The DOI matches its Crossref record; 57 of the 57 references it cites were found in a registry or an index.
Altered gene expression of histone deacetylases in mood disorder patients
Abstract
Chromatin remodeling such as changes in histone acetylation has been suggested to play an important role in the pathophysiology and treatment of mood disorders. In the present study, we investigated whether the expression of histone deacetylase (HDAC) genes are altered in mood disorder patients. We used quantitative real-time PCR to measure the mRNA levels of 11 HDACs (HDAC1-11) in peripheral white blood cells of major depressive disorder (MDD) and bipolar disorder (BPD) patients during depressive and remissive episodes and in the first-degree relatives of BPD patients. In addition, we investigated the effect of antidepressants and mood stabilizers on the mRNA levels of HDACs using mice. In MDD, the expression of HDAC2 and -5 mRNA was increased in a depressive state, but not in a remissive state, compared to controls. In BPD, the expression of HDAC4 mRNA was increased only in a depressive state, and the expression of HDAC6 and -8 was decreased in both depressive and remissive states compared to controls, whereas the first-degree relatives did not show any significant alteration in expression levels. Animal study showed that the expression of HDAC2 and -5 or HDAC4, -6 and -8 mRNAs in the mouse leukocytes were not affected by chronic treatment with antidepressants or mood stabilizers. Our data suggest that aberrant transcriptional regulation caused by the altered expression of HDACs is associated with the pathophysiology of mood disorders.
Overview
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“Interestingly, upon remission, the levels normalized to those of healthy controls”
From Epigenetics and depression (2019) · cites this paper as [25]
In the citing paper
“highlighting the potential of HDAC levels to be used as a biomarker for disease monitoring.”
From Epigenetics and depression (2019) · cites this paper as [25]
In the citing paper
“One study found elevated HDAC2 and HDAC5 levels in patients experiencing an acute depressive episode.”
From Epigenetics and depression (2019) · cites this paper as [25]
In the citing paper
“differential brain expression of HDACs was found in the postmortem in MDD.130,159”
From Epigenetic regulation in major depression and other stress-related disorders: molecular mechanisms, clinical relevance and therapeutic potential (2023) · cites this paper as [159]
In the citing paper
“Expression of HDAC2 and HDAC5 was higher during a depressive state, compared with remission, in peripheral white blood cells of patients diagnosed with MDD and bipolar disorder (BPD).159”
From Epigenetic regulation in major depression and other stress-related disorders: molecular mechanisms, clinical relevance and therapeutic potential (2023) · cites this paper as [159]
In the citing paper
“The expression of HDAC6 and HDAC8 was lower regardless of mood states compared with controls in BPD, while the HDAC4 expression was higher only in a depressive state.159”
From Epigenetic regulation in major depression and other stress-related disorders: molecular mechanisms, clinical relevance and therapeutic potential (2023) · cites this paper as [159]
In the citing paper
“Higher levels of HDAC4 and HDAC5 were found in depressed patients.”
From Epigenetic mechanisms of major depression: Targeting neuronal plasticity (2018) · cites this paper as [81]
In the citing paper
“Further, some reports have shown increased HDAC2 expression and reduced GDNF expression in patients with MDD”
