Increased Hepatic Myeloperoxidase Activity in Obese Subjects with Nonalcoholic Steatohepatitis
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Inflammation and oxidative stress are considered critical factors in the progression of nonalcoholic fatty liver disease. Myeloperoxidase (MPO) is an important neutrophil enzyme that can generate aggressive oxidants; therefore, we studied the association between MPO and nonalcoholic fatty liver disease. The distribution of inflammatory cells containing MPO in liver biopsies of 40 severely obese subjects with either nonalcoholic steatohepatitis (NASH) (n = 22) or simple steatosis (n = 18) was investigated by immunohistochemistry. MPO-derived oxidative protein modifications were identified by immunohistochemistry and correlated to hepatic gene expression of CXC chemokines and M1/M2 macrophage markers as determined by quantitative PCR. MPO plasma levels were determined by ELISA. The number of hepatic neutrophils and MPO-positive Kupffer cells was increased in NASH and was accompanied by accumulation of hypochlorite-modified and nitrated proteins, which can be generated by the MPO-H2O2 system. Liver CXC chemokine expression was higher in patients with accumulation of MPO-mediated oxidation products and correlated with hepatic neutrophil sequestration. Plasma MPO levels were elevated in NASH patients. Interestingly, neutrophils frequently surrounded steatotic hepatocytes, resembling the crown-like structures found in obese adipose tissue. Furthermore, hepatic M2 macrophage marker gene expression was increased in NASH. Our data indicate that accumulation of MPO-mediated oxidation products, partly derived from Kupffer cell MPO, is associated with induction of CXC chemokines and hepatic neutrophil infiltration and may contribute to the development of NASH.
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Levels of myeloperoxidases secreted by neutrophils are increased in the livers of MASH patients compared to the livers of patients with simple steatosis.
“Levels of myeloperoxidases (MPOs) secreted by neutrophils are increased in the livers of MASH patients compared to the livers of patients with simple steatosis(230).”
From The liver as a central "hub" of the immune system: pathophysiological implications (2025) · cites this paper as [230]
Cites
Obesity induces a phenotypic switch in adipose tissue macrophage polarization
Lumeng, C. N., Bodzin, J. L., & Saltiel, A. R. (2007) · Journal of Clinical Investigation · doi:10.1172/jci29881 · Cited by 4,664 · see citing works
Nonalcoholic Steatohepatitis: A Proposal for Grading and Staging The Histological Lesions
Brunt, E. M., Janney, C. G., Di Bisceglie, A. M., Neuschwander-Tetri, B. A., & Bacon, B. R. (1999) · American Journal of Gastroenterology · doi:10.1111/j.1572-0241.1999.01377.x · Cited by 3,907 · see citing works
DAMPs, PAMPs and alarmins: all we need to know about danger
Bianchi, M. E. (2007) · Journal of Leukocyte Biology · doi:10.1189/jlb.0306164 · Cited by 2,794 · see citing works
Cinti, S., Mitchell, G., Barbatelli, G., Murano, I., Ceresi, E., Faloia, E., Wang, S., Fortier, M., Greenberg, A. S., & Obin, M. S. (2005) · Journal of Lipid Research · doi:10.1194/jlr.m500294-jlr200 · Cited by 2,529 · see citing works
Myeloperoxidase: friend and foe
Klebanoff, S. J. (2005) · Journal of Leukocyte Biology · doi:10.1189/jlb.1204697 · Cited by 2,282 · see citing works
Nonalcoholic Steatohepatitis: Summary of An Aasld Single Topic Conference
Neuschwander‐Tetri, B. A., & Caldwell, S. H. (2003) · Hepatology · doi:10.1053/jhep.2003.50193 · Cited by 2,155 · see citing works
Obesity, Inflammation, and Insulin Resistance
Shoelson, S. E., Herrero, L., & Naaz, A. (2007) · Gastroenterology · doi:10.1053/j.gastro.2007.03.059 · Cited by 1,806 · see citing works
Formation of nitric oxide-derived inflammatory oxidants by myeloperoxidase in neutrophils
Eiserich, J. P., Hristova, M., Cross, C. E., Jones, A. D., Freeman, B. A., Halliwell, B., & van der Vliet, A. (1998) · Nature · doi:10.1038/34923 · Cited by 1,496 · see citing works
Yamaguchi, K., Yang, L., McCall, S. J., Huang, J., Yu, X. X., Pandey, S., Bhanot, S., Monia, B. P., Li, Y.-X., & Diehl, A. M. (2007) · Hepatology · doi:10.1002/hep.21655 · Cited by 1,019 · see citing works
Adipocyte Death, Adipose Tissue Remodeling, and Obesity Complications
Strissel, K. J., Stancheva, Z., Miyoshi, H., Perfield, J. W., DeFuria, J., Jick, Z., Greenberg, A. S., & Obin, M. S. (2007) · Diabetes · doi:10.2337/db07-0767 · Cited by 1,007 · see citing works
Boden, G. H. (2008) · Endocrinology and Metabolism Clinics of North America · doi:10.1016/j.ecl.2008.06.007 · Cited by 852 · see citing works
Alternative M2 Activation of Kupffer Cells by PPARδ Ameliorates Obesity-Induced Insulin Resistance
