Altered HDAC5 and CREB mRNA expressions in the peripheral leukocytes of major depression

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Wilamowska (2010) · doi:10.1001/archpsyc.1988.01800320058007 · Cited by 2,115 · see citing works

Sustained hippocampal chromatin regulation in a mouse model of depression and antidepressant action

Tsankova, N. M., Berton, O., Renthal, W., Kumar, A., Neve, R. L., & Nestler, E. J. (2006) · Nature Neuroscience · doi:10.1038/nn1659 · Cited by 1,780 · see citing works

New approaches to antidepressant drug discovery: beyond monoamines

Berton, O., & Nestler, E. J. (2006) · Nature Reviews Neuroscience · doi:10.1038/nrn1846 · Cited by 1,589 · see citing works

Chronic antidepressant administration increases the expression of cAMP response element binding protein (CREB) in rat hippocampus

Nibuya, M., Nestler, E., & Duman, R. (1996) · The Journal of Neuroscience · doi:10.1523/jneurosci.16-07-02365.1996 · Cited by 1,206 · see citing works

When not enough is too much: the role of insufficient glucocorticoid signaling in the pathophysiology of stress-related disorders

Raison, C. L., & Miller, A. H. (2003) · American Journal of Psychiatry · doi:10.1176/appi.ajp.160.9.1554 · Cited by 1,197 · see citing works

Signal-dependent nuclear export of a histone deacetylase regulates muscle differentiation

McKinsey, T. A., Zhang, C., Lu, J., & Olson, E. N. (2000) · Nature · doi:10.1038/35040593 · Cited by 1,051 · see citing works

Regulation of transcription factors by neuronal activity

West, A. E., Griffith, E. C., & Greenberg, M. E. (2002) · Nature reviews. Neuroscience · doi:10.1038/nrn987 · Cited by 604 · see citing works

Altered Responsiveness to Cocaine and Increased Immobility in the Forced Swim Test Associated with Elevated cAMP Response Element-Binding Protein Expression in Nucleus Accumbens

Pliakas, A. M., Carlson, R. R., Neve, R. L., Konradi, C., Nestler, E. J., & Carlezon, W. A. (2001) · The Journal of Neuroscience · doi:10.1523/jneurosci.21-18-07397.2001 · Cited by 509 · see citing works

cAMP Response Element-Mediated Gene Transcription Is Upregulated by Chronic Antidepressant Treatment

Thome, J., Sakai, N., Shin, K.-H., Steffen, C., Zhang, Y.-J., Impey, S., Storm, D. R., & Duman, R. S. (2000) · Journal of Neuroscience · doi:10.1523/jneurosci.20-11-04030.2000 · Cited by 507 · see citing works

The Role of CREB in Depression and Antidepressant Treatment

Blendy, J. A. (2006) · Biological Psychiatry · doi:10.1016/j.biopsych.2005.11.003 · Cited by 365 · see citing works

Inhibition of cAMP response element-binding protein or dynorphin in the nucleus accumbens produces an antidepressant-like effect

Newton, S. S., Thome, J., Wallace, T. L., Shirayama, Y., Schlesinger, L., Sakai, N., Chen, J., Neve, R., Nestler, E. J., & Duman, R. S. (2002) · The Journal of Neuroscience · doi:10.1523/jneurosci.22-24-10883.2002 · Cited by 313 · see citing works

Cellular Plasticity Cascades: Targets for the Development of Novel Therapeutics for Bipolar Disorder

Zarate, C. A., Singh, J. B., & Manji, H. K. (2006) · Biological Psychiatry · doi:10.1016/j.biopsych.2005.10.021 · Cited by 276 · see citing works

Stress models of depression: forming genetically vulnerable strains

Henn, F. A., & Vollmayr, B. (2005) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2005.03.019 · Cited by 274 · see citing works

Fluoxetine and Cocaine Induce the Epigenetic Factors MeCP2 and MBD1 in Adult Rat Brain

Cassel, S. L., Carouge, D., Gensburger, C., Anglard, P., Burgun, C., Dietrich, J., Aunis, D., & Zwiller, J. (2006) · Molecular Pharmacology · doi:10.1124/mol.106.022301 · Cited by 194 · see citing works

Valproic acid: an old drug newly discovered as inhibitor of histone deacetylases.

Göttlicher, M. (2004) · PubMed · doi:10.1007/s00277-004-0850-2 · Cited by 185 · see citing works

Lymphocyte calcium signaling from membrane to nucleus

Gallo, E. M., Canté-Barrett, K., & Crabtree, G. R. (2005) · Nature Immunology · doi:10.1038/ni1295 · Cited by 183 · see citing works

Reduced phosphorylation of cyclic AMP-responsive element binding protein in the postmortem orbitofrontal cortex of patients with major depressive disorder

Yamada, S., Yamamoto, M., Ozawa, H., Riederer, P. F., & Saito, T. (2003) · Journal of Neural Transmission · doi:10.1007/s00702-002-0810-8 · Cited by 124 · see citing works

Cyclic AMP-mediated signaling components are upregulated in the prefrontal cortex of depressed suicide victims

Odagaki, Y., Garcı́a-Sevilla, J. A., Huguelet, P., Harpe, R. L., Koyama, T., & Guimón, J. (2001) · Brain Research · doi:10.1016/s0006-8993(01)02188-6 · Cited by 64 · see citing works

