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Susceptibility of hippocampus and cerebral cortex to oxidative damage in streptozotocin treated mice: prevention by extracts of Withania somnifera and Aloe vera
Abstract
Diabetes mellitus is reported to impair the memory function in experimental animals. Since the mammalian hippocampus and cerebral cortex play a pivotal role in a diverse set of cognitive functions, such as novelty detection and memory, we examined the vulnerability of cortex and hippocampus regions of the brain to oxidative damage in streptozotocin (STZ) diabetic mice. We next examined the attenuating effect of extracts of Withania somnifera and Aloe vera on prevention of hippocampal and cortical cell degenerations. Doses of both plant extracts given to experimental animals were based on the evaluation of their total antioxidant activity and also their potency to reduce Fe(3+). We assayed lipid peroxidation (LPO) and protein carbonyl (PC) in both regions of the brain and observed the changes in memory and motor behavioral functions in diabetic and control mice. The results showed a significant (P < 0.05) increase in LPO and PC in hippocampus and cortical regions of STZ diabetic mice. We also found a significant impairment in both motor and memory behavioral functions in diabetic mice. However, when diabetic mice were supplemented with the extracts of Withania somnifera and Aloe vera, the oxidative damage in both brain regions was reduced as marked by a significant (p < 0.05) declines in both LPO and PC. The combination of extracts of Withania somnifera and Aloe vera was more effective in reducing oxidative damage in brain regions than the supplementation of single plant extract. The combination also lowered the blood glucose level in comparison to STZ diabetic mice. Memory impairment and motor dysfunction were also improved by the plant extracts supplementation. We conclude that impairments in the hippocampus and cortex in STZ diabetic mice are associated with an increased free radical mediated oxidative damage and that the supplementation of plant extracts showed preventive effects in attenuating oxidative damage in both brain regions possibly via antioxidative mechanisms.
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“W. somnifera attenuated the memory loss induced by STZ through the antioxidant mechanism [154].”
From Indian Medicinal Herbs and Formulations for Alzheimer’s Disease, from Traditional Knowledge to Scientific Assessment (2020) · cites this paper as [154]
Citations
Cites
PROTEIN MEASUREMENT WITH THE FOLIN PHENOL REAGENT
Lowry, O. H., Rosebrough, N., Farr, A. L., & Randall, R. (1951) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)52451-6 · Cited by 316,394
Assay for lipid peroxides in animal tissues by thiobarbituric acid reaction
Ohkawa, H., Ohishi, N., & Yagi, K. (1979) · Analytical Biochemistry · doi:10.1016/0003-2697(79)90738-3 · Cited by 29,746
[49] Determination of carbonyl content in oxidatively modified proteins
Levine, R. L., Garland, D. L., Oliver, C. N., Amici, A., Climent, I., Lenz, A.-G., Ahn, B. W., Shaltiel, S., & Stadtman, E. R. (1990) · Methods in enzymology on CD-ROM/Methods in enzymology · doi:10.1016/0076-6879(90)86141-h · Cited by 5,895
Benzie, I. F. F., & Strain, J. (1999) · Methods in enzymology on CD-ROM/Methods in enzymology · doi:10.1016/s0076-6879(99)99005-5 · Cited by 3,940
Role of Oxidative Stress in Development of Complications in Diabetes
Baynes, J. (1991) · Diabetes · doi:10.2337/diab.40.4.405 · Cited by 3,791
Oxidative Stress, Glutamate, and Neurodegenerative Disorders
Coyle, J. T., & Puttfarcken, P. (1993) · Science · doi:10.1126/science.7901908 · Cited by 3,762
[38] Oxidative damage to proteins: Spectrophotometric method for carbonyl assay
Reznick, A. Z., & Packer, L. (1994) · Methods in enzymology on CD-ROM/Methods in enzymology · doi:10.1016/s0076-6879(94)33041-7 · Cited by 2,455
Diabetes mellitus and the risk of dementia: The Rotterdam Study
Ott, A., Stolk, R. P., van Harskamp, F., Pols, H. A. P., Hofman, A., & Breteler, M. M. B. (1999) · Neurology · doi:10.1212/wnl.53.9.1937 · Cited by 2,175
Blockade of N -Methyl-D-Aspartate Receptors May Protect Against Ischemic Damage in the Brain
Simon, R. P., Swan, J. H., Griffiths, T., & Meldrum, B. S. (1984) · Science · doi:10.1126/science.6093256 · Cited by 1,682
The measurement and mechanism of lipid peroxidation in biological systems
Gutteridge, J. M. C., & Halliwell, B. B. (1990) · Trends in Biochemical Sciences · doi:10.1016/0968-0004(90)90206-q · Cited by 1,297
Joseph, J. A., Shukitt-Hale, B., Denisova, N. A., Bielinski, D., Martin, A., McEwen, J. J., & Bickford, P. C. (1999) · The Journal of Neuroscience · doi:10.1523/jneurosci.19-18-08114.1999 · Cited by 980
The hippocampus—what does it do?