From Epigenetic mechanisms of major depression: Targeting neuronal plasticity (2018) · cites this paper as [81]
Citations
Cites
Diagnostic and Statistical Manual of Mental Disorders
Williams, J. B. W., & First, M. B. (2013) · Oxford University Press eBooks · doi:10.1093/acrefore/9780199975839.013.104 · Cited by 109,845
Stress and the brain: from adaptation to disease
de Kloet, E. R., Joëls, M., & Holsboer, F. (2005) · Nature Reviews Neuroscience · doi:10.1038/nrn1683 · Cited by 4,621
Depression: a new animal model sensitive to antidepressant treatments
PORSOLT, R. D., LE PICHON, M., & JALFRE, M. (1977) · Nature · doi:10.1038/266730a0 · Cited by 4,451
Nestler, E. J., Barrot, M., DiLeone, R. J., Eisch, A. J., Gold, S. J., & Monteggia, L. M. (2002) · Neuron · doi:10.1016/s0896-6273(02)00653-0 · Cited by 3,217
Histone acetylation in chromatin structure and transcription
Grunstein, M. (1997) · Nature · doi:10.1038/38664 · Cited by 2,884
The Corticosteroid Receptor Hypothesis of Depression
Holsboer, F. (2000) · Neuropsychopharmacology · doi:10.1016/s0893-133x(00)00159-7 · Cited by 2,181
Valproic acid defines a novel class of HDAC inhibitors inducing differentiation of transformed cells
Göttlicher, M., Minucci, S., Zhu, P., Krämer, O. H., Schimpf, A., Giavara, S., Sleeman, J. P., Coco, F. L., Nervi, C., Pelicci, P. G., et al. (2001) · The EMBO Journal · doi:10.1093/emboj/20.24.6969 · Cited by 1,930
Sustained hippocampal chromatin regulation in a mouse model of depression and antidepressant action
Tsankova, N. M., Berton, O., Renthal, W., Kumar, A., Neve, R. L., & Nestler, E. J. (2006) · Nature Neuroscience · doi:10.1038/nn1659 · Cited by 1,780
Phiel, C. J., Zhang, F., Huang, E. Y., Guenther, M. G., Lazar, M. A., & Klein, P. S. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m101287200 · Cited by 1,758
New approaches to antidepressant drug discovery: beyond monoamines
Berton, O., & Nestler, E. J. (2006) · Nature Reviews Neuroscience · doi:10.1038/nrn1846 · Cited by 1,589
Cited by
Sorted by citations
Pathogenesis of depression: Insights from human and rodent studies
Ménard, C., Hodes, G. E., & Russo, S. J. (2016) · Neuroscience · doi:10.1016/j.neuroscience.2015.05.053 · Cited by 593
Epigenetics of the depressed brain: role of histone acetylation and methylation
Sun, H., Kennedy, P. J., & Nestler, E. J. (2013) · Neuropsychopharmacology · doi:10.1038/npp.2012.73 · Cited by 413
Molecular adaptations of the blood–brain barrier promote stress resilience vs. depression
Dudek, K. A., Dion-Albert, L., Lebel, M., LeClair, K., Labrecque, S., Tuck, E., Ferrer Perez, C., Golden, S. A., Tamminga, C., Turecki, G., et al. (2020) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1914655117 · Cited by 361
Epigenetic Mechanisms of Depression and Antidepressant Action
Vialou, V., Feng, J., Robison, A. J., & Nestler, E. J. (2013) · Annual Review of Pharmacology and Toxicology · doi:10.1146/annurev-pharmtox-010611-134540 · Cited by 277
Penner-Goeke, S., & Binder, E. B. (2019) · Dialogues in Clinical Neuroscience · doi:10.31887/dcns.2019.21.4/ebinder · Cited by 254
Yuan, M., Yang, B., Rothschild, G., Mann, J. J., Sanford, L. D., Tang, X., Huang, C., Wang, C., & Zhang, W. (2023) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-023-01519-z · Cited by 246
“158 In addition, differential brain expression of HDACs was found in the postmortem in MDD. 130,159 Expression of HDAC2 and HDAC5 was higher during a depressive state, compared with remission, in peripheral white blood cells of patients diagnosed with MDD and bipolar disorder (BPD).”
InfluentialIntegrated Neurobiology of Bipolar Disorder
