Irisin promotes fracture healing by improving osteogenesis and angiogenesis

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Irisin Enhances Osteoblast DifferentiationIn Vitro

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Irisin protects against endothelial injury and ameliorates atherosclerosis in apolipoprotein E-Null diabetic mice.

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Irisin Promotes Human Umbilical Vein Endothelial Cell Proliferation through the ERK Signaling Pathway and Partly Suppresses High Glucose-Induced Apoptosis

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Irisin Prevents Disuse-Induced Osteocyte Apoptosis

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Irisin is associated with osteoporotic fractures independently of bone mineral density, body composition or daily physical activity

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Effectiveness and safety of biodegradable Mg-Nd-Zn-Zr alloy screws for the treatment of medial malleolar fractures

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Irisin Induces Angiogenesis in Human Umbilical Vein Endothelial Cells In Vitro and in Zebrafish Embryos In Vivo via Activation of the ERK Signaling Pathway

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Irisin Alleviates Advanced Glycation End Products-Induced Inflammation and Endothelial Dysfunction via Inhibiting ROS-NLRP3 Inflammasome Signaling

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Plasma irisin is elevated in type 2 diabetes and is associated with increased E-selectin levels

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Mechanism and physical activities in bone-skeletal muscle crosstalk

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Myokine-mediated muscle-organ interactions: Molecular mechanisms and clinical significance

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Global, regional, national trends of femur fracture and machine learning prediction: Comprehensive findings and questions from global burden of disease 1990–2019

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Methods to accelerate fracture healing – a narrative review from a clinical perspective

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A novel injectable hydrogel prepared from phenylboronic acid modified gelatin and oxidized-dextran for bone tissue engineering

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Enzyme-crosslinked hyaluronic acid hydrogel scaffolds for BMSCs microenvironment and wound healing

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Irisin Modulates Inflammatory, Angiogenic, and Osteogenic Factors during Fracture Healing

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Irisin Protects Musculoskeletal Homeostasis via a Mitochondrial Quality Control Mechanism

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Role and Functions of Irisin: A Perspective on Recent Developments and Neurodegenerative Diseases

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Hyperbaric oxygen promotes bone regeneration by activating the mechanosensitive Piezo1 pathway in osteogenic progenitors

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Unlocking the Therapeutic Potential of Irisin: Harnessing Its Function in Degenerative Disorders and Tissue Regeneration

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Modified multilayered porous titanium scaffolds with silicon-doped coating surface-loaded BMP-2 prepared by microarc oxidation for bone defect repair

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Ginsenoside Rd‐Loaded Antioxidant Polymersomes to Regulate Mitochondrial Homeostasis for Bone Defect Healing in Periodontitis

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Irisin Protects against Loss of Trabecular Bone Mass and Strength in Adult Ovariectomized Mice by Stimulating Osteoblast Activity

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Irisin-loaded electrospun core-shell nanofibers as calvarial periosteum accelerate vascularized bone regeneration by activating the mitochondrial SIRT3 pathway

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Sponge as Scaffolds in Bone and Cartilage Tissue Engineering

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Extracellular matrix-mimicking cryogels composed of methacrylated fucoidan enhance vascularized skeletal muscle regeneration following volumetric muscle loss

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Poor bone health in Duchenne muscular dystrophy: a multifactorial problem beyond corticosteroids and loss of ambulation

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Magnesium as an emerging bioactive material for orthopedic applications: bedside needs lead the way from innovation to clinical translation

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Caerin 1.9–Titanium Plates Aid Implant Healing and Inhibit Bacterial Growth in New Zealand Rabbit Mandibles

Long, Y., Duan, X., Fu, Q., Liu, M., Fu, J., Song, X., Mo, R., You, H., Qin, L., Wang, T., et al. (2024) · International Dental Journal · doi:10.1016/j.identj.2024.04.020 · Cited by 9 · see citing works

Irisin mitigates osteoporotic-associated bone loss and gut dysbiosis in ovariectomized mice by modulating microbiota, metabolites, and intestinal barrier integrity

Wang, Y., Deng, H., Zhang, Z., Wu, H., Wang, X., & Zhiwen, Z. (2025) · BMC Musculoskeletal Disorders · doi:10.1186/s12891-025-08622-y · Cited by 9 · see citing works

Irisin in the modulation of bone and cartilage homeostasis: a review on osteoarthritis relief potential

Zhang, M., Xiong, W., Qiao, R., Li, M., Zhang, C., Yang, C., Zhu, Y., He, J., & Ma, Z. (2025) · Frontiers in Physiology · doi:10.3389/fphys.2025.1570157 · Cited by 9 · see citing works

