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Prevalence and incidence of postpartum depression among healthy mothers: A systematic review and meta-analysis
Abstract
This review aims to examine the prevalence and incidence of postpartum depression among healthy mothers without prior history of depression including postpartum depression and who gave birth to healthy full-term infants. A systematic search of ClinicalTrials.gov, CINAHL, EMBASE, PsycINFO, and PubMed was performed for English articles from the inception of the database to November 2017, as well as a manual search of the reference lists of the included articles, and an expert panel was consulted. Across 15,895 articles, 58 articles (N = 37,294 women) were included in the review. The incidence of postpartum depression was 12% [95% CI 0.04-0.20] while the overall prevalence of depression was 17% [95% CI 0.15-0.20] among healthy mothers without a prior history of depression. Prevalence was similar regardless of the type of diagnostic tool used; however, there were statistical differences in the prevalence between different geographical regions, with the Middle-East having the highest prevalence (26%, 95% CI 0.13-0.39) and Europe having the lowest (8%, 95% CI 0.05-0.11). There was no statistical difference in prevalence between different screening time points, but an increasing prevalence was observed beyond six months postpartum. Intervention studies often neglect healthy mothers. This review reports a similar prevalence rate of postpartum depression among mothers without history of depression when compared to mothers with history of depression. Thus, future studies should place equal emphasis on this neglected group of mothers so that targeted interventions and follow-ups can be introduced at appropriate time points.
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“The incidence was 12% [95% CI 0.04–0.20] and the overall prevalence was 17% [95% CI 0.15–0.20] [5].”
From Mental health-related telemedicine interventions for pregnant women and new mothers: a systematic literature review (2023) · cites this paper as [5]
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“0% in a systematic review andmeta-analysis that encompassed 58 studies with 37,294 postnatal women (Shorey et al., 2018).”
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“The targeted audience for this study included mothers who met the following criteria: (1) over the age of 18 years, (2) English-speaking, (3) currently living in Colorado, and (4) being pregnant or within the first 6-months postpartum.”
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“Many research studies have found that postpartum depression in mothers is common after delivery, with a prevalence rate ranging from 10% to 15%, depending on the criteria used for diagnosis (Brummelte & Galea, 2016; Shorey et al., 2018).”
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“Therefore, there was a need for a systematic review and meta–analysis, especially since it was not separately investigated in a previous study and it was only mentioned in a meta–analysis for all regions of the world, which in turn showed a higher prevalence of postpartum depression compared to other regions [30], and…”
BackgroundResultLiu, Y., Zhang, L., Guo, N., & Jiang, H. (2021) · BMC Psychiatry · doi:10.1186/s12888-021-03432-7 · Cited by 143
“5%, which was within the range of 8– 26% reported in a global review article that included 58 articles (N = 37,294 women) [44], but higher than studies reported in other areas of China [20–22].”
ResultHantsoo, L. V., Jagodnik, K. M., Novick, A. M., Baweja, R., di Scalea, T. L., Özerdem, A., McGlade, E., Simeonova, D. I., Dekel, S., Kornfield, S. L., et al. (2023) · Frontiers in Endocrinology · doi:10.3389/fendo.2023.1295261 · Cited by 175
Kroska, E. B., & Stowe, Z. N. (2020) · Obstetrics and Gynecology Clinics of North America · doi:10.1016/j.ogc.2020.05.001 · Cited by 136
Association between anemia and maternal depression: A systematic review and meta-analysis
Kang, S. Y., Kim, H.-B., & Sunwoo, S. (2020) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2020.01.001 · Cited by 108
Racine, N. M., Eirich, R., Cooke, J. E., Zhu, J., Pador, P., Dunnewold, N., & Madigan, S. L. (2021) · Infant Mental Health Journal · doi:10.1002/imhj.21959 · Cited by 136
“The postpartum period, including up to one year after the birth of a child, and early years of a child’s life are developmental stages associated with increased vulnerability to mental health difficulties for mothers (Cameron et al., 2016; Shorey et al., 2018).”
