The DOI matches its Crossref record; 43 of the 43 references it cites were found in a registry or an index; none of the 29 sources its claims cite is checked for support yet.
Maternal Smoking during Pregnancy and Newborn Neurobehavior: Effects at 10 to 27 Days
Open accessAbstract
Objective To examine effects of maternal smoking during pregnancy on newborn neurobehavior at 10 to 27 days.Study design Participants were 56 healthy infants (28 smoking-exposed, 28 unexposed) matched on maternal social class, age, and alcohol use. Maternal smoking during pregnancy was determined by maternal interview and maternal saliva cotinine. Postnatal smoke exposure was quantified by infant saliva cotinine. Infant neurobehavior was assessed through the NICU Network Neurobehavioral Scale.Results Smoking-exposed infants showed greater need for handling and worse self-regulation (P < .05) and trended toward greater excitability and arousal (P < .10) relative to matched, unexposed infants (all moderate effect sizes). In contrast to prior studies of days 0 to 5, no effects of smoking-exposure on signs of stress/abstinence or muscle tone emerged. In stratified, adjusted analyses, only effects on need for handling remained significant (P < .05, large effect size).Conclusions Effects of maternal smoking during pregnancy at 10 to 27 days are subtle and consistent with increased need for external intervention and poorer self-regulation. Along with parenting deficits, these effects may represent early precursors for long-term adverse outcomes from maternal smoking during pregnancy. That signs of abstinence shown in prior studies of 0- to 5-day-old newborns did not emerge in older newborns provides further evidence for the possibility of a withdrawal process in exposed infants.
Overview
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Written from the paper’s full text.
TL;DR
In this pilot study of 56 healthy infants assessed at 10–27 days, maternal smoking during pregnancy was associated with greater need for handling and poorer self-regulation, with trends toward greater excitability and arousal. Effects on stress/abstinence and muscle tone seen in prior 0–5-day studies did not emerge, suggesting possible withdrawal or persistent subtle dysregulation.
Key findings
- Smoking-exposed infants showed significantly worse self-regulation and greater need for handling (p < .05) and trended toward greater arousal and excitability (p < .10), with moderate unadjusted effect sizes (Cohen’s deltas = .54, .57, .45, and .52, respectively).
- In adjusted analyses, only need for handling remained significant: maternal smoking during pregnancy was associated with a 0.18-unit increase in handling (95% CI = .04–.32), with a large effect size (Cohen’s delta = .76 in Results; .73 in Discussion).
- No significant effects emerged for stress/abstinence or hypertonicity/hypotonicity scales, unlike prior findings in 0–5-day-old newborns.
- Adjusted moderate effects were also observed for excitability (Cohen’s delta = .55) and arousal (Cohen’s delta = .41), though these did not reach statistical significance.
Methods
- Participants were 56 healthy, full-term, normal-birthweight infants (28 smoking-exposed, 28 unexposed) matched on maternal social class, age, and alcohol use; infants were assessed at 10–27 days (M = 17, SD = 4).
- Maternal smoking during pregnancy was determined by maternal interview and maternal saliva cotinine (>10 ng/mL); postnatal smoke exposure was quantified by infant saliva cotinine. Neurobehavior was assessed with the NICU Network Neurobehavioral Scale (NNNS) by an examiner blind to exposure status.
- Analyses used 2-sample t-tests, chi-square tests, and logistic regression for unadjusted comparisons; conditional normal regression within strata defined by maternal SES and age adjusted for pre/postnatal second-hand smoke exposure, breast-feeding, and maternal depressive symptoms; Mantel-Haenszel stratified odds ratios were used for dichotomized hypertonicity/hypotonicity. Emphasis was placed on effect size estimation due to small sample size.
Limitations
- The paper states that definitive evidence for a neonatal nicotine withdrawal syndrome and its time course has not been established, so effects at 10–27 days cannot be definitively distinguished from prolonged withdrawal versus persistent neurotoxic effects.
- The paper states that maternal saliva cotinine was assessed in the immediate postpartum period (days 1–4, mean = day 1) rather than during pregnancy, increasing the likelihood of false-negative results for smokers.
- The paper notes greater depressive symptoms in the unexposed versus smoking-exposed group, which was puzzling and inconsistent with prior research, though not statistically significant and controlled in adjusted analyses; evident limitations include the small pilot sample, low smoking exposure levels, and selection of healthy, full-term, normal-birthweight infants, which may limit generalizability.
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A result the paper reports from its own data — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“Smoking-exposed infants showed greater need for handling and worse self-regulation (p <.05) and trended toward greater excitability and arousal (p <.10) relative to matched, unexposed infants (all moderate effect sizes).”
§ Maternal smoking during pregnancy and newborn neurobehavior: A pilot study of effects at 10–27 days > Abstract > Results
Strength:plain· not yet calibratedCausal:correlational· not yet calibratedTests✓ Asserted: passes✓ Checkable: passes? Load-bearing: unclear✓ Based: passesA result the paper reports from its own data — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“In stratified, adjusted analyses, only effects on need for handling remained significant (p<.05, large effect size).”
§ Maternal smoking during pregnancy and newborn neurobehavior: A pilot study of effects at 10–27 days > Abstract > Results
Load-bearingStrength:plain· not yet calibratedTests✓ Asserted: passes✓ Checkable: passes✓ Load-bearing: passes✓ Based: passesA result the paper reports from its own data — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“In contrast to prior studies of days 0–5, no effects of smoking-exposure on signs of stress/abstinence or muscle tone emerged.”
§ Maternal smoking during pregnancy and newborn neurobehavior: A pilot study of effects at 10–27 days > Abstract > Results
Load-bearingStrength:plain· not yet calibratedTests✓ Asserted: passes✓ Checkable: passes✓ Load-bearing: passes✓ Based: passesA result the paper reports from its own data — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“Smoking-exposed infants showed greater need for handling and worse self-regulation (p <.05) and trended toward greater excitability and arousal (p <.10) relative to matched, unexposed infants (all moderate effect sizes).”
§ Maternal smoking during pregnancy and newborn neurobehavior: A pilot study of effects at 10–27 days > Abstract > Results
Strength:plain· not yet calibratedCausal:correlational· not yet calibratedTests✓ Asserted: passes✓ Checkable: passes? Load-bearing: unclear✓ Based: passesA result the paper reports from its own data — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“Smoking-exposed infants showed greater need for handling and worse self-regulation (p <.05) and trended toward greater excitability and arousal (p <.10) relative to matched, unexposed infants (all moderate effect sizes).”
§ Maternal smoking during pregnancy and newborn neurobehavior: A pilot study of effects at 10–27 days > Abstract > Results
Tests✓ Asserted: passes✓ Checkable: passes✓ Load-bearing: passes✓ Based: passesA result the paper reports from its own data — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“Smoking-exposed infants showed greater need for handling and worse self-regulation (p <.05) and trended toward greater excitability and arousal (p <.10) relative to matched, unexposed infants (all moderate effect sizes).”
- Also stated in: § Results · plain
“In stratified, adjusted analyses, only effects on need for handling remained significant (p<.05, large effect size).”
§ Maternal smoking during pregnancy and newborn neurobehavior: A pilot study of effects at 10–27 days > Abstract > Results
Tests✓ Asserted: passes✓ Checkable: passes✓ Load-bearing: passes✓ Based: passes- Also stated in: § Results · plain
A result the paper reports from its own data — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“In contrast to prior studies of days 0–5, no effects of smoking-exposure on signs of stress/abstinence or muscle tone emerged.”
§ Maternal smoking during pregnancy and newborn neurobehavior: A pilot study of effects at 10–27 days > Abstract > Results
Load-bearingStrength:plain· not yet calibratedTests✓ Asserted: passes✓ Checkable: passes✓ Load-bearing: passes✓ Based: passesA result the paper reports from its own data — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“Patterns of effects of maternal smoking during pregnancy on infant neurobehavior at 10–27 days in the present study differed from those shown at 1–2 days in the previous study from our group.”
§ Maternal smoking during pregnancy and newborn neurobehavior: A pilot study of effects at 10–27 days > DISCUSSION
Load-bearingStrength:plain· not yet calibratedTests✓ Asserted: passes✓ Checkable: passes✓ Load-bearing: passes✓ Based: passesA result the paper reports from its own data — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“Effects on excitability and need for handling were evident in both the early and later neonatal period, suggesting persistent neurotoxic effects.”
- Also stated in: § DISCUSSION · plain
“exposure to maternal smoking during pregnancy was associated with increased need for external handling to maintain a quiet alert state, greater difficulties in self-regulation, and increased arousal and excitability at 10–27 days, past the half-life of nicotine/cotinine.”
§ Maternal smoking during pregnancy and newborn neurobehavior: A pilot study of effects at 10–27 days > DISCUSSION
Tests✓ Asserted: passes✓ Checkable: passes✓ Load-bearing: passes✓ Based: passes- Also stated in: § DISCUSSION · plain
A result the paper reports from its own data — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“although only the effects of handling attained statistical significance.”