Maletic, V., & Raison, C. L. (2014) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2014.00098 · Cited by 236
Belzeaux-R, R., Bergon, A., Jeanjean, V., Loriod, B., Formisano‐Tréziny, C., Verrier, L., Loundou, A., Baumstarck, K., Boyer, L., Gall, V., et al. (2012) · Translational Psychiatry · doi:10.1038/tp.2012.112 · Cited by 227
A putative functional role for oligodendrocytes in mood regulation
Edgar, N. M., & Sibille, E. L. (2012) · Translational Psychiatry · doi:10.1038/tp.2012.34 · Cited by 191
Dietary fiber and its associations with depression and inflammation
Swann, O. G., Kilpatrick, M., Breslin, M., & Oddy, W. H. (2020) · Nutrition Reviews · doi:10.1093/nutrit/nuz072 · Cited by 185
Epigenetic mechanisms of major depression: Targeting neuronal plasticity
Uchida, S., Yamagata, H., Seki, T., & Watanabe, Y. (2018) · Psychiatry and Clinical Neurosciences · doi:10.1111/pcn.12621 · Cited by 181
Self-citationJochems, J., Boulden, J., Lee, B. G., Blendy, J. A., Jarpe, M. B., Mazitschek, R., van Duzer, J. H., Jones, S. S., & Berton, O. (2013) · Neuropsychopharmacology · doi:10.1038/npp.2013.207 · Cited by 175
Hippocampal MicroRNA-124 Enhances Chronic Stress Resilience in Mice
Higuchi, F., Uchida, S., Yamagata, H., Abe-Higuchi, N., Hobara, T., Hara, K., Kobayashi, A., Shintaku, T., Itoh, Y., Suzuki, T., et al. (2016) · Journal of Neuroscience · doi:10.1523/jneurosci.0319-16.2016 · Cited by 158
Self-citationBürli, R. W., Luckhurst, C. A., Aziz, O., Matthews, K. L., Yates, D., Lyons, K. A., Beconi, M., McAllister, G., Breccia, P., Stott, A. J., et al. (2013) · Journal of Medicinal Chemistry · doi:10.1021/jm4011884 · Cited by 153
Histone deacetylases (HDACs) and brain function
Volmar, C.-H., & Wahlestedt, C. (2015) · Neuroepigenetics · doi:10.1016/j.nepig.2014.10.002 · Cited by 151
Li, W., Ali, T., Zheng, C., Liu, Z., He, K., Shah, F. A., Ren, Q., Rahman, S. U., Li, N., Yu, Z., et al. (2021) · Journal of Neuroinflammation · doi:10.1186/s12974-021-02091-5 · Cited by 148
Espallergues, J., Teegarden, S. L., Veerakumar, A., Boulden, J., Challis, C., Jochems, J., Chan, M., Petersen, T. L., Deneris, E. S., Matthias, P., et al. (2012) · Journal of Neuroscience · doi:10.1523/jneurosci.5634-11.2012 · Cited by 151
Schroeder, F. A., Lewis, M. C., Fass, D. M., Wagner, F. F., Zhang, Y.-L., Hennig, K. M., Gale, J., Zhao, W.-N., Reis, S., Barker, D. D., et al. (2013) · PLoS ONE · doi:10.1371/journal.pone.0071323 · Cited by 146
Biomarkers to Predict Antidepressant Response
Leuchter, A. F., Cook, I. A., Hamilton, S. P., Narr, K. L., Toga, A. W., Hunter, A. M., Faull, K. F., Whitelegge, J. P., Andrews, A. M., Loo, J., et al. (2010) · Current Psychiatry Reports · doi:10.1007/s11920-010-0160-4 · Cited by 146
Scarr, E., Millan, M. J., Bahn, S., Bertolino, A., Turck, C. W., Kapur, S., Möller, H., & Dean, B. (2015) · The International Journal of Neuropsychopharmacology · doi:10.1093/ijnp/pyv042 · Cited by 135
Altered sirtuin deacetylase gene expression in patients with a mood disorder
Abe, N., Uchida, S., Otsuki, K., Hobara, T., Yamagata, H., Higuchi, F., Shibata, T., & Watanabe, Y. (2011) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2011.01.016 · Cited by 131
Self-citationEpigenetic Modifications of Major Depressive Disorder
Saavedra, K., Molina-Márquez, A., Saavedra, N., Zambrano, T., & Salazar, L. A. (2016) · International Journal of Molecular Sciences · doi:10.3390/ijms17081279 · Cited by 129
Jiang, Y., Jakovcevski, M., Bharadwaj, R., Connor, C., Schroeder, F. A., Lin, C. L., Straubhaar, J., Martin, G., & Akbarian, S. (2010) · The Journal of Neuroscience · doi:10.1523/jneurosci.1314-10.2010 · Cited by 118