Abnormalities in the cAMP signaling pathway in post-mortem brain tissue from the Stanley Neuropathology Consortium

Stewart, R. J., Chen, B., Dowlatshahi, D. D., MacQUEEN, G. M., & Young, L. T. (2001) · Brain Research Bulletin · doi:10.1016/s0361-9230(01)00524-x · Cited by 63 · see citing works

Serotonin transporter mRNA expression in peripheral leukocytes of patients with major depression before and after treatment with paroxetine

Iga, J., Ueno, S., Yamauchi, K., Motoki, I., Shibuya‐Tayoshi, S., Ohta, K., Song, H., Morita, K., Rokutan, K., & Ohmori, T. (2005) · Neuroscience Letters · doi:10.1016/j.neulet.2005.06.048 · Cited by 61 · see citing works

Decrease of the D4 dopamine receptor messenger RNA expression in lymphocytes from patients with major depression

Rocca, P., Leo, C. D., Eva, C. E., Marchiaro, L., Milani, A. M., Musso, R., Ravizza, L., Zanalda, E., & Bogetto, F. (2002) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/s0278-5846(02)00253-1 · Cited by 57 · see citing works

Gene expression and association analysis of LIM (PDLIM5) in major depression

Iga, J., Ueno, S., Yamauchi, K., Numata, S., Motoki, I., Shibuya‐Tayoshi, S., Kinouchi, S., Ohta, K., Song, H., Morita, K., et al. (2006) · Neuroscience Letters · doi:10.1016/j.neulet.2006.02.044 · Cited by 44 · see citing works

Electroconvulsive Shock Increases the Phosphorylation of Cyclic AMP Response Element Binding Protein at Ser-133 in Rat Hippocampus but not in Cerebellum

HEE, J. S., Seong, Y., Juhnn, Y. S., Kang, U. G., Ha, K., Sik, K. Y., & Park, J.-B. (1997) · Neuropharmacology · doi:10.1016/s0028-3908(97)00047-6 · Cited by 41 · see citing works

Expression of cAMP Response Element-Binding Protein in Major Depression before and after Antidepressant Treatment

Lai, I., Hong, C., & Tsai, S. (2003) · Neuropsychobiology · doi:10.1159/000074635 · Cited by 29 · see citing works

Chromatin Remodeling: A Novel Mechanism of Psychotropic Drug Action

Newton, S. S., & Duman, R. S. (2006) · Molecular Pharmacology · doi:10.1124/mol.106.027078 · Cited by 29 · see citing works

Increased sensitivity of the inositol-phospholipid system in neutrophils from patients with acute major depressive episodes

Bohus, M., Förstner, U., Kiefer, C., Gebicke‐Haerter, P. J., Timmer, J., Spraul, G., Wark, H.-J., Hecht, H., Berger, T., & van Calker, D. (1996) · Psychiatry Research · doi:10.1016/0165-1781(96)02913-7 · Cited by 22 · see citing works

Mitogen stimulated rise of intracellular calcium concentration in single t lymphocytes from patients with major depression is reduced

Vollmayr, B., Sulger, J., Gabriel, P., & Aldenhoff, J. B. (1995) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/0278-5846(95)00265-0 · Cited by 11 · see citing works

Epigenetics of the depressed brain: role of histone acetylation and methylation

Sun, H., Kennedy, P. J., & Nestler, E. J. (2013) · Neuropsychopharmacology · doi:10.1038/npp.2012.73 · Cited by 413 · see citing works

Epigenetics and depression

Penner-Goeke, S., & Binder, E. B. (2019) · Dialogues in Clinical Neuroscience · doi:10.31887/dcns.2019.21.4/ebinder · Cited by 254 · see citing works

Epigenetic regulation in major depression and other stress-related disorders: molecular mechanisms, clinical relevance and therapeutic potential

Yuan, M., Yang, B., Rothschild, G., Mann, J. J., Sanford, L. D., Tang, X., Huang, C., Wang, C., & Zhang, W. (2023) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-023-01519-z · Cited by 246 · see citing works

Acute Effects of Psilocybin After Escitalopram or Placebo Pretreatment in a Randomized, Double‐Blind, Placebo‐Controlled, Crossover Study in Healthy Subjects

Becker, A. M., Holze, F., Grandinetti, T., Klaiber, A., Toedtli, V. E., Kolaczynska, K. E., Duthaler, U., Varghese, N., Eckert, A., Grünblatt, E., et al. (2022) · Clinical Pharmacology & Therapeutics · doi:10.1002/cpt.2487 · Cited by 184 · see citing works

Altered gene expression of histone deacetylases in mood disorder patients

Hobara, T., Uchida, S., Otsuki, K., Matsubara, T., Funato, H., Matsuo, K., Suetsugi, M., & Watanabe, Y. (2010) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2009.08.015 · Cited by 185 · see citing works

Epigenetic mechanisms of major depression: Targeting neuronal plasticity

Uchida, S., Yamagata, H., Seki, T., & Watanabe, Y. (2018) · Psychiatry and Clinical Neurosciences · doi:10.1111/pcn.12621 · Cited by 181 · see citing works