Eichenbaum, H., Otto, T., & Cohen, N. J. (1992) · Behavioral and Neural Biology · doi:10.1016/0163-1047(92)90724-i · Cited by 867
Flavonoids Protect Neuronal Cells from Oxidative Stress by Three Distinct Mechanisms
Ishige, K., Schubert, D., & Sagara, Y. (2001) · Free Radical Biology and Medicine · doi:10.1016/s0891-5849(00)00498-6 · Cited by 841
Erecińska, M., & Silver, I. A. (1989) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1038/jcbfm.1989.2 · Cited by 836
Role of oxidative stress in development of complications in diabetes
Baynes, J. W. (1991) · Diabetes · doi:10.2337/diabetes.40.4.405 · Cited by 810
Esterbauer, H., Jürgens, G., Quehenberger, O., & Koller, E. (1987) · Journal of Lipid Research · doi:10.1016/s0022-2275(20)38678-8 · Cited by 766
Conservation of hippocampal memory function in rats and humans
Bunsey, M. D., & Eichenbaum, H. (1996) · Nature · doi:10.1038/379255a0 · Cited by 752
Evidence that 4-Hydroxynonenal Mediates Oxidative Stress-Induced Neuronal Apoptosis
Kruman, I. I., Bruce‐Keller, A. J., Bredesen, D. E., Waeg, G., & Mattson, M. P. (1997) · Journal of Neuroscience · doi:10.1523/jneurosci.17-13-05089.1997 · Cited by 721
Aksenov, M. Y., & Markesbery, W. R. (2001) · Neuroscience Letters · doi:10.1016/s0304-3940(01)01636-6 · Cited by 661
Diabetes mellitus and free radicals
Wolff, S. P. (1993) · British Medical Bulletin · doi:10.1093/oxfordjournals.bmb.a072637 · Cited by 660
Protein oxidation in the brain in Alzheimer's disease
Aksenov, M. Y., Aksenova, M. V., Butterfield, D. A., Geddes, J. W., & Markesbery, W. R. (2001) · Neuroscience · doi:10.1016/s0306-4522(00)00580-7 · Cited by 505
Youdim, K. A., & Joseph, J. A. (2001) · Free Radical Biology and Medicine · doi:10.1016/s0891-5849(00)00510-4 · Cited by 437
Immobilization stress causes oxidative damage to lipid, protein, and DNA in the brain of rats
Liu, J., Wang, X., Shigenaga, M. K., Yeo, H. C. H., Mori, A., & Ames, B. N. (1996) · The FASEB Journal · doi:10.1096/fasebj.10.13.8940299 · Cited by 383
Cerebral function in diabetes mellitus
Biessels, G. J., Kappelle, A. C., Bravenboer, B., Erkelens, D. W., & Gispen, W. H. (1994) · Diabetologia · doi:10.1007/bf00417687 · Cited by 341
The Impact of Diabetes on the CNS
McCall, A. L. (1992) · Diabetes · doi:10.2337/diab.41.5.557 · Cited by 340
Does insulin dysfunction play a role in Alzheimer's disease?