Histone Deacetylases and Mood Disorders: Epigenetic Programming in Gene‐Environment Interactions
Machado‐Vieira, R., Ibrahim, L. A., & Zarate, C. A. (2010) · CNS Neuroscience & Therapeutics · doi:10.1111/j.1755-5949.2010.00203.x · Cited by 121
Pidsley, R., & Mill, J. S. (2010) · Biological Psychiatry · doi:10.1016/j.biopsych.2010.03.029 · Cited by 118
Neurodevelopmental origins of bipolar disorder: iPSC models
O’Shea, K. S., & McInnis, M. G. (2015) · Molecular and Cellular Neuroscience · doi:10.1016/j.mcn.2015.11.006 · Cited by 111
Epigenetics in depression and gut-brain axis: A molecular crosstalk
Begum, N., Mandhare, A., Tryphena, K. P., Srivastava, S., Shaikh, M. F., Singh, S. B., & Khatri, D. K. (2022) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2022.1048333 · Cited by 102
An Act of Balance Between Adaptive and Maladaptive Immunity in Depression: a Role for T Lymphocytes
Toben, C. G., & Baune, B. T. (2015) · Journal of Neuroimmune Pharmacology · doi:10.1007/s11481-015-9620-2 · Cited by 98
Kinase signalling in excitatory neurons regulates sleep quantity and depth
Kim, S. J., Hotta-Hirashima, N., Asano, F., Kitazono, T., Iwasaki, K., Nakata, S., Komiya, H., Asama, N., Matsuoka, T., Fujiyama, T., et al. (2022) · Nature · doi:10.1038/s41586-022-05450-1 · Cited by 96
Self-citationBelzeaux-R, R., Formisano‐Tréziny, C., Loundou, A., Boyer, L., Gabert, J. A., Samuelian, J., Feron, F. P., Naudin, J., & Ibrahim, E. C. (2010) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2010.04.011 · Cited by 95
Boulle, F., Massart, R., Stragier, E., Païzanis, E., Zaidan, L., Marday, S., Gabriel, C., Mocaer, E., Mongeau, R., & Lanfumey, L. (2014) · Translational Psychiatry · doi:10.1038/tp.2014.125 · Cited by 91
Tapia, M., Wandosell, F. G., & Garrido, J. J. (2010) · PLoS ONE · doi:10.1371/journal.pone.0012908 · Cited by 95
ACF chromatin-remodeling complex mediates stress-induced depressive-like behavior
Sun, H., Damez-Werno, D. M., Scobie, K. N., Shao, N.-Y., Dias, C., Rabkin, J., Koo, J. W., Korb, E., Bagot, R. C., Ahn, F. H., et al. (2015) · Nature Medicine · doi:10.1038/nm.3939 · Cited by 91
The potential use of histone deacetylase inhibitors in the treatment of depression
Fuchikami, M., Yamamoto, S., Morinobu, S., Okada, S., Yamawaki, Y., & Yamawaki, S. (2015) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2015.03.010 · Cited by 113
Dissecting bipolar disorder complexity through epigenomic approach
Ludwig, B., & Dwivedi, Y. (2016) · Molecular Psychiatry · doi:10.1038/mp.2016.123 · Cited by 88
Morris, M. J., Karra, A. S., & Monteggia, L. M. (2010) · Behavioural Pharmacology · doi:10.1097/fbp.0b013e32833c20c0 · Cited by 83
Boda, E. (2021) · European Journal of Neuroscience · doi:10.1111/ejn.14621 · Cited by 80
Hippocampal HDAC4 Contributes to Postnatal Fluoxetine-Evoked Depression-Like Behavior
Sarkar, A., Chachra, P., Kennedy, P., Pena, C. J., Desouza, L. A., Nestler, E. J., & Vaidya, V. A. (2014) · Neuropsychopharmacology · doi:10.1038/npp.2014.73 · Cited by 79
Epigenetics, Depression and Antidepressant Treatment
Menke, A., Klengel, T., & Binder, E. B. (2012) · Current Pharmaceutical Design · doi:10.2174/138161212803523590 · Cited by 80
The alteration of hypoxia inducible factor-1 (HIF-1) and its target genes in mood disorder patients
Shibata, T., Yamagata, H., Uchida, S., Otsuki, K., Hobara, T., Higuchi, F., Abe, N., & Watanabe, Y. (2013) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2013.01.003 · Cited by 80
Self-citationMokhtari, R. B., Kumar, S., Islam, S. S., Yazdanpanah, M., Adeli, K., Cutz, E., & Yeger, H. (2013) · BMC Cancer · doi:10.1186/1471-2407-13-378 · Cited by 77
