Genetic variants in nuclear-encoded mitochondrial proteins are associated with oxidative stress in obsessive compulsive disorders
Abstract
Obsessive compulsive disorder is a common psychiatric disorder defined by the presence of obsessive thoughts and repetitive compulsive actions. The mutations or polymorphic variants in mitochondrial DNA-encoded genes or nuclear genes result in oxidative stress, which has recently been associated with various psychiatric disorders. In order to understand the association of mitochondrial disorders with oxidative stress in obsessive compulsive disorder, we examined genetic variants of manganese superoxide dismutase and uncouple-2 antioxidant genes and malondialdehyde and glutathione, markers of oxidative stress. The study sample comprised 104 patients with OCD and 110 healthy controls. For manganese superoxide dismutase, the frequencies of CT (Ala/Val) genotype (p < 0.01) in patients were significantly lower than those of controls. In contrast, CC (Ala/Ala) genotype was significantly more frequent in patients than controls (p < 0.05). For uncouple-2 I/D, the frequencies of ID genotype (p < 0.01) and I allele (p < 0.05) were lower in patients as compared with controls. In contrast, DD genotype was more prevalent in patients than controls (p < 0.01). While whole blood glutathione was significantly diminished (p < 0.0001), serum malondialdehyde was significantly elevated in patients compared with controls (p < 0.0001). Malondialdehyde levels were significantly elevated in subjects with DD genotype of UCP-2 I/D (p < 0.05) and CC genotype of manganese superoxide dismutase (p < 0.05) as compared with II or ID and TT or CT genotype, respectively. Malondialdehyde levels in patients carrying CC (p < 0.05) or CT (p < 0.05) genotype were significantly higher than those of carrying TT genotype. In conclusion, CC genotype of manganese superoxide dismutase or DD genotype of UCP-2 might result in mitochondrial disorders by increasing oxidative stress in obsessive compulsive disorders.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Mitochondrial dysfunction could be an important mechanism for the pathology of obsessive-compulsive disorder.
“it seems that mitochondrial dysfunction could be an important mechanism for the pathology of OCD [45].”
From Oxidative Stress Implications in the Affective Disorders: Main Biomarkers, Animal Models Relevance, Genetic Perspectives, and Antioxidant Approaches (2016) · cites this paper as [45]
Cites
Assay for lipid peroxides in animal tissues by thiobarbituric acid reaction
Ohkawa, H., Ohishi, N., & Yagi, K. (1979) · Analytical Biochemistry · doi:10.1016/0003-2697(79)90738-3 · Cited by 29,460 · see citing works
A simple salting out procedure for extracting DNA from human nucleated cells
Miller, S. A., Dykes, D. D., & Polesky, H. F. (1988) · Nucleic Acids Research · doi:10.1093/nar/16.3.1215 · Cited by 20,341 · see citing works
The assessment of anxiety states by rating
HAMILTON, M. (1959) · British Journal of Medical Psychology · doi:10.1111/j.2044-8341.1959.tb00467.x · Cited by 11,455 · see citing works
Improved method for the determination of blood glutathione.
