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Exercise–Linked Irisin: Consequences on Mental and Cardiovascular Health in Type 2 Diabetes

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Muscle–brain crosstalk mediated by exercise-induced myokines - insights from experimental studies

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Irisin Recovers Osteoarthritic Chondrocytes In Vitro

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Irisin promotes fracture healing by improving osteogenesis and angiogenesis

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Myokines and adipokines in sarcopenia: understanding cross-talk between skeletal muscle and adipose tissue and the role of exercise

Paris, M. T., Bell, K. E., & Mourtzakis, M. (2020) · Current Opinion in Pharmacology · doi:10.1016/j.coph.2020.06.003 · Cited by 62 · see citing works

Exerkine FNDC5/irisin‐enriched exosomes promote proliferation and inhibit ferroptosis of osteoblasts through interaction with Caveolin‐1

Tao, L., Wang, J., Wang, K., Liu, Q., Li, H., Xu, S., Gu, C., & Zhu, Y. (2024) · Aging Cell · doi:10.1111/acel.14181 · Cited by 64 · see citing works

Ageing of skeletal muscle extracellular matrix and mitochondria: finding a potential link

Cai, L., Shi, L., Peng, Z., Sun, Y., & Chen, J. (2023) · Annals of Medicine · doi:10.1080/07853890.2023.2240707 · Cited by 60 · see citing works

Irisin and Incretin Hormones: Similarities, Differences, and Implications in Type 2 Diabetes and Obesity

Marrano, N., Biondi, G., Borrelli, A., Cignarelli, A., Perrini, S., Laviola, L., Giorgino, F., & Natalicchio, A. (2021) · Biomolecules · doi:10.3390/biom11020286 · Cited by 56 · see citing works

Modulation of MicroRNAs as a Potential Molecular Mechanism Involved in the Beneficial Actions of Physical Exercise in Alzheimer Disease

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Myokine-mediated muscle-organ interactions: Molecular mechanisms and clinical significance

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Association between serum irisin concentrations and sarcopenia in patients with liver cirrhosis: a cross-sectional study

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The bone anabolic effects of irisin are through preferential stimulation of aerobic glycolysis

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Sarcopenia and cachexia: molecular mechanisms and therapeutic interventions

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Renal failure suppresses muscle irisin expression, and irisin blunts cortical bone loss in mice

Kawao, N., Kawaguchi, M., Ohira, T., Ehara, H., Mizukami, Y., Takafuji, Y., & Kaji, H. (2022) · Journal of Cachexia Sarcopenia and Muscle · doi:10.1002/jcsm.12892 · Cited by 47 · see citing works

The Physiological Role of Irisin in the Regulation of Muscle Glucose Homeostasis

Yano, N., Zhao, Y., & Zhao, T. C. (2021) · Endocrines · doi:10.3390/endocrines2030025 · Cited by 46 · see citing works

Pathophysiological mechanism of acute bone loss after fracture

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Role of myokines and osteokines in cancer cachexia

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The Role of Irisin in Exercise-Mediated Bone Health

Liu, L., Guo, J., Chen, X., Tong, X., Xu, J., & Zou, J. (2021) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2021.668759 · Cited by 43 · see citing works

Exercise‐Linked Irisin Prevents Mortality and Enhances Cognition in a Mice Model of Cerebral Ischemia by Regulating Klotho Expression

Jin, Z. Y., Zhang, Z., Ke, J., Wang, Y., & Wu, H. (2021) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2021/1697070 · Cited by 42 · see citing works

Atrophic skeletal muscle fibre‐derived small extracellular vesicle miR‐690 inhibits satellite cell differentiation during ageing

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Muscle-Bone Crosstalk in Chronic Obstructive Pulmonary Disease

Zhang, L., & Sun, Y. (2021) · Frontiers in Endocrinology · doi:10.3389/fendo.2021.724911 · Cited by 42 · see citing works

Mitochondria Homeostasis and Oxidant/Antioxidant Balance in Skeletal Muscle—Do Myokines Play a Role?

