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Cited by 40Phytochemicals and Medicinal PlantsMedicinal Plants and NeuroprotectionMedicinal Plant Extracts Effects

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Potential clinical applications of Ashwagandha (Withania somnifera) in medicine and neuropsychiatry

D’Cruz, Migita, Andrade, Chittaranjan·2022·Expert Review of Clinical Pharmacology
DOI 10.1080/17512433.2022.2121699
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Abstract

Introduction Ashwagandha (ASW) is the extract of the plant Withania somnifera . It is widely used in complementary, alternative, and integrative medicine (CAIM) but is little discussed in mainstream modern medical literature. Areas covered We performed a review of potential pharmacotherapeutic properties of ASW. Studies were sourced from relevant online and offline databases. In animal models, ASW displays antioxidant activity. It has GABAergic and other neurotransmitter modulatory effects. It reduces apoptosis and promotes synaptic plasticity. It improves cognition and reverses induced cognitive deficits. It attenuates indices of stress. In human subjects, ASW enhances adaptogenesis in healthy adults. It modestly benefits generalized anxiety disorder and obsessive-compulsive disorder, and symptom severity in schizophrenia, substance use disorders, and attention deficit hyperactivity disorder. It improves sleep quality. Expert opinion ASW may confer modest benefit in certain neuropsychiatric conditions. Its benefits may arise from induction of neuroplasticity, antioxidant and anti-inflammatory effects, and modulation of GABA and glutamate, as well as other neurotransmitters. The antioxidant and anti-inflammatory actions may also benefit neurodegenerative states. Reports of clinical benefit with ASW must be interpreted with caution, given the paucity of randomized clinical trials (RCTs). Greater methodological rigor is necessary before clinical recommendations on ASW can be co…

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  • Conclusive evidence from rigorous, methodologically sound, well-designed, validated, and replicated trials does not exist for the indications for which ashwagandha is used.

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    From Ashwagandha-induced liver injury—A case series from India and literature review (2023) · cites this paper as [11]

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Metadata

Authors
D’Cruz, M., & Andrade, C.
Affiliations
  • Department of Psychiatry, National Institute of Mental Health and Neurosciences, Bangalore, India
  • National Institute of Mental Health and Neurosciences (IN)
Corresponding author
Andrade, Chittaranjan
ORCID
Andrade, Chittaranjan
Venue
Expert Review of Clinical Pharmacology
Publisher
Informa UK Limited
Published
2022-09-02
Volume
15
Issue
9
Pages
1067-1080
ISSN
  • 1751-2433 (ISSN-L)
  • 1751-2441
DOI
10.1080/17512433.2022.2121699
OpenAlex
W4294668221
Cited by
40
References
13
Citations by year
2026: 10 · 2025: 19 · 2024: 7 · 2023: 4
FWCI
1.57
Type
journal article
Language
en
Open access
closed
Locations
  • Expert Review of Clinical Pharmacology (publishedVersion)
  • PubMed (publishedVersion)
Funders
This paper was not funded
Topics
  • Health Sciences › Medicine › Complementary and alternative medicine › Phytochemicals and Medicinal Plants
  • Health Sciences › Medicine › Complementary and alternative medicine › Medicinal Plants and Neuroprotection
  • Health Sciences › Medicine › Complementary and alternative medicine › Medicinal Plant Extracts Effects
Keywords
Withania somnifera, neuropsychiatric disorders, cognitive enhancement, anxiety disorders, obsessive-compulsive disorder, schizophrenia, substance use disorders, attention deficit hyperactivity disorder, sleep quality, stress, antioxidant activity, anti-inflammatory activity, neuroplasticity, GABA modulation, glutamate, apoptosis, synaptic plasticity, neurodegeneration, complementary and alternative medicine
MeSH terms
Adult, Animals, Antioxidants, gamma-Aminobutyric Acid, Glutamates, Humans, Plant Extracts, Withania, Neuropsychiatry

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