§ Maternal smoking during pregnancy and newborn neurobehavior: A pilot study of effects at 10–27 days > DISCUSSION
Load-bearingStrength:plain· not yet calibratedTests✓ Asserted: passes✓ Checkable: passes✓ Load-bearing: passes✓ Based: passes
- It may state two separate claims as one. 27
- Probably not a substantial claim. 13
A result the paper reports from its own data — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“In addition to large effects on handling (Cohen’s delta = .76), moderate effects of MDSP were observed for both excitability and arousal (Cohen’s deltas=.55 and .41, respectively).”
§ Maternal smoking during pregnancy and newborn neurobehavior: A pilot study of effects at 10–27 days > RESULTS > NNNS Outcomes: Adjusted
Tests✓ Asserted: passes✓ Checkable: passes✓ Load-bearing: passes✓ Based: passesIt may state two separate claims as one.
- Rests on an assumption: The exposed and unexposed groups are comparable on all relevant confounders after matching and adjustment.
- Rests on an assumption: The adjustment for postnatal second-hand smoke exposure and breast-feeding is sufficient to isolate the effects of maternal smoking during pregnancy from postnatal nicotine exposure.
A result the paper reports from its own data — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“Effects of maternal smoking during pregnancy on poorer self-regulation and increased arousal were evident at 10–27 but not 1–2 days.”
- Also stated in: § DISCUSSION · plain
“exposure to maternal smoking during pregnancy was associated with increased need for external handling to maintain a quiet alert state, greater difficulties in self-regulation, and increased arousal and excitability at 10–27 days, past the half-life of nicotine/cotinine.”
§ Maternal smoking during pregnancy and newborn neurobehavior: A pilot study of effects at 10–27 days > DISCUSSION
Tests✓ Asserted: passes✓ Checkable: passes✓ Load-bearing: passes✓ Based: passesIt may state two separate claims as one.
- Also stated in: § DISCUSSION · plain
A result the paper reports from its own data — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“Smoking-exposed infants show significantly worse self-regulation and greater need for handling and trended toward greater arousal and excitability than unexposed infants (Cohen’s deltas = .54, .57, 45, and .52, respectively).”
- Also stated in: § DISCUSSION · plain
“We found evidence for greater need for handling and poorer self-regulation in exposed compared with unexposed infants at 10–27 days.”
- Also stated in: § DISCUSSION · hedged
“Although effect sizes were moderate, exposed infants trended toward greater excitability and arousal.”
§ Maternal smoking during pregnancy and newborn neurobehavior: A pilot study of effects at 10–27 days > RESULTS > NNNS Outcomes: Unadjusted
Tests✓ Asserted: passes✓ Checkable: passes✓ Load-bearing: passes✓ Based: passesIt may state two separate claims as one.
- Also stated in: § DISCUSSION · plain
A result the paper reports from its own data — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“Handling was the only continuous NNNS scale to remain significant in the adjusted analyses; maternal smoking during pregnancy was associated with a 0.18 unit increase in need for handling (95% CI= .04–.32).”
§ Maternal smoking during pregnancy and newborn neurobehavior: A pilot study of effects at 10–27 days > RESULTS > NNNS Outcomes: Adjusted
Tests✓ Asserted: passes✓ Checkable: passes✓ Load-bearing: passes✓ Based: passesIt may state two separate claims as one.
- Rests on an assumption: The exposed and unexposed groups are comparable on all relevant confounders after matching and adjustment.
- Rests on an assumption: The adjustment for postnatal second-hand smoke exposure and breast-feeding is sufficient to isolate the effects of maternal smoking during pregnancy from postnatal nicotine exposure.
In the paper
“Unlike results from the immediate newborn period,11 no significant group differences emerged for stress/abstinence or hypertonicity scales.”
- Also stated in: § DISCUSSION · plain
“In contrast to results from the immediate newborn period,11 we found no differences between exposed and unexposed groups in signs of stress/abstinence and hypertonicity.”
§ Maternal smoking during pregnancy and newborn neurobehavior: A pilot study of effects at 10–27 days > RESULTS > NNNS Outcomes: Unadjusted
What the sources say
- Not checked yetcites [11] Law, 2003, Smoking during pregnancy and newborn neurobehavior, Pediatrics source
Load-bearingStrength:plain· not yet calibratedTests✓ Asserted: passes✓ Checkable: passes✓ Load-bearing: passes✓ Based: passesIt may state two separate claims as one.
- Also stated in: § DISCUSSION · plain
A result the paper reports from its own data — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“Neither scale was significantly associated with maternal smoking during pregnancy.”
§ Maternal smoking during pregnancy and newborn neurobehavior: A pilot study of effects at 10–27 days > RESULTS > NNNS Outcomes: Adjusted
Strength:plain· not yet calibratedTests✓ Asserted: passes✓ Checkable: passes? Load-bearing: unclear✓ Based: passesIt may state two separate claims as one.
A result the paper reports from its own data — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“Mean cigarettes smoked over the pregnancy, including three months prior was 8.6 (SD = 6.0).”
§ Maternal smoking during pregnancy and newborn neurobehavior: A pilot study of effects at 10–27 days > RESULTS > Patterns of Maternal Smoking
Strength:plain· not yet calibratedTests✓ Asserted: passes✓ Checkable: passes✗ Load-bearing: fails✓ Based: passesProbably not a substantial claim. The paper’s conclusions may not depend on it.
In the paper
“Notably, smoking-exposed infants, on average, weighed only 49 grams less than unexposed infants at birth, a difference much smaller than the 200-grams typically found in prior studies.34”
§ Maternal smoking during pregnancy and newborn neurobehavior: A pilot study of effects at 10–27 days > DISCUSSION
What the sources say
- Not checked yetcites [34] Beeghly, 1994, Effects of prenatal exposure to cocaine in early infancy: toxic effects on the process of mutual regulation, Infant Ment Health J source
Tests✓ Asserted: passes✓ Checkable: passes✓ Load-bearing: passes✓ Based: passesIt may state two separate claims as one.
A result the paper reports from its own data — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“Effects of maternal smoking during pregnancy on poorer self-regulation and increased arousal were evident at 10–27 but not 1–2 days.”
- Also stated in: § DISCUSSION · plain
“exposure to maternal smoking during pregnancy was associated with increased need for external handling to maintain a quiet alert state, greater difficulties in self-regulation, and increased arousal and excitability at 10–27 days, past the half-life of nicotine/cotinine.”
§ Maternal smoking during pregnancy and newborn neurobehavior: A pilot study of effects at 10–27 days > DISCUSSION
Tests✓ Asserted: passes✓ Checkable: passes✓ Load-bearing: passes✓ Based: passesIt may state two separate claims as one.
- Also stated in: § DISCUSSION · plain
A result the paper reports from its own data — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“In contrast, effects of maternal smoking during pregnancy on signs of stress/withdrawal, and increased muscle tension were evident 1–2 but not 10–27 days.”
- Also stated in: § DISCUSSION · hedged
“That effects of smoking exposure on signs of stress/abstinence were no longer evident past the half-life of nicotine/cotinine in the present study, but were strong at 24–48 hours in our previous study, points to a possibility of a withdrawal process in infants exposed to maternal smoking during pregnancy.”
§ Maternal smoking during pregnancy and newborn neurobehavior: A pilot study of effects at 10–27 days > DISCUSSION
Tests✓ Asserted: passes✓ Checkable: passes✓ Load-bearing: passes✓ Based: passesIt may state two separate claims as one.
- Also stated in: § DISCUSSION · hedged
A result the paper reports from its own data — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“In contrast, effects of maternal smoking during pregnancy on signs of stress/withdrawal, and increased muscle tension were evident 1–2 but not 10–27 days.”
§ Maternal smoking during pregnancy and newborn neurobehavior: A pilot study of effects at 10–27 days > DISCUSSION
Tests✓ Asserted: passes✓ Checkable: passes✓ Load-bearing: passes✓ Based: passesIt may state two separate claims as one.
In the paper
“Several adjusted effect sizes in the current study were of large-to-moderate level according to Cohen’s31 nomenclature (Handling=.73, Excitability=.55, Arousal=.41)”
§ Maternal smoking during pregnancy and newborn neurobehavior: A pilot study of effects at 10–27 days > DISCUSSION
What the sources say
- Not checked yetcites Cohen’s31
Tests✓ Asserted: passes✓ Checkable: passes✓ Load-bearing: passes✓ Based: passesIt may state two separate claims as one.
A conclusion the paper draws from its own results — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“Effects of maternal smoking during pregnancy at 10–27 days are subtle and consistent with increased need for external intervention and poorer self-regulation.”
§ Maternal smoking during pregnancy and newborn neurobehavior: A pilot study of effects at 10–27 days > Abstract > Conclusions
Tests✓ Asserted: passes✓ Checkable: passes✓ Load-bearing: passes✓ Based: passesIt may state two separate claims as one.
- Rests on an assumption: Matching on socioeconomic status, maternal age, and pregnancy alcohol use adequately controls confounding by these factors for the observed associations.
What the paper did — it cites no source for this, so there is none to check. The quote shows it is in the paper.
In the paper
“Due to the small sample size, emphasis was placed upon effect size estimation, rather than hypothesis testing, so that potentially clinically significant findings could be highlighted for replication in future studies.”
