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Cited by 2,542COVID-19 Clinical Research StudiesLong-Term Effects of COVID-19SARS-CoV-2 and COVID-19 Research

Clinical, laboratory and imaging features of COVID-19: A systematic review and meta-analysis

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Rodriguez-Morales, Alfonso J., Cardona-Ospina, Jaime A., Gutiérrez-Ocampo, Estefanía, Villamizar-Peña, Rhuvi, Holguin-Rivera, Yeimer, Escalera-Antezana, Juan Pablo, Alvarado-Arnez, Lucia Elena, Bonilla-Aldana, D. Katterine +16 more·2020·Travel Medicine and Infectious Disease
DOI 10.1016/j.tmaid.2020.101623PMC PMC7102608

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Abstract

Introduction An epidemic of Coronavirus Disease 2019 (COVID-19) began in December 2019 in China leading to a Public Health Emergency of International Concern (PHEIC). Clinical, laboratory, and imaging features have been partially characterized in some observational studies. No systematic reviews on COVID-19 have been published to date. Methods We performed a systematic literature review with meta-analysis, using three databases to assess clinical, laboratory, imaging features, and outcomes of COVID-19 confirmed cases. Observational studies and also case reports, were included, and analyzed separately. We performed a random-effects model meta-analysis to calculate pooled prevalences and 95% confidence intervals (95%CI). Results 660 articles were retrieved for the time frame (1/1/2020-2/23/2020). After screening, 27 articles were selected for full-text assessment, 19 being finally included for qualitative and quantitative analyses. Additionally, 39 case report articles were included and analyzed separately. For 656 patients, fever (88.7%, 95%CI 84.5-92.9%), cough (57.6%, 95%CI 40.8-74.4%) and dyspnea (45.6%, 95%CI 10.9-80.4%) were the most prevalent manifestations. Among the patients, 20.3% (95%CI 10.0-30.6%) required intensive care unit (ICU), 32.8% presented with acute respiratory distress syndrome (ARDS) (95%CI 13.7-51.8), 6.2% (95%CI 3.1-9.3) with shock. Some 13.9% (95%CI 6.2-21.5%) of hospitalized patients had fatal outcomes (case fatality rate, CFR). Conclusion COVID-19 brings a huge burden to healthcare facilities, especially in patients with comorbidities. ICU was required for approximately 20% of polymorbid, COVID-19 infected patients and hospitalization was associated with a CFR of >13%. As this virus spreads globally, countries need to urgently prepare human resources, infrastructure and facilities to treat severe COVID-19.

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  • Patients can be in all suitable positions including prone, side-lying, upright, supine, and guided by the location of consolidations seen on imaging or found on examination [31].

    “However, the patients can be in all suitable positions including prone, side-lying, upright, supine, and guided by the location of consolidations seen on imaging or found on examination [31].”

    From Effects of short-term breathing exercises on respiratory recovery in patients with COVID-19: a quasi-experimental study (2022) · cites this paper as [31]

    The Results section, “Imaging, complications, and outcomes” (page unavailable), reports chest X-ray findings but does not discuss patient positioning. Searches for prone, side-lying, upright, and supine positions, and for positioning guided by consolidation location or examination, found no supporting passage in our copy. (LLM, conf=0.76)

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Authors
Rodriguez-Morales, A. J., Cardona-Ospina, J. A., Gutiérrez-Ocampo, E., Villamizar-Peña, R., Holguin-Rivera, Y., Escalera-Antezana, J. P., Alvarado-Arnez, L. E., Bonilla-Aldana, D. K., Franco-Paredes, C., Henao-Martinez, A. F., Paniz-Mondolfi, A., Lagos-Grisales, G. J., Ramírez-Vallejo, E., Suárez, J. A., Zambrano, L. I., Villamil-Gómez, W. E., Balbin-Ramon, G. J., Rabaan, A. A., Harapan, H., Dhama, K., Nishiura, H., Kataoka, H., Ahmad, T., & Sah, R.
Affiliations
  • Universidad Tecnológica de Pereira (CO)
  • Universidad Privada Franz Tamayo (BO)
  • National Autonomous University of Honduras (HN)
  • Universidad Científica del Sur (PE)
  • Saudi Aramco Medical Services Organization (SA)
  • Universitas Syiah Kuala (ID)
  • Indian Veterinary Research Institute (IN)
  • Hokkaido University (JP)
  • Hamamatsu University School of Medicine (JP)
  • Tribhuvan University Teaching Hospital (NP)
Corresponding author
Rodriguez-Morales, Alfonso J.
ORCID
Venue
Travel Medicine and Infectious Disease
Publisher
Elsevier BV
Published
2020-03
Volume
34
Pages
101623
ISSN
1477-8939 (ISSN-L)
DOI
10.1016/j.tmaid.2020.101623
PMC
PMC7102608
OpenAlex
W3009951436
Cited by
2,542
References
12
Citations by year
2026: 8 · 2025: 51 · 2024: 114 · 2023: 227 · 2022: 456 · 2021: 771 · 2020: 912 · 2019: 1
FWCI
27.95
Type
journal article
Language
en
Open access
Licence
Locations
  • Travel Medicine and Infectious Disease (publishedVersion)
  • Preprints.org (acceptedVersion, cc-by)
  • PubMed Central (publishedVersion)
  • PubMed (publishedVersion)
Funders
Universidad Tecnológica de Pereira
Topics
  • Health Sciences › Medicine › Infectious Diseases › COVID-19 Clinical Research Studies
  • Health Sciences › Medicine › Neurology › Long-Term Effects of COVID-19
  • Health Sciences › Medicine › Infectious Diseases › SARS-CoV-2 and COVID-19 Research
Keywords
COVID-19 pandemic, clinical features, laboratory findings, chest imaging, fever, cough, dyspnea, acute respiratory distress syndrome, shock, intensive care unit admission, case fatality rate, comorbidities, hospitalized patients
MeSH terms
Betacoronavirus, COVID-19, SARS-CoV-2, Cough, Fever, Hospitalization, Humans, Intensive Care Units, Pneumonia, Viral, Respiratory Distress Syndrome, Coronavirus Infections, Pandemics

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