Hypolipidemic Activity of Peony Seed Oil Rich in α-Linolenic, is Mediated Through Inhibition of Lipogenesis and Upregulation of Fatty Acid β-Oxidation
Abstract
Peony seed oil (PSO) is a new resource food rich in α-Linolenic Acid(ALA) (38.66%). The objective of this study was to assess the modulatory effect of PSO on lipid metabolism. Lard oil, safflower oil (SFO), and PSO were fed to wistar rats with 1% cholesterol in the diet for 60 d. Serum and liver lipids showed significant decrease in total cholesterol (TC), triglyceride (TG), and low density lipoprotein-cholesterol (LDL-C) levels in PSO fed rats compared to lard oil and SFO fed rats. ALA, eicosapentaenoic acid (EPA), and docosahexaenoic acid (DHA), contents were significantly increased, whereas linoleic acid (LA), arachidonic acid (AA) levels decreased in serum and liver of PSO fed rats. Feeding PSO increased ALA level and decreased n-6 to n-3 polyunsaturated fatty acid (PUFA) ratio. The hypolipidemic result of PSO indicated that PSO participated in the regulation of plasma lipid concentration and cholesterol metabolism in liver. The decreased expression of sterol regulatory element-binding proteins 1C (SREBP-1c), acetyl-CoA carboxylase (ACC), and fatty acid synthase (FAS)-reduced lipid synthesis; Activation of peroxisome proliferator-activator receptor (PPARα) accompanied by increase of uncoupling protein2 (UP2) and acyl-CoA oxidase (AOX) stimulated lipid metabolism and exerted an antiobesity effect via increasing energy expenditure for prevention of obesity.
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The concentration of α-linolenic acid slightly differed between the diet of group C and the IM-containing diets, and was lower in the IM-containing diets than in the diet of group C.
“Only the concentration of α-linolenic acid, which was reported to cause hypolipidemic effects in rats [32], slightly differed between the diet of group C and the IM-containing diets. However, since the dietary concentration of α-linolenic acid was even lower in the IM-containing diets than in diet of group C”
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Meyer, S., Schäfer, L., Röhrig, J., Maheshwari, G., Most, E., Zorn, H., Ringseis, R., Eder, K., & Gessner, D. K. (2020) · Nutrients · doi:10.3390/nu12040987 · Cited by 5 · see citing works
- Authors
- Su, J., Ma, C., Liu, C., Gao, C., Nie, R., & Wang, H.
- Affiliations
- Jiangnan University (CN)
- Anhui Tongling Ruipu Peony Industry Development Co., Ltd Anhui 244000 PR China
- Corresponding author
- Wang, Hongxin
- Venue
- Journal of Food Science
- Publisher
- Wiley
- Published
- 2016-03
- Volume
- 81
- Issue
- 4
- Pages
- H1001-9
- ISSN
- 0022-1147 (ISSN-L)
- 1750-3841
- OpenAlex
- W2288331010
- Cited by
- 62
- References
- 51
- Citations by year
- 2026: 4 · 2025: 6 · 2024: 4 · 2023: 13 · 2022: 8 · 2021: 4 · 2020: 11 · 2018: 7 · 2017: 4 · 2016: 1
- FWCI
- 4.18
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of Food Science (publishedVersion)
- PubMed (publishedVersion)
- Funders
- 125 Project (2012BAD33B05)
- Fundamental Research Funds for the Central Universities (JUSRP51501)
- Anhui Tongling Ruipu Peony Industry Development Co., Ltd.
- Topics
- Health Sciences › Nursing › Nutrition and Dietetics › Fatty Acid Research and Health
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Biochemistry › Lipid metabolism and biosynthesis
- Physical Sciences › Chemistry › Organic Chemistry › Edible Oils Quality and Analysis
- Keywords
- peony seed oil, alpha-linolenic acid, hypolipidemic effect, lipid metabolism, cholesterol metabolism, lipogenesis inhibition, fatty acid beta-oxidation, SREBP-1c, PPARα, acyl-CoA oxidase, UCP2, fatty acid synthase, acetyl-CoA carboxylase, serum cholesterol, triglycerides
- MeSH terms
- Uncoupling Protein 2, Animals, Hypolipidemic Agents, Energy Metabolism, Fatty Acids, Ion Channels, Lipids, Liver, Male, Obesity, Oxidation-Reduction, Plant Oils, Seeds, Up-Regulation, Rats, Wistar, alpha-Linolenic Acid, Mitochondrial Proteins, Paeonia, Acyl-CoA Oxidase, PPAR alpha, Lipogenesis, Sterol Regulatory Element Binding Protein 1
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