Cited by 121Phytochemicals and Medicinal PlantsNatural Antidiabetic Agents StudiesMedicinal Plants and Neuroprotection

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Susceptibility of hippocampus and cerebral cortex to oxidative damage in streptozotocin treated mice: prevention by extracts of Withania somnifera and Aloe vera

Parihar, M.S, Chaudhary, Madhulika, Shetty, Rajani, Hemnani, Taruna·2004·Journal of Clinical Neuroscience

DOI 10.1016/j.jocn.2003.09.008

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Abstract

Diabetes mellitus is reported to impair the memory function in experimental animals. Since the mammalian hippocampus and cerebral cortex play a pivotal role in a diverse set of cognitive functions, such as novelty detection and memory, we examined the vulnerability of cortex and hippocampus regions of the brain to oxidative damage in streptozotocin (STZ) diabetic mice. We next examined the attenuating effect of extracts of Withania somnifera and Aloe vera on prevention of hippocampal and cortical cell degenerations. Doses of both plant extracts given to experimental animals were based on the evaluation of their total antioxidant activity and also their potency to reduce Fe(3+). We assayed lipid peroxidation (LPO) and protein carbonyl (PC) in both regions of the brain and observed the changes in memory and motor behavioral functions in diabetic and control mice. The results showed a significant (P < 0.05) increase in LPO and PC in hippocampus and cortical regions of STZ diabetic mice. We also found a significant impairment in both motor and memory behavioral functions in diabetic mice. However, when diabetic mice were supplemented with the extracts of Withania somnifera and Aloe vera, the oxidative damage in both brain regions was reduced as marked by a significant (p < 0.05) declines in both LPO and PC. The combination of extracts of Withania somnifera and Aloe vera was more effective in reducing oxidative damage in brain regions than the supplementation of single plant extract. The combination also lowered the blood glucose level in comparison to STZ diabetic mice. Memory impairment and motor dysfunction were also improved by the plant extracts supplementation. We conclude that impairments in the hippocampus and cortex in STZ diabetic mice are associated with an increased free radical mediated oxidative damage and that the supplementation of plant extracts showed preventive effects in attenuating oxidative damage in both brain regions possibly via antioxidative mechanisms.

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Authors: Parihar, M. S., Chaudhary, M., Shetty, R., & Hemnani, T.
Affiliations: Vikram University (IN)
Corresponding author: Parihar, M.S
ORCID: Parihar, M.S
Venue: Journal of Clinical Neuroscience
Publisher: Elsevier BV
Published: 2004-05
Volume: 11
Issue: 4
Pages: 397-402
ISSN: 0967-5868 (ISSN-L)
DOI: 10.1016/j.jocn.2003.09.008
OpenAlex: W2066909002
Cited by: 121
References: 54
Citations by year: 2026: 1 · 2025: 1 · 2024: 5 · 2023: 4 · 2022: 6 · 2021: 4 · 2020: 7 · 2019: 6 · 2018: 8 · 2017: 8 · 2016: 7 · 2015: 12 · 2014: 10 · 2013: 12 · 2012: 7
FWCI: 12.47
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Journal of Clinical Neuroscience (publishedVersion)
PubMed (publishedVersion)
Funders: University Grants Commission
Topics: Health Sciences › Medicine › Complementary and alternative medicine › Phytochemicals and Medicinal Plants
Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Natural Antidiabetic Agents Studies
Health Sciences › Medicine › Complementary and alternative medicine › Medicinal Plants and Neuroprotection
Keywords: streptozotocin-induced diabetes, hippocampus, cerebral cortex, oxidative stress, Withania somnifera, Aloe vera, plant extracts, lipid peroxidation, protein carbonylation, memory impairment, motor impairment, antioxidant activity, blood glucose, neuroprotection
MeSH terms: Aloe, Analysis of Variance, Animals, Behavior, Animal, Blood Glucose, Cerebral Cortex, Drug Interactions, Female, Hippocampus, Memory, Motor Activity, Oxidation-Reduction, Plant Extracts, Streptozocin, Time Factors, Lipid Peroxidation, Maze Learning, Withania, Protein Carbonylation, Mice

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Susceptibility of hippocampus and cerebral cortex to oxidative damage in streptozotocin treated mice: prevention by extracts of Withania somnifera and Aloe vera

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