Kang, M. J. Y., Hawken, E., & Vazquez, G. H. (2022) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2022.860882 · Cited by 77
Morris, M. J., & Monteggia, L. M. (2013) · International Journal of Developmental Neuroscience · doi:10.1016/j.ijdevneu.2013.02.005 · Cited by 78
Caraci, F., Calabrese, F., Molteni, R., Bartova, L., Dold, M., Leggio, G. M., Fabbri, C., Mendlewicz, J., Racagni, G., Kasper, S. F., et al. (2018) · Pharmacological Reviews · doi:10.1124/pr.117.014977 · Cited by 76
Acetate supplementation produces antidepressant-like effect via enhanced histone acetylation
Huang, W., Hu, W., Cai, L., Zeng, G., Fang, W., Dai, X., Ye, Q., Chen, X., & Zhang, J. (2020) · Journal of Affective Disorders · doi:10.1016/j.jad.2020.11.121 · Cited by 73
State-dependent changes in the expression of DNA methyltransferases in mood disorder patients
Higuchi, F., Uchida, S., Yamagata, H., Otsuki, K., Hobara, T., Abe, N., Shibata, T., & Watanabe, Y. (2011) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2011.04.008 · Cited by 73
Self-citationChronic stress and antidepressant induced changes in Hdac5 and Sirt2 affect synaptic plasticity
Erburu, M. M., Muñoz-Cobo, I., Domínguez‐Andrés, J., Beltrán, E., Suzuki, T., Mai, A., Valente, S., Puerta, E., & Tordera, R. M. (2015) · European Neuropsychopharmacology · doi:10.1016/j.euroneuro.2015.08.016 · Cited by 73
Histone deacetylases (HDACs) as therapeutic target for depressive disorders
Misztak, P., Pańczyszyn-Trzewik, P., & Sowa-Kućma, M. (2017) · Pharmacological Reports · doi:10.1016/j.pharep.2017.08.001 · Cited by 73
Phillips, C. (2017) · Neural Plasticity · doi:10.1155/2017/7014146 · Cited by 72
Réus, G. Z., Abelaira, H. M., dos Santos, M. A. B., Carlessi, A. S., Tomaz, D. B., Neotti, M. V., Liranço, J. L. G., Gubert, C., Barth, M., Kapczinski, F. P., et al. (2013) · Behavioural Brain Research · doi:10.1016/j.bbr.2013.08.041 · Cited by 67
Epigenetic mechanisms in mood disorders: Targeting neuroplasticity
Fass, D. M., Schroeder, F. A., Perlis, R. H., & Haggarty, S. J. (2013) · Neuroscience · doi:10.1016/j.neuroscience.2013.01.041 · Cited by 64
Molecular mechanisms of psychiatric diseases
Blokhin, I. O., Khorkova, O., Saveanu, R. V., & Wahlestedt, C. (2020) · Neurobiology of Disease · doi:10.1016/j.nbd.2020.105136 · Cited by 64
Role of Histone Deacetylases (HDACs) in Epilepsy and Epileptogenesis
Citraro, R., Leo, A., Santoro, M., D’Agostino, G., Constanti, A., & Russo, E. (2018) · Current Pharmaceutical Design · doi:10.2174/1381612823666171024130001 · Cited by 58
Ookubo, M., Kanai, H., Aoki, H., & Yamada, N. (2013) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2013.05.028 · Cited by 60
Aldoghachi, A. F., Tor, Y. S., Redzun, S. Z., Lokman, K. A. B., Razaq, N. A. A., Shahbudin, A. F., Badamasi, I. M., Cheah, P.-S., Stanslas, J., Veerakumarasivam, A., et al. (2019) · PLOS ONE · doi:10.1371/journal.pone.0211241 · Cited by 54
The Function and related Diseases of Protein Crotonylation
Wang, S., Mu, G., Qiu, B., Wang, M., Yu, Z., Wang, W., Wang, J., & Yang, Y. (2021) · International Journal of Biological Sciences · doi:10.7150/ijbs.58872 · Cited by 53
Hsu, K., Liu, C., Lin, T. E., Hsieh, J.-H., Sung, T.-Y., Tseng, H.-J., Yang, J., & Huang, W. (2017) · Scientific Reports · doi:10.1038/s41598-017-03417-1 · Cited by 54
Epigenetics in bipolar disorder: a critical review of the literature
Legrand, A., Iftimovici, A., Khayachi, A., & Chaumette, B. (2021) · Psychiatric Genetics · doi:10.1097/ypg.0000000000000267 · Cited by 48