Gasparini, L. (2002) · Trends in Pharmacological Sciences · doi:10.1016/s0165-6147(02)02037-0 · Cited by 314
Neuroprotection and neurodegenerative disease
Vajda, F. J. E. (2002) · Journal of Clinical Neuroscience · doi:10.1054/jocn.2001.1027 · Cited by 245
Antimicrobial Agents from Higher Plants
Mitscher, L. A. (1975) · Springer eBooks · doi:10.1007/978-1-4684-0823-2_10 · Cited by 237
Kamal, A., Biessels, G. J., Duis, S., & Gispen, W. H. (2000) · Diabetologia · doi:10.1007/s001250051335 · Cited by 227
Differential accumulation of advanced glycation end products in the course of diabetic retinopathy
Hammes, H. P., Alt, A., Niwa, T., Clausen, J. T., Bretzel, R. G., Brownlee, M., & Schleicher, E. D. (1999) · Diabetologia · doi:10.1007/s001250051221 · Cited by 205
Schroeter, H., Williams, R. J., Matin, R., Iversen, L. L., & Rice-Evans, C. A. (2000) · Free Radical Biology and Medicine · doi:10.1016/s0891-5849(00)00415-9 · Cited by 184
Alzheimer's disease as a disorder of mechanisms underlying structural brain self-organization
Arendt, T. (2001) · Neuroscience · doi:10.1016/s0306-4522(00)00516-9 · Cited by 172
Hypoglycaemia: brain neurochemistry and neuropathology
Auer, R. N., & Siesjö, B. K. (1993) · Baillière s Clinical Endocrinology and Metabolism · doi:10.1016/s0950-351x(05)80210-1 · Cited by 164
Aragno, M., Brignardello, E., Tamagno, E., Gatto, V., Danni, O., & Boccuzzi, G. (1997) · Journal of Endocrinology · doi:10.1677/joe.0.1550233 · Cited by 140
Oxidative protein damage in human diabetic eye: evidence of a retinal participation
Altomare, E., Grattagliano, I., VENDEMAILE, G., Ferrari, T. M., Signorile, A., & Cardia, L. (1997) · European Journal of Clinical Investigation · doi:10.1046/j.1365-2362.1997.780629.x · Cited by 134
Neuroprotective effect of green tea extract in experimental ischemia-reperfusion brain injury
Hong, J. T., Ryu, S. R., Kim, H. J., Lee, J. K., Lee, S. H., Kim, D. B., Yun, Y. P., Ryu, J. H., Lee, B. M., & Kim, P. Y. (2000) · Brain Research Bulletin · doi:10.1016/s0361-9230(00)00348-8 · Cited by 133
Reduction and Release of Ferritin Iron By Plant Phenolics
Boyer, R. F., Clark, H. M., & LaRoche, A. P. (1988) · Journal of Inorganic Biochemistry · doi:10.1016/0162-0134(88)80025-4 · Cited by 114
Hypoglycemia, brain metabolism, and brain damage
Siesjö, B. K. (1988) · Diabetes/Metabolism Reviews · doi:10.1002/dmr.5610040203 · Cited by 114
Garlic prevents hypertension induced by chronic inhibition of nitric oxide synthesis
Pedraza‐Chaverrí, J., Tapia, E., Medina‐Campos, O. N., Granados, M. D. L. Á., & Franco, M. (1998) · Life Sciences · doi:10.1016/s0024-3205(97)01155-7 · Cited by 108
Reagan, L. P., Gorovits, N., Hoskin, E. K., Alves, S. E., Katz, E. B., Grillo, C. A., Piroli, G. G., McEwen, B. S., & Charron, M. J. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.051629798 · Cited by 106
Parihar, M. S., & Hemnani, T. (2003) · Journal of Biosciences · doi:10.1007/bf02970142 · Cited by 102
Self-citationGlucose deprivation neuronal injury in cortical culture
Monyer, H., Goldberg, M. P., & Choi, D. W. (1989) · Brain Research · doi:10.1016/0006-8993(89)90179-0 · Cited by 101
Demizu, S., Kajiyama, K., Takahashi, K., Hiraga, Y., YAMAMOTO, S., Tamura, Y., OKADA, K., & Kinoshita, T. (1988) · Chemical and Pharmaceutical Bulletin · doi:10.1248/cpb.36.3474 · Cited by 95
The impact of diabetes on the CNS
McCall, A. L. (1992) · Diabetes · doi:10.2337/diabetes.41.5.557 · Cited by 92
McIntosh, L. J., Trush, M. A., & Troncoso, J. C. (1997) · Free Radical Biology and Medicine · doi:10.1016/s0891-5849(96)00573-4 · Cited by 91