BackgroundVogel, J. P., Jung, J., Lavin, T., Simpson, G., Kluwgant, D., Abalos, E. J., Díaz, V., Downe, S. M., Filippi, V., Gallos, I. D., et al. (2023) · The Lancet Global Health · doi:10.1016/s2214-109x(23)00454-0 · Cited by 107
Shorey, S., Ng, E. D., & Chee, C. Y. I. (2021) · Scandinavian Journal of Public Health · doi:10.1177/14034948211011793 · Cited by 114
“In comparison to past reviews, our meta-analytic findings suggest a higher prevalence of antenatal depressive symptoms among pregnant women during the COVID-19 period than the preCOVID-19 period [3], and there was no difference in the prevalence of postnatal depressive symptoms between pre- and current COVID-19 period…”
ResultSelf-citationStevenson, K., Fellmeth, G. L., Edwards, S., Calvert, C., Bennett, P. R., Campbell, O. M. R., & Fuhr, D. C. (2022) · The Lancet Public Health · doi:10.1016/s2468-2667(22)00342-5 · Cited by 123
Zhao, L., Chen, J., Lan, L., Deng, N., Liao, Y., Yue, L., Chen, I., Wen, S. W., & Xie, R. (2021) · JMIR mhealth and uhealth · doi:10.2196/32544 · Cited by 112
“A systematic review comprised of 58 articles with a total of 37,294 women reported that the overall prevalence of PPD was 17% among healthy mothers [1].”
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“Therefore, screening for PPD through the Edinburgh Postnatal Depression Scale [EPDS; (29)], as recommended by the American Academy of Pediatrics, ultimately seems to be an accurate method of identifying postpartum depression.”
BackgroundInfluentialRisk factors associated with postpartum depressive symptoms: A multinational study
Bradshaw, H., Riddle, J. N., Salimgaraev, R., Zhaunova, L., & Payne, J. L. (2021) · Journal of Affective Disorders · doi:10.1016/j.jad.2021.12.121 · Cited by 89
Riseup-PPD-COVID-19 Group, Motrico, E., Bina, R., Domínguez‐Salas, S., Mateus, V., Contreras-García, Y., Carrasco‐Portiño, M., Ajaz, E., Apter, G., Christoforou, A., et al. (2021) · BMC Public Health · doi:10.1186/s12889-021-10330-w · Cited by 106
Estimation of postpartum depression risk from electronic health records using machine learning
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“Postpartum depression (PPD) is one of the most common complications of childbearing, estimated to affect 10–15% of mothers worldwide, with higher incidence rates in developing countries [1].”
BackgroundFactors Influencing Quality of Life in Early Postpartum Women
Jeong, Y. J., Nho, J., Kim, H. Y., & Kim, J. Y. (2021) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph18062988 · Cited by 81
“A recent meta-analysis reported that postpartum depression affects approximately 17% of healthy women [11].”
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Aoyagi, S., & Tsuchiya, K. J. (2019) · Journal of obstetrics and gynaecology research · doi:10.1111/jog.14064 · Cited by 91
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“10 In Europe, as well as in Oceania, a particularly high prevalence of antenatal anxiety was also found (41%, 42%).”
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“2%, which was higher than the global prevalence of postpartum depression described before the COVID-19 lockdown, which ranged from 14 to 20% among healthy mothers without a prior history of depression [37]; moreover, the prevalence found in our study was three times higher than the prevalence reported for North Americ…”
ResultHanach, N., de Vries, N., Radwan, H., & Bissani, N. (2021) · Midwifery · doi:10.1016/j.midw.2020.102906 · Cited by 75
Psychological risks to mother–infant bonding during the COVID-19 pandemic
Liu, C. H., Hyun, S., Mittal, L. P., & Erdei, C. (2021) · Pediatric Research · doi:10.1038/s41390-021-01751-9 · Cited by 82
Martínez‐Vázquez, S., Hernández‐Martínez, A., Rodríguez‐Almagro, J., Delgado‐Rodríguez, M., & Martínez‐Galiano, J. M. (2022) · Midwifery · doi:10.1016/j.midw.2022.103297 · Cited by 78
Intense connection and love: The experiences of autistic mothers
Dugdale, A.-S., Thompson, A. R., Leedham, A. T., Beail, N., & Freeth, M. (2021) · Autism · doi:10.1177/13623613211005987 · Cited by 79
“This aligns with research that suggests relationships between autistic adults involve a sense of acceptance and belonging (Sinclair, 2010) and peer support from other autistic adults can be highly valuable (Bertilsdotter Rosqvist, 2019; Sosnowy et al., 2019).”