The Role of Dietary Histone Deacetylases (HDACs) Inhibitors in Health and Disease

Bassett, S. A., & Barnett, M. P. G. (2014) · Nutrients · doi:10.3390/nu6104273 · Cited by 182 · see citing works

Design, Synthesis, and Biological Evaluation of Potent and Selective Class IIa Histone Deacetylase (HDAC) Inhibitors as a Potential Therapy for Huntington’s Disease

Bürli, R. W., Luckhurst, C. A., Aziz, O., Matthews, K. L., Yates, D., Lyons, K. A., Beconi, M., McAllister, G., Breccia, P., Stott, A. J., et al. (2013) · Journal of Medicinal Chemistry · doi:10.1021/jm4011884 · Cited by 153 · see citing works

Biomarkers to Predict Antidepressant Response

Leuchter, A. F., Cook, I. A., Hamilton, S. P., Narr, K. L., Toga, A. W., Hunter, A. M., Faull, K. F., Whitelegge, J. P., Andrews, A. M., Loo, J., et al. (2010) · Current Psychiatry Reports · doi:10.1007/s11920-010-0160-4 · Cited by 140 · see citing works

Epigenetics and depression: return of the repressed

Dalton, V. S., Kolshus, E., & McLoughlin, D. M. (2013) · Journal of Affective Disorders · doi:10.1016/j.jad.2013.10.028 · Cited by 134 · see citing works

Biomarkers for Psychiatry: The Journey from Fantasy to Fact, a Report of the 2013 CINP Think Tank: Figure 1.

Scarr, E., Millan, M. J., Bahn, S., Bertolino, A., Turck, C. W., Kapur, S., Möller, H., & Dean, B. (2015) · The International Journal of Neuropsychopharmacology · doi:10.1093/ijnp/pyv042 · Cited by 135 · see citing works

Stimulated Gene Expression Profiles as a Blood Marker of Major Depressive Disorder

Spijker, S., van Zanten, J. S., de Jong, S., Penninx, B. W. J. H., van Dyck, R., Zitman, F. G., Smit, J. H., Ylstra, B., Smit, A. B., & Hoogendijk, W. J. G. (2010) · Biological Psychiatry · doi:10.1016/j.biopsych.2010.03.017 · Cited by 125 · see citing works

Epigenetic Modifications of Major Depressive Disorder

Saavedra, K., Molina-Márquez, A., Saavedra, N., Zambrano, T., & Salazar, L. A. (2016) · International Journal of Molecular Sciences · doi:10.3390/ijms17081279 · Cited by 124 · see citing works

Omics-Based Biomarkers: Application of Metabolomics in Neuropsychiatric Disorders

Sethi, S., & Brietzke, E. M. (2015) · The International Journal of Neuropsychopharmacology · doi:10.1093/ijnp/pyv096 · Cited by 122 · see citing works

Blood biomarkers and treatment response in major depression

Mora, C., Zonca, V., Riva, M. A., & Cattaneo, A. (2018) · Expert Review of Molecular Diagnostics · doi:10.1080/14737159.2018.1470927 · Cited by 107 · see citing works

Early life stress increases stress vulnerability through BDNF gene epigenetic changes in the rat hippocampus

Seo, M. K., Ly, N. N., Lee, C. H., Cho, H. Y., Choi, C. M., Nhu, L. H., Lee, J. G., Lee, B. J., Kim, G.-M., Yoon, B. J., et al. (2016) · Neuropharmacology · doi:10.1016/j.neuropharm.2016.02.009 · Cited by 100 · see citing works

Epigenetics in depression and gut-brain axis: A molecular crosstalk

Begum, N., Mandhare, A., Tryphena, K. P., Srivastava, S., Shaikh, M. F., Singh, S. B., & Khatri, D. K. (2022) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2022.1048333 · Cited by 99 · see citing works

Clinical variations modulate patterns of gene expression and define blood biomarkers in major depression

Belzeaux-R, R., Formisano‐Tréziny, C., Loundou, A., Boyer, L., Gabert, J. A., Samuelian, J., Feron, F. P., Naudin, J., & Ibrahim, E. C. (2010) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2010.04.011 · Cited by 95 · see citing works

The potential use of histone deacetylase inhibitors in the treatment of depression

Fuchikami, M., Yamamoto, S., Morinobu, S., Okada, S., Yamawaki, Y., & Yamawaki, S. (2015) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2015.03.010 · Cited by 111 · see citing works

A new paradigm for the prediction of antidepressant treatment response

Leuchter, A. F., Cook, I. A., Hunter, A. M., & Korb, A. S. (2009) · Dialogues in Clinical Neuroscience · doi:10.31887/dcns.2009.11.4/afleuchter · Cited by 90 · see citing works

Gene Expression Studies in Major Depression

Mehta, D., Menke, A., & Binder, E. B. (2010) · Current Psychiatry Reports · doi:10.1007/s11920-010-0100-3 · Cited by 87 · see citing works

Consensus paper of the WFSBP Task Force on Genetics: Genetics, epigenetics and gene expression markers of major depressive disorder and antidepressant response

Fabbri, C., Hosák, L., Mößner, R., Giegling, I., Mandelli, L., Bellivier, F., Claes, S. J., Collier, D. A., Corrales, A., DeLisi, L. E., et al. (2016) · The World Journal of Biological Psychiatry · doi:10.1080/15622975.2016.1208843 · Cited by 81 · see citing works

