The Devastating Clinical Consequences of Child Abuse and Neglect: Increased Disease Vulnerability and Poor Treatment Response in Mood Disorders

Lippard, Elizabeth T.C.; Nemeroff, Charles B.

doi:10.1176/appi.ajp.2019.19010020

Cited by 527Child Abuse and TraumaChild Welfare and AdoptionChild and Adolescent Psychosocial and Emotional Development

The Devastating Clinical Consequences of Child Abuse and Neglect: Increased Disease Vulnerability and Poor Treatment Response in Mood Disorders

Open access

Lippard, Elizabeth T.C., Nemeroff, Charles B.·2020·American Journal of Psychiatry

DOI 10.1176/appi.ajp.2019.19010020PMC PMC6939135

Open this paper in CoChat — free account Open PDF

Abstract

A large body of evidence has demonstrated that exposure to childhood maltreatment at any stage of development can have long-lasting consequences. It is associated with a marked increase in risk for psychiatric and medical disorders. This review summarizes the literature investigating the effects of childhood maltreatment on disease vulnerability for mood disorders, specifically summarizing cross-sectional and more recent longitudinal studies demonstrating that childhood maltreatment is more prevalent and is associated with increased risk for first mood episode, episode recurrence, greater comorbidities, and increased risk for suicidal ideation and attempts in individuals with mood disorders. It summarizes the persistent alterations associated with childhood maltreatment, including alterations in the hypothalamic-pituitary-adrenal axis and inflammatory cytokines, which may contribute to disease vulnerability and a more pernicious disease course. The authors discuss several candidate genes and environmental factors (for example, substance use) that may alter disease vulnerability and illness course and neurobiological associations that may mediate these relationships following childhood maltreatment. Studies provide insight into modifiable mechanisms and provide direction to improve both treatment and prevention strategies.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Integrity signals

Registry

Crossref · 10.1176/appi.ajp.2019.19010020

Cites

230 of 230 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Not all individuals who experience life stress develop MDD and/or a physical disease.
“not all individuals who experience life stress develop MDD and/or a physical disease153,154.”
From Comorbidity between major depressive disorder and physical diseases: a comprehensive review of epidemiology, mechanisms and management (2023) · cites this paper as [154]
The Underlying Mechanisms section states that not all individuals who experience childhood maltreatment develop mood disorders, supporting the claim’s point about differing vulnerability to depression. It does not extend that statement to life stress generally or to physical disease. (LLM, conf=0.86)
Experimental — accuracy not yet measured
Early life stress due to childhood abuse and/or neglect has been linked to increased risk of psychiatric illness onset and recurrence, increased disease severity and poor treatment response.
“Early life stress (ELS) due to childhood abuse and/or neglect has been linked to increased risk of psychiatric illness onset and recurrence, increased disease severity and poor treatment response (pharmacotherapy and psychotherapy) (148, 149).”
From Childhood Trauma, the HPA Axis and Psychiatric Illnesses: A Targeted Literature Synthesis (2022) · cites this paper as [149]
Recent research on childhood abuse and neglect emphasises the lasting effects on the risks for depression not only in childhood and adolescence, but also later in life and in subsequent generations.
“Recent research on childhood abuse and neglect, for instance, emphasises the lasting effects on the risks for depression not only in childhood and adolescence, but also later in life and in subsequent generations. 11”
From Time for united action on depression: a Lancet–World Psychiatric Association Commission (2022) · cites this paper as [11]