§ Maternal smoking during pregnancy and newborn neurobehavior: A pilot study of effects at 10–27 days > METHODS > Procedures
Load-bearingStrength:plain· not yet calibratedTests✓ Asserted: passes✓ Checkable: passes✓ Load-bearing: passes✓ Based: passesProbably not a substantial claim.
In the paper
“NNNS items are scored and combined into summary scales (Tables I and II) with coefficient alphas ranging from 0.56–0.85.26”
§ Maternal smoking during pregnancy and newborn neurobehavior: A pilot study of effects at 10–27 days > METHODS > Measures
What the sources say
- Not checked yetcites [26] Lester, 2004, Summary statistics of neonatal intensive care unit network neurobehavioral scale scores from the maternal lifestyle study: a quasinormative sample, Pediatrics source
Strength:plain· not yet calibratedTests✓ Asserted: passes✓ Checkable: passes✗ Load-bearing: fails✓ Based: passesProbably not a substantial claim. The paper’s conclusions may not depend on it.
What the paper did — it cites no source for this, so there is none to check. The quote shows it is in the paper.
In the paper
“Both maternal self-report and a bioassay were used to identify smoking exposure during pregnancy.”
§ Maternal smoking during pregnancy and newborn neurobehavior: A pilot study of effects at 10–27 days > METHODS
Strength:plain· not yet calibratedTests✓ Asserted: passes✓ Checkable: passes✗ Load-bearing: fails✓ Based: passesProbably not a substantial claim. The paper’s conclusions may not depend on it.
What the paper did — it cites no source for this, so there is none to check. The quote shows it is in the paper.
In the paper
“Exposed and unexposed infants were selected to be healthy, full-term, and normal birthweight.”
§ Maternal smoking during pregnancy and newborn neurobehavior: A pilot study of effects at 10–27 days > Abstract > Conclusions
Load-bearingStrength:plain· not yet calibratedTests✓ Asserted: passes✓ Checkable: passes✓ Load-bearing: passes✓ Based: passesProbably not a substantial claim.
What the paper did — it cites no source for this, so there is none to check. The quote shows it is in the paper.
In the paper
“Maternal cotinine was included to confirm maternal self-report of smoking; infant cotinine provided a biomarker for postnatal nicotine exposure via second-hand smoke and/or breast milk.”
§ Maternal smoking during pregnancy and newborn neurobehavior: A pilot study of effects at 10–27 days > DISCUSSION
Load-bearingStrength:plain· not yet calibratedTests✓ Asserted: passes✓ Checkable: passes✓ Load-bearing: passes✓ Based: passesIt may state two separate claims as one.
A conclusion the paper draws from its own results — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“Thus, examining infants at 10–27 days is less likely to indicate acute effects of nicotine or nicotine withdrawal and may represent a neurobehavioral profile more consistent with early vulnerability to long-term behavioral deficits.”
§ Maternal smoking during pregnancy and newborn neurobehavior: A pilot study of effects at 10–27 days > Abstract > Conclusions
Tests✓ Asserted: passes✓ Checkable: passes✓ Load-bearing: passes✓ Based: passesIt may state two separate claims as one.
In the paper
“and is readily passed from mother to infant, with fetal concentrations reaching approximately 90% of maternal values.20”
§ Maternal smoking during pregnancy and newborn neurobehavior: A pilot study of effects at 10–27 days > METHODS > Measures
What the sources say
- Not checked yetcites [20] Donnenfeld, 1993, Simultaneous fetal and maternal cotinine levels in pregnant women smokers, Am J Obstet Gynecol source
Strength:plain· not yet calibratedCausal:direct· not yet calibratedTests✓ Asserted: passes✓ Checkable: passes? Load-bearing: unclear✓ Based: passesIt may state two separate claims as one.
None of the sources cited for this claim have been checked yet.
In the paper
“The exam is sensitive to effects of intrauterine drug exposure22, 23 but also captures the normative range of behaviors.”
§ Maternal smoking during pregnancy and newborn neurobehavior: A pilot study of effects at 10–27 days > METHODS > Measures
What the sources say
- Not checked yetcites [22] Lester, 2002, The Maternal Lifestyle Study: effects of substance exposure during pregnancy on neurodevelopmental outcome in 1-month-old infants, Pediatrics source
- Not checked yetcites [23] Johnson, 2001, Buprenorphine treatment of pregnant opioid-dependent women: maternal and neonatal outcomes, Drug Alcohol Depend source
Load-bearingStrength:plain· not yet calibratedTests✓ Asserted: passes✓ Checkable: passes✓ Load-bearing: passes✓ Based: passesIt may state two separate claims as one.
What the paper did — it cites no source for this, so there is none to check. The quote shows it is in the paper.
In the paper
“Examiner blind for home visits was assured through requests to mother (e.g., hide smoking paraphernalia, no discussion of smoking status with examiner, return of second-hand smoke questionnaire in sealed envelope) and examiner training focused on multiple sources for signs/smells of smoke—e.g., other smokers in the home or mother.”
§ Maternal smoking during pregnancy and newborn neurobehavior: A pilot study of effects at 10–27 days > METHODS > Procedures
Tests✓ Asserted: passes✓ Checkable: passes✓ Load-bearing: passes✓ Based: passesProbably not a substantial claim. It may state two separate claims as one.
None of the sources cited for this claim have been checked yet.
In the paper
“The NNNS was developed for the National Institutes of Health to assess effects of prenatal drug exposure in infants.12, 21”
§ Maternal smoking during pregnancy and newborn neurobehavior: A pilot study of effects at 10–27 days > METHODS > Measures
What the sources say
Strength:plain· not yet calibratedTests✓ Asserted: passes✓ Checkable: passes✗ Load-bearing: fails✓ Based: passesProbably not a substantial claim. The paper’s conclusions may not depend on it.
A conclusion the paper draws from its own results — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“The pattern of results suggests that smoking-exposed infants were more irritable and less able to self-soothe than unexposed infants.”
§ Maternal smoking during pregnancy and newborn neurobehavior: A pilot study of effects at 10–27 days > DISCUSSION
Tests✓ Asserted: passes✓ Checkable: passes✓ Load-bearing: passes✓ Based: passesIt may state two separate claims as one.
- Rests on an assumption: The exposed and unexposed groups are comparable on all relevant confounders after matching and adjustment.
- Rests on an assumption: The adjustment for postnatal second-hand smoke exposure and breast-feeding is sufficient to isolate the effects of maternal smoking during pregnancy from postnatal nicotine exposure.
A conclusion the paper draws from its own results — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“The profile of a smoking-exposed infant in the later neonatal period includes greater need for external intervention to maintain a quiet alert state (either to arouse infant from a sleeping state or calm infant from a crying state), greater difficulty in self-regulation, and a tendency toward increased arousal and excitability.”
§ Maternal smoking during pregnancy and newborn neurobehavior: A pilot study of effects at 10–27 days > DISCUSSION
Tests✓ Asserted: passes✓ Checkable: passes✓ Load-bearing: passes✓ Based: passesIt may state two separate claims as one.
- Rests on an assumption: The exposed and unexposed groups are comparable on all relevant confounders after matching and adjustment.
- Rests on an assumption: The adjustment for postnatal second-hand smoke exposure and breast-feeding is sufficient to isolate the effects of maternal smoking during pregnancy from postnatal nicotine exposure.
What the paper did — it cites no source for this, so there is none to check. The quote shows it is in the paper.
In the paper
“In addition to comparability between groups, further strengths of this study include model-based adjustment for potential confounds in the pre and postnatal periods (breast-feeding, maternal and infant second-hand smoke exposure, maternal depressive symptoms), and use of biomarkers for maternal and infant nicotine.”
§ Maternal smoking during pregnancy and newborn neurobehavior: A pilot study of effects at 10–27 days > DISCUSSION
Load-bearingStrength:plain· not yet calibratedTests✓ Asserted: passes✓ Checkable: passes✓ Load-bearing: passes✓ Based: passesIt may state two separate claims as one.
What the paper did — it cites no source for this, so there is none to check. The quote shows it is in the paper.
In the paper
“Smoking mothers were of comparable gravida, parity, social class, and employment to non-smoking mothers, and displayed similarly low levels of alcohol use and similar caffeine consumption.”
§ Maternal smoking during pregnancy and newborn neurobehavior: A pilot study of effects at 10–27 days > DISCUSSION
Load-bearingStrength:plain· not yet calibratedTests✓ Asserted: passes✓ Checkable: passes✓ Load-bearing: passes✓ Based: passesIt may state two separate claims as one.
None of the sources cited for this claim have been checked yet.
In the paper
“The calendar-based TLFB is a reliable, valid structured clinical interview designed to gather detailed information on substance use using anchor points to facilitate recall.27, 28”
§ Maternal smoking during pregnancy and newborn neurobehavior: A pilot study of effects at 10–27 days > METHODS > Procedures
What the sources say
- Not checked yetcites [27] Sobell, 1992, Timeline Followback: A technique for assessing self-reported alcohol consumption
- Not checked yetcites [28] Sobell, 1996, The reliability of the Timeline Followback (TLFB) method as applied to drug, cigarette, and the cannabis use
Strength:plain· not yet calibratedTests✓ Asserted: passes✓ Checkable: passes✗ Load-bearing: fails✓ Based: passesProbably not a substantial claim. The paper’s conclusions may not depend on it.