Hippocampal HDAC4 Contributes to Postnatal Fluoxetine-Evoked Depression-Like Behavior

Sarkar, A., Chachra, P., Kennedy, P., Pena, C. J., Desouza, L. A., Nestler, E. J., & Vaidya, V. A. (2014) · Neuropsychopharmacology · doi:10.1038/npp.2014.73 · Cited by 79 · see citing works

International Union of Basic and Clinical Pharmacology CIV: The Neurobiology of Treatment-resistant Depression: From Antidepressant Classifications to Novel Pharmacological Targets

Caraci, F., Calabrese, F., Molteni, R., Bartova, L., Dold, M., Leggio, G. M., Fabbri, C., Mendlewicz, J., Racagni, G., Kasper, S. F., et al. (2018) · Pharmacological Reviews · doi:10.1124/pr.117.014977 · Cited by 73 · see citing works

Gene expression biomarkers of response to citalopram treatment in major depressive disorder

Mamdani, F., Berlim, M. T., Beaulieu, M.-M., Labbe, A., Mérette, C., & Turecki, G. (2011) · Translational Psychiatry · doi:10.1038/tp.2011.12 · Cited by 72 · see citing works

Histone deacetylases (HDACs) as therapeutic target for depressive disorders

Misztak, P., Pańczyszyn-Trzewik, P., & Sowa-Kućma, M. (2017) · Pharmacological Reports · doi:10.1016/j.pharep.2017.08.001 · Cited by 70 · see citing works

Epigenetic mechanisms in mood disorders: Targeting neuroplasticity

Fass, D. M., Schroeder, F. A., Perlis, R. H., & Haggarty, S. J. (2013) · Neuroscience · doi:10.1016/j.neuroscience.2013.01.041 · Cited by 62 · see citing works

Class IIa histone deacetylases: conducting development and differentiation

Martin, M., Kettmann, R., & Dequiedt, F. (2009) · The International Journal of Developmental Biology · doi:10.1387/ijdb.082698mm · Cited by 62 · see citing works

Regulation of mRNA expression encoding chaperone and co-chaperone proteins of the glucocorticoid receptor in peripheral blood: association with depressive symptoms during pregnancy

Katz, E. R., Stowe, Z. N., Newport, D. J., Kelley, M. E., Pace, T. W. W., Cubells, J. F., & Binder, E. B. (2011) · Psychological Medicine · doi:10.1017/s0033291711002121 · Cited by 58 · see citing works

Transcriptomic predictors of inflammation-induced depressed mood

Cho, J. H.-J., Irwin, M. R., Eisenberger, N. I., Lamkin, D. M., & Cole, S. W. (2019) · Neuropsychopharmacology · doi:10.1038/s41386-019-0316-9 · Cited by 54 · see citing works

Novel Class IIa-Selective Histone Deacetylase Inhibitors Discovered Using an in Silico Virtual Screening Approach

Hsu, K., Liu, C., Lin, T. E., Hsieh, J.-H., Sung, T.-Y., Tseng, H.-J., Yang, J., & Huang, W. (2017) · Scientific Reports · doi:10.1038/s41598-017-03417-1 · Cited by 54 · see citing works

Epigenetic mechanisms impacted by chronic stress across the rodent lifespan

Dion, A., Muñoz, P., & Franklin, T. B. (2022) · Neurobiology of Stress · doi:10.1016/j.ynstr.2022.100434 · Cited by 54 · see citing works

Effects of Histone Modification in Major Depressive Disorder

Wu, M.-S., Li, X., Liu, C., Xu, Q., Huang, J., Gu, S., & Chen, J. (2021) · Current Neuropharmacology · doi:10.2174/1570159x19666210922150043 · Cited by 53 · see citing works

Histone acetylation and expression of mono-aminergic transmitters synthetases involved in CUS-induced depressive rats

Liu, D., Qiu, H.-M., Fei, H.-Z., Hu, X.-Y., Xia, H.-J., Wang, L.-J., Qin, L.-J., Jiang, X.-H., & Zhou, Q.-X. (2014) · Experimental Biology and Medicine · doi:10.1177/1535370213513987 · Cited by 49 · see citing works

Epigenetic Targeting of Histone Deacetylases in Diagnostics and Treatment of Depression

Park, H., Kim, J., Ahn, S. H., & Ryu, H. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22105398 · Cited by 50 · see citing works

Effects of maternal separation and antidepressant drug on epigenetic regulation of the brain‐derived neurotrophic factor exon I promoter in the adult rat hippocampus

Park, S. W., Seo, M. K., Lee, J. G., Hiền, L. T. T., & Kim, Y. H. (2017) · Psychiatry and Clinical Neurosciences · doi:10.1111/pcn.12609 · Cited by 48 · see citing works

Identification and replication of RNA-Seq gene network modules associated with depression severity

Le, T. T., Savitz, J. B., Suzuki, H., Misaki, M., Teague, T. K., White, B. C., Marino, J. H., Wiley, G. B., Gaffney, P. M., Drevets, W. C., et al. (2018) · Translational Psychiatry · doi:10.1038/s41398-018-0234-3 · Cited by 47 · see citing works