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Influence of life stress on depression: moderation by a polymorphism in the 5-HTT gene
Caspi, A., Sugden, K., Moffitt, T. E., Taylor, A., Craig, I. W., Harrington, H., McClay, J., Mill, J., Martin, J., Braithwaite, A., et al. (2003) · Science · doi:10.1126/science.1083968 · Cited by 8,120 · see citing works
The effect of multiple adverse childhood experiences on health: a systematic review and meta-analysis.
Hughes, K., Bellis, M. A., Hardcastle, K. A., Sethi, D., Butchart, A., Mikton, C., Jones, L., & Dunne, M. P. (2017) · The Lancet Public Health · doi:10.1016/s2468-2667(17)30118-4 · Cited by 5,255 · see citing works
The enduring effects of abuse and related adverse experiences in childhood: A convergence of evidence from neurobiology and epidemiology
Anda, R. F., Felitti, V. J., Bremner, J. D., Walker, J. D., Whitfield, C., Perry, B. D., Dube, S. R., & Giles, W. H. (2006) · European archives of psychiatry and clinical neuroscience · doi:10.1007/s00406-005-0624-4 · Cited by 4,292 · see citing works
Epigenetic regulation of the glucocorticoid receptor in human brain associates with childhood abuse
McGowan, P. O., Sasaki, A., D'Alessio, A. C., Dymov, S., Labonté, B., Szyf, M., Turecki, G., & Meaney, M. J. (2009) · Nature Neuroscience · doi:10.1038/nn.2270 · Cited by 3,531 · see citing works
The Long-Term Health Consequences of Child Physical Abuse, Emotional Abuse, and Neglect: A Systematic Review and Meta-Analysis
Norman, R. E., Byambaa, M., De, R., Butchart, A., Scott, J., & Vos, T. (2012) · PLoS Medicine · doi:10.1371/journal.pmed.1001349 · Cited by 3,387 · see citing works
C-reactive protein concentration and risk of coronary heart disease, stroke, and mortality: an individual participant meta-analysis
(2010) · The Lancet · doi:10.1016/s0140-6736(09)61717-7 · Cited by 2,546 · see citing works
Adverse childhood experiences and the risk of depressive disorders in adulthood
Chapman, D. P., Whitfield, C. L., Felitti, V. J., Dube, S. R., Edwards, V. J., & Anda, R. F. (2004) · Journal of Affective Disorders · doi:10.1016/j.jad.2003.12.013 · Cited by 2,267 · see citing works
THE EFFECTS OF STRESSFUL LIFE EVENTS ON DEPRESSION
Kessler, R. C. (1997) · Annual Review of Psychology · doi:10.1146/annurev.psych.48.1.191 · Cited by 2,111 · see citing works
The effects of childhood maltreatment on brain structure, function and connectivity
Teicher, M. H., Samson, J. A., Anderson, C. M., & Ohashi, K. (2016) · Nature Reviews Neuroscience · doi:10.1038/nrn.2016.111 · Cited by 1,856 · see citing works
The link between childhood trauma and depression: insights from HPA axis studies in humans
Heim, C., Newport, D. J., Mletzko, T., Miller, A. H., & Nemeroff, C. B. (2008) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2008.03.008 · Cited by 1,704 · see citing works
Self-citation
Childhood Maltreatment Predicts Unfavorable Course of Illness and Treatment Outcome in Depression: A Meta-Analysis
Nanni, V., Uher, R., & Danese, A. (2012) · American Journal of Psychiatry · doi:10.1176/appi.ajp.2011.11020335 · Cited by 1,480 · see citing works
Annual research review: enduring neurobiological effects of childhood abuse and neglect
Teicher, M. H., & Samson, J. A. (2016) · Journal of Child Psychology and Psychiatry · doi:10.1111/jcpp.12507 · Cited by 1,473 · see citing works
Allele-specific FKBP5 DNA demethylation mediates gene–childhood trauma interactions
Klengel, T., Mehta, D., Anacker, C., Rex-Haffner, M., Pruessner, J. C., Pariante, C. M., Pace, T. W. W., Mercer, K. B., Mayberg, H. S., Bradley, B., et al. (2013) · Nature Neuroscience · doi:10.1038/nn.3275 · Cited by 1,447 · see citing works
Self-citation
Association of <emph type="ital">FKBP5</emph> Polymorphisms and Childhood Abuse With Risk of Posttraumatic Stress Disorder Symptoms in Adults
Binder, E. B. (2008) · JAMA · doi:10.1001/jama.299.11.1291 · Cited by 1,362 · see citing works
Lasting epigenetic influence of early-life adversity on the BDNF gene
Roth, T. L., Lubin, F. D., Funk, A. J., & Sweatt, J. D. (2009) · Biological Psychiatry · doi:10.1016/j.biopsych.2008.11.028 · Cited by 1,273 · see citing works
Childhood maltreatment predicts adult inflammation in a life-course study
Danese, A., Pariante, C. M., Caspi, A., Taylor, A., & Poulton, R. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0610362104 · Cited by 1,264 · cited 1× · see citing works
“Childhood maltreatment is associated with systemic inflammation (86, 87) as assessed by measurements of C-reactive pro-”
Method
Adverse Childhood Experiences and Smoking During Adolescence and Adulthood
Anda, R. F. (1999) · JAMA · doi:10.1001/jama.282.17.1652 · Cited by 1,256 · see citing works
Adult psychiatric outcomes of bullying and being bullied by peers in childhood and adolescence
Copeland, W. E., Wolke, D., Angold, A., & Costello, E. J. (2013) · JAMA Psychiatry · doi:10.1001/jamapsychiatry.2013.504 · Cited by 1,247 · see citing works
Pathways underlying neuroprogression in bipolar disorder: Focus on inflammation, oxidative stress and neurotrophic factors
Berk, M., Kapczinski, F., Andreazza, A. C., Dean, O. M., Giorlando, F., Maes, M., Yücel, M., Gama, C. S., Dodd, S., Dean, B., et al. (2011) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2010.10.001 · Cited by 1,178 · see citing works
Agreement Between Prospective and Retrospective Measures of Childhood Maltreatment: A Systematic Review and Meta-analysis
Baldwin, J. R., Reuben, A., Newbury, J. B., & Danese, A. (2019) · JAMA Psychiatry · doi:10.1001/jamapsychiatry.2019.0097 · Cited by 1,094 · see citing works
A Prospective Investigation of Major Depressive Disorder and Comorbidity in Abused and Neglected Children Grown Up
Spatz Widom, C., DuMont, K., & Czaja, S. J. (2007) · Archives of General Psychiatry · doi:10.1001/archpsyc.64.1.49 · Cited by 1,059 · see citing works
Sexual abuse and lifetime diagnosis of psychiatric disorders: Systematic review and meta-analysis
Chen, L. P., Murad, M. H., Paras, M. L., Colbenson, K. M., Sattler, A. L., Goranson, E. N., Elamin, M. B., Seime, R. J., Shinozaki, G., Prokop, L. J., et al. (2010) · Mayo Clinic Proceedings · doi:10.4065/mcp.2009.0583 · Cited by 1,056 · see citing works
A systematic review and meta-analysis of clinical studies on major depression and BDNF levels: implications for the role of neuroplasticity in depression