Beutler, E., Duron, O., & KELLY, B. M. (1963) · PubMed · Cited by 6,932 · see citing works
Functional architecture of basal ganglia circuits: neural substrates of parallel processing
Alexander, G. E., & Crutcher, M. D. (1990) · Trends in Neurosciences · doi:10.1016/0166-2236(90)90107-l · Cited by 4,131 · see citing works
The Yale-Brown Obsessive Compulsive Scale: II. Validity
Goodman, W. K. (1989) · Archives of General Psychiatry · doi:10.1001/archpsyc.1989.01810110054008 · Cited by 2,799 · see citing works
The Yale-Brown Obsessive-Compulsive Scale: Measures of internal consistency
Kim, S. W., Dysken, M. W., Pheley, A. M., & Hoover, K. M. (1994) · Psychiatry Research · doi:10.1016/0165-1781(94)90039-6 · Cited by 2,361 · see citing works
Zelko, I. N., Mariani, T. J., & Folz, R. J. (2002) · Free Radical Biology and Medicine · doi:10.1016/s0891-5849(02)00905-x · Cited by 2,212 · see citing works
Korshunov, S. S., Skulachev, V. P., & Starkov, A. A. (1997) · FEBS Letters · doi:10.1016/s0014-5793(97)01159-9 · Cited by 1,727 · see citing works
Scandalios, J. G. (2005) · Brazilian Journal of Medical and Biological Research · doi:10.1590/s0100-879x2005000700003 · Cited by 1,142 · see citing works
Arsenijevic, D., Onuma, H., Pecqueur, C., Raimbault, S., Manning, B. S., Miroux, B., Couplan, E., Alves‐Guerra, M., Goubern, M., Surwit, R. S., et al. (2000) · Nature Genetics · doi:10.1038/82565 · Cited by 1,079 · see citing works
Lebovitz, R. M., Zhang, H., Vogel, H., Cartwright, J., Dionne, L., Lu, N., Huang, S., & Matzuk, M. M. (1996) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.93.18.9782 · Cited by 1,023 · see citing works
Mitochondrial Glutathione, a Key Survival Antioxidant
Marı́, M., Morales, A., Colell, A., García‐Ruiz, C., & Fernández-Checa, J. C. (2009) · Antioxidants and Redox Signaling · doi:10.1089/ars.2009.2695 · Cited by 982 · see citing works
Mitochondrial DNA mutations and human disease
Tuppen, H. A. L., Blakely, E. L., Turnbull, D. M., & Taylor, R. W. (2010) · Biochimica et Biophysica Acta (BBA) - Bioenergetics · doi:10.1016/j.bbabio.2009.09.005 · Cited by 676 · see citing works
Gawryluk, J. W., Wang, J.-F., Andreazza, A. C., Shao, L., & Young, L. T. (2011) · The International Journal of Neuropsychopharmacology · doi:10.1017/s1461145710000805 · Cited by 594 · see citing works
Schizophrenia: glutathione deficit in cerebrospinal fluid and prefrontal cortex in vivo
Do, K. Q., Trabesinger, A. H., Kirsten‐Krüger, M., Lauer, C. J., Dydak, U., Hell, D., Holsboer, F., Boesiger, P., & Cuénod, M. (2000) · European Journal of Neuroscience · doi:10.1046/j.1460-9568.2000.00229.x · Cited by 540 · see citing works
Adibhatla, R. M., & Hatcher, J. F. (2010) · Antioxidants & Redox Signaling · doi:10.1089/ars.2009.2668 · Cited by 480 · see citing works
Oxidative stress and the pathogenesis of neurodegenerative disorders.
