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Cited by 10Child Abuse and TraumaBipolar Disorder and TreatmentPsychopathy, Forensic Psychiatry, Sexual Offending

Early sexual or physical abuse in female and male mood disorder patients

Visioli, Caterina, Tondo, Leonardo, Miola, Alessandro, Pinna, Marco, Contu, Martina, Baldessarini, Ross J.·2023·Journal of Psychiatric Research
DOI 10.1016/j.jpsychires.2023.10.015
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Abstract

Early abuse has been associated with psychiatric morbidity but comparisons of bipolar (BD) and major depressive (MDD) disorder subjects with versus without early sexual or physical abuse are rare. Patients (n = 684) diagnosed with a DSM-5-TR major mood disorder were evaluated and followed for several years at mood disorder centers to compare details of history and clinical status in participants with versus without early sexual or physical abuse. Early history of sexual (16.2%) or physical abuse (11.9%) was prevalent; 5.15% reported both. Both types of abuse were much more prevalent with BD than MDD. Sexual abuse was associated with younger illness-onset and somewhat younger menarche in females; both abuse-types were associated with familial mood disorders, especially BD. Prospective, long-term illness episode-frequency, depressions or [hypo]manias/year and %-time [hypo]manic all were greater following sexual abuse but morbidity measures did not differ following physical abuse. Prevalence of suicidal behavior ranked: double (48.5%) > physical (32.1%) > sexual (30.3%) abuse, and with BD > MDD (OR = 2.31). Recall bias and not using psychometric instruments to define abuse severity or type may limit interpretation of findings. Early sexual (more than physical) abuse, led to greater morbidity and both abuses were strongly associated with familial mood disorders and greater suicidal risk, especially with double-abuse and BD diagnosis. We support a bilateral relationship between abuse and diagnosis of BD: abuse may facilitate early appearance of BD but also may result from the actions of abusive BD family members.

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Authors
Visioli, C., Tondo, L., Miola, A., Pinna, M., Contu, M., & Baldessarini, R. J.
Affiliations
  • Harvard University (US)
  • University of Padua (IT)
  • University of Cagliari (IT)
Corresponding author
Miola, Alessandro
ORCID
Venue
Journal of Psychiatric Research
Publisher
Elsevier BV
Published
2023-11
Volume
167
Pages
125-131
ISSN
0022-3956 (ISSN-L)
DOI
10.1016/j.jpsychires.2023.10.015
OpenAlex
W4387642911
Cited by
10
References
68
Citations by year
2026: 1 · 2025: 5 · 2024: 4
FWCI
2.91
Type
journal article
Language
en
Open access
closed
Licence
Locations
  • Journal of Psychiatric Research (publishedVersion)
  • PubMed (publishedVersion)
  • Padua Research Archive (University of Padova) (submittedVersion)
Funders
  • Bruce J. Anderson Foundation
  • Aretaeus Foundation of Rome
Topics
  • Social Sciences › Psychology › Clinical Psychology › Child Abuse and Trauma
  • Health Sciences › Medicine › Psychiatry and Mental health › Bipolar Disorder and Treatment
  • Social Sciences › Psychology › Clinical Psychology › Psychopathy, Forensic Psychiatry, Sexual Offending
Keywords
child sexual abuse, child physical abuse, bipolar disorder, major depressive disorder, mood disorders, suicidal behavior, disease onset, menarche, abuse prevalence, abuse severity
MeSH terms
Physical Abuse, Adolescent, Adult, Bipolar Disorder, Child, Major Depressive Disorder, Female, Humans, Male, Middle Aged, Psychiatric Status Rating Scales, Sex Offenses, Prevalence, Age of Onset, Mood Disorders, Young Adult

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