What the paper did — it cites no source for this, so there is none to check. The quote shows it is in the paper.
In the paper
“Notably, no significant differences emerged between groups for infant characteristics including Apgar scores, gestational age, birthweight (< 50 gram difference between groups), breast-feeding, second-hand smoke exposure, and maternal depression, providing further evidence of successful matching between exposure groups.”
§ Maternal smoking during pregnancy and newborn neurobehavior: A pilot study of effects at 10–27 days > RESULTS > Demographic and Medical Characteristics
Load-bearingStrength:plain· not yet calibratedTests✓ Asserted: passes✓ Checkable: passes✓ Load-bearing: passes✓ Based: passesIt may state two separate claims as one.
What the paper did — it cites no source for this, so there is none to check. The quote shows it is in the paper.
In the paper
“The NNNS was administered to infants at post-birth days 10 – 27 (M = 17) by a certified examiner blind to infant exposure status.”
§ Maternal smoking during pregnancy and newborn neurobehavior: A pilot study of effects at 10–27 days > METHODS > Procedures
Load-bearingStrength:plain· not yet calibratedTests✓ Asserted: passes✓ Checkable: passes✓ Load-bearing: passes✓ Based: passesProbably not a substantial claim. It may state two separate claims as one.
A conclusion the paper draws from its own results — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“That effects of smoking exposure on signs of stress/abstinence were no longer evident past the half-life of nicotine/cotinine in the present study, but were strong at 24–48 hours in our previous study, points to a possibility of a withdrawal process in infants exposed to maternal smoking during pregnancy.”
§ Maternal smoking during pregnancy and newborn neurobehavior: A pilot study of effects at 10–27 days > DISCUSSION
Tests✓ Asserted: passes✓ Checkable: passes✓ Load-bearing: passes✓ Based: passesIt may state two separate claims as one.
- Rests on an assumption: The half-life of nicotine/cotinine in newborns is short enough that 10–27 days is past it.
- Rests on an assumption: In the previous study from our group, effects of smoking exposure on signs of stress/abstinence were strong at 24–48 hours.
A conclusion the paper draws from its own results — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“we cannot rule out the possibility that effects shown at 10–27 days in this study represent prolonged symptoms of withdrawal rather than persistent neurotoxic effects.”
§ Maternal smoking during pregnancy and newborn neurobehavior: A pilot study of effects at 10–27 days > DISCUSSION
Tests✓ Asserted: passes✓ Checkable: passes✓ Load-bearing: passes✓ Based: passesProbably not a substantial claim.
- Rests on an assumption: Definitive evidence for a neonatal nicotine withdrawal syndrome and its time course has not been established.
A conclusion the paper draws from its own results — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“That these effects are evident in the first month suggests the possibility of early identification of offspring who may, in combination with exposure to poor parenting and other postnatal factors, be at greater risk for later adverse neurobehavioral outcomes.”
§ Maternal smoking during pregnancy and newborn neurobehavior: A pilot study of effects at 10–27 days > DISCUSSION
Tests✓ Asserted: passes✓ Checkable: passes✓ Load-bearing: passes✓ Based: passesIt may state two separate claims as one.
A conclusion the paper draws from its own results — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“Given that these moderate-to-large neurobehavioral effects from maternal smoking during pregnancy emerged in infants exposed to low levels of smoking and selected as healthy and normal birthweight, even greater effects may be evident in infants exposed to higher levels of smoking, low birthweight infants, and/or infants who show additional complications related to maternal smoking.”
§ Maternal smoking during pregnancy and newborn neurobehavior: A pilot study of effects at 10–27 days > DISCUSSION
Strength:hedged· not yet calibratedCausal:conditional· not yet calibratedTests✓ Asserted: passes✓ Checkable: passes? Load-bearing: unclear✓ Based: passesIt may state two separate claims as one.
What the paper did — it cites no source for this, so there is none to check. The quote shows it is in the paper.
In the paper
“greater levels of depressive symptoms in the unexposed versus smoking-exposed group is puzzling and inconsistent with prior research.”
§ Maternal smoking during pregnancy and newborn neurobehavior: A pilot study of effects at 10–27 days > DISCUSSION
Strength:plain· not yet calibratedCausal:correlational· not yet calibratedTests✓ Asserted: passes✓ Checkable: passes✗ Load-bearing: fails✓ Based: passesProbably not a substantial claim. The paper’s conclusions may not depend on it.
What the paper did — it cites no source for this, so there is none to check. The quote shows it is in the paper.
In the paper
“although inclusion of maternal saliva cotinine to verify self-report of smoking is a strength of the study”
§ Maternal smoking during pregnancy and newborn neurobehavior: A pilot study of effects at 10–27 days > DISCUSSION
Strength:plain· not yet calibratedTests✓ Asserted: passes✓ Checkable: passes✗ Load-bearing: fails✓ Based: passesProbably not a substantial claim. The paper’s conclusions may not depend on it.
A conclusion the paper draws from its own results — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“Differing results from prior studies may be related to our use of a control group matched on socio-economic status.”
§ Maternal smoking during pregnancy and newborn neurobehavior: A pilot study of effects at 10–27 days > DISCUSSION
Strength:hedged· not yet calibratedCausal:conditional· not yet calibratedTests✓ Asserted: passes✓ Checkable: passes✗ Load-bearing: fails✗ Based: failsProbably not a substantial claim. The paper’s conclusions may not depend on it. The paper may give no reason why it holds.
In the paper
“Results from our group are complemented by Godding et al, 13 who also found evidence for withdrawal symptoms and neurological deficits in newborns exposed to maternal smoking during pregnancy.”
§ Maternal smoking during pregnancy and newborn neurobehavior: A pilot study of effects at 10–27 days > DISCUSSION
What the sources say
- Not checked yetcites Godding et al, 13
Tests✓ Asserted: passes✓ Checkable: passes✓ Load-bearing: passes✓ Based: passesIt may state two separate claims as one.
The paper relies on this without support.
Matching on socioeconomic status, maternal age, and pregnancy alcohol use adequately controls confounding by these factors for the observed associations.
“By design, smokers and non-smokers were matched for common confounders as in prior studies: socioeconomic status, alcohol use, and age.”
The paper relies on this without support.
The NNNS stress/abstinence scale reveals signs of neonatal abstinence following exposure to other drugs of abuse.
“Exposed infants also showed higher scores on the NNNS stress-scale—a scale demonstrated to reveal signs of neonatal abstinence following exposure to other drugs of abuse.”
The paper relies on this without support.
The exposed and unexposed groups are comparable on all relevant confounders after matching and adjustment.
“A notable strength of the present study was the care taken to achieve strict comparability between exposed and unexposed groups by matching on covariates identified in prior studies.”
The paper relies on this without support.
The adjustment for postnatal second-hand smoke exposure and breast-feeding is sufficient to isolate the effects of maternal smoking during pregnancy from postnatal nicotine exposure.
“In addition to comparability between groups, further strengths of this study include model-based adjustment for potential confounds in the pre and postnatal periods (breast-feeding, maternal and infant second-hand smoke exposure, maternal depressive symptoms), and use of biomarkers for maternal and infant nicotine.”
The paper relies on this without support.
Definitive evidence for a neonatal nicotine withdrawal syndrome and its time course has not been established.
“because definitive evidence for a neonatal nicotine withdrawal syndrome and its time course have not been established”
The paper relies on this without support.
The half-life of nicotine/cotinine in newborns is short enough that 10–27 days is past it.
“past the half-life of nicotine/cotinine”
“no longer evident past the half-life of nicotine/cotinine in the present study”
The paper relies on this without support.
In the previous study from our group, effects of smoking exposure on signs of stress/abstinence were strong at 24–48 hours.
“but were strong at 24–48 hours in our previous study”
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“Studies later in the neonatal period (10-30 days) found continued or emerging behavioral effects on self-regulation, attention, need for external soothing or handling, and arousal”
From Developmental toxicity of nicotine: A transdisciplinary synthesis and implications for emerging tobacco products (2017) · cites this paper as [127]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
Each contradiction between two passages listed here was confirmed by an independent check.
Adjusted handling effect size reported as both .76 and .73
MinorThe Results and Discussion give different Cohen's deltas for the adjusted effect on handling.
“In addition to large effects on handling (Cohen’s delta = .76), moderate effects of MDSP were observed for both excitability and arousal”
“Several adjusted effect sizes in the current study were of large-to-moderate level according to Cohen’s31 nomenclature (Handling=.73, Excitability=.55, Arousal=.41)”
Citations
Cites
Statistical Power Analysis for the Behavioral Sciences
Muller, K. E., & Cohen, J. (1989) · Technometrics · doi:10.2307/1270020 · Cited by 99,603
Statistical power analysis for the behavioral sciences
Cohen, J. (1990) · Computers Environment and Urban Systems · doi:10.1016/0198-9715(90)90050-4 · Cited by 65,417
The CES-D Scale: A Self-Report Depression Scale for Research in the General Population
Radloff, L. S. (1977) · Applied Psychological Measurement · doi:10.1177/014662167700100306 · Cited by 53,267
Statistical Power Analysis for the Behavioral Sciences (2nd ed.).