Odegaard, J. I., Ricardo-González, R. R., Eagle, A. R., Vats, D., Morel, C. R., Goforth, M. H., Subramanian, V., Mukundan, L., Ferrante, A. W., & Chawla, A. (2008) · Cell Metabolism · doi:10.1016/j.cmet.2008.04.003 · Cited by 840 · see citing works
Sugiyama, S., Okada, Y., Sukhova, G. K., Virmani, R., Heinecke, J. W., & Libby, P. (2001) · American Journal Of Pathology · doi:10.1016/s0002-9440(10)64036-9 · Cited by 699 · see citing works
Lotze, M. T., Zeh, H. J., Rubartelli, A., Sparvero, L. J., Amoscato, A. A., Washburn, N. R., DeVera, M., Liang, X., Tör, M., & Billiar, T. R. (2007) · Immunological Reviews · doi:10.1111/j.1600-065x.2007.00579.x · Cited by 634 · see citing works
Mammalian Heme Peroxidases: From Molecular Mechanisms to Health Implications
Davies, M. J., Hawkins, C. L., Pattison, D. I., & Rees, M. D. (2008) · Antioxidants and Redox Signaling · doi:10.1089/ars.2007.1927 · Cited by 556 · see citing works
Seki, S., Kitada, T., Yamada, T., Sakaguchi, H., Nakatani, K., & Wakasa, K. (2002) · Journal of Hepatology · doi:10.1016/s0168-8278(02)00073-9 · Cited by 523 · see citing works
Lipid-induced oxidative stress causes steatohepatitis in mice fed an atherogenic diet
Matsuzawa, N., Takamura, T., Kurita, S., Misu, H., Ota, T., Ando, H., Yokoyama, M., Honda, M., Zen, Y., Nakanuma, Y., et al. (2007) · Hepatology · doi:10.1002/hep.21874 · Cited by 516 · see citing works
Cytokines and Nash: A Pilot Study of the Effects of Lifestyle Modification and Vitamin E
Kugelmas, M., Hill, D. B., Vivian, B., Marsano, L. S., & McClain, C. J. (2003) · Hepatology · doi:10.1053/jhep.2003.50316 · Cited by 503 · see citing works
Formation of Nitrating and Chlorinating Species by Reaction of Nitrite with Hypochlorous Acid
Eiserich, J. P., Cross, C. E., Jones, A. D., Halliwell, B., & van der Vliet, A. (1996) · Journal of Biological Chemistry · doi:10.1074/jbc.271.32.19199 · Cited by 447 · see citing works
New vistas on macrophage differentiation and activation
Mantovani, A., Sica, A., & Locati, M. (2006) · European Journal of Immunology · doi:10.1002/eji.200636910 · Cited by 431 · see citing works
Myeloperoxidase: a target for new drug development?
Malle, E., Furtmüller, P. G., Sattler, W., & Obinger, C. (2007) · British Journal of Pharmacology · doi:10.1038/sj.bjp.0707358 · Cited by 411 · see citing works
Self-citationPalmitic acid induces production of proinflammatory cytokine interleukin-8 from hepatocytes
Joshi‐Barve, S., Barve, S. S., Amancherla, K., Gobejishvili, L., Hill, D. B., Cave, M. C., Hote, P., & McClain, C. J. (2007) · Hepatology · doi:10.1002/hep.21752 · Cited by 406 · see citing works
Berson, A., de Beco, V., Lettéron, P., Robin, M. A., Moreau, C., Elkahwaji, J. E., Verthier, N., Feldmann, G., Fromenty, B., & Pessayre, D. (1998) · Gastroenterology · doi:10.1016/s0016-5085(98)70590-6 · Cited by 402 · see citing works
Protein tyrosine nitration—Functional alteration or just a biomarker?
Souza, J. M., Peluffo, G., & Radí, R. (2008) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2008.04.010 · Cited by 394 · see citing works
Nonalcoholic Fatty Liver Disease: Cytokine-Adipokine Interplay and Regulation of Insulin Resistance
Tilg, H., & Hotamışlıgil, G. S. (2006) · Gastroenterology · doi:10.1053/j.gastro.2006.05.054 · Cited by 385 · see citing works
Schneider, J. J., Unholzer, A., Schaller, M., Schäfer‐Korting, M., & Körting, H. C. (2005) · Journal of Molecular Medicine · doi:10.1007/s00109-005-0657-1 · Cited by 378 · see citing works
Role of Neutrophils in the Pathogenesis of Acute Inflammatory Liver Injury
Ramaiah, S. K., & Jaeschke, H. (2007) · Toxicologic Pathology · doi:10.1080/01926230701584163 · Cited by 327 · see citing works
Zeyda, M., & Stulnig, T. M. (2007) · Immunology Letters · doi:10.1016/j.imlet.2007.07.003 · Cited by 307 · see citing works
Immunohistochemical and genetic evidence of myeloperoxidase involvement in multiple sclerosis
Nagra, R. M., Becher, B., Tourtellotte, W. W., Antel, J. P., Gold, D. P., Paladino, T., Smith, R. A., Nelson, J. R., & Reynolds, W. F. (1997) · Journal of Neuroimmunology · doi:10.1016/s0165-5728(97)00089-1 · Cited by 284 · see citing works
Neutrophil Activation in Morbid Obesity, Chronic Activation of Acute Inflammation
Nijhuis, J., Rensen, S. S., Slaats, Y., van Dielen, F. M. H., Buurman, W. A., & Greve, J. W. M. (2009) · Obesity · doi:10.1038/oby.2009.113 · Cited by 263 · see citing works
Self-citationGeorge, J., Pera, N., Phung, N., Leclercq, I. A., Hou, J. Y., & Farrell, G. C. (2003) · Journal of Hepatology · doi:10.1016/s0168-8278(03)00376-3 · Cited by 247 · see citing works
Malle, E., Waeg, G., Schreiber, R., Gröne, E. F., Sattler, W., & Gröne, H. (2000) · European Journal of Biochemistry · doi:10.1046/j.1432-1327.2000.01498.x · Cited by 245 · see citing works
Self-citationWillment, J. A., Lin, H.-H., Reid, D. M., Taylor, P. R., Williams, D. L., Wong, S. Y. C., Gordon, S., & Brown, G. D. (2003) · The Journal of Immunology · doi:10.4049/jimmunol.171.9.4569 · Cited by 238 · see citing works