Brunoni, A. R., Lopes, M., & Fregni, F. (2008) · International Journal of Neuropsychopharmacology · doi:10.1017/s1461145708009309 · Cited by 972 · see citing works
Long-term physical and mental health consequences of childhood physical abuse: results from a large population-based sample of men and women
Springer, K. W., Sheridan, J., Kuo, D., & Carnes, M. (2007) · Child Abuse & Neglect · doi:10.1016/j.chiabu.2007.01.003 · Cited by 964 · see citing works
Childhood maltreatment and characteristics of adult depression: Meta-analysis
Nelson, J., Klumparendt, A., Doebler, P., & Ehring, T. (2017) · British Journal of Psychiatry · doi:10.1192/bjp.bp.115.180752 · Cited by 822 · cited 7× · see citing works
“emotional abusecomparedwith studiesusingothermeasures to investigate childhood maltreatment (12).”
BackgroundInfluential
Childhood trauma associated with smaller hippocampal volume in women with major depression
Vythilingam, M., Heim, C., Newport, J., Miller, A. H., Anderson, E., Bronen, R., Brummer, M., Staib, L., Vermetten, E., Charney, D. S., et al. (2002) · American Journal of Psychiatry · doi:10.1176/appi.ajp.159.12.2072 · Cited by 812 · see citing works
Self-citation
Epigenomic Profiling Reveals DNA-Methylation Changes Associated with Major Psychosis
Mill, J., Tang, T., Kaminsky, Z., Khare, T., Yazdanpanah, S., Bouchard, L., Jia, P., Assadzadeh, A., Flanagan, J., Schumacher, A., et al. (2008) · The American Journal of Human Genetics · doi:10.1016/j.ajhg.2008.01.008 · Cited by 773 · see citing works
Paradise lost: the neurobiological and clinical consequences of child abuse and neglect
Nemeroff, C. B. (2016) · Neuron · doi:10.1016/j.neuron.2016.01.019 · Cited by 768 · see citing works
Self-citation
Maltreatment in childhood substantially increases the risk of adult depression and anxiety in prospective cohort studies: systematic review, meta-analysis, and proportional attributable fractions
Li, M., D'Arcy, C., & Meng, X. (2016) · Psychological Medicine · doi:10.1017/s0033291715002743 · Cited by 751 · see citing works
The role of early life stress as a predictor for alcohol and drug dependence
Enoch, M.-A. (2011) · Psychopharmacology · doi:10.1007/s00213-010-1916-6 · Cited by 668 · see citing works
Childhood emotional maltreatment and later psychological distress among college students: The mediating role of maladaptive schemas
Wright, M. O., Crawford, E., & Del Castillo, D. (2009) · Child Abuse & Neglect · doi:10.1016/j.chiabu.2008.12.007 · Cited by 657 · see citing works
Elevated inflammation levels in depressed adults with a history of childhood maltreatment
Danese, A., Moffitt, T. E., Pariante, C. M., Ambler, A., Poulton, R., & Caspi, A. (2008) · Archives of General Psychiatry · doi:10.1001/archpsyc.65.4.409 · Cited by 641 · see citing works
Sticks, stones, and hurtful words: relative effects of various forms of childhood maltreatment
Teicher, M. H., Samson, J. A., Polcari, A., & McGreenery, C. E. (2006) · American Journal of Psychiatry · doi:10.1176/ajp.2006.163.6.993 · Cited by 634 · see citing works
Research Review: The neurobiology and genetics of maltreatment and adversity
McCrory, E., De Brito, S. A., & Viding, E. (2010) · Journal of Child Psychology and Psychiatry · doi:10.1111/j.1469-7610.2010.02271.x · Cited by 598 · see citing works
Sexual and physical abuse in childhood is associated with depression and anxiety over the life course: systematic review and meta-analysis
Lindert, J., Ehrenstein, O. S. V., Grashow, R. G., Gal, G., Brähler, E., & Weisskopf, M. G. (2013) · International Journal of Public Health · doi:10.1007/s00038-013-0519-5 · Cited by 594 · see citing works
Adult mental health consequences of peer bullying and maltreatment in childhood: two cohorts in two countries
Lereya, S. T., Copeland, W. E., Costello, E. J., & Wolke, D. (2015) · The Lancet Psychiatry · doi:10.1016/s2215-0366(15)00165-0 · Cited by 590 · see citing works
Associations between depression and specific childhood experiences of abuse and neglect: A meta-analysis
Infurna, M. R., Reichl, C., Parzer, P., Schimmenti, A., Bifulco, A. T., & Kaess, M. (2015) · Journal of Affective Disorders · doi:10.1016/j.jad.2015.09.006 · Cited by 582 · see citing works
Magnetic resonance imaging volumes of the hippocampus and the amygdala in women with borderline personality disorder and early traumatization
Driessen, M., Herrmann, J., Stahl, K., Zwaan, M., Meier, S., Hill, A., Osterheider, M., & Petersen, D. (2000) · Archives of General Psychiatry · doi:10.1001/archpsyc.57.12.1115 · Cited by 562 · see citing works
The role of specific early trauma in adult depression: A meta-analysis of published literature. Childhood trauma and adult depression
Mandelli, L., Petrelli, C., & Serretti, A. (2015) · European Psychiatry · doi:10.1016/j.eurpsy.2015.04.007 · Cited by 549 · see citing works
Interactions between BDNF Val66Met polymorphism and early life stress predict brain and arousal pathways to syndromal depression and anxiety
Gatt, J. M., Nemeroff, C. B., Dobson-Stone, C., Paul, R. H., Bryant, R. A., Schofield, P. R., Gordon, E., Kemp, A. H., & Williams, L. M. (2009) · Molecular Psychiatry · doi:10.1038/mp.2008.143 · Cited by 525 · see citing works
Self-citation
Childhood sexual abuse as a risk factor for depression in women: Psychosocial and neurobiological correlates
Weiss, E. L., Longhurst, J. G., & Mazure, C. M. (1999) · American Journal of Psychiatry · doi:10.1176/ajp.156.6.816 · Cited by 517 · see citing works
Childhood emotional abuse and neglect as predictors of psychological and physical symptoms in women presenting to a primary care practice
Spertus, I. L., Yehuda, R., Wong, C. M., Halligan, S., & Seremetis, S. V. (2003) · Child Abuse & Neglect · doi:10.1016/j.chiabu.2003.05.001 · Cited by 509 · see citing works
Childhood trauma and risk for PTSD: Relationship to intergenerational effects of trauma, parental PTSD, and cortisol excretion
YEHUDA, R., HALLIGAN, S. L., & GROSSMAN, R. (2001) · Development and Psychopathology · doi:10.1017/s0954579401003170 · Cited by 490 · see citing works
Stressful life experiences, alcohol consumption, and alcohol use disorders: the epidemiologic evidence for four main types of stressors
Keyes, K. M., Hatzenbuehler, M. L., & Hasin, D. S. (2011) · Psychopharmacology · doi:10.1007/s00213-011-2236-1 · Cited by 486 · see citing works
Chapter 21 Like mother, like daughter: evidence for non-genomic transmission of parental behavior and stress responsivity