Lachenbruch, P. A., & Cohen, J. (1989) · Journal of the American Statistical Association · doi:10.2307/2290095 · Cited by 37,421
Hapeman, D. E., & Agresti, A. (1991) · Technometrics · doi:10.1080/00401706.1991.10484817 · Cited by 9,407
Sobell, L. C., & Sobell, M. B. (1992) · Measuring Alcohol Consumption · doi:10.1007/978-1-4612-0357-5_3 · Cited by 4,110
Neonatal Behavioral Assessment Scale
Salkind, N. J. (2005) · Encyclopedia of Human Development · doi:10.4135/9781412952484.n438 · Cited by 1,328
Comparison of tests used to distinguish smokers from nonsmokers
Jarvis, M. J., Tunstall-Pedoe, H., Feyerabend, C., Vesey, C., & Saloojee, Y. (1987) · American Journal of Public Health · doi:10.2105/ajph.77.11.1435 · Cited by 994
Martin, J. A., Hamilton, B. E., Sutton, P. D., Ventura, S. J., Menacker, F., & Munson, M. L. (2003) · PubMed · Cited by 908
Hapeman, D. E., & Agresti, A. (1991) · Technometrics · doi:10.2307/1269056 · Cited by 814
Flagged first, then by citations
Research works printed but not linked: 1
- Buka, 2000, Evidence of a link between prenatal exposure to nicotine and risk of tobacco dependence in a 30-year prospective cohort study, Nicotine Tob Res, 2, 287
Cited by
Sorted by citations
Developmental Consequences of Fetal Exposure to Drugs: What We Know and What We Still Must Learn
Ross, E. J., Graham, D. L., Money, K. M., & Stanwood, G. D. (2014) · Neuropsychopharmacology · doi:10.1038/npp.2014.147 · Cited by 515
Neonatal Neurobehavior Predicts Medical and Behavioral Outcome
Liu, J., Bann, C., Lester, B. M., Tronick, E. Z., Das, A., LaGasse, L. L., Bauer, C. R., Shankaran, S., & Bada, H. S. (2009) · PEDIATRICS · doi:10.1542/peds.2009-0204 · Cited by 211
Self-citationDevelopmental consequences of prenatal tobacco exposure
Cornelius, M. D., & Day, N. L. (2009) · Current Opinion in Neurology · doi:10.1097/wco.0b013e328326f6dc · Cited by 209
Prenatal exposure to bisphenol A and phthalates and infant neurobehavior
Yolton, K. A., Xu, Y. Y., Strauss, D., Altaye, M., Calafat, A. M., & Khoury, J. C. (2011) · Neurotoxicology and Teratology · doi:10.1016/j.ntt.2011.08.003 · Cited by 199
England, L. J., Aagaard, K., Bloch, M., Conway, K., Cosgrove, K., Grana, R., Gould, T. J., Hatsukami, D., Jensen, F., Kandel, D., et al. (2017) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2016.11.013 · Cited by 181
Self-citationPrenatal methamphetamine exposure and neonatal neurobehavioral outcome in the USA and New Zealand
LaGasse, L. L., Wouldes, T. A., Newman, E., Smith, L. M., Shah, R. Z., Derauf, C., Huestis, M. A., Arria, A. M., Grotta, S. A. D., Wilcox, T., et al. (2010) · Neurotoxicology and Teratology · doi:10.1016/j.ntt.2010.06.009 · Cited by 108
Self-citationBublitz, M. H., & Stroud, L. R. (2011) · Nicotine & Tobacco Research · doi:10.1093/ntr/ntr191 · Cited by 114
Self-citationStroud, L. R., Papandonatos, G. D., Rodriguez, D., McCallum, M., Salisbury, A. L., Phipps, M. G., Lester, B., Huestis, M. A., Niaura, R., Padbury, J. F., et al. (2014) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2014.05.017 · Cited by 104
“Previous work has also revealed effects of MSDP on behavioral dysregulation in the neonatal period, including increased irritability and motor activity, and attention and self-regulation deficits (Law et al., 2003; Stroud et al., 2009; Yolton et al., 2009).”
BackgroundMaternal smoking during pregnancy and neonatal behavior: a large-scale community study
Stroud, L. R., Paster, R. L., Goodwin, M. S., Shenassa, E., Buka, S., Niaura, R., Rosenblith, J. F., & Lipsitt, L. P. (2009) · PEDIATRICS · doi:10.1542/peds.2008-2084 · Cited by 96
Cornelius, M. D., Genna, N. M. D., Leech, S. L., Willford, J. A., Goldschmidt, L., & Day, N. L. (2011) · Neurotoxicology and Teratology · doi:10.1016/j.ntt.2010.08.006 · Cited by 99
“The effects of PCSE range from irritability and poor self-regulation during infancy [47,64,65] to behavior problems during childhood [14,34,53,57,70].”
Associations Between Secondhand Smoke Exposure and Sleep Patterns in Children
Yolton, K. A., Xu, Y. Y., Khoury, J. C., Succop, P. S., Lanphear, B. P., Beebe, D. W., & Owens, J. A. (2010) · PEDIATRICS · doi:10.1542/peds.2009-0690 · Cited by 96
Neonatal neurobehavior effects following buprenorphine versus methadone exposure
Coyle, M. G., Salisbury, A. L., Lester, B. M., Jones, H. E., Lin, H., Graf‐Rohrmeister, K., & Fischer, G. (2012) · Addiction · doi:10.1111/j.1360-0443.2012.04040.x · Cited by 92
“The NICU Network Neurobehavioral Scale (NNNS) has been used to describe the neurobehavioral effects of fetal exposure to opiates [1,11–13], cocaine [14] methamphetamines [15] and nicotine [16,25].”
Self-citationNeurobehavioral Assessment Predicts Motor Outcome in Preterm Infants
Stephens, B. E., Liu, J., Lester, B. M., LaGasse, L. L., Shankaran, S., Bada, H. S., Bauer, C. R., Das, A., & Higgins, R. D. (2009) · The Journal of Pediatrics · doi:10.1016/j.jpeds.2009.09.042 · Cited by 81
Self-citationJansson, L. M., DiPietro, J. A., Elko, A., Williams, E. L., Milio, L. A., & Vélez, M. L. (2011) · Drug and Alcohol Dependence · doi:10.1016/j.drugalcdep.2011.10.003 · Cited by 77
Examining the joint contribution of placental NR3C1 and HSD11B2 methylation for infant neurobehavior
Appleton, A. A., Lester, B. M., Armstrong, D. A., Lesseur, C., & Marsit, C. J. (2014) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2014.11.004 · Cited by 72
Self-citationLong-Term Reprogramming of Cardiovascular Function in Infants of Active Smokers
Cohen, G., Jeffery, H. E., Lagercrantz, H., & Katz‐Salamon, M. (2010) · Hypertension · doi:10.1161/hypertensionaha.109.142695 · Cited by 70
NICU Network Neurobehavioral Scale Profiles Predict Developmental Outcomes in a Low‐Risk Sample
Sucharew, H. J., Khoury, J. C., Xu, Y. Y., Succop, P. S., & Yolton, K. A. (2012) · Paediatric and Perinatal Epidemiology · doi:10.1111/j.1365-3016.2012.01288.x · Cited by 68
Grandchild of the NBAS : The NICU N etwork N eurobehavioral S cale ( NNNS )
Tronick, E., & Lester, B. M. (2013) · Journal of Child and Adolescent Psychiatric Nursing · doi:10.1111/jcap.12042 · Cited by 68
“In another short-term longitudinal study, Stroud et al. (2009) examined the effects of maternal smoking during pregnancy on newborn neurobehavior at 10–27 days.”
BackgroundSelf-citationChisolm, M. S., Fitzsimons, H., Leoutsakos, J., Acquavita, S. P., Heil, S. H., Wilson-Murphy, M., Tuten, M., Kaltenbach, K. A., Martin, P., Winklbaur, B., et al. (2013) · Nicotine & Tobacco Research · doi:10.1093/ntr/nts274 · Cited by 63
“sudden infant death syndrome) (Bada et al., 2005; Conter et al., 1995; D’Onofrio et al., 2003; Knopik et al., 2005; McCowan & Horgan, 2009; Salihu et al., 2008; Stroud et al., 2009; Thiriez et al., 2009) and the already high risk of medical complica-”
BackgroundAltered placental DNA methylation patterns associated with maternal smoking: current perspectives
Maccani, J. Z. J., & Maccani, M. (2015) · Advances in Genomics and Genetics · doi:10.2147/agg.s61518 · Cited by 62
“Ongoing cohort studies may help to further discern the risks posed by MCSDP to infant and child health outcomes, including risks for respiratory disorders, 110,111,113,114,116 adverse neurodevelopmental outcomes, 15,16,60,61,64,85,145 and obesity, 17–19 all of which have been linked to MCSDP.”