Reynolds, A. D., Laurie, C., Mosley, R., & Gendelman, H. (2007) · International review of neurobiology · doi:10.1016/s0074-7742(07)82016-2 · Cited by 443 · see citing works
The modified Hamilton rating scale for depression: Reliability and validity
Miller, I. W., Bishop, S. B., Norman, W. H., & Maddever, H. M. (1985) · Psychiatry Research · doi:10.1016/0165-1781(85)90057-5 · Cited by 411 · see citing works
Oxidative stress, mitochondrial dysfunction and cellular stress response in Friedreich's ataxia
Calabrese, V., Lodi, R., Tonon, C., D’Agata, V., Sapienza, M. A., Scapagnini, G., Mangiameli, A., Pennisi, G., Stella, A. M. G., & Butterfield, D. A. (2005) · Journal of the Neurological Sciences · doi:10.1016/j.jns.2005.03.012 · Cited by 407 · see citing works
Twin Studies on Obsessive–Compulsive Disorder: A Review
Grootheest, D. S. V., Cath, D. C., Beekman, A. T. F., & Boomsma, D. I. (2005) · Twin Research and Human Genetics · doi:10.1375/twin.8.5.450 · Cited by 401 · see citing works
Glutathione, iron and Parkinson’s disease
Bharath, S., Hsu, M., Kaur, D., Rajagopalan, S., & Andersen, J. K. (2002) · Biochemical Pharmacology · doi:10.1016/s0006-2952(02)01174-7 · Cited by 394 · see citing works
Calcium‐dependent mitochondrial function and dysfunction in neurons
Pivovarova, N. B., & Andrews, S. (2010) · FEBS Journal · doi:10.1111/j.1742-4658.2010.07754.x · Cited by 382 · see citing works
Walder, K. R. (1998) · Human Molecular Genetics · doi:10.1093/hmg/7.9.1431 · Cited by 293 · see citing works
Mancuso, C. (2006) · Frontiers in bioscience · doi:10.2741/2130 · Cited by 290 · see citing works
A family study of early-onset obsessive-compulsive disorder
do Rosário, M. C., Leckman, J. F., Cúri, M., Quatrano, S., Katsovitch, L., Miguel, E. C., & Pauls, D. L. (2005) · American Journal of Medical Genetics Part B Neuropsychiatric Genetics · doi:10.1002/ajmg.b.30149 · Cited by 272 · see citing works
A family study of obsessive‐compulsive disorder with pediatric probands
Hanna, G. L., Himle, J. A., Curtis, G. C., & Gillespie, B. W. (2005) · American Journal of Medical Genetics Part B Neuropsychiatric Genetics · doi:10.1002/ajmg.b.30138 · Cited by 194 · see citing works
Kuloğlu, M., Atmaca, M., Tezcan, E., Geçici, Ö., Tunckol, H., & Üstündağ, B. (2002) · Neuropsychobiology · doi:10.1159/000063573 · Cited by 178 · see citing works
Gender differences in obsessive–compulsive symptom dimensions
Labad, J., Menchon, J. M., Alonso, P., Segalas, C., Jimenez, S., Jaurrieta, N., Leckman, J. F., & Vallejo, J. (2008) · Depression and Anxiety · doi:10.1002/da.20332 · Cited by 172 · see citing works
Guidot, D. M., McCord, J. M., Wright, R. M., & Repine, J. E. (1993) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)74369-5 · Cited by 149 · see citing works
Tek, C., Uluǧ, B., Rezaki, B. G., Tanriverdi, N., Mercan, S., Demir, B., & Vargel, S. (1995) · Acta Psychiatrica Scandinavica · doi:10.1111/j.1600-0447.1995.tb09801.x · Cited by 147 · see citing works
The genetics of obsessive compulsive disorder: a review of the evidence
Pauls, D. L. (2008) · American Journal of Medical Genetics Part C: Seminars in Medical Genetics · doi:10.1002/ajmg.c.30168 · Cited by 142 · see citing works
Gender in obsessive–compulsive disorder: clinical and genetic findings
Lochner, C., Hemmings, S. M. J., Kinnear, C. J., Moolman-Smook, J. C., Corfield, V. A., Knowles, J. A., Niehaus, D. J. H., & Stein, D. J. (2004) · European Neuropsychopharmacology · doi:10.1016/s0924-977x(03)00063-4 · Cited by 141 · see citing works