Formation of Nitric Oxide–Derived Oxidants by Myeloperoxidase in Monocytes
Hazen, S. L., Zhang, R., Shen, Z., Wu, W., Podrez, E. A., MacPherson, J. C., Schmitt, D. C., Mitra, S. N., Mukhopadhyay, C., Chen, Y., et al. (1999) · Circulation Research · doi:10.1161/01.res.85.10.950 · Cited by 228 · see citing works
Oxidative damage to extracellular matrix and its role in human pathologies
Rees, M. D., Kennett, E. C., Whitelock, J. M., & Davies, M. J. (2008) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2008.03.016 · Cited by 206 · see citing works
Maher, J. J., León, P., & Ryan, J. C. (2008) · Hepatology · doi:10.1002/hep.22399 · Cited by 204 · see citing works
Hawkins, C. L., & Davies, M. J. (1999) · Biochemical Journal · doi:10.1042/bj3400539 · Cited by 201 · see citing works
Pathogenesis of Non-alcoholic Steatohepatitis: Human Data
Edmison, J. M., & McCullough, A. J. (2007) · Clinics in Liver Disease · doi:10.1016/j.cld.2007.02.011 · Cited by 193 · see citing works
van Dielen, F. M. H., Buurman, W. A., Hadfoune, M., Nijhuis, J., & Greve, J. W. (2004) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2003-032125 · Cited by 158 · see citing works
Self-citationMacdonald, G. A., Bridle, K. R., Ward, P. J., Walker, N. I., Houglum, K., George, D. K., Smith, J. L., Powell, L. W., Crawford, D. H., & Ramm, G. A. (2001) · Journal of Gastroenterology and Hepatology · doi:10.1046/j.1440-1746.2001.02445.x · Cited by 156 · see citing works
Brown, K. E., Brunt, E. M., & Heinecke, J. W. (2001) · American Journal Of Pathology · doi:10.1016/s0002-9440(10)63059-3 · Cited by 144 · see citing works
Ikura, Y., Ohsawa, M., Suekane, T., Fukushima, H., Itabe, H., Jomura, H., Nishiguchi, S., Inoue, T., Naruko, T., Ehara, S., et al. (2006) · Hepatology · doi:10.1002/hep.21070 · Cited by 140 · see citing works
Nitrotyrosine in plasma of celiac disease patients as detected by a new sandwich ELISA
ter Steege, J. C. A., Koster‐Kamphuis, L., van Straaten, E. A., Forget, P. P., & Buurman, W. A. (1998) · Free Radical Biology and Medicine · doi:10.1016/s0891-5849(98)00184-1 · Cited by 138 · see citing works
Self-citationMalle, E., Hazell, L. J., Stocker, R., Sattler, W., Esterbauer, H., & Waeg, G. (1995) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.15.7.982 · Cited by 136 · see citing works
Self-citationThe Role of Cytokines and Chemokines in the Development of Steatohepatitis
Lalor, P. F., Faint, J., Aarbodem, Y., Hübscher, S. G., & Adams, D. (2007) · Seminars in Liver Disease · doi:10.1055/s-2007-979470 · Cited by 128 · see citing works
Starring stellate cells in liver immunology
Winau, F., Breunig, C., Darmoise, A., & Kaufmann, S. H. E. (2007) · Current Opinion in Immunology · doi:10.1016/j.coi.2007.10.006 · Cited by 87 · see citing works
Kawai, Y., Kiyokawa, H., Kimura, Y., Kato, Y., Tsuchiya, K., & Terao, J. (2006) · Biochemistry · doi:10.1021/bi0610909 · Cited by 78 · see citing works
Gröne, H., Gröne, E. F., & Malle, E. (2002) · Laboratory Investigation · doi:10.1038/labinvest.3780390 · Cited by 72 · see citing works
Self-citationHypochlorite-Modified LDL: Chemotactic Potential and Chemokine Induction in Human Monocytes
Woenckhaus, C., Kaufmann, A. M., Bußfeld, D., Gemsa, D., Sprenger, H., & Gröne, H. (1998) · Clinical Immunology and Immunopathology · doi:10.1006/clin.1997.4453 · Cited by 46 · see citing works
Fragmentation of extracellular matrix by hypochlorous acid
Woods, A. A., & Davies, M. J. (2003) · Biochemical Journal · doi:10.1042/bj20030715 · Cited by 45 · see citing works
Phenotypic Change and Proliferation of Murine Kupffer Cells by Colony-Stimulating Factors
Hashimoto, S., YAMADA, M., Yanai, N., KAWASHIMA, T., & Motoyoshi, K. (1996) · Journal of Interferon & Cytokine Research · doi:10.1089/jir.1996.16.237 · Cited by 9 · see citing works
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Koyama, Y., & Brenner, D. A. (2017) · Journal of Clinical Investigation · doi:10.1172/jci88881 · Cited by 1,295 · see citing works
Neutrophils mediate insulin resistance in mice fed a high-fat diet through secreted elastase
Talukdar, S., Oh, D. Y., Bandyopadhyay, G. K., Li, D., Xu, J., McNelis, J., Lu, M. M., Li, P., Yan, Q., Zhu, Y., et al. (2012) · Nature Medicine · doi:10.1038/nm.2885 · Cited by 966 · see citing works
The role of macrophages in nonalcoholic fatty liver disease and nonalcoholic steatohepatitis
Kazankov, K., Jørgensen, S. M. D., Thomsen, K. L., Møller, H. J., Vilstrup, H., George, J., Schuppan, D., & Grønbæk, H. (2019) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/s41575-018-0082-x · Cited by 941 · see citing works
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Diverse novel functions of neutrophils in immunity, inflammation, and beyond
Mócsai, A. (2013) · The Journal of Experimental Medicine · doi:10.1084/jem.20122220 · Cited by 679 · see citing works
