The DOI matches its Crossref record; 57 of the 57 references it cites were found in a registry or an index.
Altered gene expression of histone deacetylases in mood disorder patients
Abstract
Chromatin remodeling such as changes in histone acetylation has been suggested to play an important role in the pathophysiology and treatment of mood disorders. In the present study, we investigated whether the expression of histone deacetylase (HDAC) genes are altered in mood disorder patients. We used quantitative real-time PCR to measure the mRNA levels of 11 HDACs (HDAC1-11) in peripheral white blood cells of major depressive disorder (MDD) and bipolar disorder (BPD) patients during depressive and remissive episodes and in the first-degree relatives of BPD patients. In addition, we investigated the effect of antidepressants and mood stabilizers on the mRNA levels of HDACs using mice. In MDD, the expression of HDAC2 and -5 mRNA was increased in a depressive state, but not in a remissive state, compared to controls. In BPD, the expression of HDAC4 mRNA was increased only in a depressive state, and the expression of HDAC6 and -8 was decreased in both depressive and remissive states compared to controls, whereas the first-degree relatives did not show any significant alteration in expression levels. Animal study showed that the expression of HDAC2 and -5 or HDAC4, -6 and -8 mRNAs in the mouse leukocytes were not affected by chronic treatment with antidepressants or mood stabilizers. Our data suggest that aberrant transcriptional regulation caused by the altered expression of HDACs is associated with the pathophysiology of mood disorders.
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In the citing paper
“Interestingly, upon remission, the levels normalized to those of healthy controls”
From Epigenetics and depression (2019) · cites this paper as [25]
In the citing paper
“highlighting the potential of HDAC levels to be used as a biomarker for disease monitoring.”
From Epigenetics and depression (2019) · cites this paper as [25]
In the citing paper
“One study found elevated HDAC2 and HDAC5 levels in patients experiencing an acute depressive episode.”
From Epigenetics and depression (2019) · cites this paper as [25]
In the citing paper
“differential brain expression of HDACs was found in the postmortem in MDD.130,159”
From Epigenetic regulation in major depression and other stress-related disorders: molecular mechanisms, clinical relevance and therapeutic potential (2023) · cites this paper as [159]
In the citing paper
“Expression of HDAC2 and HDAC5 was higher during a depressive state, compared with remission, in peripheral white blood cells of patients diagnosed with MDD and bipolar disorder (BPD).159”
From Epigenetic regulation in major depression and other stress-related disorders: molecular mechanisms, clinical relevance and therapeutic potential (2023) · cites this paper as [159]
In the citing paper
“The expression of HDAC6 and HDAC8 was lower regardless of mood states compared with controls in BPD, while the HDAC4 expression was higher only in a depressive state.159”
From Epigenetic regulation in major depression and other stress-related disorders: molecular mechanisms, clinical relevance and therapeutic potential (2023) · cites this paper as [159]
In the citing paper
“Higher levels of HDAC4 and HDAC5 were found in depressed patients.”
From Epigenetic mechanisms of major depression: Targeting neuronal plasticity (2018) · cites this paper as [81]
In the citing paper
“Further, some reports have shown increased HDAC2 expression and reduced GDNF expression in patients with MDD”
From Epigenetic mechanisms of major depression: Targeting neuronal plasticity (2018) · cites this paper as [81]
Citations
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Valproic acid defines a novel class of HDAC inhibitors inducing differentiation of transformed cells
Göttlicher, M., Minucci, S., Zhu, P., Krämer, O. H., Schimpf, A., Giavara, S., Sleeman, J. P., Coco, F. L., Nervi, C., Pelicci, P. G., et al. (2001) · The EMBO Journal · doi:10.1093/emboj/20.24.6969 · Cited by 1,930
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Pathogenesis of depression: Insights from human and rodent studies
Ménard, C., Hodes, G. E., & Russo, S. J. (2016) · Neuroscience · doi:10.1016/j.neuroscience.2015.05.053 · Cited by 593
Epigenetics of the depressed brain: role of histone acetylation and methylation
Sun, H., Kennedy, P. J., & Nestler, E. J. (2013) · Neuropsychopharmacology · doi:10.1038/npp.2012.73 · Cited by 413
Molecular adaptations of the blood–brain barrier promote stress resilience vs. depression
Dudek, K. A., Dion-Albert, L., Lebel, M., LeClair, K., Labrecque, S., Tuck, E., Ferrer Perez, C., Golden, S. A., Tamminga, C., Turecki, G., et al. (2020) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1914655117 · Cited by 361
Epigenetic Mechanisms of Depression and Antidepressant Action
Vialou, V., Feng, J., Robison, A. J., & Nestler, E. J. (2013) · Annual Review of Pharmacology and Toxicology · doi:10.1146/annurev-pharmtox-010611-134540 · Cited by 277
Penner-Goeke, S., & Binder, E. B. (2019) · Dialogues in Clinical Neuroscience · doi:10.31887/dcns.2019.21.4/ebinder · Cited by 254
Metadata
- Authors
- Hobara, T., Uchida, S., Otsuki, K., Matsubara, T., Funato, H., Matsuo, K., Suetsugi, M., & Watanabe, Y.
- Affiliations
- Yamaguchi University (JP)
- Corresponding author
- Watanabe, Yoshifumi
- Venue
- Journal of Psychiatric Research
- Publisher
- Elsevier BV
- Published
- 2010-04
- Volume
- 44
- Issue
- 5
- Pages
- 263-270
- ISSN
- 0022-3956 (ISSN-L)
- OpenAlex
- W2148160168
- Cited by
- 185
- References
- 57
- Citations by year
- 2026: 9 · 2025: 7 · 2024: 9 · 2023: 6 · 2022: 7 · 2021: 17 · 2020: 18 · 2019: 11 · 2018: 10 · 2017: 16 · 2016: 10 · 2015: 15 · 2014: 9 · 2013: 16 · 2012: 9
- FWCI
- 3.35
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of Psychiatric Research (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Ministry of Education, Culture, Sports, Science and Technology
- Ministry of Health, Labour and Welfare
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Histone Deacetylase Inhibitors Research
- Health Sciences › Medicine › Pharmacology (medical) › Treatment of Major Depression
- Health Sciences › Medicine › Psychiatry and Mental health › Bipolar Disorder and Treatment
- Keywords
- histone deacetylase, mood disorders, major depressive disorder, bipolar disorder, HDAC2, HDAC5, HDAC4, HDAC6, HDAC8, gene expression, peripheral blood leukocytes, leukocytes, histone acetylation, chromatin remodeling, antidepressants, mood stabilizers, first-degree relatives
- MeSH terms
- Animals, Antidepressive Agents, Clomipramine, Corticotropin-Releasing Hormone, Dexamethasone, Disease Models, Animal, Female, Gene Expression Regulation, Histone Deacetylases, Humans, Hydrocortisone, Male, Mice, Inbred BALB C, Mice, Inbred C57BL, Middle Aged, RNA, Messenger, Swimming, Paroxetine, Mood Disorders, Mice
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