Epigenetic mechanisms impacted by chronic stress across the rodent lifespan
Dion, A., Muñoz, P., & Franklin, T. B. (2022) · Neurobiology of Stress · doi:10.1016/j.ynstr.2022.100434 · Cited by 54
Wu, Y., Hou, F., Wang, X., Kong, Q., Han, X., & Bai, B. (2016) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2016.00114 · Cited by 52
Effects of Histone Modification in Major Depressive Disorder
Wu, M.-S., Li, X., Liu, C., Xu, Q., Huang, J., Gu, S., & Chen, J. (2021) · Current Neuropharmacology · doi:10.2174/1570159x19666210922150043 · Cited by 56
Effects of promoter methylation on increased expression of polyamine biosynthetic genes in suicide
Gross, J. A., Fiori, L. M., Labonté, B., López, J. P., & Turecki, G. (2012) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2012.11.016 · Cited by 51
An epigenome-wide association study of early-onset major depression in monozygotic twins
Roberson‐Nay, R., Lapato, D. M., Wolen, A. R., Lancaster, E. E., Webb, B. T., Verhulst, B., Hettema, J. M., & York, T. P. (2020) · Translational Psychiatry · doi:10.1038/s41398-020-00984-2 · Cited by 67
Epigenetic Targeting of Histone Deacetylases in Diagnostics and Treatment of Depression
Park, H., Kim, J., Ahn, S. H., & Ryu, H. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22105398 · Cited by 54
Histone Modifications in Major Depressive Disorder and Related Rodent Models
Deussing, J. M., & Jakovcevski, M. (2017) · Advances in experimental medicine and biology · doi:10.1007/978-3-319-53889-1_9 · Cited by 46
Epigenetic mechanisms of stress and depression
Chmielewska, N., Szyndler, J., Maciejak, P., & Płaźnik, A. (2019) · Psychiatria Polska · doi:10.12740/pp/94375 · Cited by 49
Lin, H., Geng, X., Dang, W., Wu, B., Dai, Z., Li, Y., Yang, Y., Zhang, H., & Shi, J. (2012) · Brain Research · doi:10.1016/j.brainres.2012.01.053 · Cited by 44
Tinnitus psychopharmacology: A comprehensive review of its pathomechanisms and management
Fornaro, M. (2010) · Neuropsychiatric Disease and Treatment · doi:10.2147/ndt.s10361 · Cited by 45
Neuroanatomical Profile of Antimaniac Effects of Histone Deacetylases Inhibitors
Arent, C. O., Valvassori, S. S., Fries, G. R., Stertz, L., Ferreira, C. L., Lopes-Borges, J., Mariot, E., Varela, R. B., Ornell, F. R., Kapczinski, F. P., et al. (2011) · Molecular Neurobiology · doi:10.1007/s12035-011-8178-0 · Cited by 45
Epigenetic marks and their relationship with BDNF in the brain of suicide victims
Misztak, P., Pańczyszyn-Trzewik, P., Nowak, G., & Sowa-Kućma, M. (2020) · PLoS ONE · doi:10.1371/journal.pone.0239335 · Cited by 44
State‐related alterations of gene expression in bipolar disorder: a systematic review
Munkholm, K., Vinberg, M., Berk, M., & Kessing, L. V. (2012) · Bipolar Disorders · doi:10.1111/bdi.12005 · Cited by 43
Differential SLC1A2 Promoter Methylation in Bipolar Disorder With or Without Addiction
Jia, Y., Choi, Y., Ayers-Ringler, J. R., Biernacka, J. M., Geske, J. R., Lindberg, D. R., McElroy, S. L., Frye, M. A., Choi, D., & Veldić, M. (2017) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2017.00217 · Cited by 43
The importance of epigenetics in diagnostics and treatment of major depressive disorder
Czarny, P., Białek, K., Ziółkowska, S., Strycharz, J., Barszczewska, G., & Sliwinski, T. (2021) · Journal of Personalized Medicine · doi:10.3390/jpm11030167 · Cited by 37
Altered expression of long noncoding RNAs in patients with major depressive disorder
Seki, T., Yamagata, H., Uchida, S., Chen, C., Kobayashi, A., Kobayashi, M., Harada, K., Matsuo, K., Watanabe, Y., & Nakagawa, S. (2019) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2019.07.004 · Cited by 42