Immune cell-mediated features of non-alcoholic steatohepatitis
Huby, T., & Gautier, E. L. (2022) · Nature Reviews Immunology · doi:10.1038/s41577-021-00639-3 · Cited by 573 · see citing works
Peiseler, M., Schwabe, R., Hampe, J., Kubes, P., Heikenwälder, M., & Tacke, F. (2022) · Journal of Hepatology · doi:10.1016/j.jhep.2022.06.012 · Cited by 564 · see citing works
van der Windt, D. J., Sud, V., Zhang, H., Varley, P. R., Goswami, J., Yazdani, H. O., Tohme, S. T., Loughran, P., O'Doherty, R. M., Minervini, M. I., et al. (2018) · Hepatology · doi:10.1002/hep.29914 · Cited by 482 · see citing works
Kwok, R., Tse, Y. ‐., Wong, G. L. ‐., Ha, Y., Lee, A. U., Ngu, M. C., Chan, H. L. ‐., & Wong, V. W. ‐. (2014) · Alimentary Pharmacology & Therapeutics · doi:10.1111/apt.12569 · Cited by 405 · see citing works
Oxidative Stress as a Critical Factor in Nonalcoholic Fatty Liver Disease Pathogenesis
Spahis, S., DELVIN, E. E., Borys, J.-M., & Levy, E. H. (2016) · Antioxidants and Redox Signaling · doi:10.1089/ars.2016.6776 · Cited by 386 · see citing works
Non-alcoholic fatty liver disease: The diagnosis and management
El-Kader, S. M. A. (2015) · World Journal of Hepatology · doi:10.4254/wjh.v7.i6.846 · Cited by 381 · see citing works
Zhao, Z., Xin, F., Xue, Y., Hu, Z., Han, Y., Ma, F., Zhou, D., Liu, X., Cui, A., Liu, Z., et al. (2019) · Experimental & Molecular Medicine · doi:10.1038/s12276-019-0304-5 · Cited by 353 · see citing works
Kupffer cell activation is a causal factor for hepatic insulin resistance
Lanthier, N., Molendi‐Coste, O., Horsmans, Y., van Rooijen, N., Cani, P. D., & Leclercq, I. A. (2009) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00391.2009 · Cited by 258 · see citing works
IL-17 Signaling Accelerates the Progression of Nonalcoholic Fatty Liver Disease in Mice
Harley, I. T. W., Stankiewicz, T. E., Giles, D. A., Softic, S., Flick, L. M., Cappelletti, M., Sheridan, R. M., Xanthakos, S. A., Steinbrecher, K. A., Sartor, R. B., et al. (2013) · Hepatology · doi:10.1002/hep.26746 · Cited by 252 · see citing works
Tanwar, S., Rhodes, F., Srivastava, A., Trembling, P. M., & Rosenberg, W. M. (2020) · World Journal of Gastroenterology · doi:10.3748/wjg.v26.i2.109 · Cited by 253 · see citing works
Meakin, P. J., Chowdhry, S., Sharma, R. S., Ashford, F. B., Walsh, S. V., McCrimmon, R. J., Dinkova‐Kostova, A. T., Dillon, J. F., Hayes, J. D., & Ashford, M. L. J. (2014) · Molecular and Cellular Biology · doi:10.1128/mcb.00677-14 · Cited by 229 · see citing works
Nonalcoholic fatty liver disease in adults: current concepts in etiology, outcomes, and management
Marjot, T., Moolla, A., Cobbold, J. F., Hodson, L., & Tomlinson, J. W. (2020) · Endocrine Reviews · doi:10.1210/endrev/bnz009 · Cited by 228 · see citing works
Non-Alcoholic Steatohepatitis: A Review of Its Mechanism, Models and Medical Treatments
Peng, C. Y., Stewart, A. G., Woodman, O. L., Ritchie, R. H., & Qin, C. X. (2020) · Frontiers in Pharmacology · doi:10.3389/fphar.2020.603926 · Cited by 225 · see citing works
Pathogenesis of nonalcoholic steatohepatitis
Liu, W., Baker, R. D., Bhatia, T., Zhu, L., & Baker, S. S. (2016) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-016-2161-x · Cited by 225 · see citing works
Liver fibrosis in NAFLD/NASH: from pathophysiology towards diagnostic and therapeutic strategies
Parola, M., & Pinzani, M. (2023) · Molecular Aspects of Medicine · doi:10.1016/j.mam.2023.101231 · Cited by 226 · see citing works
Recent advances in nonalcoholic fatty liver disease
Cheung, O., & Sanyal, A. J. (2009) · Current Opinion in Gastroenterology · doi:10.1097/mog.0b013e3283294a18 · Cited by 218 · see citing works
Itoh, M., Kato, H., Suganami, T., Konuma, K., Marumoto, Y., Terai, S., Sakugawa, H., Kanai, S., Hamaguchi, M., Fukaishi, T., et al. (2013) · PLoS ONE · doi:10.1371/journal.pone.0082163 · Cited by 211 · see citing works
Ye, D., Yang, K., Zang, S., Lin, Z., Chau, H.-T., Wang, Y., Zhang, J., Shi, J., Xu, A., Lin, S., et al. (2016) · Journal of Hepatology · doi:10.1016/j.jhep.2016.05.041 · Cited by 197 · see citing works
Immune and inflammatory pathways in NASH
Ganz, M., & Szabó, G. (2013) · Hepatology International · doi:10.1007/s12072-013-9468-6 · Cited by 188 · see citing works
Dendritic Cells Limit Fibroinflammatory Injury in Nonalcoholic Steatohepatitis in Mice
Henning, J. R., Graffeo, C. S., Rehman, A., Fallon, N. C., Zambirinis, C. P., Ochi, A., Barilla, R., Jamal, M., Deutsch, M., Greco, S., et al. (2013) · Hepatology · doi:10.1002/hep.26267 · Cited by 185 · see citing works
Neutrophils in liver diseases: pathogenesis and therapeutic targets
Liu, K., Wang, F., & Xu, R. (2020) · Cellular and Molecular Immunology · doi:10.1038/s41423-020-00560-0 · Cited by 177 · see citing works
Nonalcoholic fatty liver disease: A main driver of insulin resistance or a dangerous liaison?
