blotting, Western, Biomarkers, Neurofilament Proteins, Protein Isoforms

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Neurofilament phosphoforms: Surrogate markers for axonal injury, degeneration and loss

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Self-check

Citations

Cites

Cited by

Related

Metadata

Record

About these checks