Self-citationTranscriptomic and epigenomic biomarkers of antidepressant response
Belzeaux-R, R., Lin, R., Ju, C., Chay, M.-A., Fiori, L. M., Lutz, P.-É., & Turecki, G. (2017) · Journal of Affective Disorders · doi:10.1016/j.jad.2017.08.087 · Cited by 46
Genetic Variation in the Epigenetic Machinery and Mental Health
Murgatroyd, C., & Spengler, D. (2012) · Current Psychiatry Reports · doi:10.1007/s11920-012-0255-1 · Cited by 43
Stertz, L., Fries, G. R., de Aguiar, B. W., Pfaffenseller, B., Valvassori, S. S., Gubert, C., Ferreira, C. L., Moretti, M., Ceresér, K. M. M., Kauer‐Sant’Anna, M., et al. (2013) · Brazilian Journal of Psychiatry · doi:10.1590/1516-4446-2013-1094 · Cited by 41
Hampel, M., Bron, J. E., Taggart, J. B., & Leaver, M. J. (2013) · Aquatic Toxicology · doi:10.1016/j.aquatox.2013.12.018 · Cited by 40
Histone Deacetylase Gene Expression Following Binge Alcohol Consumption in Rats and Humans
López‐Moreno, J. A., Marcos, M., Calleja‐Conde, J., Echeverry‐Alzate, V., Bühler, K., Costa‐Alba, P., Bernardo, E., Laso, F. J., de Fonseca, F. R., Nadal, R. A., et al. (2015) · Alcoholism Clinical and Experimental Research · doi:10.1111/acer.12850 · Cited by 39
Micale, V., Bartolomeo, M. D., Martino, S. D., Štark, T., Dell’Osso, B. M., Drago, F., & D’Addario, C. (2022) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2022.108279 · Cited by 41
Crotonylation and disease: Current progress and future perspectives
Yang, P., Qin, Y., Zeng, L., He, Y., Xie, Y., Cheng, X., Huang, W. G., & Cao, L. (2023) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2023.115108 · Cited by 42
Biological tests for major depressive disorder that involve leukocyte gene expression assays
Watanabe, S., Iga, J., Ishii, K., Numata, S., Shimodera, S., Fujita, H., & Ohmori, T. (2015) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2015.03.004 · Cited by 38
Álvarez-Mon, M. Á., Ortega, M. A., Montero, C. G., Fraile‐Μartinez, O., Monserrat, J., Lahera, G., Mora, F., Rodríguez-Quiroga, A., Fernández-Rojo, S., Quintero, J., et al. (2021) · Pharmaceuticals · doi:10.3390/ph14080821 · Cited by 38
Pusalkar, M., Suri, D., Kelkar, A., Bhattacharya, A., Galande, S., & Vaidya, V. A. (2015) · Developmental Psychobiology · doi:10.1002/dev.21365 · Cited by 36
The epigenome and postnatal environmental influences in psychotic disorders
Pishva, E., Kenis, G., van den Hove, D., Lesch, K., Boks, M. P., van Os, J., & Rutten, B. P. F. (2014) · Social Psychiatry and Psychiatric Epidemiology · doi:10.1007/s00127-014-0831-2 · Cited by 36
Synaptically Localized Transcriptional Regulators in Memory Formation
Uchida, S., & Shumyatsky, G. P. (2017) · Neuroscience · doi:10.1016/j.neuroscience.2017.07.023 · Cited by 33
Self-citationYamagata, H., Uchida, S., Matsuo, K., Harada, K., Kobayashi, A., Nakashima, M., Higuchi, F., Watanuki, T., Matsubara, T., & Watanabe, Y. (2017) · Journal of Affective Disorders · doi:10.1016/j.jad.2017.08.057 · Cited by 33
Self-citationSingh, H., Wray, N. H., Schappi, J. M., & Rasenick, M. M. (2018) · Neuropsychopharmacology · doi:10.1038/s41386-018-0016-x · Cited by 34
RetractedCoding and Noncoding Gene Expression Biomarkers in Mood Disorders and Schizophrenia
Mamdani, F., Martin, M. V., Lencz, T., Rollins, B. L., Robinson, D. G., Moon, E. A., Malhotra, A. K., & Vawter, M. P. (2013) · Disease Markers · doi:10.1155/2013/748095 · Cited by 33
Ketamine in Bipolar Disorder: A Review
Wilkowska, A., Szałach, Ł. P., & Cubała, W. J. (2020) · Neuropsychiatric Disease and Treatment · doi:10.2147/ndt.s282208 · Cited by 35
Qiao, M., Jiang, Q., Liu, Y., Hu, X.-Y., Wang, L., Zhou, Q., & Qiu, H. (2019) · Neuroreport · doi:10.1097/wnr.0000000000001191 · Cited by 31