Gruben, N., Shiri‐Sverdlov, R., Koonen, D. P. Y., & Hofker, M. H. (2014) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2014.08.004 · Cited by 153 · see citing works
Dapagliflozin slows the progression of the renal and liver fibrosis associated with type 2 diabetes
Tang, L., Wu, Y., Tian, M., Sjöström, C. D., Johansson, U., Peng, X.-R., Smith, D. M., & Huang, Y. (2017) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00086.2017 · Cited by 150 · see citing works
Gambino, R., Musso, G., & Cassader, M. (2010) · Antioxidants and Redox Signaling · doi:10.1089/ars.2009.3058 · Cited by 146 · see citing works
Pulli, B., Ali, M., Iwamoto, Y., Zeller, M. W. G., Schob, S., Linnoila, J. J., & Chen, J. W. (2015) · Antioxidants & Redox Signaling · doi:10.1089/ars.2014.6108 · Cited by 143 · see citing works
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Obesity and gastrointestinal cancer: the interrelationship of adipose and tumour microenvironments
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Nati, M., Haddad, D., Birkenfeld, A. L., Koch, C. A., Chavakis, T., & Chatzigeorgiou, A. (2016) · Reviews in Endocrine and Metabolic Disorders · doi:10.1007/s11154-016-9339-2 · Cited by 132 · see citing works
Ganji, S. H., Kashyap, M. L., & Kamanna, V. S. (2015) · Metabolism · doi:10.1016/j.metabol.2015.05.002 · Cited by 131 · see citing works
Reiniers, M. J., van Golen, R. F., van Gulik, T. M., & Heger, M. (2013) · Antioxidants and Redox Signaling · doi:10.1089/ars.2013.5486 · Cited by 131 · see citing works
Molecular imaging of fibrosis: recent advances and future directions
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Keleher, M. R., Zaidi, R., Shah, S., Oakley, M. E., Pavlatos, C., Idrissi, S. E., Xing, X., Li, D., Wang, T., & Cheverud, J. M. (2018) · PLoS ONE · doi:10.1371/journal.pone.0192606 · Cited by 122 · see citing works
Mesenchymal Stem Cell-Derived Extracellular Vesicles in Liver Immunity and Therapy
Wu, R., Fan, X., Wang, Y., Shen, M., Zheng, Y., Zhao, S., & Yang, L. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.833878 · Cited by 123 · see citing works
Rouault, C., Pellegrinelli, V., Schilch, R., Cotillard, A., Poitou, C., Tordjman, J., Sell, H., Clément, K., & Lacasa, D. (2013) · Endocrinology · doi:10.1210/en.2012-1415 · Cited by 119 · see citing works
Rehg, J. E., Bush, D. A., & Ward, J. M. (2012) · Toxicologic Pathology · doi:10.1177/0192623311430695 · Cited by 117 · see citing works
Rensen, S. S., Bieghs, V., Xanthoulea, S., Arfianti, E., Bakker, J. A., Shiri-Sverdlov, R., Hofker, M. H., Greve, J. W., & Buurman, W. A. (2012) · PLoS ONE · doi:10.1371/journal.pone.0052411 · Cited by 116 · see citing works
Self-citationZhang, P.-W., Chen, F.-X., Li, D., Ling, W.-H., & Guo, H.-H. (2015) · Medicine · doi:10.1097/md.0000000000000758 · Cited by 116 · see citing works
Comparative reactivity of myeloperoxidase-derived oxidants with mammalian cells
Rayner, B. S., Love, D. T., & Hawkins, C. L. (2014) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2014.03.004 · Cited by 114 · see citing works
Crosstalk Between Liver Macrophages and Surrounding Cells in Nonalcoholic Steatohepatitis
Li, H., Zhou, Y., Wang, H., Zhang, M., Qiu, P., Zhang, M., Zhang, R., Zhao, Q., & Liu, J. (2020) · Frontiers in Immunology · doi:10.3389/fimmu.2020.01169 · Cited by 114 · see citing works
Myeloperoxidase: Bridging the gap in neurodegeneration
Ray, R. S., & Katyal, A. (2016) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2016.06.031 · Cited by 114 · see citing works
Gaens, K. H. J., Niessen, P. M. G., Rensen, S. S., Buurman, W. A., Greve, J. W. M., Driessen, A., Wolfs, M. G. M., Hofker, M. H., Bloemen, J. G., Dejong, C. H., et al. (2012) · Journal of Hepatology · doi:10.1016/j.jhep.2011.07.028 · Cited by 109 · see citing works
Self-citationLebeaupin, C., Vallée, D., Rousseau, D., Patouraux, S., Bonnafous, S., Adam, G., Luciano, F., Luci, C., Anty, R., Iannelli, A., et al. (2018) · Hepatology · doi:10.1002/hep.29847 · Cited by 108 · see citing works
Magee, N. S., Zou, A., & Zhang, Y. (2016) · BioMed Research International · doi:10.1155/2016/5170402 · Cited by 108 · see citing works
Low-Density Lipoprotein Modified by Myeloperoxidase in Inflammatory Pathways and Clinical Studies
Delporte, C., Antwerpen, P. V., Vanhamme, L., Roumeguère, T., & Boudjeltia, K. Z. (2013) · Mediators of Inflammation · doi:10.1155/2013/971579 · Cited by 108 · see citing works
Non-alcoholic steatohepatitis: The role of oxidized low-density lipoproteins