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“Systematic reviews and meta-analyses reported a prevalence of PND of 20.7 % during pregnancy (Yin et al., 2021), and 17.0 % in the post-partum period (Hahn-Holbrook et al., 2018; Shorey et al., 2018).”
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“Previous systematic reviews reported the prevalence of depression and anxiety in the postpartum period as 17% and 15%, respectively [63,64].”
BackgroundExercise During Pregnancy and Prenatal Depression: A Systematic Review and Meta-Analysis
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“However, this finding is higher than the global magnitude of PPD, which is 17% [41].”
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“%) in the Europe [53].”
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“Postpartum depression (PPD) is a common mental health problem among new parents (Cameron et al., 2016; Shorey et al., 2018).”
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“PPD is one of the major complications during postpartum, with an estimated prevalence between 17% and 47% [10,11].”
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Lee, Y.-L., Tien, Y., Bai, Y.-S., Lin, C.-K., Yin, C.-S., Chung, C.-H., Sun, C.-A., Huang, S.-H., Huang, Y.-C., Chien, W.-C., et al. (2022) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph19095118 · Cited by 61
“A meta-analysis including studies from 1989 to 2016 indicated that the prevalence of PPD ranged between 13% and 19% [2].”
MethodMental disorder in pregnancy and the early postpartum
Cantwell, R. (2021) · Anaesthesia · doi:10.1111/anae.15424 · Cited by 63
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“This corresponds with findings from another review [16], but the prevalence of PND varies across Asia itself as well, and South Asia collectively has higher PND rates than Western countries [17-18].”
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Prevalence and incidence of postpartum depression and environmental factors: The IGEDEPP cohort
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“e PPD (12.9 %). These results are consistent with different international studies, evaluating PPD prevalence between 10 and 20 % during the first year postpartum (Ko et al., 2012; Heron et al., 2004; Shorey et al., 2018). Many factors can explain this range: the studies are heterogeneous in terms of population, timing…”
ResultInfluentialSmith, M. S., Cairns, L., Pullen, L., Opondo, C., Fellmeth, G. L., & Alderdice, F. A. (2021) · Journal of Affective Disorders · doi:10.1016/j.jad.2021.11.011 · Cited by 54
Palfreyman, A., & Gazeley, U. (2022) · Social Science & Medicine · doi:10.1016/j.socscimed.2022.115413 · Cited by 60
“…higher prevalence of peri-natal mental disorders in low-and middle-income countries (LMICs) than high-income countries (HICs) (Fisher et al., 2012; Shorey et al., 2018; Dennis et al., 2017; Fawcett et al., 2019), and self-harm is now a leading cause of pregnancy-related death in multiple LMICs…”
Radoš, S. N., Akik, B. K., Žutić, M., Muñoz, M. D. L. F. R., Uriko, K., Motrico, E., Moreno-Peral, P., Apter, G., & den Berg, M. P. L. (2024) · Comprehensive Psychiatry · doi:10.1016/j.comppsych.2024.152456 · Cited by 74
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“A recent systematic review and meta-analysis showed that the prevalence of postpartum depression among healthy women who have never had depressive episodes stands at 17% (6).”
BackgroundNguyen, C. T. T., Sandhi, A., Lee, G. T., Nguyen, L. T. K., & Kuo, S.-Y. (2023) · Journal of Affective Disorders · doi:10.1016/j.jad.2022.11.015 · Cited by 53
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“It is estimated that 1 in 5 women develop a mental health problem in the perinatal period (Hahn-Holbrook et al., 2018; World Health Organization, 2015), with depression and anxiety among the most prevalent conditions (Shorey et al., 2018).”