Salisbury, A. L., Wisner, K. L., Pearlstein, T. B., Battle, C. L., Stroud, L. R., & Lester, B. M. (2011) · Depression and Anxiety · doi:10.1002/da.20883 · Cited by 59
“[63–66]”
Self-citationOstlund, B. D., Vlisides‐Henry, R. D., Crowell, S. E., Raby, K. L., Terrell, S., Brown, M. A., Tinajero, R., Shakiba, N., Monk, C. E., Shakib, J. H., et al. (2019) · Development and Psychopathology · doi:10.1017/s0954579419000440 · Cited by 61
“…maternal depression performed worse in domains such as arousal, excitability, and regulation, compared to their unexposed peers (see Conradt, Sheinkopf, et al., 2013; Law et al., 2003; Napiorkowski et al., 1996; and Stroud et al., 2009, for similar results related to prenatal substance exposure).”
BackgroundResultPrenatal tobacco exposure: Developmental outcomes in the neonatal period.
Espy, K. A., Fang, H., Johnson, C., Stopp, C., Wiebe, S. A., & Respass, J. (2011) · Developmental Psychology · doi:10.1037/a0020724 · Cited by 67
Healthy Newborns' Neurobehavior: Norms and Relations to Medical and Demographic Factors
Fink, N., Tronick, E. Z., Olson, K. L., & Lester, B. M. (2012) · The Journal of Pediatrics · doi:10.1016/j.jpeds.2012.05.036 · Cited by 52
Self-citationStroud, L. R., Papandonatos, G. D., Salisbury, A. L., PHIPPS, M. G., Huestis, M. A., NIAURA, R. S., Padbury, J. F., Marsit, C. J., & Lester, B. M. (2016) · Child Development · doi:10.1111/cdev.12482 · Cited by 51
Self-citationPrenatal Tobacco Exposure, Biomarkers for Tobacco in Meconium, and Neonatal Growth Outcomes
Himes, S. K., Stroud, L. R., Scheidweiler, K. B., NIAURA, R. S., & Huestis, M. A. (2012) · The Journal of Pediatrics · doi:10.1016/j.jpeds.2012.10.045 · Cited by 50
Self-citationVardavas, C. I., Patelarou, E., Chatzi, L., Roumeliotaki, T., Sarri, K. O., Murphy, S. E., Koutis, A. D., Kafatos, A. G., & Kogevinas, M. (2010) · Journal of Epidemiology · doi:10.2188/jea.je20090156 · Cited by 50
Low-level prenatal exposure to nicotine and infant neurobehavior
Yolton, K., Khoury, J., Xu, Y., Succop, P., Lanphear, B., Bernert, J. T., & Lester, B. (2009) · Neurotoxicology and Teratology · doi:10.1016/j.ntt.2009.07.004 · Cited by 52
“2 Newborn Neurobehavior The number of infants receiving scores on habituation and hypertonicity subscales of the NNNS were too small for meaningful interpretation (n = 29 and n = 13, respectively), so we excluded these subscales from analyses in accordance with other researchers who have used the NNNS as an outcome [1…”
BackgroundResultInfluentialSelf-citationChanges in Smoking Patterns During Pregnancy
Eiden, R. D., Homish, G. G., Colder, C. R., Schuetze, P. A., Gray, T. R., & Huestis, M. A. (2013) · Substance Use & Misuse · doi:10.3109/10826084.2013.787091 · Cited by 46
“Smoking during pregnancy is harmful for mother and child, with increased risk for prenatal complications such as risk for abruption, placenta previa, perinatal mortality, impaired fetal growth, higher neonatal stress and irritability, hearing loss, and respiratory problems (Cornelius & Day, 2000; Cornelius, Leech, & G…”
BackgroundNeonatal Abstinence Syndrome: Essentials for the Practitioner
Siu, A., & Robinson, C. A. (2014) · The Journal of Pediatric Pharmacology and Therapeutics · doi:10.5863/1551-6776-19.3.147 · Cited by 46
Kiblawi, Z. N., Smith, L. M., Diaz, S. D., LaGasse, L. L., Derauf, C., Newman, E., Shah, R., Arria, A. M., Huestis, M. A., Haning, W., et al. (2013) · Substance Abuse · doi:10.1080/08897077.2013.814614 · Cited by 44
“Prenatal nicotine exposure has been associated with increased excitability, hypertonicity, need for handling and stress/abstinence scores at birth,(25) with increased need for handling persisting to 1 month of age.(38) Prenatal cocaine exposure has been associated with increased central nervous system stress, poor vis…”
BackgroundSelf-citationNatural drugs, not so natural effects: Neonatal abstinence syndrome secondary to ‘kratom’
Davidson, L., Rawat, M., Stojanovski, S. D., & Chandrasekharan, P. K. (2018) · Journal of Neonatal-Perinatal Medicine · doi:10.3233/npm-1863 · Cited by 44
Anger, Hostility, and Aggression as Predictors of Persistent Smoking During Pregnancy
Eiden, R. D., Leonard, K. E., Colder, C. R., Homish, G. G., Schuetze, P. A., Gray, T. R., & Huestis, M. A. (2011) · Journal of Studies on Alcohol and Drugs · doi:10.15288/jsad.2011.72.926 · Cited by 41
“…such as risk of abruption, placenta previa, perinatal mortality, impaired fetal growth, higher neonatal stress and irritability, hearing loss, and respiratory problems (Andres and Day, 2000; Cornelius and Day, 2000; Cornelius et al., 2004; Fried, 1998; Mccartney et al., 1994; Stroud et al., 2009).”
BackgroundPrenatal exposure to tobacco and cannabis: Effects on autonomic and emotion regulation
Eiden, R. D., Schuetze, P. A., Shisler, S., & Huestis, M. A. (2018) · Neurotoxicology and Teratology · doi:10.1016/j.ntt.2018.04.007 · Cited by 47
“…there is robust evidence of the association between PTE and arousal dysregulation in the neonatal period (Espy et al., 2011; Jacobson et al., 1984; Stroud et al., 2009), a smaller literature in infancy (Wiebe et al., 2014; Schuetze et al., 2017), and a larger literature on problem behavior in…”
BackgroundAssessment and Evaluation of the High Risk Neonate: The NICU Network Neurobehavioral Scale
Lester, B. M., Andreozzi, L. M., Tronick, E. Z., & Bigsby, R. (2014) · Journal of Visualized Experiments · doi:10.3791/3368 · Cited by 40
Self-citationHernández‐Martínez, C., Arija, V., Escribano, J., & Canals, J. (2011) · Early Human Development · doi:10.1016/j.earlhumdev.2011.10.004 · Cited by 39
“However, several authors have hypothesized that the isolated symptoms (irritability and hypertonicity) observed in the newborns of mothers who smoke heavily can also be explained by the nicotine withdrawal syndrome as a result of chronic prenatal exposure to high levels of tobacco smoke [21,46,47].”
BackgroundMethodResultFroggatt, S., Covey, J. A., & Reissland, N. (2019) · Acta Paediatrica · doi:10.1111/apa.15132 · Cited by 47
A new look at quantifying tobacco exposure during pregnancy using fuzzy clustering
Fang, H., Johnson, C., Stopp, C. D., & Espy, K. A. (2011) · Neurotoxicology and Teratology · doi:10.1016/j.ntt.2010.08.003 · Cited by 37
“We then validated our results by examining the effect of the new exposure grouping on irritable reactivity (IR) in neonates, measured by regulatory responses to auditory and visual stimuli, as well as to routine handing [13,32,38,44,49,51,68].”
ResultAnalysis of the Risk Factors Associated With Obstructive Sleep Apnea Syndrome in Chinese Children
Xiao, L., Su, S., Liang, J., Jiang, Y., Yan, S., & Ding, L. (2022) · Frontiers in Pediatrics · doi:10.3389/fped.2022.900216 · Cited by 40
Impact of maternal prenatal smoking on fetal to infant neurobehavioral development
Stroud, L. R., McCallum, M., & Salisbury, A. L. (2018) · Development and Psychopathology · doi:10.1017/s0954579418000676 · Cited by 35
Self-citationPrenatal tobacco and marijuana co-use: Impact on newborn neurobehavior
Stroud, L. R., Papandonatos, G. D., McCallum, M., Kehoe, T., Salisbury, A. L., & Huestis, M. A. (2018) · Neurotoxicology and Teratology · doi:10.1016/j.ntt.2018.09.003 · Cited by 37
“…(self-regulation), increased need for external soothing (need for handling), decreased attention to stimuli (attention/orientation), and alterations in motor activity (including increased lethargy and arousal) (Espy et al., 2011; Stroud et al., 2016; Stroud et al., 2009b; Yolton et al., 2009).”