Duval, C., Nègre‐Salvayre, A., Doglio, A., Salvayre, R., Pénicaud, L., & Casteilla, L. (2002) · Biochemistry and Cell Biology · doi:10.1139/o02-158 · Cited by 136 · see citing works
SIMILAR AND DISSIMILAR MANIFESTATIONS OF OBSESSIVE-COMPULSIVE NEUROSIS IN MONOZYGOTIC TWINS
Inouye, E. (1965) · American Journal of Psychiatry · doi:10.1176/ajp.121.12.1171 · Cited by 122 · see citing works
De Bilbao, F., Arsenijevic, D., Vallet, P., Hjelle, O. P., Ottersen, O. P., Bouras, C., Raffin, Y., Abou, K., Langhans, W., Collins, S., et al. (2004) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2004.02432.x · Cited by 108 · see citing works
Dean, O. M., van den Buuse, M., Bush, A. I., Copolov, D., Ng, F., Dodd, S., & Berk, M. (2009) · Current Medicinal Chemistry · doi:10.2174/092986709788803060 · Cited by 101 · see citing works
Behl, A., Swami, G., Sircar, S., Bhatia, M. S., & Banerjee, B. (2010) · Neuropsychobiology · doi:10.1159/000306591 · Cited by 93 · see citing works
Yanovski, J. A., Diament, A. L., Sovik, K. N., Nguyen, T. T., Li, H., Sebring, N. G., & Warden, C. H. (2000) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/71.6.1405 · Cited by 90 · see citing works
Erşan, S., Bakır, S., Erşan, E. E., & Doğan, O. (2006) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2006.03.034 · Cited by 90 · see citing works
Wang, S., Wang, F., Shi, X., Dai, J., Peng, Y., Guo, X., Wang, X., Shen, H., & Hu, Z. (2009) · European Journal of Cancer · doi:10.1016/j.ejca.2009.04.024 · Cited by 81 · see citing works
Treatment of late-onset OCD following basal ganglia infarct
Carmin, C. N., Wiegartz, P. S., Yunus, U., & Gillock, K. L. (2002) · Depression and Anxiety · doi:10.1002/da.10024 · Cited by 80 · see citing works
Grasbon-Frodl, E. M., Kösel, S., Rieß, O., Müller, U., Mehraein, P., & Graeber, M. B. (1999) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.1998.9998 · Cited by 79 · see citing works
Mitochondrial proton leak: a role for uncoupling proteins 2 and 3?
Porter, R. K. (2001) · Biochimica et Biophysica Acta (BBA) - Bioenergetics · doi:10.1016/s0005-2728(00)00246-2 · Cited by 78 · see citing works
Applying Bradford Hill's Criteria for Causation to Neuropsychiatry
van Reekum, R., Streiner, D. L., & Conn, D. K. (2001) · Journal of Neuropsychiatry · doi:10.1176/jnp.13.3.318 · Cited by 76 · see citing works
Epidemiologia do transtorno obsessivo-compulsivo: uma revisão
Torres, A. R., & Lima, M. C. P. (2005) · Brazilian Journal of Psychiatry · doi:10.1590/s1516-44462005000300015 · Cited by 66 · see citing works
Connectivity between mitochondrial functions and psychiatric disorders
Hroudová, J., & Fišar, Z. (2011) · Psychiatry and Clinical Neurosciences · doi:10.1111/j.1440-1819.2010.02178.x · Cited by 62 · see citing works
Pathophysiology of fatty acid oxidation disorders
Bennett, M. J. (2009) · Journal of Inherited Metabolic Disease · doi:10.1007/s10545-010-9170-y · Cited by 62 · see citing works
Mitochondrial Ca2+, the secret behind the function of uncoupling proteins 2 and 3?
Graier, W. F., Trenker, M., & Malli, R. (2008) · Cell Calcium · doi:10.1016/j.ceca.2008.01.001 · Cited by 59 · see citing works
Brambilla, F., Bellodi, L., Perna, G., Arancio, C., & Bertani, A. (1997) · Biological Psychiatry · doi:10.1016/s0006-3223(96)00549-5 · Cited by 46 · see citing works
Regulation of mitochondrial dynamics and neurodegenerative diseases.