Epigenetic profiling of human brain differential DNA methylation networks in schizophrenia

Lee, S.-A., & Huang, K.-C. (2016) · BMC Medical Genomics · doi:10.1186/s12920-016-0229-y · Cited by 46 · see citing works

Alterations in leukocyte transcriptional control pathway activity associated with major depressive disorder and antidepressant treatment

Mellon, S. H., Wolkowitz, O. M., Schonemann, M. D., Epel, E. S., Rosser, R., Burke, H. B., Mahan, L., Reus, V. I., Stamatiou, D., Liew, C. C., et al. (2016) · Translational Psychiatry · doi:10.1038/tp.2016.79 · Cited by 45 · see citing works

Epigenetic mechanisms of stress and depression

Chmielewska, N., Szyndler, J., Maciejak, P., & Płaźnik, A. (2019) · Psychiatria Polska · doi:10.12740/pp/94375 · Cited by 46 · see citing works

A method for biomarker measurements in peripheral blood mononuclear cells isolated from anxious and depressed mice: β-arrestin 1 protein levels in depression and treatment

Mendez‐David, I., Ali, Z. E., Hen, R., Falissard, B., Corruble, E., Gardier, A. M., Kerdine‐Römer, S., & David, D. J. P. (2013) · Frontiers in Pharmacology · doi:10.3389/fphar.2013.00124 · Cited by 43 · see citing works

The importance of epigenetics in diagnostics and treatment of major depressive disorder

Czarny, P., Białek, K., Ziółkowska, S., Strycharz, J., Barszczewska, G., & Sliwinski, T. (2021) · Journal of Personalized Medicine · doi:10.3390/jpm11030167 · Cited by 37 · see citing works

Altered expression of long noncoding RNAs in patients with major depressive disorder

Seki, T., Yamagata, H., Uchida, S., Chen, C., Kobayashi, A., Kobayashi, M., Harada, K., Matsuo, K., Watanabe, Y., & Nakagawa, S. (2019) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2019.07.004 · Cited by 42 · see citing works

Transcriptomic and epigenomic biomarkers of antidepressant response

Belzeaux-R, R., Lin, R., Ju, C., Chay, M.-A., Fiori, L. M., Lutz, P.-É., & Turecki, G. (2017) · Journal of Affective Disorders · doi:10.1016/j.jad.2017.08.087 · Cited by 43 · see citing works

Genetic Variation in the Epigenetic Machinery and Mental Health

Murgatroyd, C., & Spengler, D. (2012) · Current Psychiatry Reports · doi:10.1007/s11920-012-0255-1 · Cited by 41 · see citing works

Molecular assessment of depression from mRNAs in the peripheral leukocytes

Iga, J., Ueno, S., & Ohmori, T. (2008) · Annals of Medicine · doi:10.1080/07853890802082088 · Cited by 39 · see citing works

Aberrant REST-mediated transcriptional regulation in major depressive disorder

Otsuki, K., Uchida, S., Wakabayashi, Y., Matsubara, T., Hobara, T., Funato, H., & Watanabe, Y. (2009) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2009.09.009 · Cited by 37 · see citing works

Biological tests for major depressive disorder that involve leukocyte gene expression assays

Watanabe, S., Iga, J., Ishii, K., Numata, S., Shimodera, S., Fujita, H., & Ohmori, T. (2015) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2015.03.004 · Cited by 38 · see citing works

Serum brain-derived neurotrophic factor and glucocorticoid receptor levels in lymphocytes as markers of antidepressant response in major depressive patients: A pilot study

Rojas, P. S., Rosemarie Fritsch, M., Rojas, R., Jara, P., & Fiedler, J. L. (2011) · Psychiatry Research · doi:10.1016/j.psychres.2011.04.032 · Cited by 37 · see citing works

Dysregulation of leukocyte gene expression in women with medication-refractory depression versus healthy non-depressed controls

Iacob, E., Light, K. C., Tadler, S. C., Weeks, H. R., White, A. T., Hughen, R. W., VanHaitsma, T. A., Bushnell, L., & Light, A. R. (2013) · BMC Psychiatry · doi:10.1186/1471-244x-13-273 · Cited by 36 · see citing works

Coding and Noncoding Gene Expression Biomarkers in Mood Disorders and Schizophrenia

Mamdani, F., Martin, M. V., Lencz, T., Rollins, B. L., Robinson, D. G., Moon, E. A., Malhotra, A. K., & Vawter, M. P. (2013) · Disease Markers · doi:10.1155/2013/748095 · Cited by 31 · see citing works

Antidepressant mechanisms of venlafaxine involving increasing histone acetylation and modulating tyrosine hydroxylase and tryptophan hydroxylase expression in hippocampus of depressive rats

Qiao, M., Jiang, Q., Liu, Y., Hu, X.-Y., Wang, L., Zhou, Q., & Qiu, H. (2019) · Neuroreport · doi:10.1097/wnr.0000000000001191 · Cited by 31 · see citing works

Cyclic-AMP response element binding protein (CREB) in the neutrophils of depressed patients

Ren, X., Dwivedi, Y., Mondal, A. C., & Pandey, G. N. (2010) · Psychiatry Research · doi:10.1016/j.psychres.2010.04.013 · Cited by 28 · see citing works

Long-term imipramine treatment increases N-methyl-d-aspartate receptor activity and expression via epigenetic mechanisms

Nghia, N. A., Hirasawa, T., Kasai, H., Obata, C., Moriishi, K., Mochizuki, K., Koizumi, S., & Kubota, T. (2015) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2015.02.010 · Cited by 26 · see citing works

Gene expression: Biomarker of antidepressant therapy?