BackgroundResultInfluentialSelf-citationMaternal smoking during pregnancy and long-term neurological morbidity of the offspring
Gutvirtz, G., Wainstock, T., Landau, D., & Sheiner, E. (2018) · Addictive Behaviors · doi:10.1016/j.addbeh.2018.08.013 · Cited by 35
Wakschlag, L. S., Henry, D. B., Blair, J., Dukić, V., Burns, J. L., & Pickett, K. E. (2011) · Neurotoxicology and Teratology · doi:10.1016/j.ntt.2010.07.002 · Cited by 34
Risk factors for poor neonatal adaptation after exposure to antidepressants in utero
Kieviet, N., Hoppenbrouwers, C., Dolman, K. M., Berkhof, J. H., Wennink, H., & Honig, A. (2015) · Acta Paediatrica · doi:10.1111/apa.12921 · Cited by 32
“These factors were the type of antidepressant (SSRI, SNRI or NaSSA) (3,6,10–12), dosage of the antidepressant (2,4,14,15), tobacco smoking during the last trimester of pregnancy (3,7,10,16), increased anxiety and depression scores in the third trimester and after the delivery according to the HADS (3,10,11), type of f…”
BackgroundMethodPrenatal Programming of Infant Neurobehaviour in a Healthy Population
Appleton, A. A., Murphy, M., Koestler, D. C., Lesseur, C., Paquette, A. G., Padbury, J. F., Lester, B. M., & Marsit, C. J. (2016) · Paediatric and Perinatal Epidemiology · doi:10.1111/ppe.12294 · Cited by 30
Self-citationEffect of maternal substance abuse on the fetus, neonate, and child
Bailey, N. A., & Diaz-Barbosa, M. (2018) · Pediatrics In Review · doi:10.1542/pir.2017-0201 · Cited by 34
Chang, C.-W., Chang, C.-H., Chuang, H., Cheng, H., Lin, C.-I., Chen, H.-T., & Yang, C. (2022) · Environmental Health · doi:10.1186/s12940-022-00868-6 · Cited by 26
“The possible mechanism is through acetylcholine stimulation and activation of dopaminergic pathways in the central neurologic system [50].”
BackgroundCYP1A1 Modifies the Effect of Maternal Exposure to Environmental Tobacco Smoke on Child Behavior
Hsieh, C., Jeng, S., Su, Y.-N., Liao, H.-F., Hsieh, W., Wu, K., & Chen, P. (2010) · Nicotine & Tobacco Research · doi:10.1093/ntr/ntq157 · Cited by 23
Determining the impact of prenatal tobacco exposure on self-regulation at 6 months.
Wiebe, S. A., Fang, H., Johnson, C., James, K. E., & Espy, K. A. (2014) · Developmental Psychology · doi:10.1037/a0035904 · Cited by 22
“Numerous studies spanning several decades have found differences in arousal, attention, reaction to stress, and soothability between tobacco-exposed (TE) and non-exposed (NE) neonates (Espy et al., 2011; Jacobson, Fein, Jacobson, Schwartz, & Dowler, 1984; Mansi et al., 2007; Stroud et al., 2009).”
BackgroundChisolm, M. S., Cheng, D., & Terplan, M. (2013) · Journal of Substance Abuse Treatment · doi:10.1016/j.jsat.2013.07.010 · Cited by 22
“It is known to increase risk of impaired fetal growth, pre-term birth, and low birthweight, in addition to other adverse pregnancy and neonatal outcomes (Bada et al., 2005; Conter, Cortinovis, Rogari, & Riva, 1995; Knopik et al., 2005; Salihu et al., 2008; Stroud et al., 2009; Thiriez et al., 2009).”
BackgroundLabardee, R. M., Swartzwelder, J., Gebhardt, K. E., Pardi, J. A., Dawsey, A. C., Dixon, R. B., & Cotten, S. W. (2017) · Clinical Biochemistry · doi:10.1016/j.clinbiochem.2017.09.016 · Cited by 22
Lin, B., Ostlund, B. D., Conradt, E. D., LaGasse, L. L., & Lester, B. M. (2018) · Development and Psychopathology · doi:10.1017/s0954579418000391 · Cited by 22
“…period in comparison to nonexposed peers (Bauer et al., 2005; Law et al., 2003; Lester et al., 2002; Oberlander et al., 2010; Smith et al., 2008; Stroud et al., 2009), as well as increased negative emotionality and reactivity in infancy (Lester et al., 2009; O’Connor, 2001; Richardson,…”
BackgroundInfluentialSelf-citationMcCrory, C., & Layte, R. (2012) · Research on Child and Adolescent Psychopathology · doi:10.1007/s10802-012-9640-9 · Cited by 25
The Impacts of Cord Blood Cotinine and Glutathione-S-Transferase Gene Polymorphisms on Birth Outcome
Huang, K.-H., Chou, A., Jeng, S., Ng, S., Hsieh, C., Chen, M., Chen, P., & Hsieh, W. (2017) · Pediatrics & Neonatology · doi:10.1016/j.pedneo.2016.08.006 · Cited by 20
Barros, M. C. D. M., Mitsuhiro, S. S., Chalem, E., Laranjeira, R., & Guinsburg, R. (2011) · Clinics · doi:10.1590/s1807-59322011000900016 · Cited by 15
Measures of infant self‐regulation during the first year of life: A systematic review
Pinto, T. M., & Figueiredo, B. (2023) · Infant and Child Development · doi:10.1002/icd.2414 · Cited by 20
Sullivan, M. C., Miller, R. J., Fontaine, L. A., & Lester, B. M. (2012) · Journal of Obstetric, Gynecologic & Neonatal Nursing · doi:10.1111/j.1552-6909.2011.01322.x · Cited by 16
“, 1996), tobacco (Law et al., 2003; Stroud et al., 2009; Yolton et al., 2009), marijuana (de Moraes Barros et al.”
BackgroundSelf-citationAjarem, J. S., Al-Basher, G., Allam, A. A., & Mahmoud, A. M. (2017) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2017/5985219 · Cited by 15
“In addition, exposed infants showed poor selfregulation within the first month of life [23].”
BackgroundEarliest Appropriate Time for Administering Neurobehavioral Assessment in Newborn Infants
Xu, Y. Y., Yolton, K. A., & Khoury, J. C. (2010) · PEDIATRICS · doi:10.1542/peds.2010-1121 · Cited by 14
Liao, C., Chen, Y.-J., Lee, J.-F., Lu, C.-L., & Chen, C. (2012) · Tzu Chi Medical Journal · doi:10.1016/j.tcmj.2012.08.003 · Cited by 13
“Using a similar methodology, they tested infants aged 10e27 days [10].”
MethodNovel Withdrawal Symptoms of a Neonate Prenatally Exposed to a Fentanyl Analog
Nellhaus, E. M., Murray, S., Hansen, Z., Loudin, S., & Davies, T. H. (2018) · Journal of Pediatric Health Care · doi:10.1016/j.pedhc.2018.08.014 · Cited by 13
Neonatal Outcomes after Combined Opioid and Nicotine Exposure in Utero: A Scoping Review
Isaacs, K. R., Atreyapurapu, S., Alyusuf, A., Ledgerwood, D. M., Finnegan, L. P., Chang, K., Ma, T., & Washio, Y. (2021) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph181910215 · Cited by 13
“Given that significant tobacco consumption in women who are pregnant and not taking opioids can result in infant nicotine withdrawal signs [21,22] and noticeable poor neonatal outcomes [9,23–25], it is critical to review whether prenatal exposure to both nicotine and opioids (for treatment of OUD, treatment of pain, o…”
BackgroundBeltrán-Castillo, S., Bravo, K., & Eugenín, J. L. (2023) · Advances in experimental medicine and biology · doi:10.1007/978-3-031-32554-0_10 · Cited by 12
Prenatal tobacco exposure influences cerebral oxygenation in preterm infants
Verhagen, E. A., ter Horst, H. J., Kooi, E. M. W., Keating, P., van den Berg, P. P., & Bos, A. F. (2011) · Early Human Development · doi:10.1016/j.earlhumdev.2011.03.002 · Cited by 13
“Tobacco exposure during pregnancy increases the risk for preterm birth, low birth weight, smaller head circumference, neurological deficits, sudden infant death syndrome, and adverse neurobehavioral outcome in the long term, including attention deficit disorders and hyperactivity [3–6].”
BackgroundTobacco smoke exposure as a risk factor for obstructive sleep apnea in children
Włodarska, A., & Doboszyńska, A. (2020) · Pediatrics International · doi:10.1111/ped.14191 · Cited by 11
Ostlund, B. D., Pérez‐Edgar, K. E., Shisler, S., Terrell, S., Godleski, S. A., Schuetze, P. A., & Eiden, R. D. (2021) · Development and Psychopathology · doi:10.1017/s0954579421001000 · Cited by 13
“Behaviorally, prenatal cigarette exposure increases risk for irritability and higher arousal in the early neonatal period (Stroud et al., 2009), problems with self-soothing and attention/orienting in the later neonatal period (Espy et al.”
