CoChat
Sign Up
Cited by 327Cannabis and Cannabinoid ResearchPain Mechanisms and TreatmentsPain Management and Opioid Use

The DOI matches its Crossref record; 80 of the 84 references it cites were found in a registry or an index.

A Randomized, Placebo-Controlled, Crossover Trial of Cannabis Cigarettes in Neuropathic Pain

Open access
Wilsey, Barth, Marcotte, Thomas, Tsodikov, Alexander, Millman, Jeanna, Bentley, Heather, Gouaux, Ben, Fishman, Scott·2008·The Journal of Pain
DOI 10.1016/j.jpain.2007.12.010PMC PMC4968043
Open this paper in CoChat — free account

Abstract

Unlabelled The Food and Drug Administration (FDA), Substance Abuse and Mental Health Services Administration (SAMHSA), and the National Institute for Drug Abuse (NIDA) report that no sound scientific studies support the medicinal use of cannabis. Despite this lack of scientific validation, many patients routinely use "medical marijuana," and in many cases this use is for pain related to nerve injury. We conducted a double-blinded, placebo-controlled, crossover study evaluating the analgesic efficacy of smoking cannabis for neuropathic pain. Thirty-eight patients with central and peripheral neuropathic pain underwent a standardized procedure for smoking either high-dose (7%), low-dose (3.5%), or placebo cannabis. In addition to the primary outcome of pain intensity, secondary outcome measures included evoked pain using heat-pain threshold, sensitivity to light touch, psychoactive side effects, and neuropsychological performance. A mixed linear model demonstrated an analgesic response to smoking cannabis. No effect on evoked pain was seen. Psychoactive effects were minimal and well-tolerated, with some acute cognitive effects, particularly with memory, at higher doses.Perspective This study adds to a growing body of evidence that cannabis may be effective at ameliorating neuropathic pain, and may be an alternative for patients who do not respond to, or cannot tolerate, other drugs. However, the use of marijuana as medicine may be limited by its method of administration (smoking) and modest acute cognitive effects, particularly at higher doses.

Overview

Integrity signals

Registry

Crossref · 10.1016/j.jpain.2007.12.010

Cites

80 of 80 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Verification

Claims the paper makes

We couldn’t retrieve this paper’s full text, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Citations

Cites

Flagged first, then by citations

4 of the 84 references couldn’t be matched to a known paper.

Research works printed but not linked: 4

  1. Ad Hoc Group of Experts, Report to the Director, National Institutes of Health: Workshop on the Medical Utility of Marijuana, February 19-20, 1997
  2. Bostrom, 2005, Gonzales v Raich, Issues Law Med, 21, 47
  3. Gieringer, 1996, Marijuana research: Waterpipe study, MAPS (Multidisciplinary Association for Psychedelic Studies) Bull, 6, 59
  4. Schnelle, 1999, Results of a standardized survey on the medical use of cannabis products in the German-speaking area, Forsch Komplementarmed, 6, 28

Cited by

Sorted by citations

See all 327

Related

See all

Metadata

Authors
Wilsey, B., Marcotte, T., Tsodikov, A., Millman, J., Bentley, H., Gouaux, B., & Fishman, S.
Affiliations
  • VA Northern California Health Care System (US)
  • University of California San Diego (US)
  • University of California Davis Medical Center (US)
Corresponding author
Wilsey, Barth
ORCID
Venue
The Journal of Pain
Publisher
Elsevier BV
Published
2008-06
Volume
9
Issue
6
Pages
506-521
ISSN
1526-5900 (ISSN-L)
DOI
10.1016/j.jpain.2007.12.010
PMC
PMC4968043
OpenAlex
W2133895281
Cited by
327
References
84
Citations by year
2026: 5 · 2025: 9 · 2024: 13 · 2023: 11 · 2022: 19 · 2021: 20 · 2020: 25 · 2019: 30 · 2018: 34 · 2017: 23 · 2016: 20 · 2015: 27 · 2014: 22 · 2013: 19 · 2012: 12
FWCI
8.88
Type
journal article
Language
en
Open access
Licence
Locations
  • Journal of Pain (publishedVersion)
  • PubMed (publishedVersion)
  • PubMed Central (acceptedVersion)
Funders
  • National Institutes of Health (UL1TR000002)
  • National Institute on Drug Abuse
  • National Center for Research Resources (UL1RR024146)
  • National Center for Advancing Translational Sciences
  • Center for Medicinal Cannabis Research, University of California, San Diego
Topics
  • Health Sciences › Medicine › Pharmacology (medical) › Cannabis and Cannabinoid Research
  • Health Sciences › Medicine › Physiology (medical) › Pain Mechanisms and Treatments
  • Health Sciences › Medicine › Anesthesiology and Pain Medicine › Pain Management and Opioid Use
Keywords
cannabis, neuropathic pain, medical cannabis, analgesic efficacy, pain intensity, evoked pain, psychoactive effects, cognitive effects, memory, dose-response relationship, central pain, peripheral neuropathic pain
MeSH terms
Adult, Affect, Aged, Cannabinoids, Dose-Response Relationship, Drug, Double-Blind Method, Humans, Marijuana Smoking, Middle Aged, Neuralgia, Neuropsychological Tests, Pain Measurement, Time Factors, Linear Models, Cross-Over Studies

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review