Menke, A. (2013) · International Review of Psychiatry · doi:10.3109/09540261.2013.825580 · Cited by 25 · see citing works

The molecular basis of depression: implications of sex-related differences in epigenetic regulation

Kawatake-Kuno, A., Murai, T., & Uchida, S. (2021) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2021.708004 · Cited by 23 · see citing works

A Multiscale View of the Mechanisms Underlying Ketamine’s Antidepressant Effects: An Update on Neuronal Calcium Signaling

Kawatake-Kuno, A., Murai, T., & Uchida, S. (2021) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2021.749180 · Cited by 26 · see citing works

Distinct Expression Pattern of Epigenetic Machinery Genes in Blood Leucocytes and Brain Cortex of Depressive Patients

Rey, R., Chauvet‐Gélinier, J., Suaud‐Chagny, M., Ragot, S., Bonin, B., d’Amato, T., & Teyssier, J. (2018) · Molecular Neurobiology · doi:10.1007/s12035-018-1406-0 · Cited by 20 · see citing works

Epigenetic Regulation of Resistance to Emotional Stress: Possible Involvement of 5-HT1A Receptor–Mediated Histone Acetylation

Tsuji, M., Miyagawa, K., & Takeda, H. (2014) · Journal of Pharmacological Sciences · doi:10.1254/jphs.14r07cp · Cited by 19 · see citing works

Valproic acid administration exerts protective effects against stress-related anhedonia in rats

Goudarzi, M., Nahavandi, A., Mehrabi, S., Eslami, M., Shahbazi, A., & Barati, M. (2020) · Journal of Chemical Neuroanatomy · doi:10.1016/j.jchemneu.2020.101768 · Cited by 18 · see citing works

Association study of CREB1 with Major Depressive Disorder and related phenotypes

Hettema, J. M., An, S., van den Oord, E. J. C. G., Neale, M. C., Kendler, K. S., & Chen, X. (2009) · American Journal of Medical Genetics Part B Neuropsychiatric Genetics · doi:10.1002/ajmg.b.30935 · Cited by 19 · see citing works

Mechanisms of extracellular signal-regulated kinase/cAMP response element-binding protein/brain-derived neurotrophic factor signal transduction pathway in depressive disorder.

Wang, H., Zhang, Y., & Qiao, M. (2013) · PubMed Central · doi:10.3969/j.issn.1673-5374.2013.09.009 · Cited by 18 · see citing works

Antidepressant-like Effects of Combined Fluoxetine and Zinc Treatment in Mice Exposed to Chronic Restraint Stress Are Related to Modulation of Histone Deacetylase

Misztak, P., Sowa-Kućma, M., Pańczyszyn-Trzewik, P., Szewczyk, B., & Nowak, G. (2021) · Molecules · doi:10.3390/molecules27010022 · Cited by 15 · see citing works

Ingestion of taxifolin-rich foods affects brain activity, mental fatigue, and the whole blood transcriptome in healthy young adults: a randomized, double-blind, placebo-controlled, crossover study

Shinozaki, F., Kamei, A., Shimada, K., Matsuura, H., Shibata, T., Ikeuchi, M., Yasuda, K., Oroguchi, T., Kishimoto, N., Takashimizu, S., et al. (2023) · Food & Function · doi:10.1039/d2fo03151e · Cited by 16 · see citing works

Transcriptional biomarkers of response to pharmacological treatments in severe mental disorders: A systematic review

Pisanu, C., Severino, G., Toma, I. D., Dierssen, M., Fusar‐Poli, P., Gennarelli, M., Lió, P., Maffioletti, E., Maron, E., Mehta, D., et al. (2022) · European Neuropsychopharmacology · doi:10.1016/j.euroneuro.2021.12.005 · Cited by 15 · see citing works

Early Enriched Environment Prevents Epigenetic p11 Gene Changes Induced by Adulthood Stress in Mice

Seo, M. K., Choi, A., Seog, D., Lee, J. G., & Park, S. W. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22041928 · Cited by 14 · see citing works

New Approaches to the Pharmacological Management of Major Depressive Disorder

Witkin, J. M., & Li, X. (2009) · Advances in pharmacology · doi:10.1016/s1054-3589(08)57009-8 · Cited by 14 · see citing works

Trichostatin A relieves anxiety-and depression-like symptoms in APP/PS1 mice

Su, Q., Ren, Y.-H., Liu, G.-W., Gao, Y., Zhang, J. Y., Zhang, J.-N., Pei, X.-X., & Li, T. (2024) · Frontiers in Pharmacology · doi:10.3389/fphar.2024.1333235 · Cited by 13 · see citing works

Co-expression network of mRNA and DNA methylation in first-episode and drug-naive adolescents with major depressive disorder

Tao, Y., Zhang, H., Jin, M., Xu, H., Zou, S., Deng, F., Huang, L., Zhang, H., Wang, X., Tang, X., et al. (2023) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2023.1065417 · Cited by 9 · see citing works