Champagne, F., & Meaney, M. J. (2001) · Progress in Brain Research · doi:10.1016/s0079-6123(01)33022-4 · Cited by 455 · see citing works
Early Life Stress and Morphometry of the Adult Anterior Cingulate Cortex and Caudate Nuclei
Cohen, R. A., Grieve, S., Hoth, K. F., Paul, R. H., Sweet, L., Tate, D., Gunstad, J., Stroud, L., McCaffery, J., Hitsman, B., et al. (2006) · Biological Psychiatry · doi:10.1016/j.biopsych.2005.12.016 · Cited by 439 · see citing works
The role of early adverse experience and adulthood stress in the prediction of neuroendocrine stress reactivity in women: a multiple regression analysis
Heim, C., Newport, D. J., Wagner, D., Wilcox, M. M., Miller, A. H., & Nemeroff, C. B. (2002) · Depression and Anxiety · doi:10.1002/da.10015 · Cited by 433 · see citing works
Self-citation
Childhood maltreatment is associated with altered fear circuitry and increased internalizing symptoms by late adolescence
Herringa, R. J., Birn, R. M., Ruttle, P. L., Burghy, C. A., Stodola, D. E., Davidson, R. J., & Essex, M. J. (2013) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1310766110 · Cited by 426 · see citing works
Childhood maltreatment and unfavourable clinical outcomes in bipolar disorder: a systematic review and meta-analysis
Agnew‐Blais, J. C., & Danese, A. (2016) · The Lancet Psychiatry · doi:10.1016/s2215-0366(15)00544-1 · Cited by 421 · see citing works
Can bipolar disorder be viewed as a multi-system inflammatory disease?
Leboyer, M., Soreca, I., Scott, J., Frye, M., Henry, C., Tamouza, R., & Kupfer, D. J. (2012) · Journal of Affective Disorders · doi:10.1016/j.jad.2011.12.049 · Cited by 417 · see citing works
Early physical and sexual abuse associated with an adverse course of bipolar illness
Leverich, G. S., McElroy, S. L., Suppes, T. M., Keck, P. E., Denicoff, K. D., Nolen, W. A., Altshuler, L. L., Rush, A. J., Kupka, R., Frye, M. A., et al. (2002) · Biological Psychiatry · doi:10.1016/s0006-3223(01)01239-2 · Cited by 415 · see citing works
The Relation Between Child Maltreatment and Adolescent Suicidal Behavior: A Systematic Review and Critical Examination of the Literature
Miller, A. B., Esposito-Smythers, C. L., Weismoore, J. T., & Renshaw, K. D. (2013) · Clinical Child and Family Psychology Review · doi:10.1007/s10567-013-0131-5 · Cited by 412 · see citing works
Prospectively Ascertained Child Maltreatment and Its Association With DSM-IV Mental Disorders in Young Adults
Scott, K. M., Smith, D. R., & Ellis, P. M. (2010) · Archives of General Psychiatry · doi:10.1001/archgenpsychiatry.2010.71 · Cited by 381 · see citing works
The importance of childhood trauma and childhood life events for chronicity of depression in adults
Wiersma, J. E., Hovens, J. G. F. M., van Oppen, P., Giltay, E. J., van Schaik, D. J. F., Beekman, A. T. F., & Penninx, B. W. J. H. (2009) · The Journal of Clinical Psychiatry · doi:10.4088/jcp.08m04521 · Cited by 358 · cited 1× · see citing works
“(19), in an analysis of 1,230 adults with major depressive disorder drawn from the Netherlands Study of Depression and Anxiety, found that childhood maltreatment (measured with the Childhood Trauma Interview) was associated with chronicity of depression, defined as being depressed for $24 months over the past 4 years,…”
Background
Corticostriatal-limbic gray matter morphology in adolescents with self-reported exposure to childhood maltreatment
Edmiston, E. E. (2011) · Archives of Pediatrics & Adolescent Medicine · doi:10.1001/archpediatrics.2011.565 · Cited by 341 · see citing works
Gray matter abnormalities in childhood maltreatment: a voxel-wise meta-analysis
Lim, L., Radua, J., & Rubia, K. (2014) · American Journal of Psychiatry · doi:10.1176/appi.ajp.2014.13101427 · Cited by 336 · see citing works
Type and timing of adverse childhood experiences differentially affect severity of PTSD, dissociative and depressive symptoms in adult inpatients
Schalinski, I., Teicher, M. H., Nischk, D., Hinderer, E., Müller, O., & Rockstroh, B. (2016) · BMC Psychiatry · doi:10.1186/s12888-016-1004-5 · Cited by 327 · see citing works
Maternal, not paternal, PTSD is related to increased risk for PTSD in offspring of Holocaust survivors
Yehuda, R., Bell, A., Bierer, L. M., & Schmeidler, J. (2008) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2008.01.002 · Cited by 326 · see citing works
Interaction of childhood stress with hippocampus and prefrontal cortex volume reduction in major depression
Frodl, T., Reinhold, E., Koutsouleris, N., Reiser, M., & Meisenzahl, E. M. (2010) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2010.01.006 · Cited by 323 · see citing works
Collaborative meta-analysis finds no evidence of a strong interaction between stress and 5-HTTLPR genotype contributing to the development of depression
Culverhouse, R., Saccone, N. L., Horton, A. C., Ma, Y., Anstey, K. J., Banaschewski, T., Burmeister, M., Cohen‐Woods, S., Étain, B., Fisher, H. L., et al. (2017) · Molecular Psychiatry · doi:10.1038/mp.2017.44 · Cited by 321 · see citing works
Decreased Cortical Representation of Genital Somatosensory Field After Childhood Sexual Abuse
Heim, C. M., Mayberg, H. S., Mletzko, T., Nemeroff, C. B., & Pruessner, J. C. (2013) · American Journal of Psychiatry · doi:10.1176/appi.ajp.2013.12070950 · Cited by 318 · see citing works
Self-citation
Childhood maltreatment and DSM-IV adult mental disorders: Comparison of prospective and retrospective findings
Scott, K. M., McLaughlin, K. A., Smith, D. A. R., & Ellis, P. M. (2012) · British Journal of Psychiatry · doi:10.1192/bjp.bp.111.103267 · Cited by 317 · see citing works
Adverse childhood experiences (ACEs) and later-life depression: perceived social support as a potential protective factor
Cheong, E. V., Sinnott, C., Dahly, D. L., & Kearney, P. M. (2017) · BMJ Open · doi:10.1136/bmjopen-2016-013228 · Cited by 311 · see citing works
Childhood maltreatment and its effect on neurocognitive functioning: timing and chronicity matter
Cowell, R. A., Cicchetti, D., Rogosch, F. A., & Toth, S. L. (2015) · Development and Psychopathology · doi:10.1017/s0954579415000139 · Cited by 307 · cited 1× · see citing works
“(60) investigated the timing and duration of childhood maltreatment in 223 maltreated children between the ages of 3 and 9 and found that children who were maltreated during in-”
Background
Sex Differences in the Pathways to Major Depression: A Study of Opposite-Sex Twin Pairs
Kendler, K. S., & Gardner, C. O. (2014) · American Journal of Psychiatry · doi:10.1176/appi.ajp.2013.13101375 · Cited by 307 · see citing works