Han, X.-J., Tomizawa, K., Fujimura, A., Ohmori, I., Nishiki, T., Matsushita, M., & Matsui, H. (2011) · PubMed · doi:10.18926/amo/43824 · Cited by 41 · see citing works
Wang, Y., SAMUELS, J. F., Chang, Y.-P. C., Grados, M. A., Greenberg, B. D., Knowles, J. A., McCracken, J. T., Rauch, S. L., Murphy, D. L., Rasmussen, S. A., et al. (2008) · American Journal of Medical Genetics Part B Neuropsychiatric Genetics · doi:10.1002/ajmg.b.30760 · Cited by 34 · see citing works
Hamilton anksiyete değerlendirme öiçeği, değerlendiriciler arası güvenirlik ve geçerlik çalışması
Yazici, M., Demir, B., Tanrıverdi, N., Karaağaoğlu, E., & Yolaç, P. (1998) · Turkish Journal of Psychiatry · Cited by 34 · see citing works
Britt, S. G., Chiu, V. W. S., Redpath, G. T., & VandenBerg, S. R. (1992) · Journal of Receptor Research · doi:10.3109/10799899209074791 · Cited by 29 · see citing works
Nakamura, K., Chen, C., Sekine, Y., Iwata, Y., Anitha, A., Loh, E., Takei, N., Suzuki, A., Kawai, M., Takebayashi, K., et al. (2006) · Human Genetics · doi:10.1007/s00439-006-0189-y · Cited by 29 · see citing works
Lin, Y. H., Han, Y., Xu, J., Cao, L., Gao, J., Xie, N., Zhao, X., Jiang, H., & Chi, Z. (2010) · Cellular and Molecular Neurobiology · doi:10.1007/s10571-010-9524-x · Cited by 29 · see citing works
Brambilla, F., Perna, G., Bussi, R., & Bellodi, L. (2000) · Psychoneuroendocrinology · doi:10.1016/s0306-4530(99)00061-x · Cited by 28 · see citing works
Uncoupling protein 2 influences dopamine secretion in PC12h cells
Yamada, S., Isojima, Y., Yamatodani, A., & Nagai, K. (2003) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.2003.02005.x · Cited by 27 · see citing works
A 45‐bp Insertion/Deletion Polymorphism of Uncoupling Protein 2 in Relation to Obesity in Tongans
Duarte, N., Colagiuri, S., Palu, T., Wang, X. L., & Wilcken, D. E. L. (2003) · Obesity Research · doi:10.1038/oby.2003.72 · Cited by 22 · see citing works
Obsessive-Compulsive Disorder With Mitochondrial Disease
Lacey, C. J., & Salzberg, M. R. (2008) · Psychosomatics · doi:10.1176/appi.psy.49.6.540 · Cited by 19 · see citing works
Applying Bradford Hill's Criteria for Causation to Neuropsychiatry: Challenges and Opportunities
van Reekum, R. (2001) · Journal of Neuropsychiatry · doi:10.1176/appi.neuropsych.13.3.318 · Cited by 19 · see citing works
Effects of nerve growth factor on brain glutathione‐related enzymes from aged rats
Cruz-Aguado, R., Fernández‐Verdecia, C., Díaz-Suárez, C. M., González‐Monzón, O., Antúnez-Potashkina, I., & Bergado, J. A. (1998) · Fundamental and Clinical Pharmacology · doi:10.1111/j.1472-8206.1998.tb00983.x · Cited by 11 · see citing works
Mitochondrial Dysfunction and Neurodegenerative Diseases
Byvaltsev, V. A., Sudakov, N. P., Nikiforov, S. B., & Konstantinov, Y. M. (2010) · World Neurosurgery · doi:10.1016/j.wneu.2010.08.015 · Cited by 3 · see citing works
Aquaron, R., Lacombe, D., Topi, G. C., & Lamoril, J. (1992) · PubMed · Cited by 1 · see citing works
Flagged first, then by citations
1 of the 65 references couldn’t be matched to a known paper.