Irisin: A Potentially Fresh Insight into the Molecular Mechanisms Underlying Vascular Aging

Wang, Y., Wang, M., & Wang, Y. (2023) · Aging and Disease · doi:10.14336/ad.2023.1112 · Cited by 10 · see citing works

The emerging roles of irisin in vascular calcification

Wang, S., Hu, S., & Pan, Y. (2024) · Frontiers in Endocrinology · doi:10.3389/fendo.2024.1337995 · Cited by 8 · see citing works

FTO SUMOylation regulates the differentiation of bone marrow mesenchymal stromal cells in inflammatory bowel disease-induced bone loss

Wang, H., Guo, J., Li, L., Xie, H., Zhang, J., Zhang, W., Liu, Y., Ma, Q., Wang, S., Yuan, P., et al. (2025) · Cell Reports · doi:10.1016/j.celrep.2025.115953 · Cited by 8 · see citing works

Irisin prevents trabecular bone damage and tumor invasion in a mouse model of multiple myeloma

Zerlotin, R., Oranger, A., Pignataro, P., Dicarlo, M., Sanesi, L., Suriano, C., Storlino, G., Rizzi, R., Mestice, A., Gioia, S. D., et al. (2024) · JBMR Plus · doi:10.1093/jbmrpl/ziae066 · Cited by 8 · see citing works

Efficacy of tibial cortex transverse transport in treating diabetic foot ulcer and its effect on serum omentin-1 and irisin levels

Wen, Y., Chen, L., Lan, J., & Li, L. (2024) · Diabetology & Metabolic Syndrome · doi:10.1186/s13098-024-01400-1 · Cited by 7 · see citing works

Typhae Pollen active subfraction exerts antiangiogenic effect in benign prostatic hyperplasia via regulating the VEGF signaling pathway and arachidonic acid metabolism

Chen, L., Chen, D., Li, J., Guo, J., Lin, M., Chen, F., Du, H., Du, H., Liu, D., Guo, S., et al. (2025) · Phytomedicine · doi:10.1016/j.phymed.2025.157237 · Cited by 7 · see citing works

Exercise mimetics: molecular mechanisms, biological and therapeutic effects

Zhang, J., Shao, Q., 程腾, Lin, J., Tang, Y., Lu, H., Zhang, Y., Yu, Z., & Cao, L. (2026) · Molecular Biomedicine · doi:10.1186/s43556-026-00483-8 · Cited by 8 · see citing works

The Combination of Sodium Tanshinone IIA Sulfonate and Mesenchymal Stem Cell-derived Exosomes Against Spinal Cord Injury via VEGF Pathway

Luo, D., Ma, L., Pan, Z., Chen, L., Hu, Z., Liang, C., Wang, Z., Xiao, Z., Lin, D., Li, J., et al. (2025) · Molecular Neurobiology · doi:10.1007/s12035-025-05422-2 · Cited by 6 · see citing works

Regulation of Immune Inflammation and Promotion of Periodontal Bone Regeneration by Irisin-Loaded Bioactive Glass Nanoparticles

Hu, W., Lu, Y., Duan, Y., Yang, Y., Wang, M., Guo, J., Xu, J., Lü, X., & Ma, Q. (2024) · Langmuir · doi:10.1021/acs.langmuir.3c02894 · Cited by 6 · see citing works

Recent advances in the multifaceted mechanisms of catalpol in treating osteoporosis

Li, N., Mu, X., Zhang, S., & Wang, H. (2025) · Frontiers in Pharmacology · doi:10.3389/fphar.2025.1560715 · Cited by 5 · see citing works

Protective role of irisin on bone in osteoporosis: a systematic review of rodent studies

Li, J., Fu, X., Shi, H., Jing, J., Zheng, Q., & Xu, Z. (2025) · Osteoporosis International · doi:10.1007/s00198-025-07470-9 · Cited by 6 · see citing works

FBN2 promotes the proliferation, mineralization, and differentiation of osteoblasts to accelerate fracture healing

Huang, J. L., Huang, J., Li, N., Wang, L., & Xiao, Q. (2025) · Scientific Reports · doi:10.1038/s41598-025-89215-6 · Cited by 5 · see citing works

Lamb1-mediated Wnt/β-catenin signaling pathway drives endothelial angiogenesis for fracture healing

Yang, Y., Li, H., Ma, Z., Li, Z., & Gu, J. (2025) · Gene · doi:10.1016/j.gene.2025.149481 · Cited by 5 · see citing works