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A focused review of myokines as a potential contributor to muscle hypertrophy from resistance-based exercise

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The myokine Fibcd1 is an endogenous determinant of myofiber size and mitigates cancer-induced myofiber atrophy

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Irisin and ALCAT1 mediated aerobic exercise-alleviated oxidative stress and apoptosis in skeletal muscle of mice with myocardial infarction

Ren, W., Xu, Z., Pan, S., Ma, Y., Li, H., Wu, F., Bo, W., Cai, M., & Tian, Z. (2022) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2022.10.321 · Cited by 40 · see citing works

Myokines in treatment-naïve patients with cancer-associated cachexia

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Assessment of the association between paraspinal muscle degeneration and quality of life in patients with degenerative lumbar scoliosis

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Elucidating the Contribution of Skeletal Muscle Ion Channels to Amyotrophic Lateral Sclerosis in search of new therapeutic options

Camerino, G. M., Fonzino, A., Conte, E., De Bellis, M., Mele, A., Liantonio, A., Tricarico, D., Tarantino, N., Dobrowolny, G., Musarò, A., et al. (2019) · Scientific Reports · doi:10.1038/s41598-019-39676-3 · Cited by 38 · see citing works

Curcumin in Combination with Aerobic Exercise Improves Follicular Dysfunction via Inhibition of the Hyperandrogen‐Induced IRE1α/XBP1 Endoplasmic Reticulum Stress Pathway in PCOS‐Like Rats

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IGF-1 Signaling Regulates Mitochondrial Remodeling during Myogenic Differentiation

Guan, X., Yan, Q., Wang, D., Du, G., & Zhou, J. (2022) · Nutrients · doi:10.3390/nu14061249 · Cited by 38 · see citing works

Musculoskeletal health in children and adolescents

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Morroniside ameliorates inflammatory skeletal muscle atrophy via inhibiting canonical and non-canonical NF-κB and regulating protein synthesis/degradation

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Protein Nutritional Support: The Classical and Potential New Mechanisms in the Prevention and Therapy of Sarcopenia

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Energy metabolism and frailty: The potential role of exercise-induced myokines – A narrative review

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Identification of irisin as a therapeutic agent that inhibits oxidative stress and fibrosis in a murine model of chronic pancreatitis

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The Role of Exercise in Cancer-Related Sarcopenia and Sarcopenic Obesity

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Serum irisin level is independent of sarcopenia and related muscle parameters in older adults

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Sarcopenia: recent advances for detection, progression, and metabolic alterations along with therapeutic targets

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Irisin Is Controlled by Farnesoid X Receptor and Regulates Cholesterol Homeostasis

Li, H., Shen, J., Wu, T., Kuang, J., Liu, Q., Cheng, S., Pu, S., Chen, L., Li, R., Li, Y., et al. (2019) · Frontiers in Pharmacology · doi:10.3389/fphar.2019.00548 · Cited by 33 · see citing works

Crosstalk between fat tissue and muscle, brain, liver, and heart in obesity: cellular and molecular perspectives

Jia, Z., Wang, Z., Pan, H., Zhang, J., Wang, Q., Zhou, C., & Liu, J. (2024) · European journal of medical research · doi:10.1186/s40001-024-02176-w · Cited by 32 · see citing works

Role of noncanonical Wnt ligands and Ror‐family receptor tyrosine kinases in the development, regeneration, and diseases of the musculoskeletal system

Kamizaki, K., Endo, M., Minami, Y., & Kobayashi, Y. (2020) · Developmental Dynamics · doi:10.1002/dvdy.151 · Cited by 32 · see citing works

Myokine, a key cytokine for physical exercise to alleviate sarcopenic obesity

Zhang, L., Lv, J., Wang, C., Ren, Y., & Ming, Y. (2022) · Molecular Biology Reports · doi:10.1007/s11033-022-07821-3 · Cited by 32 · see citing works

Control of muscle satellite cell function by specific exercise‐induced cytokines and their applications in muscle maintenance

Guo, Q., Luo, Q., & Song, G. (2024) · Journal of Cachexia Sarcopenia and Muscle · doi:10.1002/jcsm.13440 · Cited by 32 · see citing works

Irisin Serum Levels in Metabolic Syndrome Patients Treated with Three Different Diets: A Post-Hoc Analysis from a Randomized Controlled Clinical Trial

Osella, A. R., Colaianni, G., Correale, M., Pesole, P. L., Bruno, I., Buongiorno, C., Deflorio, V., Leone, C. M., Colucci, S. C., Grano, M., et al. (2018) · Nutrients · doi:10.3390/nu10070844 · Cited by 31 · see citing works

Targeting AMPK with Irisin: Implications for metabolic disorders, cardiovascular health, and inflammatory conditions — A systematic review

Laurindo, L. F., Rodrigues, V. D., Laurindo, L. F., Cherain, L. M. A., de Lima, E. P., Boaro, B. L., Oliveira, J. D. S. C., Chagas, E. F. B., Catharin, V. C. S., Haber, J. F. D. S., et al. (2024) · Life Sciences · doi:10.1016/j.lfs.2024.123230 · Cited by 31 · see citing works

Low Serum Irisin Concentration Is Associated with Poor Outcomes in Patients with Acute Pancreatitis, and Irisin Administration Protects Against Experimental Acute Pancreatitis

Ren, Y., Qiu, M., Zhang, J., Bi, J., Wang, M., Hu, L., Du, Z., Li, T., Zhang, L., Wang, Y., et al. (2019) · Antioxidants and Redox Signaling · doi:10.1089/ars.2019.7731 · Cited by 29 · see citing works

Irisin promotes C2C12 myoblast proliferation via ERK-dependent CCL7 upregulation

Lee, J., Park, J., Kim, Y. H., Lee, N. H., & Song, K. (2019) · PLoS ONE · doi:10.1371/journal.pone.0222559 · Cited by 29 · see citing works

Are Skeletal Muscle Changes during Prolonged Space Flights Similar to Those Experienced by Frail and Sarcopenic Older Adults?

