Cited by 62Phytochemicals and Medicinal PlantsAlzheimer's disease research and treatmentsMedicinal Plants and Neuroprotection

An Aqueous Extract of Withania somnifera Root Inhibits Amyloid β Fibril Formation In Vitro

Kumar, Suresh, Harris, Robin J., Seal, Christopher J., Okello, Edward J.·2012·Phytotherapy Research

Abstract

The ability of an aqueous extract of W. somnifera L. Dunal (Family: Solanaceae) roots to inhibit fibril formation by the amyloid-β peptide in vitro was investigated. W. somnifera is used extensively in traditional Ayurvedic medicine as a nerve tonic with reputed memory enhancing properties. Inhibition of fibrillogenesis measured by transmission electron microscopy and ThT fluorescence assay showed that an aqueous extract of W. somnifera strongly inhibited Aβ fibril formation in a concentration-dependent manner, when compared with control samples. These results suggest that the aqueous extract of W. somnifera root has an ability to inhibit the formation of mature amyloid-β fibrils in vitro, which are known to lead to amyloid plaque formation in vivo.

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Crossref · 10.1002/ptr.3512

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29 of 29 references verified0 citation errors · 0 not checkable

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Authors
Kumar, S., Harris, R. J., Seal, C. J., & Okello, E. J.
Affiliations
  • Guru Gobind Singh Indraprastha University (IN)
  • Johannes Gutenberg University Mainz (DE)
  • Newcastle University (GB)
Corresponding author
Okello, Edward J.
Venue
Phytotherapy Research
Publisher
Wiley
Published
2011-05-12
Volume
26
Issue
1
Pages
113-117
ISSN
  • 0951-418X (ISSN-L)
  • 1099-1573
OpenAlex
W2112486905
Cited by
62
References
29
Citations by year
2026: 2 · 2025: 5 · 2024: 4 · 2023: 4 · 2022: 7 · 2021: 8 · 2020: 7 · 2019: 6 · 2018: 3 · 2017: 3 · 2016: 2 · 2015: 1 · 2014: 4 · 2013: 3 · 2012: 3
FWCI
8.54
Type
journal article
Language
en
Open access
closed
Locations
  • Phytotherapy Research (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Complementary and alternative medicine › Phytochemicals and Medicinal Plants
  • Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
  • Health Sciences › Medicine › Complementary and alternative medicine › Medicinal Plants and Neuroprotection
Keywords
Withania somnifera, ashwagandha root, aqueous plant extract, amyloid-beta, fibril formation inhibition, amyloid plaques, Alzheimer's disease, neuroprotection, Ayurveda
MeSH terms
Amyloid, Cells, Cultured, Dose-Response Relationship, Drug, Fluorescence, Medicine, Ayurvedic, Phytotherapy, Plant Extracts, Amyloid beta-Peptides, Plant Roots, Withania, Microscopy, Electron, Transmission, Plaque, Amyloid

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