Ribeiro, A. C. R., Jahr, F. M., Hawkins, E., Kronfol, M. M., Younis, R. M., McClay, J. L., & Deshpande, L. S. (2021) · Life Sciences · doi:10.1016/j.lfs.2021.119765 · Cited by 30
Epigenetic Mechanisms in Psychiatric Diseases and Epigenetic Therapy
Karslı-Çeppioğlu, S. (2016) · Drug Development Research · doi:10.1002/ddr.21340 · Cited by 31
Inkster, B., Simmons, A., Cole, J. H., Schoof, E. M., Linding, R., Nichols, T., Muglia, P., Holsboer, F., Sämann, P. G., McGuffin, P., et al. (2018) · Psychiatric Genetics · doi:10.1097/ypg.0000000000000203 · Cited by 29
Elovainio, M. J., Taipale, T., Seppälä, I., Mononen, N., Raitoharju, E., Jokela, M. M., Pulkki-Råbäck, L., Illig, T., Waldenberger, M., Hakulinen, C. A., et al. (2015) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2015.09.017 · Cited by 30
Ghosh, S., Sinha, J. K., Khandelwal, N., Chakravarty, S., Kumar, A., & Raghunath, M. (2018) · Nutritional Neuroscience · doi:10.1080/1028415x.2018.1548676 · Cited by 29
Singh, H., Chmura, J., Bhaumik, R., Pandey, G. N., & Rasenick, M. M. (2020) · Journal of Neuroscience · doi:10.1523/jneurosci.3033-19.2020 · Cited by 28
Yamagata, H., Uchida, S., Matsuo, K., Harada, K., Kobayashi, A., Nakashima, M., Nakano, M., Otsuki, K., Abe-Higuchi, N., Higuchi, F., et al. (2017) · Scientific Reports · doi:10.1038/s41598-017-03291-x · Cited by 27
Self-citationSIRT2 inhibition reverses anhedonia in the VGLUT1+/− depression model
Muñoz-Cobo, I., Belloch, F. B., Diaz-Perdigón, T., Puerta, E., & Tordera, R. M. (2017) · Behavioural Brain Research · doi:10.1016/j.bbr.2017.07.045 · Cited by 28
Seo, M. K., Kim, S.-G., Seog, D., Bahk, W., Kim, S.-H., Park, S. W., & Lee, J. G. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21176331 · Cited by 24
Metadata
- Authors
- Hobara, T., Uchida, S., Otsuki, K., Matsubara, T., Funato, H., Matsuo, K., Suetsugi, M., & Watanabe, Y.
- Affiliations
- Yamaguchi University (JP)
- Corresponding author
- Watanabe, Yoshifumi
- Venue
- Journal of Psychiatric Research
- Publisher
- Elsevier BV
- Published
- 2010-04
- Volume
- 44
- Issue
- 5
- Pages
- 263-270
- ISSN
- 0022-3956 (ISSN-L)
- OpenAlex
- W2148160168
- Cited by
- 185
- References
- 57
- Citations by year
- 2026: 9 · 2025: 7 · 2024: 9 · 2023: 6 · 2022: 7 · 2021: 17 · 2020: 18 · 2019: 11 · 2018: 10 · 2017: 16 · 2016: 10 · 2015: 15 · 2014: 9 · 2013: 16 · 2012: 9
- FWCI
- 3.35
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of Psychiatric Research (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Ministry of Education, Culture, Sports, Science and Technology
- Ministry of Health, Labour and Welfare
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Histone Deacetylase Inhibitors Research
- Health Sciences › Medicine › Pharmacology (medical) › Treatment of Major Depression
- Health Sciences › Medicine › Psychiatry and Mental health › Bipolar Disorder and Treatment
- Keywords
- histone deacetylase, mood disorders, major depressive disorder, bipolar disorder, HDAC2, HDAC5, HDAC4, HDAC6, HDAC8, gene expression, peripheral blood leukocytes, leukocytes, histone acetylation, chromatin remodeling, antidepressants, mood stabilizers, first-degree relatives
- MeSH terms
- Animals, Antidepressive Agents, Clomipramine, Corticotropin-Releasing Hormone, Dexamethasone, Disease Models, Animal, Female, Gene Expression Regulation, Histone Deacetylases, Humans, Hydrocortisone, Male, Mice, Inbred BALB C, Mice, Inbred C57BL, Middle Aged, RNA, Messenger, Swimming, Paroxetine, Mood Disorders, Mice
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
