The association between cognitive impairment and quality of life in patients with early multiple sclerosis
Abstract
Cognitive deficits are common in patients with multiple sclerosis (MS) and may be observed early in the course of the disease. Current knowledge about the association between cognitive impairment and health-related quality of life (HQOL) in patients with early MS is limited. We used a well-established battery of cognitive tests and standardized HQOL measures to examine the associations between overall and domain-specific cognitive performance and quality of life in patients with early MS. Ninety-two patients with CIS or MS diagnosed in the previous three years participating in the CLIMB Natural History Study underwent a neurologic examination, neuropsychological evaluation and quality of life assessment. Associations between cognitive scores and HQOL measures were examined. There were no differences between cognitively impaired versus unimpaired subjects on any of the HQOL measures. After controlling for depression, scores on tests of information processing speed were significantly associated with several measures of HQOL including physical well-being, fatigue, and social support. In all cases, correlations between HQOL and cognitive measures were mild. These findings were observed in patients with limited cognitive impairment and minimal physical disability. Our results suggest that cognitive remediation programs aimed at improving cognitive skills may also improve quality of life for patients with early MS.
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Quality of life is reduced in people with multiple sclerosis.
“Reductions in quality of life (QOL) exist among individuals with multiple sclerosis (MS).”
From Quality of life and psychological well-being in the early stages of multiple sclerosis (MS): importance of adopting a biopsychosocial model (2018) · cites this paper as [16]
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- Authors
- Glanz, B. I., Healy, B. C., Rintell, D. J., Jaffin, S. K., Bakshi, R., & Weiner, H. L.
- Affiliations
- Brigham and Women's Hospital (US)
- Corresponding author
- Glanz, Bonnie I.
- Venue
- Journal of the Neurological Sciences
- Publisher
- Elsevier BV
- Published
- 2010-03
- Volume
- 290
- Issue
- 1-2
- Pages
- 75-79
- ISSN
- 0022-510X (ISSN-L)
- OpenAlex
- W2055969760
- Cited by
- 124
- References
- 41
- Citations by year
- 2026: 3 · 2025: 5 · 2024: 5 · 2023: 6 · 2022: 5 · 2021: 9 · 2020: 5 · 2019: 3 · 2018: 13 · 2017: 7 · 2016: 11 · 2015: 10 · 2014: 5 · 2013: 6 · 2012: 13
- FWCI
- 7.07
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- Locations
- Journal of the Neurological Sciences (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Pathology and Forensic Medicine › Multiple Sclerosis Research Studies
- Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Cancer-related cognitive impairment studies
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Keywords
- multiple sclerosis, cognitive impairment, health-related quality of life, early multiple sclerosis, processing speed, cognitive remediation, fatigue, social support, physical well-being, depression, clinical trial participants
- MeSH terms
- Adaptation, Psychological, Adult, Cognition, Cognition Disorders, Depressive Disorder, Disability Evaluation, Fatigue, Female, Health Status, Health Surveys, Humans, Male, Middle Aged, Multiple Sclerosis, Neuropsychological Tests, Quality of Life, Severity of Illness Index, Social Support, Cognitive Behavioral Therapy, Disease Progression
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