Early-life experience, epigenetics, and the developing brain
Kundakovic, M., & Champagne, F. A. (2015) · Neuropsychopharmacology · doi:10.1038/npp.2014.140 · Cited by 304 · see citing works
DEVELOPMENTAL TIMING OF CHILD MALTREATMENT AND SYMPTOMS OF DEPRESSION AND SUICIDAL IDEATION IN YOUNG ADULTHOOD: RESULTS FROM THE NATIONAL LONGITUDINAL STUDY OF ADOLESCENT HEALTH
Dunn, E. C., McLaughlin, K. A., Slopen, N. B., Rosand, J. M., & Smoller, J. W. (2013) · Depression and Anxiety · doi:10.1002/da.22102 · Cited by 299 · see citing works
The long-term health outcomes of childhood abuse: An overview and a call to action
Springer, K. W., Sheridan, J., Kuo, D., & Carnes, M. (2003) · Journal of General Internal Medicine · doi:10.1046/j.1525-1497.2003.20918.x · Cited by 299 · see citing works
Disparities in Adverse Childhood Experiences among Sexual Minority and Heterosexual Adults: Results from a Multi-State Probability-Based Sample
Andersen, J. P., & Blosnich, J. R. (2013) · PLoS ONE · doi:10.1371/journal.pone.0054691 · Cited by 298 · see citing works
Relationship of childhood maltreatment to the onset and course of major depression in adulthood
Bernet, C. Z., & Stein, M. B. (1999) · Depression and Anxiety · doi:10.1002/(sici)1520-6394(1999)9:4 · Cited by 289 · see citing works
Interaction of FKBP5, a Stress-Related Gene, with Childhood Trauma Increases the Risk for Attempting Suicide
Roy, A., Gorodetsky, E., Yuan, Q., Goldman, D., & Enoch, M.-A. (2010) · Neuropsychopharmacology · doi:10.1038/npp.2009.236 · Cited by 282 · see citing works
Is developmental timing of trauma exposure associated with depressive and post-traumatic stress disorder symptoms in adulthood?
Dunn, E. C., Nishimi, K., Powers, A., & Bradley, B. (2017) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2016.09.004 · Cited by 275 · see citing works
Interaction of FKBP5 Gene Variants and Adverse Life Events in Predicting Depression Onset: Results From a 10-Year Prospective Community Study
Zimmermann, P., Brückl, T., Nocon, A., Pfister, H., Binder, E. B., Uhr, M., Lieb, R., Moffitt, T. E., Caspi, A., Holsboer, F., et al. (2011) · American Journal of Psychiatry · doi:10.1176/appi.ajp.2011.10111577 · Cited by 262 · see citing works
Chronic childhood adversity and onset of psychopathology during three life stages: Childhood, adolescence and adulthood
Benjet, C. L., Borges, G. L. G., & Medina‐Mora, M. E. (2010) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2010.01.004 · Cited by 261 · see citing works
The impact of early adverse care on HPA axis development: Nonhuman primate models
Sánchez, M. M. (2006) · Hormones and Behavior · doi:10.1016/j.yhbeh.2006.06.012 · Cited by 247 · see citing works
Effect of childhood trauma on adult depression and neuroendocrine function: sex-specific moderation by CRH receptor 1 gene
Heim, C. (2009) · Frontiers in Behavioral Neuroscience · doi:10.3389/neuro.08.041.2009 · Cited by 245 · see citing works
Childhood maltreatment and clinical outcomes of bipolar disorder
Daruy-Filho, L., Brietzke, E. M., Lafer, B., & Grassi‐Oliveira, R. (2011) · Acta Psychiatrica Scandinavica · doi:10.1111/j.1600-0447.2011.01756.x · Cited by 240 · see citing works
Child maltreatment in autism spectrum disorder and intellectual disability: results from a population‐based sample
McDonnell, C. G., Boan, A. D., Bradley, C. C., Seay, K. D., Charles, J. M., & Carpenter, L. A. (2018) · Journal of Child Psychology and Psychiatry · doi:10.1111/jcpp.12993 · Cited by 237 · see citing works
Childhood Maltreatment, Depression, and Suicidal Ideation: Critical Importance of Parental and Peer Emotional Abuse during Developmental Sensitive Periods in Males and Females
Khan, A., McCormack, H., Bolger, E. A., McGreenery, C. E., Vitaliano, G. D., Polcari, A. M., & Teicher, M. H. (2015) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2015.00042 · Cited by 235 · see citing works
Moderation of Adult Depression by a Polymorphism in the FKBP5 Gene and Childhood Physical Abuse in the General Population
Appel, K., Schwahn, C., Mahler, J., Schulz, A., Spitzer, C., Fenske, K., Stender, J., Barnow, S., John, U., Teumer, A., et al. (2011) · Neuropsychopharmacology · doi:10.1038/npp.2011.81 · Cited by 234 · see citing works
Deviations from the expectable environment in early childhood and emerging psychopathology
Humphreys, K. L., & Zeanah, C. H. (2015) · Neuropsychopharmacology · doi:10.1038/npp.2014.165 · Cited by 231 · see citing works
Childhood trauma history is linked to abnormal brain connectivity in major depression
Yu, M., Linn, K. A., Shinohara, R. T., Oathes, D. J., Cook, P. A., Duprat, R., Moore, T. M., Oquendo, M. A., Phillips, M. L., McInnis, M. G., et al. (2019) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1900801116 · Cited by 229 · see citing works
The role of child sexual abuse in the etiology of suicide and non-suicidal self-injury
Maniglio, R. (2011) · Acta Psychiatrica Scandinavica · doi:10.1111/j.1600-0447.2010.01612.x · Cited by 225 · see citing works
Structural variations in prefrontal cortex mediate the relationship between early childhood stress and spatial working memory
Hanson, J. L., Chung, M. K., Avants, B. B., Rudolph, K. D., Shirtcliff, E. A., Gee, J. C., Davidson, R. J., & Pollak, S. D. (2012) · Journal of Neuroscience · doi:10.1523/jneurosci.0307-12.2012 · Cited by 219 · see citing works
Child sexual abuse in the etiology of depression: a systematic review of reviews
Maniglio, R. (2010) · Depression and Anxiety · doi:10.1002/da.20687 · Cited by 219 · see citing works
Genetic and Environmental Predictors of Early Alcohol Use
Kaufman, J., Yang, B.-Z., Douglas-Palumberi, H., Crouse-Artus, M., Lipschitz, D., Krystal, J. H., & Gelernter, J. (2007) · Biological Psychiatry · doi:10.1016/j.biopsych.2006.06.039 · Cited by 216 · see citing works
Hippocampal atrophy in major depression: a function of childhood maltreatment rather than diagnosis?
Opel, N., Redlich, R., Zwanzger, P., Grotegerd, D., Arolt, V., Heindel, W., Konrad, C., Kugel, H., & Dannlowski, U. (2014) · Neuropsychopharmacology · doi:10.1038/npp.2014.145 · Cited by 214 · see citing works
Defective Inflammatory Pathways in Never-Treated Depressed Patients Are Associated with Poor Treatment Response
Syed, S. A., Beurel, E., Loewenstein, D., Lowell, J. A., Craighead, W. E., Dunlop, B. W., Mayberg, H. S., Dhabhar, F. S., Dietrich, W. D., Keane, R. W., et al. (2018) · Neuron · doi:10.1016/j.neuron.2018.08.001 · Cited by 212 · see citing works