Combining Psychodynamic Psychotherapy and Pharmacotherapy

Gorman, J. M. (2016) · Psychodynamic Psychiatry · doi:10.1521/pdps.2016.44.2.183 · Cited by 10 · see citing works

The Role of Epigenetic Dysregulation in Suicidal Behaviors

Fiori, L. M., & Turecki, G. (2020) · Current topics in behavioral neurosciences · doi:10.1007/7854_2020_160 · Cited by 9 · see citing works

Antidepressant effect of the novel histone deacetylase-5 inhibitor T2943 in a chronic restraint stress mouse model

Du, J., Liu, N., Ma, L., Liu, R., Zuo, D., Lan, X., Yang, J., Wei, W., Peng, X., & Yu, J. (2024) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2024.116176 · Cited by 8 · see citing works

Identification of Novel Signal Transduction, Immune Function, and Oxidative Stress Genes and Pathways by Topiramate for Treatment of Methamphetamine Dependence Based on Secondary Outcomes

Niu, T., Li, J., Wang, J., Ma, J. Z., & Li, M. D. (2017) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2017.00271 · Cited by 8 · see citing works

Gene expression-based biological test for major depressive disorder: an advanced study

Watanabe, S., Numata, S., Iga, J., Kinoshita, M., Umehara, H., Ishii, K., & Ohmori, T. (2017) · Neuropsychiatric Disease and Treatment · doi:10.2147/ndt.s120038 · Cited by 8 · see citing works

Role of histone deacetylases in neuroplasticity impairments and inflammation in major depression

Garayo, A., Azqueta, A., & Tordera, R. M. (2024) · Neuroscience Applied · doi:10.1016/j.nsa.2024.104081 · Cited by 7 · see citing works

Gene Expression of Inflammation Markers in Depression

Ciobanu, L. G., & Baune, B. T. (2018) · Elsevier eBooks · doi:10.1016/b978-0-12-811073-7.00011-8 · Cited by 6 · see citing works

Novel histone deacetylase-5 inhibitor T2943 exerts an anti-depressive effect in mice by enhancing GRID1 expression

Du, J., Liu, R., Ma, L., Liu, Y., Wei, W., Liu, N., Cao, Q., & Yu, J. (2025) · Scientific Reports · doi:10.1038/s41598-025-88670-5 · Cited by 6 · see citing works

Lysine (K)-Deacetylase Inhibitors: The Real Next Step To Neuropsychiatric And Neurodegenerative Disorders?

Rosenstock, T. R. (2014) · Zenodo (CERN European Organization for Nuclear Research) · doi:10.5281/zenodo.886877 · Cited by 5 · see citing works

Precision Psychiatry: Personalized Clinical Approach to Depression

Perna, G., Balletta, R., & Nemeroff, C. B. (2017) · Springer eBooks · doi:10.1007/978-981-10-6580-4_21 · Cited by 5 · see citing works

Depression: epigenetics and epitranscriptomic modifications

Banerjee, S., Shrilaxmi, M. S., Banerjee, S., Prajwal, B. G., Smith, C., D’Mello, S. R., & Dastidar, S. G. (2025) · The World Journal of Biological Psychiatry · doi:10.1080/15622975.2025.2602171 · Cited by 4 · see citing works

Identification of Cancer Driver Genes based on Dynamic Incentive Model

Hu, Z., Li, G., Luo, X., Peng, W., Liu, J., Zhu, X., & Wu, J. (2024) · IEEE Transactions on Computational Biology and Bioinformatics · doi:10.1109/tcbb.2024.3467119 · Cited by 4 · see citing works

The Role of Epigenetic Factors in the Development of Depressive Disorders

Mustafin, R. N., Enikeeva, R. F., Davydova, Y. D., & Хуснутдинова, Э. К. (2018) · Russian Journal of Genetics · doi:10.1134/s1022795418120104 · Cited by 4 · see citing works

Epigenetic, neuroplasticity, and adrenergic targets associated with major depression in immune cells

Cortés-Erice, M., Garayo, A., Fernández-Ovejero, R., Aubá, E., Lizaso, S., Aldaz, P., Bes‐Rastrollo, M., Gil, J. L., Barrado, L., Ortuño, F., et al. (2026) · Scientific Reports · doi:10.1038/s41598-026-36954-9 · Cited by 3 · see citing works

Perspectives for an Integrated Biomarker Approach to Drug Discovery and Development

Antonijevic, I. A., Artymyshyn, R. P., Forray, C., Rabacchi, S. A., Smith, K. E., Swanson, C. J., Tamm, J. A., Mazin, W., & Gerald, C. (2008) · Springer eBooks · doi:10.1007/978-0-387-79251-4_15 · Cited by 3 · see citing works

Genetic Determinants of the Association between Osteoarthritis and Psychiatric Disorders

Chen, W., Zhu, J., Han, X., Zeng, Y., Hou, C., Qu, Y., Yang, H., Hu, Y., Sun, Y., & Song, H. (2023) · Depression and Anxiety · doi:10.1155/2023/5253920 · Cited by 2 · see citing works

The Role of Histone Deacetylases in Neurodegenerative Diseases and Small-Molecule Inhibitors as a Potential Therapeutic Approach