Cannavò, A., Carandina, A., Corbi, G., Tobaldini, E., Montano, N., & Arosio, B. (2022) · Life · doi:10.3390/life12122139 · Cited by 28 · see citing works

FNDC1 is a myokine that promotes myogenesis and muscle regeneration

Zhang, R. X., Zhai, Y. Y., Ding, R., Huang, J. H., Shi, X., Liu, H., Liu, X. P., Zhang, J. F., Lu, J. F., Zhang, Z., et al. (2024) · The EMBO Journal · doi:10.1038/s44318-024-00285-0 · Cited by 28 · see citing works

Cleavage of FNDC5 and insights into its maturation process

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Osteosarcopenia in Patients with Chronic Obstructive Pulmonary Diseases: Which Pathophysiologic Implications for Rehabilitation?

Lippi, L., Folli, A., Curci, C., D’Abrosca, F., Moalli, S., Mezian, K., Alessandro de, S. I. R. E., & Invernizzi, M. (2022) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph192114314 · Cited by 28 · see citing works

Irisin interaction with adipose tissue secretions by exercise training and flaxseed oil supplement

Shirvani, H., & Rahmati-Ahmadabad, S. (2019) · Lipids in Health and Disease · doi:10.1186/s12944-019-0960-4 · Cited by 27 · see citing works

Moderate Intensity Aerobic Exercise Potential Favorable Effect Against COVID-19: The Role of Renin-Angiotensin System and Immunomodulatory Effects

Arazi, H., Falahati, A., & Suzuki, K. (2021) · Frontiers in Physiology · doi:10.3389/fphys.2021.747200 · Cited by 27 · see citing works

Irisin response to downhill running exercise in humans

Tsuchiya, Y., Mizuno, S., & Goto, K. (2018) · Physical Activity and Nutrition · doi:10.20463/jenb.2018.0011 · Cited by 26 · see citing works

Irisin Protects Musculoskeletal Homeostasis via a Mitochondrial Quality Control Mechanism

Zhao, C., Wu, Y., Zhu, S., Liu, H., & Xu, S. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms251810116 · Cited by 30 · see citing works

Rates of myogenesis and myofiber numbers are reduced in late gestation IUGR fetal sheep

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Muscle-bone axis in children with chronic kidney disease: current knowledge and future perspectives

Karava, V., Dotis, J., Christoforidis, A., Kondou, A., & Printza, N. G. (2021) · Pediatric Nephrology · doi:10.1007/s00467-021-04936-w · Cited by 25 · see citing works

Vitamin D Increases Irisin Serum Levels and the Expression of Its Precursor in Skeletal Muscle

Sanesi, L., Dicarlo, M., Pignataro, P., Zerlotin, R., Pugliese, F., Columbu, C., Carnevale, V., Tunnera, S., Scillitani, A., Grano, M., et al. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24044129 · Cited by 25 · see citing works

Characterization of the role of Irisin in skeletal muscle growth and repair

Reza, M. M. (2017) · doi:10.32657/10356/72482

Irisin Improves Differentiation through Preserved Mitochondrial Function in Mouse C2C12 Skeletal Muscle Cells

Slate‐Romano, J., Yano, N., Kulthinee, S., Wang, L., Zhang, L. Z., & Zhao, T. C. (2022) · The FASEB Journal · doi:10.1096/fasebj.2022.36.s1.l8074

Irisin and musculoskeletal health

Colaianni, G., Cinti, S., Colucci, S., & Grano, M. (2017) · Annals of the New York Academy of Sciences · doi:10.1111/nyas.13345 · Cited by 158 · see citing works

Irisin treatment improves healing of dystrophic skeletal muscle

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Muscles proteome analysis; irisin administration mimics some molecular effects of exercise in quadriceps muscle

Momenzadeh, S., Zamani, S., Tabrizi, Z. P. F., Barreiro, C., & Jami, M. (2021) · Biochimie · doi:10.1016/j.biochi.2021.06.016 · Cited by 14 · see citing works