Cited by
Sorted by citations
A Critical Review of Magnetic Resonance Spectroscopy Studies of Obsessive-Compulsive Disorder
Brennan, B. P., Rauch, S. L., Jensen, J. E., & Pope, H. G. (2012) · Biological Psychiatry · doi:10.1016/j.biopsych.2012.06.023 · Cited by 141 · see citing works
Pagano, G., Talamanca, A. A., Castello, G., Cordero, M. D., d’Ischia, M., Gadaleta, M. N., Pallardó, F. V., Petrović, S. Ž., Tiano, L., & Zatterale, A. (2014) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2014/541230 · Cited by 137 · see citing works
Brand, M. D. (2020) · Critical Reviews in Biochemistry and Molecular Biology · doi:10.1080/10409238.2020.1828258 · Cited by 123 · see citing works
Balmus, I. M., Ciobica, A., Antioch, I., Dobrin, R., & Timofte, D. (2016) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2016/3975101 · Cited by 103 · see citing works
“In the same way, it seems that mitochondrial dysfunction could be an important mechanism for the pathology of OCD [45].”
BackgroundInfluentialMaia, A., Oliveira, J., Lajnef, M., Mallet, L., Tamouza, R., Leboyer, M., & Oliveira-Maia, A. J. (2019) · Acta Psychiatrica Scandinavica · doi:10.1111/acps.13026 · Cited by 72 · see citing works
Oxidative imbalance in child and adolescent patients with obsessive compulsive disorder
Kandemir, H., Abuhandan, M., Aksoy, N., Savik, E., & Kaya, C. (2013) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2013.08.010 · Cited by 48 · see citing works
Converging evidence points towards a role of insulin signaling in regulating compulsive behavior
van de Vondervoort, I. I. G. M., Amiri, H., Bruchhage, M. M. K., Oomen, C. A., Rustogi, N., Cooper, J. D., van Asten, J. J. A., Heerschap, A., Bahn, S., Williams, S., et al. (2019) · Translational Psychiatry · doi:10.1038/s41398-019-0559-6 · Cited by 38 · see citing works
Lower Posterior Cingulate Cortex Glutathione Levels in Obsessive-Compulsive Disorder
Brennan, B. P., Jensen, J. E., Perriello, C., Pope, H. G., Jenike, M. A., Hudson, J. I., Rauch, S. L., & Kaufman, M. J. (2015) · Biological Psychiatry Cognitive Neuroscience and Neuroimaging · doi:10.1016/j.bpsc.2015.12.003 · Cited by 32 · see citing works
Ilješ, A. P., Kastelic, M., Porcelli, S., Serretti, A., Makovec, M. R., Plesničar, B. K., & Dolžan, V. (2014) · Alcohol and Alcoholism · doi:10.1093/alcalc/agu088 · Cited by 29 · see citing works
Vreeland, A., Calaprice, D., Or‐Geva, N., Frye, R. E., Agalliu, D., Lachman, H. M., Pittenger, C., Pallanti, S., Williams, K., Ma, M., et al. (2023) · Developmental Neuroscience · doi:10.1159/000534261 · Cited by 28 · see citing works
An empirical review on oxidative stress markers and their relevance in obsessive-compulsive disorder
Kar, S., & Choudhury, I. (2016) · International journal of Nutrition Pharmacology Neurological Diseases · doi:10.4103/2231-0738.191641 · Cited by 26 · see citing works
Alemany-Navarro, M., Costas, J., Real, E., Segalàs, C., Bertolín, S., Domènech, L., Rabionet, R., Carracedo, Á., Menchón, J. M., & Alonso, P. (2019) · Translational Psychiatry · doi:10.1038/s41398-019-0410-0 · Cited by 24 · see citing works
Striatal Magnetic Resonance Spectroscopy Abnormalities in Young Adult Sapap3 Knockout Mice
Mintzopoulos, D., Gillis, T. E., Robertson, H. R., Dalia, T. N., Feng, G., Rauch, S. L., & Kaufman, M. J. (2015) · Biological Psychiatry Cognitive Neuroscience and Neuroimaging · doi:10.1016/j.bpsc.2015.10.001 · Cited by 23 · see citing works