Bürli, R. W., Thomas, E. A., & Beaumont, V. (2010) · Topics in medicinal chemistry · doi:10.1007/7355_2010_10 · Cited by 2 · see citing works

Epigenetics of Suicidal Behaviour

Turecki, G. (2015) · Advances in biological psychiatry · doi:10.1159/000434738 · Cited by 2 · see citing works

Role of Microbiota-Derived Exosomes in Gut–Brain Communication for the Treatment of Brain Disorders

Agnihotri, T. G., Gomte, S. S., Peddinti, V., Rout, B., Shewale, R. S., Janjal, P., & Jain, A. (2024) · Springer eBooks · doi:10.1007/978-981-99-8373-5_9 · Cited by 1 · see citing works

Genetic and epigenetic predictors of antidepressant response

Lyndon, S. (2026) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2026.111738 · Cited by 1 · see citing works

A classifier driven approach to find biomarkers for affective disorders from transcription profiles in blood

Mazin, W., Tamm, J. A., Antonijevic, I. A., Abdourahman, A., Das, M., Artymyshyn, R. P., Søgaard, B., Walker, M., Savić, D., Matić, G. M., et al. (2016) · Advances in Precision Medicine · doi:10.18063/apm.2016.01.003 · Cited by 1 · see citing works

Neurobiologic correlates of depression: illustration of challenges in bench-to-bedside translation

Jones, B. E. (2020) · Elsevier eBooks · doi:10.1016/b978-0-12-820007-0.00037-4 · Cited by 1 · see citing works

Epigenetics of major depressive disorder

Braun, P., & Potash, J. (2021) · Epigenetics in Psychiatry · doi:10.1016/b978-0-12-823577-5.00002-7

Effets anxiolytiques/antidépresseurs et neurogéniques des ligands du récepteur 5-HT4 chez la Souris : rôle de la protéine β-arrestin 1

Mendez‐David, I. (2013) · doi:10.70675/3b74ce4cz68acz4446zbe46zb1542d4e9391 · Cited by 1 · see citing works

Histone Deacetylase Inhibitors: A Brief Overview Of Their Role And Medicinal Chemistry

Angibaud, P. R., Emelen, K. V., & Arts, J. (2010) · Burger's Medicinal Chemistry and Drug Discovery · doi:10.1002/0471266949.bmc213

Epigenetic Mechanisms of Early Adverse Experience in the Development of Depression

Seo, M. K., Lee, J. G., Park, S. W., Lee, B. J., Baek, J. H., & Kim, Y. H. (2014) · 대한정신약물학회지

Exploring the biological basis of affective disorders

Mazin, W., & Erik Mosekilde, B. (2008)

Efeito de antagonistas do receptor NMDA sobre a metilação do DNA

Montezuma, K. (2017) · Digital Library of Theses and Dissertations (Universidade de São Paulo) · doi:10.11606/d.60.2017.tde-24102016-163014

Screening of a Histone Methyltransferase Inhibitor in Animal Models of Psychiatric Illness

Kosowan, J. (2014) · TSpace (University of Toronto)

Epigenetics of suicidal behaviors

Fiori, L. M., & Turecki, G. (2020) · Elsevier eBooks · doi:10.1016/b978-0-12-814297-4.00014-5

Epigenetic, neuroplasticity, and adrenergic targets associated with major depression in immune cellsPreprint

Cortés-Erice, M., Garayo, A., Fernández-Ovejero, R., Aubá, E., Lizaso, S., Aldaz, P., Bes‐Rastrollo, M., Gil, J. L., Barrado, L., Ortuño, F., et al. (2025) · Research Square · doi:10.21203/rs.3.rs-7178520/v1

The study on the gene expression of cyclic AMP response element-binding protein in peripheral leucocyte from patients with major depression

Kai-d, J. (2010) · Zhongguo shenjing jingshen jibing zazhi

Serotonin transporter mRNA expression in peripheral leukocytes of patients with major depression before and after treatment with paroxetine

Iga, J., Ueno, S., Yamauchi, K., Motoki, I., Shibuya‐Tayoshi, S., Ohta, K., Song, H., Morita, K., Rokutan, K., & Ohmori, T. (2005) · Neuroscience Letters · doi:10.1016/j.neulet.2005.06.048 · Cited by 61 · see citing works

Follow-up of brain-derived neurotrophic factor (BDNF) during a one-year antidepressant treatment.

Catena, M., Marazziti, D., Piccinni, A., Debbio, A. D., Consoli, G., Veltri, A., Golia, F., Schiavi, E., Palla, A., Picchetti, M., et al. (2007) · European Psychiatry · doi:10.1016/j.eurpsy.2007.01.758

Cyclic-AMP response element binding protein (CREB) in the neutrophils of depressed patients

Ren, X., Dwivedi, Y., Mondal, A. C., & Pandey, G. N. (2010) · Psychiatry Research · doi:10.1016/j.psychres.2010.04.013 · Cited by 28 · see citing works

Increased temporal cortex CREB concentrations and antidepressant treatment in major depression

Young, L. T., Dowlatshahi, D. D., MacQUEEN, G. M., & Wang, J. F. (1998) · The Lancet · doi:10.1016/s0140-6736(05)79827-5 · Cited by 306 · see citing works