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Cited by 169Long-Term Effects of COVID-19Infectious Encephalopathies and EncephalitisCOVID-19 Clinical Research Studies

The DOI matches its Crossref record; 15 of the 19 references it cites were found in a registry or an index.

Neurological manifestations and COVID-19: Experiences from a tertiary care center at the Frontline

Open access
Pinna, Pranusha, Grewal, Parneet, Hall, Julianne P., Tavarez, Tachira, Dafer, Rima M., Garg, Rajeev, Osteraas, Nicholas D., Pellack, Danielle R., Asthana, Anjali, Fegan, Kelsey, Patel, Vikram, Conners, James J., John, Sayona, Silva, Ivan Da·2020·Journal of the Neurological Sciences
DOI 10.1016/j.jns.2020.116969PMC PMC7832569
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Abstract

Objective To report neurological manifestations seen in patients hospitalized with Coronavirus disease 2019 (COVID-19) from a large academic medical center in Chicago, Illinois. Methods We retrospectively reviewed data records of 50 patients with COVID-19 who were evaluated by the neurology services from March 1, 2020 - April 30, 2020. Patients were categorized into 2 groups based on timing of developing neurological manifestations: the "Neuro first" group had neurological manifestations upon initial assessment, and the "COVID first" group developed neurological symptoms greater than 24 h after hospitalization. The demographics, comorbidities, disease severity and neurological symptoms and diagnoses of both groups were analyzed. Statistical analysis was performed to compare the two groups. Results A total of 50 patients (48% African American and 24% Latino) were included in the analysis. Most common neurological manifestations observed were encephalopathy (n = 30), cerebrovascular disease (n = 20), cognitive impairment (n = 13), seizures (n = 13), hypoxic brain injury (n = 7), dysgeusia (n = 5), and extraocular movement abnormalities (n = 5). The "COVID-19 first" group had more evidence of physiologic disturbances on arrival with a more severe/critical disease course (83.3% vs 53.8%, p 0.025). Conclusion Neurologic manifestations of COVID-19 are highly variable and can occur prior to the diagnosis of or as a complication of the viral infection. Despite similar baseline comorbidities and demographics, the COVID-19 patients who developed neurologic symptoms later in hospitalization had more severe disease courses. Differently from previous studies, we noted a high percentage of African American and Latino individuals in both groups.

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Authors
Pinna, P., Grewal, P., Hall, J. P., Tavarez, T., Dafer, R. M., Garg, R., Osteraas, N. D., Pellack, D. R., Asthana, A., Fegan, K., Patel, V., Conners, J. J., John, S., & Silva, I. D.
Affiliations
Rush University Medical Center (US)
Corresponding author
Pinna, Pranusha
ORCID
Venue
Journal of the Neurological Sciences
Publisher
Elsevier BV
Published
2020-08
Volume
415
Pages
116969
ISSN
0022-510X (ISSN-L)
DOI
10.1016/j.jns.2020.116969
PMC
PMC7832569
OpenAlex
W3033833391
Cited by
169
References
19
Citations by year
2026: 2 · 2025: 3 · 2024: 9 · 2023: 21 · 2022: 45 · 2021: 61 · 2020: 28
FWCI
16.78
Type
journal article
Language
en
Open access
Licence
Locations
  • Journal of the Neurological Sciences (publishedVersion)
  • PubMed Central (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Clinical Neurology › Long-Term Effects of COVID-19
  • Health Sciences › Medicine › Infectious Diseases › Infectious Encephalopathies and Encephalitis
  • Health Sciences › Medicine › Infectious Diseases › COVID-19 Clinical Research Studies
Keywords
COVID-19 pandemic, neurological symptoms, encephalopathy, cerebrovascular disease, cognitive impairment, seizures, hypoxic brain injury, dysgeusia, disease severity, racial disparities, African American patients, Hispanic patients
MeSH terms
Betacoronavirus, COVID-19, SARS-CoV-2, Chicago, Female, Humans, Male, Middle Aged, Nervous System Diseases, Pneumonia, Viral, Retrospective Studies, Time Factors, Comorbidity, Coronavirus Infections, Pandemics, Tertiary Care Centers

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