Walenbergh, S. M. A., Koek, G. H., Bieghs, V., & Shiri‐Sverdlov, R. (2012) · Journal of Hepatology · doi:10.1016/j.jhep.2012.11.014 · Cited by 101 · see citing works
Self-citationNASH and atherosclerosis are two aspects of a shared disease: Central role for macrophages
Bieghs, V., Rensen, P. C. N., Hofker, M. H., & Shiri‐Sverdlov, R. (2011) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2011.08.041 · Cited by 96 · see citing works
Self-citationTwo Faces of Neutrophils in Liver Disease Development and Progression
Cho, Y., & Szabó, G. (2020) · Hepatology · doi:10.1002/hep.31680 · Cited by 98 · see citing works
The Roles of Neutrophils in the Pathogenesis of Liver Diseases
Tang, J., Yan, Z.-J., Feng, Q., Yu, L., & Wang, H. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.625472 · Cited by 96 · see citing works
The Role of Myeloid-Derived Cells in the Progression of Liver Disease
Weston, C. J., Zimmermann, H. W., & Adams, D. (2019) · Frontiers in Immunology · doi:10.3389/fimmu.2019.00893 · Cited by 91 · see citing works
Bieghs, V., van Gorp, P. J., Walenbergh, S. M. A., Gijbels, M. J., Verheyen, F., Buurman, W. A., Briles, D. E., Hofker, M. H., Binder, C. J., & Shiri‐Sverdlov, R. (2012) · Hepatology · doi:10.1002/hep.25660 · Cited by 94 · see citing works
Self-citationMyeloperoxidase and elastase are only expressed by neutrophils in normal and in inflammed liver
Amanzada, A., Malik, I. A., Nischwitz, M., Sultan, S., Naz, N., & Ramadori, G. P. (2011) · Histochemistry and Cell Biology · doi:10.1007/s00418-011-0787-1 · Cited by 94 · see citing works
Oxidative Stress and Pro-Inflammatory Status in Patients with Non-Alcoholic Fatty Liver Disease
Monserrat-Mesquida, M., Quetglas‐Llabrés, M. M., Abbate, M., Montemayor, S., Mascaró, C. M., Casares, M., Tejada, S., Abete, I., Zulet, M. Á., Tur, J. A., et al. (2020) · Antioxidants · doi:10.3390/antiox9080759 · Cited by 93 · see citing works
Atanasovska, B., Rensen, S. S., van der Sijde, M. R., Marsman, G., Kumar, V., Jonkers, I. H., Withoff, S., Shiri‐Sverdlov, R., Greve, J. W. M., Faber, K. N., et al. (2017) · Hepatology · doi:10.1002/hep.29034 · Cited by 86 · see citing works
Self-citationRole of Neutrophils in the Pathogenesis of Nonalcoholic Steatohepatitis
Hwang, S., Yun, H., Moon, S., Cho, Y. E., & Gao, B. (2021) · Frontiers in Endocrinology · doi:10.3389/fendo.2021.751802 · Cited by 84 · see citing works
Association of obesity with leukocyte count in obese individuals without metabolic syndrome
Ryder, E., Diez‐Ewald, M., Mosquera, J., Fernández, É., Pedreáñez, A. B., Vargas, R., Peña, C., & Fernández, N. (2014) · Diabetes & Metabolic Syndrome Clinical Research & Reviews · doi:10.1016/j.dsx.2014.09.002 · Cited by 84 · see citing works
Liang, W., Lindeman, J. H. N., Menke, A. L., Koonen, D. P. Y., Morrison, M. C., Havekes, L. M., van den Hoek, A. M., & Kleemann, R. (2014) · Laboratory Investigation · doi:10.1038/labinvest.2014.11 · Cited by 83 · see citing works
Zang, S., Wang, L., Ma, X., Zhu, G., Zhuang, Z., Xun, Y., Zhao, F., Yang, W., Liu, J., Luo, Y., et al. (2015) · Cell Biochemistry and Biophysics · doi:10.1007/s12013-015-0682-9 · Cited by 80 · see citing works
The “Domino effect” in MASLD: The inflammatory cascade of steatohepatitis
Mladenić, K., Lenartić, M., Marinović, S., Polić, B., & Wensveen, F. M. (2024) · European Journal of Immunology · doi:10.1002/eji.202149641 · Cited by 76 · see citing works
Solari, N. E. F., Inzaugarat, M. E., Baz, P., Matteo, E. D., Lezama, C., Galoppo, M., Galoppo, C., & Cherñavsky, A. C. (2012) · Journal of Clinical Immunology · doi:10.1007/s10875-011-9635-2 · Cited by 78 · see citing works
Naturally Occurring Organohalogen Compounds—A Comprehensive Review
Gribble, G. W. (2023) · Fortschritte der Chemie Organischer Naturstoffe/Fortschritte der Chemie organischer Naturstoffe/Progress in the chemistry of organic natural products · doi:10.1007/978-3-031-26629-4_1 · Cited by 80 · see citing works
Chung, M., Park, H. J., Manautou, J. E., Koo, S. I., & Bruno, R. S. (2011) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2011.01.001 · Cited by 77 · see citing works
Fatty Liver Disease-Alcoholic and Non-Alcoholic: Similar but Different
Malnick, S. D. H., Alin, P., Somin, M., & Neuman, M. G. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms232416226 · Cited by 73 · see citing works
Zhao, E., Cheng, Y., Yu, C., Li, H., & Fan, X. (2023) · Annals of Medicine · doi:10.1080/07853890.2023.2197652 · Cited by 72 · see citing works