3D‐Printed Multidimensional Bionic Mg‐MC/PLGA Composite for Tailored Repair of Segmental Long Bone Defects

Liu, S., Zhou, S., Zou, T., Hou, G., Xiao, Q., Li, L., Yang, J., Chen, W., Zhang, Y., & Lv, H. (2025) · Advanced Healthcare Materials · doi:10.1002/adhm.202501938 · Cited by 4 · see citing works

Expression of endogenous Irisin and associated markers during periodontitis progression and repair in male rats

Perdonsini, L. S. C., Roth, J. V. S., Ribas, P. A. T., Takarada, H. K., Borges, M. O., Reitmeyer, F. B., Zielak, J. C., & Steffens, J. P. (2025) · Periodontal and Implant Research · doi:10.1007/s41894-025-00159-6 · Cited by 4 · see citing works

Autologous myokine-loaded pre-vascularized bioactive scaffold enhances bone augmentation

Wang, C., Qiu, Y., Yang, Y., Dai, Q., Cao, X., Shao, L., & Zhao, F. (2024) · Composites Part B Engineering · doi:10.1016/j.compositesb.2024.111967 · Cited by 4 · see citing works

Osteoporotic thoracolumbar spine fractures in the elderly: alterations in GNRI and BMP-2 in delayed union and associated factors

Qian, X. (2024) · American Journal of Translational Research · doi:10.62347/afix5363 · Cited by 4 · see citing works

The role of Irisin in modulating hypoxia-related disorders: New insights and implications for cancer therapy

Khalili‐Tanha, G., Shoari, A., & Nazari, E. (2025) · Aspects of Molecular Medicine · doi:10.1016/j.amolm.2025.100068 · Cited by 3 · see citing works

Clinical value of cystatin S in patients with colorectal cancer chemotherapy

Tingting, H., Deng, S., Xia, D., Jin, K., & Mei, C. (2025) · Frontiers in Oncology · doi:10.3389/fonc.2025.1640646 · Cited by 3 · see citing works

Physico-biological and in vivo evaluation of irisin loaded 45S5 porous bioglass granules for bone regeneration

Ali, M., Farwa, U., Park, S.-S., Kim, Y.-S., & Lee, B. (2023) · Biomaterials Advances · doi:10.1016/j.bioadv.2023.213326 · Cited by 3 · see citing works

Bone formation by Irisin-Poly vinyl alchol modified bioglass ceramic beads in the rabbit model

Park, S.-S., Farwa, U., Kim, H.-D., Kim, Y., & Lee, B. (2024) · Journal of Materials Science Materials in Medicine · doi:10.1007/s10856-024-06788-w · Cited by 2 · see citing works

The Effects of Irisin and Bevacizumab on Hyaline Cartilage Regeneration in Osteochondral Defects: An Experimental Study in Rats

Açan, A. E., Aydın, M. E., Bulmuş, Ö., Özcan, E., Karakılıç, A., Turan, G., & Bayırlı, S. (2025) · Clinics in Orthopedic Surgery · doi:10.4055/cios24502 · Cited by 2 · see citing works

Mechanical response microRNA-145a-5p alleviates osteoarthritis by inhibiting inflammation and promoting chondrogenesis

Du, J., Zhang, Z., Bai, D., Zhu, T., & Jiang, D. (2025) · PeerJ · doi:10.7717/peerj.19905 · Cited by 2 · see citing works

Predictive model of delayed union of tibial and fibular fractures based on PGC-1α, NOS, and Runx2

Wang, B., Shi, Z., Li, D., & Yu, J. (2025) · European journal of medical research · doi:10.1186/s40001-025-03247-2 · Cited by 2 · see citing works

Protective effects of irisin in sarcopenia: a promising treatment

Chen, Y., Li, G., Gao, F., Li, R., Yang, M., Ge, Y., & Wu, X. (2026) · Journal of Orthopaedic Translation · doi:10.1016/j.jot.2026.101090 · Cited by 2 · see citing works

Physical exercise therapy as an anti-aging strategy for osteosarcopenia: a narrative review

Liu, T. T., Zhang, P., Dong, W. T., Gong, Y. L., Fang, Z. J., Li, N., & Ma, X. (2026) · Frontiers in Aging · doi:10.3389/fragi.2026.1791384 · Cited by 2 · see citing works

Irisin alleviates steroid-induced vascular dysfunction by regulating the αVβ5-c-Abl-Caveolin-1 signaling pathway