BackgroundParental mental health screening in the NICU: a psychosocial team initiative
Grunberg, V. A., Geller, P. A., Hoffman, C., Njoroge, W., Ahmed, A., & Patterson, C. A. (2021) · Journal of Perinatology · doi:10.1038/s41372-021-01217-0 · Cited by 51
Prevalence and risk factors of postpartum depression among women living in the United Arab Emirates
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“[3] which found that prevalence estimates were statistically significant when stratified by geographical region (p < 0.”
BackgroundStevens, A. W. M. M., Goossens, P. J. J., der Klein, E. A. M. K.-V., Draisma, S., Honig, A., & Kupka, R. (2019) · Journal of Affective Disorders · doi:10.1016/j.jad.2019.02.018 · Cited by 53
Association between premenstrual dysphoric disorder and perinatal depression: a systematic review
Pereira, D., Pessoa, A. R., Madeira, N. G. G. F., Macedo, A., & Pereira, A. T. (2021) · Archives of Women s Mental Health · doi:10.1007/s00737-021-01177-6 · Cited by 48
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Risk Factors for Postpartum Depression Based on Genetic and Epigenetic Interactions
Luo, F., Zhu, Z., Du, Y., Chen, L., & Cheng, Y. (2023) · Molecular Neurobiology · doi:10.1007/s12035-023-03313-y · Cited by 56
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Recommendations for the prevention and treatment of postpartum depression
Dominiak, M., Antosik-Wójcińska, A. Z., Baron, M., Mierzejewski, P., & Święcicki, Ł. (2021) · Ginekologia Polska · doi:10.5603/gp.a2020.0141 · Cited by 63
Association between perinatal pain and postpartum depression: A systematic review and meta-analysis
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“Postpartum depression was the most common mental disorder in postpartum women (Pham et al., 2018), with a prevalence rate reported to be about 17% (Shorey et al., 2018).”
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“8% reported in recent large-scale meta-analyses conducted prior to the pandemic (Hahn-Holbrook et al. 2018; Shorey et al. 2018), which perhaps speaks to the extra stress faced by birthing individuals during our study period (i.”
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“Due to the diverse economic levels and screening awareness, the incidence of PPD is different in various regions and may be underestimated (Shorey et al., 2018).”
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“Meta-analyses estimate between 10% and 25% of mothers and 10% and 26% of partners are affected by postpartum depression or significant symptoms of depression [4, 19] and that mothers’ and partners’ depressive symptoms are positively related [4, 20].”
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“For the mother, the benefits include better physical and psychological well- being, namely an attenuated stress response and healthier sleep patterns while breastfeeding (Lara- Cinisomo et al., 2017; Simon et al., 2016).”
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“This may not be of major importance, since a systematic review and meta-analysis found no statistically significant difference in the prevalence of postpartum depression between time points for screening in the early period after birth, but an increasing prevalence was observed beyond 6 months postpartum [42].”
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Metadata
- Authors
- Shorey, S., Chee, C. Y. I., Ng, E. D., Chan, Y. H., Tam, W. W. S., & Chong, Y. S.
- Affiliations
- National University of Singapore (SG)
- National University Hospital (SG)
- Corresponding author
- Shorey, Shefaly
- ORCID
- Venue
- Journal of Psychiatric Research
- Publisher
- Elsevier BV
- Published
- 2018-09
- Volume
- 104
- Pages
- 235-248
- ISSN
- 0022-3956 (ISSN-L)
- OpenAlex
- W2885511794
- Cited by
- 1,055
- References
- 106
- Citations by year
- 2026: 127 · 2025: 160 · 2024: 181 · 2023: 175 · 2022: 166 · 2021: 136 · 2020: 76 · 2019: 28 · 2018: 4
- FWCI
- 11.06
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of Psychiatric Research (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Maternal Mental Health During Pregnancy and Postpartum
- Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Maternal and Neonatal Healthcare
- Health Sciences › Medicine › Obstetrics and Gynecology › Maternal and Perinatal Health Interventions
- Keywords
- postpartum depression, prevalence, incidence, term infants, postpartum screening, diagnostic tools, regional variation, postpartum period
- MeSH terms
- Female, Humans, Mothers, Incidence, Prevalence, Databases, Factual, Depression, Postpartum
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