Oxidative imbalance in child and adolescent patients with obsessive compulsive disorder
Abstract
Various psychological, social, genetic and biochemical factors are thought to be involved in etiology of obsessive-compulsive disorder (OCD). To the best of our knowledge there are no studies investigating the effects of free radicals in children and adolescents with OCD. This study evaluated total oxidant and antioxidant status, oxidative stress index, and arylesterase and paraoxonase activity in children and adolescents with OCD. The study included 28 patients diagnosed with OCD and 36 healthy children as an age- and sex-matched control group. Their serum total oxidant status (TOS) and total antioxidant status (TAS) were measured and the oxidative stress index (OSI) was calculated. Although serum TOS and OSI values in the OCD patients were significantly higher than those in the control group (p = 0.008, p < 0.001, respectively), TAS and paraxonase activity were significantly lower ( p < 0.001 for both). However, no statistically significant difference in arylesterase activity was found (p > 0.05). The increase in oxidative status and decrease in antioxidants in patients with OCD demonstrate that oxidative stress may have an important role in the pathophysiology of the disease. It has been suggested that drugs that contain antioxidants should be added to conventional pharmacotherapy during follow-up.
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Increased oxidative damage occurs quite often in obsessive-compulsive disorder.
“also in obsessive-compulsive disorder [17]”
From Oxidative Stress Implications in the Affective Disorders: Main Biomarkers, Animal Models Relevance, Genetic Perspectives, and Antioxidant Approaches (2016) · cites this paper as [17]
An oxidative imbalance has been reported in obsessive-compulsive disorder patients.
“an oxidative imbalance has been reported in OCD patients”
From Oxidative Stress Implications in the Affective Disorders: Main Biomarkers, Animal Models Relevance, Genetic Perspectives, and Antioxidant Approaches (2016) · cites this paper as [17]
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Mirzazadeh, H., Ghaeminia, Y., Niaei, A. M., Kamran, M., Jahromi, L. R., & Moshfeghinia, R. (2025) · BMC Psychiatry · doi:10.1186/s12888-025-06856-7 · Cited by 4 · see citing works
Potential biomarkers and therapeutic targets for obsessive compulsive disorder
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Oxidative Imbalance in Children and Adolescents with Autism Spectrum Disorder
Ozturk, O., Başay, Ö., Başay, B. K., Alaçam, H., Büber, A., Kaptanoğlu, B., Enli, Y., Dogan, M., Tuncer, Ö. F., & KARDEŞLER, A. Ç. (2016) · Klinik Psikofarmakoloji Bülteni-Bulletin of Clinical Psychopharmacology · doi:10.5455/bcp.20160323105909 · Cited by 4 · see citing works
Özkan, Y., Kandemır, H., Sapmaz, Ş. Y., & Taneli, F. (2021) · Journal of Obsessive-Compulsive and Related Disorders · doi:10.1016/j.jocrd.2021.100649 · Cited by 4 · see citing works
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Shorter telomere length in obsessive-compulsive disorder: another evidence of neuroprogression?
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Investigating the Role of Oxidative Stress Parameters in the Spectrum of Preschool Anxiety Disorders
Cuhacioglu, E., Doğan, Ö., Ozturk, H. H., & Uytun, M. Ç. (2026) · Early Intervention in Psychiatry · doi:10.1111/eip.70242
- Authors
- Kandemir, H., Abuhandan, M., Aksoy, N., Savik, E., & Kaya, C.
- Affiliations
- Harran University (TR)
- Venue
- Journal of Psychiatric Research
- Publisher
- Elsevier BV
- Published
- 2013-11
- Volume
- 47
- Issue
- 11
- Pages
- 1831-1834
- ISSN
- 0022-3956 (ISSN-L)
- OpenAlex
- W2053687646
- Cited by
- 48
- References
- 59
- Citations by year
- 2026: 2 · 2025: 3 · 2024: 2 · 2023: 4 · 2022: 1 · 2021: 8 · 2020: 3 · 2019: 3 · 2018: 4 · 2017: 2 · 2016: 8 · 2015: 8
- FWCI
- 5.93
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of Psychiatric Research (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Social Sciences › Psychology › Clinical Psychology › Obsessive-Compulsive Spectrum Disorders
- Health Sciences › Medicine › Biochemistry › Antioxidant Activity and Oxidative Stress
- Social Sciences › Psychology › Clinical Psychology › Psychoanalysis and Psychopathology Research
- Keywords
- obsessive-compulsive disorder, oxidative stress, children and adolescents, total oxidant status, total antioxidant status, oxidative stress index, arylesterase, paraoxonase, free radicals, antioxidant therapy
- MeSH terms
- Adolescent, Antioxidants, Child, Female, Humans, Male, Obsessive-Compulsive Disorder, Psychiatric Status Rating Scales, Oxidants, Oxidative Stress
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