Self-citation
The Role of NFkB in Drug Addiction: Beyond Inflammation
Nennig, S. E., & Schank, J. R. (2016) · Alcohol and Alcoholism · doi:10.1093/alcalc/agw098 · Cited by 211 · see citing works
Polygenic interactions with environmental adversity in the aetiology of major depressive disorder
Mullins, N., Power, R. A., Fisher, H. L., Hanscombe, K. B., Euesden, J., Iniesta, R., Levinson, D. F., Weissman, M. M., Potash, J. B., Shi, J., et al. (2015) · Psychological Medicine · doi:10.1017/s0033291715002172 · Cited by 210 · see citing works
Effect of polygenic risk scores on depression in childhood trauma
Peyrot, W. J., Milaneschi, Y., Abdellaoui, A., Sullivan, P. F., Hottenga, J. J., Boomsma, D. I., & Penninx, B. W. J. H. (2014) · British Journal of Psychiatry · doi:10.1192/bjp.bp.113.143081 · Cited by 209 · see citing works
Exposure to violence, a risk for suicide in youths and young adults. A meta-analysis of longitudinal studies
Castellví, P., Miranda‐Mendizábal, A., Parés‐Badell, O., Almenara, J., Alonso, I., Blasco, M. J., Cebrià, A., Gabilondo, A., Gili, M., Lagares, C., et al. (2017) · Acta Psychiatrica Scandinavica · doi:10.1111/acps.12679 · Cited by 207 · see citing works
Comorbidity for Alcoholism and Depression
Merikangas, K. R., & Gelernter, C. S. (1990) · Psychiatric Clinics of North America · doi:10.1016/s0193-953x(18)30339-3 · Cited by 197 · see citing works
Synergistic Childhood Adversities and Complex Adult Psychopathology
Putnam, K. T., Harris, W. W., & Putnam, F. W. (2013) · Journal of Traumatic Stress · doi:10.1002/jts.21833 · Cited by 191 · see citing works
Epigenetic Influence of Stress and the Social Environment
Gudsnuk, K. M., & Champagne, F. A. (2012) · ILAR Journal · doi:10.1093/ilar.53.3-4.279 · Cited by 185 · see citing works
<scp>FKBP5</scp> and emotional neglect interact to predict individual differences in amygdala reactivity
White, M. G., Bogdan, R., Fisher, P. M., Muñoz, K. E., Williamson, D. E., & Hariri, A. R. (2012) · Genes, Brain and Behavior · doi:10.1111/j.1601-183x.2012.00837.x · Cited by 180 · see citing works
Differences in adverse childhood experiences (ACEs) and quality of physical and mental health between transgender and cisgender sexual minorities
Schnarrs, P. W., Stone, A. L., Salcido, R., Baldwin, A., Georgiou, C., & Nemeroff, C. B. (2019) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2019.09.001 · Cited by 180 · see citing works
Self-citation
Interactive Effects of the Serotonin Transporter 5-HTTLPR Polymorphism and Stressful Life Events on College Student Drinking and Drug Use
Covault, J., Tennen, H. A., Armeli, S., Conner, T. S., Herman, A. I., Cillessen, A. H. N., & Kranzler, H. R. (2006) · Biological Psychiatry · doi:10.1016/j.biopsych.2006.05.018 · Cited by 179 · see citing works
The relation of emotional maltreatment to early adolescent competence: Developmental processes in a prospective study
Shaffer, A., Yates, T. M., & Egeland, B. R. (2009) · Child Abuse & Neglect · doi:10.1016/j.chiabu.2008.12.005 · Cited by 176 · see citing works
Childhood maltreatment, altered limbic neurobiology, and substance use relapse severity via trauma-specific reductions in limbic gray matter volume
Van Dam, N. T., Rando, K., Potenza, M. N., Tuit, K., & Sinha, R. (2014) · JAMA Psychiatry · doi:10.1001/jamapsychiatry.2014.680 · Cited by 172 · see citing works
Mineralocorticoid receptor Iso/Val (rs5522) genotype moderates the association between previous childhood emotional neglect and amygdala reactivity
Bogdan, R., Williamson, D. E., & Hariri, A. R. (2012) · American Journal of Psychiatry · doi:10.1176/appi.ajp.2011.11060855 · Cited by 165 · see citing works
Child abuse, neural structure, and adolescent psychopathology: a longitudinal study
Busso, D. S., McLaughlin, K. A., Brueck, S., Peverill, M., Gold, A. L., & Sheridan, M. A. (2017) · Journal of the American Academy of Child & Adolescent Psychiatry · doi:10.1016/j.jaac.2017.01.013 · Cited by 164 · see citing works
When Emotional Pain Becomes Physical: Adverse Childhood Experiences, Pain, and the Role of Mood and Anxiety Disorders
Sachs‐Ericsson, N., Sheffler, J., Stanley, I. H., Piazza, J. R., & Preacher, K. J. (2017) · Journal of Clinical Psychology · doi:10.1002/jclp.22444 · Cited by 164 · see citing works
Associations between suicidal behavior and childhood abuse and neglect: A meta-analysis
Liu, J., Fang, Y., Gong, J., Cui, X., Meng, T., Xiao, B., He, Y., Shen, Y., & Luo, X. (2017) · Journal of Affective Disorders · doi:10.1016/j.jad.2017.03.060 · Cited by 162 · see citing works
Translating basic research knowledge on the biological embedding of early-life stress into novel approaches for the developmental programming of lifelong health
Heim, C. M., Entringer, S., & Buss, C. (2019) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2018.12.011 · Cited by 158 · see citing works
The role of environmental exposures as risk factors for bipolar disorder: A systematic review of longitudinal studies
Marangoni, C., Hernández, M., & Faedda, G. L. (2016) · Journal of Affective Disorders · doi:10.1016/j.jad.2015.12.055 · Cited by 158 · see citing works
Paternal Influences on Offspring Development: Behavioural and Epigenetic Pathways
Braun, K., & Champagne, F. A. (2014) · Journal of Neuroendocrinology · doi:10.1111/jne.12174 · Cited by 157 · see citing works
The influence of gene–environment interactions on alcohol consumption and alcohol use disorders: A comprehensive review
Young‐Wolff, K. C., Enoch, M., & Prescott, C. A. (2011) · Clinical Psychology Review · doi:10.1016/j.cpr.2011.03.005 · Cited by 157 · see citing works
Reduced posterior hippocampal volume in posttraumatic stress disorder
Bonne, O., Vythilingam, M., Inagaki, M., Wood, S., Neumeister, A., Nugent, A. C., Snow, J., Luckenbaugh, D. A., Bain, E. E., Drevets, W. C., et al. (2008) · The Journal of Clinical Psychiatry · doi:10.4088/jcp.v69n0707 · Cited by 156 · see citing works
Developmental timing of trauma exposure and emotion dysregulation in adulthood: Are there sensitive periods when trauma is most harmful?
Dunn, E. C., Nishimi, K. M., Gomez, S. H., Powers, A. D., & Bradley, B. (2017) · Journal of Affective Disorders · doi:10.1016/j.jad.2017.10.045 · Cited by 154 · see citing works
Associations of Lesbian, Gay, Bisexual, Transgender, and Questioning–Inclusive Sex Education With Mental Health Outcomes and School-Based Victimization in U.S. High School Students