Kang, J. I., Park, C. I., Lin, J., Kim, S. T., Kim, H. W., & Kim, S. J. (2021) · Journal of Psychiatry and Neuroscience · doi:10.1503/jpn.200238 · Cited by 21 · see citing works
Mohammadi, A. H., Balandeh, E., & Milajerdi, A. (2021) · Annals of General Psychiatry · doi:10.1186/s12991-021-00354-2 · Cited by 18 · see citing works
Özkan, Y., Kandemır, H., Sapmaz, Ş. Y., Taneli, F., Özdemir, H., & Özkan, Ö. G. (2021) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2021.05.084 · Cited by 11 · see citing works
Dietary quality and nutrient intake in adults with obsessive–compulsive disorder
Nguyen, T. P., Cribb, L., Ng, C. H., Byrne, G. J., Castle, D. J., Brakoulias, V., Blair‐West, S., Oliver, G., Ee, C., Dean, O. M., et al. (2021) · BJPsych Open · doi:10.1192/bjo.2021.1039 · Cited by 11 · see citing works
Mohammadi, A. H., Balandeh, E., Hasani, J., Karimian, M., Arabshahi, V., Pourfarzam, M., Bahmani, F., & Namazi, G. (2024) · BioMed Research International · doi:10.1155/2024/9979582 · Cited by 7 · see citing works
Foyet, H. S., Balmuș, I.-M., Hervé, N. A. H., Acha, A. E., Guenné, S., Kiendrébeogo, M., & Ciobica, A. S. (2017) · Journal of Complementary and Integrative Medicine · doi:10.1515/jcim-2016-0059 · Cited by 6 · see citing works
Mitochondrial Dysfunction in Psychiatric Disorders
Rossignol, D. A., & Frye, R. E. (2014) · Oxidative stress in applied basic research and clinical practice · doi:10.1007/978-1-4939-0440-2_12 · Cited by 5 · see citing works
Eghdami, S., Saeidi, M., Gunturu, S., Boroon, M., & Shalbafan, M. (2025) · Life · doi:10.3390/life15101585 · Cited by 4 · see citing works
Potential biomarkers and therapeutic targets for obsessive compulsive disorder
Sudesh, R., Vashishth, R., Rajesh, K. M., Batra, D. R., Venkatesan, S., Sultania, A., & Ahmad, F. (2023) · Biochemia Medica · doi:10.11613/bm.2024.010503 · Cited by 4 · see citing works
Hebda‐Bauer, E. K., Hagenauer, M. H., Munro, D. B., Blandino, P., Meng, F., Arakawa, K., Chitre, A. S., Ozel, A. B., Mohammadi, P., Watson, S. J., et al. (2022) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2022.07.14.500129 · Cited by 4 · see citing works
Tsermpini, E. E., Goričar, K., Plesničar, B. K., Ilješ, A. P., & Dolžan, V. (2023) · Antioxidants · doi:10.3390/antiox13010020 · Cited by 3 · see citing works
Hebda‐Bauer, E. K., Hagenauer, M. H., Munro, D. B., Blandino, P., Meng, F., Arakawa, K., Stead, J. D. H., Chitre, A. S., Ozel, A. B., Mohammadi, P., et al. (2025) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2025.1469467 · Cited by 3 · see citing works
Mahdavinia, M., Chaab, M., Kouti, L., Sayyah, M., & Zeidooni, L. (2021) · Jundishapur Journal of Natural Pharmaceutical Products · doi:10.5812/jjnpp.57324 · Cited by 2 · see citing works
Mohammadi, A. H., Balandeh, E., Hasani, J., Karimian, M., Pourfarzam, M., Bahmani, F., & Namazi, G. (2021) · Research Square · doi:10.21203/rs.3.rs-1158115/v1 · Cited by 2 · see citing works
Çelik, Y. S., Okumuş, H. G., Kaşak, M., Okyar, G., Çimen, B., Öztürk, Y., Efe, A., & Erel, Ö. (2025) · Journal of Molecular Neuroscience · doi:10.1007/s12031-025-02428-2 · Cited by 1 · see citing works
Alzheimer's disease - neurological or psychiatric disorder?