BackgroundAssessment and Evaluation of the High Risk Neonate: The NICU Network Neurobehavioral Scale
Lester, B. M., Andreozzi, L. M., Tronick, E. Z., & Bigsby, R. (2014) · Journal of Visualized Experiments · doi:10.3791/3368-v · Cited by 10
Self-citationStroud, L. R., Bublitz, M. H., Crespo, F. A., Lester, B. M., & Salisbury, A. L. (2020) · Neurotoxicology and Teratology · doi:10.1016/j.ntt.2020.106894 · Cited by 8
Self-citationMiller-Thomas, T., Leoutsakos, J., Terplan, M., Brigham, E. P., & Chisolm, M. S. (2014) · Journal of Addiction Medicine · doi:10.1097/adm.0000000000000068 · Cited by 8
“Maternal smoking increases the risk of impaired fetal growth, preterm birth, and low birth weight, among other poor birth outcomes (D’Onofrio et al., 2003; Bada et al., 2005; Knopik et al., 2005; Salihu et al., 2008; McCowan & Horgan, 2009; Stroud et al., 2009; Thiriez et al., 2009).”
BackgroundBertini, G., Elia, S. N., Lori, S., & Dani, C. (2019) · Acta Paediatrica · doi:10.1111/apa.14762 · Cited by 8
Parental tobacco consumption and child development
Santos, N. F., & Costa, R. A. (2015) · Jornal de Pediatria · doi:10.1016/j.jped.2014.09.006 · Cited by 7
“It consists of 150 items, which are distributed in levels (1-30).”
BackgroundHsieh, C., Jeng, S., Wu, K., Su, Y.-N., Liao, H.-F., Hsieh, W., & Chen, P. (2011) · Nicotine & Tobacco Research · doi:10.1093/ntr/ntr124 · Cited by 5
Polycyclic Aromatic Hydrocarbons in Maternal and Cord Blood Plasma
Radmacher, P. G., Looney, S. W., & Myers, S. R. (2010) · Polycyclic aromatic compounds · doi:10.1080/10406631003800639 · Cited by 5
“A maternal cotinine concentration of 35 ng/mL was chosen as a cut-point to distinguish between two groups of women: those whose tobacco smoke exposure was limited (none-light) and those whose smoke exposure was more substantial (moderate-heavy) (50, 80, 91).”
MethodAntidepressants during pregnancy, risks for mother and child
Ververs, T. F. (2009) · Utrecht University Repository (Utrecht University) · Cited by 5
Sehgal, N., Brennan, P. A., Dunlop, A. L., Liang, D., Corwin, E. J., Tan, Y., Everson, T. M., Caudle, W. M., Panuwet, P., D'Souza, P. E., et al. (2025) · Neurotoxicology and Teratology · doi:10.1016/j.ntt.2025.107536 · Cited by 4
In Utero Exposure to Nicotine, Cocaine, and Amphetamines
Singer, L. T., Min, M. O., Lang, A., & Minnes, S. (2016) · Springer eBooks · doi:10.1007/978-3-319-32358-9_3 · Cited by 4
Balbuena, L., Mela, M., & Ahmed, A. (2023) · Nordic Studies on Alcohol and Drugs · doi:10.1177/14550725231206015 · Cited by 5
“Infants of smoking mothers experience nicotine withdrawal about 10 h after birth and show greater need for handling (Stroud et al., 2009).”
BackgroundRaith, W., Resch, B., & Urlesberger, B. (2014) · Deutsche Zeitschrift für Akupunktur · doi:10.1016/j.dza.2014.07.003 · Cited by 3
Liska, S. R. (2013) · Neonatal Network The Journal of Neonatal Nursing · doi:10.1891/0730-0832.33.1.5 · Cited by 3
Newborn Neurobehavior and the Development of Infant Mental Health
Lester, B. M., Conradt, E. D., & Tronick, E. (2024) · Springer eBooks · doi:10.1007/978-3-031-48627-2_10 · Cited by 2
Self-citationSalisbury, A. L. (2010) · doi:10.1002/9781444324617.ch3 · Cited by 2
Self-citationLooking Ahead to a Tobacco-Free Generation
Bearer, C. F., & Stefanak, M. (2008) · The Journal of Pediatrics · doi:10.1016/j.jpeds.2008.09.049 · Cited by 2
Collins, B. N., & Nair, U. S. (2013) · Wiley eBooks · doi:10.1002/9781394260454.ch6 · Cited by 2
Evaluation of Medication Use and Drug Abuse During Pregnancy in Tehran
Kazemian, M., Fallahi, M., Afjeh, S., Fakhraee, S., & Sanii, S. (2019) · Journal of Comprehensive Pediatrics · doi:10.5812/compreped.66257 · Cited by 2
“Passive smoking also endangers the mother and fetus (34-37).”
BackgroundPaludetto, R., & Raimondi, F. (2012) · Springer eBooks · doi:10.1007/978-88-470-1405-3_54 · Cited by 1
“came to similar conclusions (Stroud et al. 2009).”
Azuonwu, O. (2017) · Journal of Lung Pulmonary & Respiratory Research · doi:10.15406/jlprr.2017.04.00140 · Cited by 1
Paludetto, R., Capasso, L., & Raimondi, F. (2016) · Springer eBooks · doi:10.1007/978-3-319-18159-2_194-1 · Cited by 1
Nicotine Use During Pregnancy: Cessation and Treatment Strategies
Shirwani, A., Kuller, J. A., Dotters-Katz, S. K., & Addae-Konadu, K. (2023) · Obstetrical & Gynecological Survey · doi:10.1097/ogx.0000000000001191 · Cited by 1
Parental tobacco consumption and child development
Santos, N. F., & Costa, R. A. (2015) · Jornal de Pediatria (Versão em Português) · doi:10.1016/j.jpedp.2015.04.002 · Cited by 1
Paludetto, R., Capasso, L., & Raimondi, F. (2018) · Springer eBooks · doi:10.1007/978-3-319-29489-6_194 · Cited by 1
Reeve, T. A. (2016) · Summit (Simon Fraser University) · Cited by 1
The neurotoxic effects of prenatal nicotine exposure may impair breastfeeding
Gunnerbeck, A. (2019) · Acta Paediatrica · doi:10.1111/apa.14854 · Cited by 1
“turbances have also been noticeable after possible withdrawal symptoms have vanished (4,5).”
BackgroundSmoking during pregnancy and child mental health and wellbeing : evidence, policy and practice
Vanderbloemen, L. (2013) · White Rose eTheses Online (University of Leeds, The University of Sheffield, University of York)
Executive functions and neurotoxic exposure
Kelderman, J. (2012) · Cambridge University Press eBooks · doi:10.1017/cbo9780511977954.017
GSTM1/T1 Genotypes and Benzo(A)Pyrene Hemoglobin Adducts in Maternal and Fetal Blood
Myers, S. R., Wright, T. L., Barnes, B., Radmacher, P. G., & CUNNINGHAM, C. (2010) · Polycyclic aromatic compounds · doi:10.1080/10406638.2010.483676
Cerebral oxygenation in newborn infants at risk
Verhagen, E. A. (2012)
A Review on Effect of Smoking During Pregnancy
Ahuja, D. A., & Juneja, R. (2022) · International Journal of Innovative Research in Engineering & Management · doi:10.55524/ijirem.2022.9.1.95
Verma, R. P., Luke, N., & Fogel, J. (2025) · Journal of Neonatal-Perinatal Medicine · doi:10.1177/19345798251324450
“36 Such infants may demonstrate acute withdrawal symptoms similar to those witnessed with illicit drugs and, in later life, learning and behavioral problems, and obesity.”
Lovgren, A., Swann‐Thomsen, H. E., & Aubuchon-Endsley, N. L. (2025) · Journal of Reproductive and Infant Psychology · doi:10.1080/02646838.2025.2541880
Metadata
- Authors
- Stroud, L. R., Paster, R. L., Papandonatos, G. D., Niaura, R., Salisbury, A. L., Battle, C., Lagasse, L. L., & Lester, B.
- Affiliations
- Brown University (US)
- Corresponding author
- Stroud, Laura R.
- ORCID
- Venue
- The Journal of Pediatrics
- Publisher
- Elsevier BV
- Published
- 2009-01
- Volume
- 154
- Issue
- 1
- Pages
- 10-16
- ISSN
- 0022-3476 (ISSN-L)
- PMC
- PMC3026585
- OpenAlex
- W2059713626
- Cited by
- 102
- References
- 43
- Citations by year
- 2026: 1 · 2025: 3 · 2024: 1 · 2023: 4 · 2022: 3 · 2021: 2 · 2020: 2 · 2019: 5 · 2018: 9 · 2017: 4 · 2016: 6 · 2015: 4 · 2014: 10 · 2013: 9 · 2012: 10
- FWCI
- 8.61
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- The Journal of Pediatrics (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- Robert Wood Johnson Foundation
- National Institutes of Health
- National Institute of Mental Health (R01MH078033, K23MH065443)
- National Institute on Drug Abuse (R03DA014394)
- Topics
- Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Prenatal Substance Exposure Effects
- Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Infant Development and Preterm Care
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Smoking Behavior and Cessation
- Keywords
- smoking during pregnancy, prenatal tobacco exposure, NICU Network Neurobehavioral Scale, self-regulation, infant arousal, infant withdrawal
- MeSH terms
- Adult, Cotinine, Female, Humans, Infant, Newborn, Male, Maternal-Fetal Exchange, Neonatal Abstinence Syndrome, Pilot Projects, Pregnancy, Prenatal Exposure Delayed Effects, Saliva, Smoking, Infant Behavior, Maternal Exposure, Young Adult
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