The Role of Innate Immune Cells in Nonalcoholic Fatty Liver Disease
Nati, M., Chung, K., & Chavakis, T. (2021) · Journal of Innate Immunity · doi:10.1159/000518407 · Cited by 75 · see citing works
Hepatic Macrophage as a Key Player in Fatty Liver Disease
Xu, L., Liu, W., Bai, F., Xu, Y., Liang, X., Ma, C., & Gao, L. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.708978 · Cited by 72 · see citing works
Immunomodulatory functions of FXR
Fiorucci, S., Zampella, A., Ricci, P., Distrutti, E., & Biagioli, M. (2022) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2022.111650 · Cited by 73 · see citing works
Mitochondria and Redox Signaling in Steatohepatitis
Morris, E. M., Rector, R. S., Thyfault, J. P., & Ibdah, J. A. (2010) · Antioxidants and Redox Signaling · doi:10.1089/ars.2010.3795 · Cited by 71 · see citing works
The immune landscape in nonalcoholic steatohepatitis
Narayanan, S., Surette, F. A., & Hahn, Y. S. (2016) · Immune Network · doi:10.4110/in.2016.16.3.147 · Cited by 64 · see citing works
Nonalcoholic Fatty Liver Disease and the Coronary Artery Disease
Treeprasertsuk, S., López-Jiménez, F. A., & Lindor, K. D. (2010) · Digestive Diseases and Sciences · doi:10.1007/s10620-010-1241-2 · Cited by 69 · see citing works
The Interplay Between Tissue Niche and Macrophage Cellular Metabolism in Obesity
Daemen, S., & Schilling, J. D. (2020) · Frontiers in Immunology · doi:10.3389/fimmu.2019.03133 · Cited by 65 · see citing works
Macrophages in metabolic associated fatty liver disease
Alharthi, J., Latchoumanin, O., George, J., & Eslam, M. (2020) · World Journal of Gastroenterology · doi:10.3748/wjg.v26.i16.1861 · Cited by 65 · see citing works
The microcirculation in adipose tissue inflammation
Scalia, R. G. (2013) · Reviews in Endocrine and Metabolic Disorders · doi:10.1007/s11154-013-9236-x · Cited by 65 · see citing works
Immunological Mechanisms in the Pathophysiology of Non-Alcoholic Steatohepatitis
Vonghia, L., Michielsen, P. P., & Francque, S. (2013) · International Journal of Molecular Sciences · doi:10.3390/ijms141019867 · Cited by 64 · see citing works
Morrison, M. C., Mulder, P., Salic, K., Verheij, J., Liang, W., van Duyvenvoorde, W., Menke, A. L., Kooistra, T., Kleemann, R., & Wielinga, P. Y. (2016) · International Journal of Obesity · doi:10.1038/ijo.2016.74 · Cited by 63 · see citing works
Role of Selenoprotein W in participating in the progression of non-alcoholic fatty liver disease
Miao, Z., Wang, W., Miao, Z., Cao, Q., & Xu, S. (2024) · Redox Biology · doi:10.1016/j.redox.2024.103114 · Cited by 62 · see citing works
Ibusuki, R., Uto, H., Arima, S., Mawatari, S., Setoguchi, Y., Iwashita, Y., Hashimoto, S., Maeda, T., Tanoue, S., Kanmura, S., et al. (2013) · Liver International · doi:10.1111/liv.12203 · Cited by 61 · see citing works
Hepatic Immune Microenvironment in Alcoholic and Nonalcoholic Liver Disease
Byun, J., & Yi, H.-S. (2017) · BioMed Research International · doi:10.1155/2017/6862439 · Cited by 57 · see citing works
Fat-laden macrophages modulate lobular inflammation in nonalcoholic steatohepatitis (NASH)
Jindal, A., Bruzzì, S., Sutti, S., Locatelli, I., Bozzola, C., Paternostro, C., Parola, M., & Albano, E. (2015) · Experimental and Molecular Pathology · doi:10.1016/j.yexmp.2015.06.015 · Cited by 60 · see citing works
Fukushima, H., Yamashina, S., Arakawa, A., Taniguchi, G., Aoyama, T., Uchiyama, A., Kon, K., Ikejima, K., & Watanabe, S. (2018) · Hepatology Research · doi:10.1111/hepr.13071 · Cited by 59 · see citing works
Moayedfard, Z., Sani, F., Alizadeh, A. A., Lankarani, K. B., Zarei, M., & Azarpira, N. (2022) · Stem Cell Research & Therapy · doi:10.1186/s13287-022-02929-6 · Cited by 59 · see citing works
Shamsuzzaman, S., Deaton, R. A., Salamon, A., Doviak, H., Serbulea, V., Milosek, V. M., Evans, M. A., Karnewar, S., Saibaba, S., Alencar, G. F., et al. (2024) · Circulation · doi:10.1161/circulationaha.123.067931 · Cited by 58 · see citing works
Advances in functional and molecular MRI technologies in chronic liver diseases
Zhou, I. Y., Catalano, O. A., & Caravan, P. D. (2020) · Journal of Hepatology · doi:10.1016/j.jhep.2020.06.020 · Cited by 58 · see citing works
Zhang, Z., Wang, S., Zhu, Z., & Nie, B. (2023) · Computers in Biology and Medicine · doi:10.1016/j.compbiomed.2023.106724 · Cited by 57 · see citing works
Niacin for treatment of nonalcoholic fatty liver disease (NAFLD): novel use for an old drug?