Culmsee, C., Bondada, S., & Mattson, M. P. (2001) · Molecular Brain Research · doi:10.1016/s0169-328x(01)00008-0 · Cited by 78
Immunological evidence for increased oxidative stress in diabetic rats
Traverso, N., Menini, S., Cosso, L., Odetti, P. R., Albano, E., Pronzato, M. A., & Marinari, U. M. (1998) · Diabetologia · doi:10.1007/s001250050902 · Cited by 68
The hippocampus and memory: a comparative and ethological perspective
SUZUKI, W. A. (2000) · Current Opinion in Neurobiology · doi:10.1016/s0959-4388(00)00148-3 · Cited by 67
Biessels, G. J., & Gispen, W. H. (1996) · Life Sciences · doi:10.1016/0024-3205(96)00316-5 · Cited by 64
Seo, S. Y., Kim, E. Y., Kim, H., & Gwag, B. J. (1999) · Journal of Neuroscience · doi:10.1523/jneurosci.19-20-08849.1999 · Cited by 53
Oxidative Protein Damage in Type I Diabetic Patients With and Without Complications
Çakatay, U., Telci, A., Salman, S., Satman, L., & Sıvas, A. (2000) · Endocrine Research · doi:10.3109/07435800009066174 · Cited by 50
Büyükokuroğlu, M. E., Gepdíremen, A., Hacımüftüoğlu, A., & Oktay, M. (2002) · Journal of Ethnopharmacology · doi:10.1016/s0378-8741(02)00286-6 · Cited by 49
Tanaka, K., Nagara, H., Kobayashi, T., & Goto, I. (1989) · Brain Research · doi:10.1016/0006-8993(89)91198-0 · Cited by 38
Mitscher, L. A., Park, Y. H., Omoto, S., Clark, G. W., & Clark, D. (1978) · Heterocycles · doi:10.3987/r-1978-11-1533 · Cited by 27
Does mitochondrial respiratory chain dysfunction have a role in common neurodegenerative disorders?
Byrne, E. (2002) · Journal of Clinical Neuroscience · doi:10.1054/jocn.2001.0991 · Cited by 24
Differential phosphorylation at Ser473 and Thr308 of Akt-1 in rat brain following hypoglycemic coma
Ouyang, Y., Zhang, X., He, Q., Wang, G., Siesjö, B. K., & Hu, B. R. (2000) · Brain Research · doi:10.1016/s0006-8993(00)02618-4 · Cited by 22
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Metadata
- Authors
- Parihar, M. S., Chaudhary, M., Shetty, R., & Hemnani, T.
- Affiliations
- Vikram University (IN)
- Corresponding author
- Parihar, M.S
- ORCID
- Parihar, M.S
- Venue
- Journal of Clinical Neuroscience
- Publisher
- Elsevier BV
- Published
- 2004-05
- Volume
- 11
- Issue
- 4
- Pages
- 397-402
- ISSN
- 0967-5868 (ISSN-L)
- OpenAlex
- W2066909002
- Cited by
- 121
- References
- 54
- Citations by year
- 2026: 1 · 2025: 1 · 2024: 5 · 2023: 4 · 2022: 6 · 2021: 4 · 2020: 7 · 2019: 6 · 2018: 8 · 2017: 8 · 2016: 7 · 2015: 12 · 2014: 10 · 2013: 12 · 2012: 7
- FWCI
- 12.47
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of Clinical Neuroscience (publishedVersion)
- PubMed (publishedVersion)
- Funders
- University Grants Commission
- Topics
- Health Sciences › Medicine › Complementary and alternative medicine › Phytochemicals and Medicinal Plants
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Natural Antidiabetic Agents Studies
- Health Sciences › Medicine › Complementary and alternative medicine › Medicinal Plants and Neuroprotection
- Keywords
- streptozotocin-induced diabetes, hippocampus, cerebral cortex, oxidative stress, Withania somnifera, Aloe vera, plant extracts, lipid peroxidation, protein carbonylation, memory impairment, motor impairment, antioxidant activity, blood glucose, neuroprotection
- MeSH terms
- Aloe, Analysis of Variance, Animals, Behavior, Animal, Blood Glucose, Cerebral Cortex, Drug Interactions, Female, Hippocampus, Memory, Motor Activity, Oxidation-Reduction, Plant Extracts, Streptozocin, Time Factors, Lipid Peroxidation, Maze Learning, Withania, Protein Carbonylation, Mice
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