Proulx, C. N., Coulter, R. W. S., Egan, J. E., Matthews, D. D., & Mair, C. (2019) · Journal of Adolescent Health · doi:10.1016/j.jadohealth.2018.11.012 · Cited by 152 · cited 1× · see citing works
“and educational interventions, which may decrease peer victimization and cyberbullying (236, 237).”
Background
The stress sensitization hypothesis: Understanding the course of bipolar disorder
Dienes, K., Hammen, C. L., Henry, R. M., Cohen, A. N., & Daley, S. E. (2006) · Journal of Affective Disorders · doi:10.1016/j.jad.2006.04.009 · Cited by 149 · see citing works
Mediation of the influence of childhood maltreatment on depression relapse by cortical structure: a 2-year longitudinal observational study
Opel, N., Redlich, R., Dohm, K., Zaremba, D., Goltermann, J., Repple, J., Flint, C., Grotegerd, D., Leehr, E. J., Böhnlein, J., et al. (2019) · The Lancet Psychiatry · doi:10.1016/s2215-0366(19)30044-6 · Cited by 145 · see citing works
Developmental change in amygdala reactivity during adolescence: effects of family history of depression and stressful life events
Swartz, J. R., Williamson, D. E., & Hariri, A. R. (2015) · American Journal of Psychiatry · doi:10.1176/appi.ajp.2014.14020195 · Cited by 144 · see citing works
Structural equation modeling of repeated retrospective reports of childhood maltreatment: Modeling of reports of child maltreatment
Fergusson, D. M., Horwood, L. J., & Boden, J. M. (2011) · International Journal of Methods in Psychiatric Research · doi:10.1002/mpr.337 · Cited by 139 · see citing works
SLC6A4 methylation as an epigenetic marker of life adversity exposures in humans: A systematic review of literature
Provenzi, L., Giorda, R., Beri, S., & Montirosso, R. (2016) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2016.08.021 · Cited by 139 · see citing works
Childhood abuse in late-life depression
Comijs, H. C., van Exel, E., van der Mast, R. C., Paauw, A., Oude Voshaar, R., & Stek, M. L. (2013) · Journal of Affective Disorders · doi:10.1016/j.jad.2012.11.010 · Cited by 123 · see citing works
Child maltreatment as a risk factor for opioid dependence: Comparison of family characteristics and type and severity of child maltreatment with a matched control group
Conroy, E., Degenhardt, L. J., Mattick, R. P., & Nelson, E. C. (2009) · Child Abuse & Neglect · doi:10.1016/j.chiabu.2008.09.009 · Cited by 123 · see citing works
Does Childhood Trauma Moderate Polygenic Risk for Depression? A Meta-analysis of 5765 Subjects From the Psychiatric Genomics Consortium
Peyrot, W. J., der Auwera, S. V., Milaneschi, Y., Dolan, C. V., Madden, P. A. F., Sullivan, P. F., Strohmaier, J., Ripke, S., Rietschel, M., Nivard, M. G., et al. (2017) · Biological Psychiatry · doi:10.1016/j.biopsych.2017.09.009 · Cited by 122 · see citing works
Relationship of childhood physical and sexual abuse to adult bipolar disorder
Hyun, M., Friedman, S. D., & Dünner, D. L. (2000) · Bipolar Disorders · doi:10.1034/j.1399-5618.2000.020206.x · Cited by 120 · see citing works
METHYLATION OF SEROTONIN RECEPTOR 3A IN ADHD, BORDERLINE PERSONALITY, AND BIPOLAR DISORDERS: LINK WITH SEVERITY OF THE DISORDERS AND CHILDHOOD MALTREATMENT: Research Article: Epigenetics of 5HT 3A R in Psychiatric Disorders
Perroud, N., Zewdie, S., Stenz, L., Adouan, W., Bavamian, S., Prada, P., Nicastro, R., Hasler, R., Nallet, A., Piguet, C., et al. (2016) · Depression and Anxiety · doi:10.1002/da.22406 · Cited by 120 · see citing works
Childhood sexual and physical abuse: age at exposure modulates impact on functional outcome in early psychosis patients
Alameda, L., Ferrari, C., Baumann, P., Gholam‐Rezaee, M., Do, K. Q., & Conus, P. (2015) · Psychological Medicine · doi:10.1017/s0033291715000690 · Cited by 119 · see citing works
Evidence for a sensitive period in the effects of early life stress on hippocampal volume
Humphreys, K. L., King, L. S., Sacchet, M. D., Camacho, M. C., Colich, N. L., Ordaz, S. J., Ho, T. C., & Gotlib, I. H. (2018) · Developmental Science · doi:10.1111/desc.12775 · Cited by 118 · see citing works
Clinical risk factors for bipolar disorders: A systematic review of prospective studies
Faedda, G. L., Serra, G., Marangoni, C., Salvatore, P., Sani, G., Vázquez, G. H., Tondo, L., Girardi, P., Baldessarini, R. J., & Koukopoulos, A. (2014) · Journal of Affective Disorders · doi:10.1016/j.jad.2014.07.013 · Cited by 117 · see citing works
Childhood stress, grown-up brain networks: corticolimbic correlates of threat-related early life stress and adult stress response
Kaiser, R. H., Clegg, R. A., Goer, F., Pechtel, P., Beltzer, M., Vitaliano, G. D., Olson, D. P., Teicher, M. H., & Pizzagalli, D. A. (2017) · Psychological Medicine · doi:10.1017/s0033291717002628 · Cited by 113 · see citing works
Family history of suicidal behavior and early traumatic experiences: Additive effect on suicidality and course of bipolar illness?
Carballo, J. J., Harkavy‐Friedman, J., Burke, A. K., Sher, L., Baca‐García, E., Sullivan, G. M., Grunebaum, M. F., Parsey, R. V., Mann, J. J., & Oquendo, M. A. (2008) · Journal of Affective Disorders · doi:10.1016/j.jad.2007.12.225 · Cited by 111 · see citing works
Contributions of the social environment to first-onset and recurrent mania
Gilman, S. E., Ni, M. Y., Dunn, E. C., Breslau, J. A., McLaughlin, K. A., Smoller, J. W., & Perlis, R. H. (2014) · Molecular Psychiatry · doi:10.1038/mp.2014.36 · Cited by 110 · see citing works
Differences and similarities in the serotonergic diathesis for suicide attempts and mood disorders: a 22-year longitudinal gene–environment study
Brezo, J., Bureau, A., Mérette, C., Jomphe, V, Barker, E. D., Vitaro, F., Hébert, M., Carbonneau, R., Tremblay, R. E., & Turecki, G. (2010) · Molecular Psychiatry · doi:10.1038/mp.2009.19 · Cited by 109 · see citing works
Suicidal behaviour and associated risk factors among opioid‐dependent individuals: a case–control study
Maloney, E. A., Degenhardt, L. J., Darke, S. G., Mattick, R. P., & Nelson, E. C. (2007) · Addiction · doi:10.1111/j.1360-0443.2007.01971.x · Cited by 109 · see citing works
Prevalence and correlates of physical and sexual abuse in children and adolescents with bipolar disorder
Romero, S., Birmaher, B. B., Axelson, D., Goldstein, T. R., Goldstein, B. I., Gill, M. K., Iosif, A., Strober, M. A., Hunt, J., Esposito-Smythers, C. L., et al. (2008) · Journal of Affective Disorders · doi:10.1016/j.jad.2008.04.005 · Cited by 108 · see citing works