Fang, L., Li, W., Zhao, H., Wang, W., Gao, H., Wang, P., Zhang, X., Lv, R., Xu, F., Chen, J., et al. (2025) · Biochemical Pharmacology · doi:10.1016/j.bcp.2025.116870 · Cited by 2 · see citing works

Serum VEGF and ANGPT1 as angiogenesis markers may predict the outcomes of older adults with hip fractures

Yao, Y., Xing, Y., Zhao, Z., Fan, W., & Chu, Q. (2025) · Frontiers in Medicine · doi:10.3389/fmed.2025.1654448 · Cited by 2 · see citing works

DAPK2 promotes autophagy to accelerate the progression of ossification of the posterior longitudinal ligament through the mTORC1 complex

Shi, L., YIN, J., Chen, Y., Shi, J., & Miao, J. (2024) · Biocell · doi:10.32604/biocell.2024.049562 · Cited by 1 · see citing works

Looking forward to a better 2023 and beyond

Li, G. (2022) · Journal of Orthopaedic Translation · doi:10.1016/j.jot.2022.12.004

Gut microbiota and skeletal muscle axis in sports performance through nutrological activation of irisin and microRNAs: a systematic review

Lopes, H. M., Nogueira, M. A., Alves, M. C., Carvalho, R. D. O., Cano, A. C. S., Soares, V. C., Izidorio, F. T., Pereira, J. D. S., Salvá, M. D. A., & Alves, T. V. (2024) · International Journal of Nutrology · doi:10.54448/ijn24303

P24 Loaded Gelatin‐Hydroxyapatite‐Tricalcium Phosphate Scaffold Induces Bone Regeneration by Activating the ERK / ELK1 / PLA2G3 Pathway

Fu, L., Liu, Y., Xu, S., Zhou, Y., Huang, J., Qiu, J. F., Huang, P., Zhang, C., Yang, J., Song, J., et al. (2025) · Journal of Biomedical Materials Research Part A · doi:10.1002/jbm.a.37891

Alkaline phosphatase predicts short-term postoperative outcome in adult patients with moyamoya disease

Sun, W., Wang, H., He, Q., Li, J., Liu, C., Zheng, Z., Mou, S., Zhang, B., Zhao, Z., Tao, C., et al. (2025) · Frontiers in Neurology · doi:10.3389/fneur.2025.1606348

Systemic irisin treatment modulates cognitive function through VEGF-associated hippocampal vascular signaling in chronic cerebral hypoperfusion

Karakılıç, A., Bulmuş, Ö., Özcan, E., Turan, G., Aksöz, E., Şafak, B., & Özer, Y. E. (2026) · Neuropeptides · doi:10.1016/j.npep.2026.102613

Research Progress on the Role of the Myokine Irisin in Osteogenesis

翟, 乃. (2026) · Advances in Clinical Medicine · doi:10.12677/acm.2026.1641397

Neuro-immune-bone axis in post-traumatic bone regeneration: temporal regulation, dysregulation mechanisms, and therapeutic implications

Wang, Z., & Zhang, H. (2026) · Frontiers in Immunology · doi:10.3389/fimmu.2026.1911131

Irisin Modulates Inflammatory, Angiogenic, and Osteogenic Factors during Fracture Healing

Oranger, A., Zerlotin, R., Buccoliero, C., Sanesi, L., Storlino, G., Schipani, E., Kozloff, K. M., Mori, G., Colaianni, G., Colucci, S. C., et al. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24031809 · Cited by 28 · see citing works

Systemic Administration of Recombinant Irisin Accelerates Fracture Healing in Mice

Colucci, S. C., Buccoliero, C., Sanesi, L., Errede, M., Colaianni, G., Annese, T., Khan, M. P., Zerlotin, R., Dicarlo, M., Schipani, E., et al. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms221910863 · Cited by 40 · see citing works

The Irisin Hormone Profile and Expression in Human Bone Tissue in the Bone Healing Process in Patients

Serbest, S., Tiftikçi, U., Tosun, H. B., & Kısa, Ü. (2017) · Medical Science Monitor · doi:10.12659/msm.906293 · Cited by 52 · see citing works

Effect of recombinant irisin on recombinant human bone morphogenetic protein-2 induced osteogenesis and osteoblast differentiation

Ohyama, Y., Ohta, Y., Sugama, R., Minoda, Y., Masuda, S., Terai, H., & Nakamura, H. (2024) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2024.150787 · Cited by 6 · see citing works

Effect of Irisin on the Osteogenic Differentiation of Rat Bone Marrow Mesenchymal Stem Cells

Tian, M., & He, H. (2026) · Journal of Biochemical and Molecular Toxicology · doi:10.1002/jbt.70692