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Cited by 98Diabetes Management and ResearchDiabetes and associated disordersDiabetes Management and Education

Cognitive functioning in children with early onset type 1 diabetes and severe hypoglycemia

Strudwick, Susan K., Carne, Christy, Gardiner, John, Foster, Jonathan K., Davis, Elizabeth A., Jones, Timothy W.·2005·The Journal of Pediatrics
DOI 10.1016/j.jpeds.2005.06.010
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Abstract

Objective To investigate whether severe hypoglycemia in young children with early-onset type 1 diabetes (T1DM) is associated with subsequent abnormalities in cognitive status.Study design Recruitment was from a large population-based database of children and adolescents with T1DM. Children and adolescents with early-onset T1DM (<6 years) were eligible for the study. Diabetic individuals (n = 41) with a prospectively documented history of seizure or coma were compared with peers with no history of severe hypoglycemic events (n = 43). A comprehensive test battery of learning and memory was used together with intellectual and behavioral measures.Results No significant group differences were revealed on the intellectual, memory, or behavioral measures. Similarly, those participants with a history of early first seizure did not differ from their peers with no seizures. There were no significant group differences on the memory subtests that were examined given their potential sensitivity to compromised hippocampal function.Conclusions There was no clear evidence from this cohort that episodes of seizure or coma, even those occurring in very early childhood, resulted in broad cognitive dysfunction, nor was there evidence of specific memory difficulties at the time of testing in children and adolescents with early-onset T1DM.

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Authors
Strudwick, S. K., Carne, C., Gardiner, J., Foster, J. K., Davis, E. A., & Jones, T. W.
Affiliations
  • Princess Margaret Hospital for Children (AU)
  • The Kids Research Institute Australia (AU)
Corresponding author
Jones, Timothy W.
ORCID
Venue
The Journal of Pediatrics
Publisher
Elsevier BV
Published
2005-11
Volume
147
Issue
5
Pages
680-685
ISSN
0022-3476 (ISSN-L)
DOI
10.1016/j.jpeds.2005.06.010
OpenAlex
W2037745461
Cited by
98
References
43
Citations by year
2026: 1 · 2025: 3 · 2024: 2 · 2023: 3 · 2022: 2 · 2021: 4 · 2020: 3 · 2019: 4 · 2018: 6 · 2017: 3 · 2016: 8 · 2015: 5 · 2014: 7 · 2013: 4 · 2012: 5
FWCI
2.07
Type
journal article
Language
en
Open access
closed
Licence
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations
  • The Journal of Pediatrics (publishedVersion)
  • PubMed (publishedVersion)
  • Murdoch University Research Portal (submittedVersion)
  • UWA Profiles and Research Repository (UWA) (submittedVersion)
  • Australasian Journal of Paramedicine (submittedVersion)
Topics
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes Management and Research
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Diabetes and associated disorders
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes Management and Education
Keywords
type 1 diabetes, early-onset diabetes, severe hypoglycemia, hypoglycemic coma, hypoglycemic seizures, cognitive function, memory, learning, intellectual functioning, behavioral problems, children and adolescents, hippocampal function
MeSH terms
Child, Child Behavior, Child, Preschool, Cognition Disorders, Cross-Sectional Studies, Diabetes Mellitus, Type 1, Female, Humans, Hypoglycemia, Insulin Coma, Intelligence, Male, Memory, Seizures, Western Australia, Case-Control Studies, Age of Onset

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