Cited by 688Skin and Cellular Biology ResearchHereditary Neurological DisordersMultiple Sclerosis Research Studies

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Neurofilament phosphoforms: Surrogate markers for axonal injury, degeneration and loss

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Petzold, Axel·2005·Journal of the Neurological Sciences

DOI 10.1016/j.jns.2005.03.015

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Abstract

This review on the role of neurofilaments as surrogate markers for axonal degeneration in neurological diseases provides a brief background to protein synthesis, assembly, function and degeneration. Methodological techniques for quantification are described and a protein nomenclature is proposed. The relevance for recognising anti-neurofilament autoantibodies is noted. Pathological implications are discussed in view of immunocytochemical, cell-culture and genetic findings. With reference to the present symposium on multiple sclerosis, the current literature on body fluid levels of neurofilaments in demyelinating disease is summarised.

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Axonal transection in the lesions of multiple sclerosis
Trapp, B. D., Peterson, J., Ransohoff, R. M., Rudick, R., Mörk, S., & Bö, L. (1998) · New England Journal of Medicine · doi:10.1056/nejm199801293380502 · Cited by 4,029
The cell: a molecular approach
(1997) · Choice Reviews Online · doi:10.5860/choice.35-0264 · Cited by 1,465
Monoclonal antibodies distinguish phosphorylated and nonphosphorylated forms of neurofilaments in situ.
Sternberger, L. A., & Sternberger, N. H. (1983) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.80.19.6126 · Cited by 1,158
A Structural Scaffolding of Intermediate Filaments in Health and Disease
Fuchs, E. V., & Cleveland, D. W. (1998) · Science · doi:10.1126/science.279.5350.514 · Cited by 1,013
The slow component of axonal transport. Identification of major structural polypeptides of the axon and their generality among mammalian neurons.
Hoffman, P. N., & Lasek, R. J. (1975) · The Journal of Cell Biology · doi:10.1083/jcb.66.2.351 · Cited by 941
Local modulation of neurofilament phosphorylation, axonal caliber, and slow axonal transport by myelinating Schwann cells
de Waegh, S. M., Lee, V. M. ‐., & Brady, S. T. (1992) · Cell · doi:10.1016/0092-8674(92)90183-d · Cited by 743
Neurofilament gene expression: a major determinant of axonal caliber.
Hoffman, P. N., Cleveland, D. W., Griffin, J. W., Landes, P. W., Cowan, N. J., & Price, D. L. (1987) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.84.10.3472 · Cited by 719
A Mechanistic Analysis of Nondisruptive Axonal Injury: A Review
Maxwell, W. L., Povlishock, J. T., & Graham, D. I. (1997) · Journal of Neurotrauma · doi:10.1089/neu.1997.14.419 · Cited by 564
Increased expression of neurofilament subunit NF-L produces morphological alterations that resemble the pathology of human motor neuron disease
Xu, Z. (1993) · Cell · doi:10.1016/0092-8674(93)90157-l · Cited by 543
Minocycline Provides Neuroprotection Against N -Methyl- d -aspartate Neurotoxicity by Inhibiting Microglia
Tikka, T., & Koıstınaho, J. (2001) · The Journal of Immunology · doi:10.4049/jimmunol.166.12.7527 · Cited by 539

Show all 135 references

Research works printed but not linked: 2

Bö L, Grey matter pathology in early MS. In: Miller, DH, Filipi M, A.J. Thompson, editors. MAGNIMS Clinically Isolated Syndrome Workshop, The National Hospital for Neurology and Neurosurgery, Queen Square, London, WC1N 3BG, 22.–23. Jan. MS NMR Research, Unit, Department of Neuroinflammation; 2004.
Julien, 1999, Neurofilament functions in health and disease, Curr Opin Neurobiol, 9, 554, 10.1016/S0959-4388(99)00004-5 · DOI

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Authors: Petzold, A.
Affiliations: UCL Queen Square Institute of Neurology (GB)
Corresponding author: Petzold, Axel
ORCID: Petzold, Axel
Venue: Journal of the Neurological Sciences
Publisher: Elsevier BV
Published: 2005-06
Volume: 233
Issue: 1-2
Pages: 183-198
ISSN: 0022-510X (ISSN-L)
DOI: 10.1016/j.jns.2005.03.015
OpenAlex: W2133652987
Cited by: 688
References: 135
Citations by year: 2026: 26 · 2025: 44 · 2024: 40 · 2023: 49 · 2022: 46 · 2021: 65 · 2020: 42 · 2019: 54 · 2018: 38 · 2017: 27 · 2016: 24 · 2015: 23 · 2014: 38 · 2013: 27 · 2012: 24
FWCI: 1.17
Type: journal article
Language: en
Open access: green
discovery.ucl.ac.uk
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Journal of the Neurological Sciences (publishedVersion)
PubMed (publishedVersion)
UCL Discovery (University College London) (submittedVersion)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Skin and Cellular Biology Research
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Hereditary Neurological Disorders
Health Sciences › Medicine › Clinical Neurology › Multiple Sclerosis Research Studies
Keywords: neurofilaments, axonal injury, axonal degeneration, surrogate markers, neurofilament assembly, multiple sclerosis, demyelinating disease, neurodegeneration
MeSH terms: Animals, Axons, Enzyme-Linked Immunosorbent Assay, Glycosylation, Humans, Immunohistochemistry, Models, Biological, Nerve Degeneration, Phosphorylation, Blotting, Western, Biomarkers, Neurofilament Proteins, Protein Isoforms

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Neurofilament phosphoforms: Surrogate markers for axonal injury, degeneration and loss

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