Kashyap, M. L., Ganji, S. H., Nakra, N. K., & Kamanna, V. S. (2019) · Journal of clinical lipidology · doi:10.1016/j.jacl.2019.10.006 · Cited by 55 · see citing works
Neutrophil heterogeneity and plasticity: unveiling the multifaceted roles in health and disease
He, W., Yan, L., Hu, D., Hao, J., Liou, Y., & Luo, G. (2025) · MedComm · doi:10.1002/mco2.70063 · Cited by 55 · see citing works
Wu, L., Gao, X., Guo, Q., Li, J., Yao, J., Yan, K., Xu, Y., Jiang, X., Ye, D., & Guo, J. (2020) · Hepatology International · doi:10.1007/s12072-020-10081-7 · Cited by 52 · see citing works
Molden, E. (2021) · Expert Opinion on Drug Metabolism & Toxicology · doi:10.1080/17425255.2021.1974400 · Cited by 55 · see citing works
The liver as a central "hub" of the immune system: pathophysiological implications
Ronca, V., Gerussi, A., Collins, P., Parente, A., Oo, Y. H., & Invernizzi, P. (2025) · Physiological Reviews · doi:10.1152/physrev.00004.2023 · Cited by 59 · see citing works
Reversal of high-fat diet-induced hepatic steatosis by n-3 LCPUFA: Role of PPAR-α and SREBP-1c
Dossi, C. G., Tapia, G. S., Espinosa, A., Videla, L. A., & D'Espessailles, A. (2014) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2014.04.011 · Cited by 51 · see citing works
Yang, Y., Lu, H.-H., Wang, W.-T., & Liau, I. (2011) · Analytical Chemistry · doi:10.1021/ac202077x · Cited by 51 · see citing works
Complement Alternative Pathway Activation in Human Nonalcoholic Steatohepatitis
Segers, F. M., Verdam, F. J., de Jonge, C., Boonen, B., Driessen, A., Shiri-Sverdlov, R., Bouvy, N. D., Greve, J. W. M., Buurman, W. A., & Rensen, S. S. (2014) · PLoS ONE · doi:10.1371/journal.pone.0110053 · Cited by 50 · see citing works
Self-citationMeyer, M., Schwärzler, J., Jukic, A., & Tilg, H. (2024) · Biomolecules · doi:10.3390/biom14040476 · Cited by 50 · see citing works
Rahman, M. M., Muse, A. Y., Khan, D. M. I. O., Ahmed, I. H., Subhan, N., Reza, H. M., Alam, M. A., Nahar, L., & Sarker, S. D. (2017) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2017.05.101 · Cited by 50 · see citing works
Therapeutic Targeting of Myeloperoxidase Attenuates NASH in Mice
Koop, A. C., Thiele, N. D., Steins, D., Michaëlsson, E., Wehmeyer, M., Scheja, L., Steglich, B., Huber, S., Schulze zur Wiesch, J., Lohse, A. W., et al. (2020) · Hepatology Communications · doi:10.1002/hep4.1566 · Cited by 48 · see citing works
- Authors
- Rensen, S. S., Slaats, Y., Nijhuis, J., Jans, A., Bieghs, V., Driessen, A., Malle, E., Greve, J. W., & Buurman, W. A.
- Affiliations
- Maastricht University Medical Centre (NL)
- Medical University of Graz (AT)
- Corresponding author
- Rensen, Sander S.
- Venue
- The American Journal of Pathology
- Publisher
- Elsevier BV
- Published
- 2009-10
- Volume
- 175
- Issue
- 4
- Pages
- 1473-1482
- ISSN
- 0002-9440 (ISSN-L)
- PMC
- PMC2751544
- OpenAlex
- W2009998546
- Cited by
- 290
- References
- 51
- Citations by year
- 2026: 7 · 2025: 19 · 2024: 33 · 2023: 22 · 2022: 31 · 2021: 21 · 2020: 23 · 2019: 14 · 2018: 16 · 2017: 9 · 2016: 21 · 2015: 16 · 2014: 11 · 2013: 15 · 2012: 13
- FWCI
- 7.19
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- American Journal Of Pathology (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Research Publications (Maastricht University) (publishedVersion, other-oa)
- Research Publications (Maastricht University) (submittedVersion, other-oa)
- Funders
- Austrian Science Fund (P19074-B05)
- Topics
- Health Sciences › Medicine › Epidemiology › Liver Disease Diagnosis and Treatment
- Life Sciences › Immunology and Microbiology › Immunology › Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Health Sciences › Medicine › Hepatology › Liver physiology and pathology
- Keywords
- myeloperoxidase, nonalcoholic steatohepatitis, non-alcoholic fatty liver disease, obesity, Kupffer cells, oxidative stress, CXC chemokines, M2 macrophages, nitrated proteins, liver inflammation
- MeSH terms
- Adult, Alcohols, Cell Count, Fatty Liver, Female, Humans, Hypochlorous Acid, Kupffer Cells, Liver, Male, Peroxidase, Neutrophils, Nitrates, Obesity, Phenotype, Biomarkers, Chemokines, CXC
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