Poalelungi, A., & Popescu, B. O. (2013) · Romanian Journal of Neurology · doi:10.37897/rjn.2013.1.1 · Cited by 1 · see citing works
Relationship Between Oxidative Stress and Obsessive–compulsive Disorder
Rabe‐Jabłońska, J., & Dietrich‐Muszalska, A. (2014) · Oxidative stress in applied basic research and clinical practice · doi:10.1007/978-1-4939-0440-2_6 · Cited by 1 · see citing works
Genetic Factors and Gene–Environment Interactions
Maron, E., & Shlik, J. (2014) · Wiley eBooks · doi:10.1002/9781118775349.ch14 · Cited by 1 · see citing works
Mohammadi, A. H., Balandeh, E., Hasani, J., Karimian, M., Pourfarzam, M., Bahmani, F., & Namazi, G. (2022) · Research Square · doi:10.21203/rs.3.rs-1158115/v2 · Cited by 1 · see citing works
Shavitt, R. G. (2020) · Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature · doi:10.3410/f.736601699.793580438
Shavitt, R. G. (2020) · Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature · doi:10.3410/f.735010629.793580430
Examining mitochondrial genetic variation in obsessive-compulsive disorderPreprint
Gonçalves, V. F., Santos, F. C. D., Giannoulis, S., Lisoway, A. J., Wong, C., Zai, C. C. H., Zai, G. C., Kennedy, J. L., & Richter, M. A. (2025) · Research Square · doi:10.21203/rs.3.rs-6149169/v1
Portnova, G., Khayrullina, G., Proskurnina, E., Verma, R., & Martynova, O. (2026) · BMC Psychiatry · doi:10.1186/s12888-026-08244-1
- Authors
- Orhan, N., Kucukali, C. I., Cakir, U., Seker, N., & Aydin, M.
- Affiliations
- Istanbul University (TR)
- Başkent University (TR)
- Venue
- Journal of Psychiatric Research
- Publisher
- Elsevier BV
- Published
- 2012-02
- Volume
- 46
- Issue
- 2
- Pages
- 212-218
- ISSN
- 0022-3956 (ISSN-L)
- OpenAlex
- W1983472283
- Cited by
- 36
- References
- 65
- Citations by year
- 2026: 1 · 2025: 4 · 2024: 1 · 2023: 3 · 2022: 2 · 2021: 6 · 2020: 3 · 2019: 3 · 2017: 1 · 2016: 2 · 2015: 2 · 2014: 5 · 2013: 2 · 2012: 1
- FWCI
- 2.75
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of Psychiatric Research (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Yale University
- Topics
- Social Sciences › Psychology › Clinical Psychology › Obsessive-Compulsive Spectrum Disorders
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Glutathione Transferases and Polymorphisms
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Mitochondrial Function and Pathology
- Keywords
- obsessive-compulsive disorder, oxidative stress, mitochondrial DNA-encoded proteins, manganese superoxide dismutase, UCP2, genetic polymorphism, malondialdehyde, glutathione, mitochondrial disease
- MeSH terms
- Uncoupling Protein 2, Adult, Female, Genotype, Glutathione, Humans, Ion Channels, Male, Malondialdehyde, Middle Aged, Obsessive-Compulsive Disorder, Retrospective Studies, Superoxide Dismutase, Lipid Peroxidation, Linkage Disequilibrium, Logistic Models, Odds Ratio, Oxidative Stress, Polymorphism, Single Nucleotide, Mitochondrial Proteins
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