Homelessness, Mental Health and Suicidality Among LGBTQ Youth Accessing Crisis Services
Rhoades, H., Rusow, J., Bond, D., Lanteigne, A., Fulginiti, A., & Goldbach, J. T. (2018) · Child Psychiatry and Human Development · doi:10.1007/s10578-018-0780-1 · Cited by 104 · see citing works
Longitudinal Trajectories of Depression Symptoms in Adolescence: Psychosocial Risk Factors and Outcomes
Ellis, R., Seal, M. L., Simmons, J. G., Whittle, S., Schwartz, O., Byrne, M. L., & Allen, N. B. (2016) · Child Psychiatry & Human Development · doi:10.1007/s10578-016-0682-z · Cited by 103 · see citing works
Childhood trauma, family history, and their association with mood disorders in early adulthood
Jansen, K., Cardoso, T. A., Fries, G. R., Branco, J. C., Silva, R. A., Kauer‐Sant’Anna, M., Kapczinski, F. P., & Magalhães, P. V. D. S. (2016) · Acta Psychiatrica Scandinavica · doi:10.1111/acps.12551 · Cited by 103 · see citing works
Affective lability mediates the association between childhood trauma and suicide attempts, mixed episodes and co-morbid anxiety disorders in bipolar disorders
Aas, M., Henry, C., Bellivier, F., Lajnef, M., Gard, S., Kahn, J. P., Lagerberg, T. V., Aminoff, S. R., Bjella, T. D., Leboyer, M., et al. (2016) · Psychological Medicine · doi:10.1017/s0033291716003081 · Cited by 103 · see citing works
Psychosocial stressors and the prognosis of major depression: a test of Axis IV
Gilman, S. E., Trinh, N., Smoller, J. W., D, M. F. M., Murphy, J. M., & Breslau, J. A. (2012) · Psychological Medicine · doi:10.1017/s0033291712001080 · Cited by 102 · see citing works
Reduced gray matter volume in psychotic disorder patients with a history of childhood sexual abuse
Sheffield, J. M., Williams, L. E., Woodward, N. D., & Heckers, S. (2013) · Schizophrenia Research · doi:10.1016/j.schres.2012.10.032 · Cited by 101 · see citing works
Amygdala and hippocampus volumes are differently affected by childhood trauma in patients with bipolar disorders and healthy controls
Janiri, D., Sani, G., Rossi, P. D., Piras, F., Iorio, M., Banaj, N., Giuseppin, G., Spinazzola, E., Maggiora, M., Ambrosi, E., et al. (2017) · Bipolar Disorders · doi:10.1111/bdi.12516 · Cited by 99 · see citing works
Childhood adversity, adult stress, and the risk of major depression or generalized anxiety disorder in US soldiers: a test of the stress sensitization hypothesis
Bandoli, G., Campbell-Sills, L., Kessler, R. C., Heeringa, S. G., Nock, M. K., Rosellini, A. J., Sampson, N. A., Schoenbaum, M., Ursano, R. J., & Stein, M. B. (2017) · Psychological Medicine · doi:10.1017/s0033291717001064 · Cited by 97 · cited 1× · see citing works
“Soldiers exposed to childhood maltreatment have a greater risk for depression or anxiety following recent life stressors (94).”
Background
Neuroimmune Interface in the Comorbidity between Alcohol Use Disorder and Major Depression
Neupane, S. P. (2016) · Frontiers in Immunology · doi:10.3389/fimmu.2016.00655 · Cited by 97 · see citing works
Variation in the oxytocin receptor gene is associated with increased risk for anxiety, stress and depression in individuals with a history of exposure to early life stress
Myers, A., Williams, L. M., Gatt, J. M., McAuley, E. Z., Dobson‐Stone, C., Schofield, P. R., & Nemeroff, C. B. (2014) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2014.08.021 · Cited by 95 · see citing works
Self-citation
A cognitive vulnerability–stress perspective on bipolar spectrum disorders in a normative adolescent brain, cognitive, and emotional development context
Alloy, L. B., Abramson, L. Y., Walshaw, P. D., Keyser, J. D., & Gerstein, R. K. (2006) · Development and Psychopathology · doi:10.1017/s0954579406060524 · Cited by 90 · see citing works
Microglia and alcohol meet at the crossroads: Microglia as critical modulators of alcohol neurotoxicity
Henriques, J. F., Portugal, C. C., Canedo, T., Relvas, J. B., Summavielle, T., & Socodato, R. (2018) · Toxicology Letters · doi:10.1016/j.toxlet.2017.11.002 · Cited by 89 · see citing works
The Serotonin Transporter Promoter Variant (5-HTTLPR), Stress, and Depression Meta-analysis Revisited: Evidence of Genetic Moderation
Karg, K., Burmeister, M., Shedden, K., & Sen, S. (2011) · Archives of General Psychiatry · doi:10.1001/archgenpsychiatry.2010.189 · Cited by 87 · see citing works
Examining perceived stress, childhood trauma and interpersonal trauma in individuals with drug addiction
Garami, J., Valikhani, A., Parkes, D., Haber, P., Mahlberg, J., Misiak, B., Frydecka, D., & Moustafa, A. A. (2019) · Psychological Reports · doi:10.1177/0033294118764918 · Cited by 87 · see citing works
Early life stress and the anxious brain: evidence for a neural mechanism linking childhood emotional maltreatment to anxiety in adulthood
Fonzo, G. A., Ramsawh, H. J., Flagan, T., Simmons, A. N., Sullivan, S. G., Allard, C. B., Paulus, M. P., & Stein, M. B. (2015) · Psychological Medicine · doi:10.1017/s0033291715002603 · Cited by 85 · see citing works
The Behavioral and Immunological Impact of Maternal Separation: A Matter of Timing
Roque, S., Mesquita, A. R., Palha, J. A., Sousa, N., & Correia‐Neves, M. (2014) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2014.00192 · Cited by 85 · see citing works
Childhood maltreatment severity is associated with elevated C-reactive protein and body mass index in adults with schizophrenia and bipolar diagnoses
Aas, M., Dieset, I., Hope, S., Hoseth, E. Z., Mørch, R. H., Reponen, E. J., Steen, N. E., Laskemoen, J. F., Ueland, T., Aukrust, P., et al. (2017) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2017.06.005 · Cited by 84 · see citing works
Are there sensitive periods when child maltreatment substantially elevates suicide risk? Results from a nationally representative sample of adolescents: G<scp>omez et al</scp>.
Gomez, S. H., Tse, J., Wang, Y., Turner, B., Millner, A. J., Nock, M. K., & Dunn, E. C. (2017) · Depression and Anxiety · doi:10.1002/da.22650 · Cited by 84 · see citing works
Gene-environment interactions between CRHR1 variants and physical assault in suicide attempts
Ben-Efraim, Y. J., Wasserman, D., Wasserman, J., & Sokolowski, M. (2011) · Genes, Brain and Behavior · doi:10.1111/j.1601-183x.2011.00703.x · Cited by 83 · see citing works
Childhood trauma and treatment outcome in bipolar disorder
Çakır, S., Durak, R. T., Özyıldırım, İ., İnce, E., & Şar, V. (2015) · Journal of Trauma & Dissociation · doi:10.1080/15299732.2015.1132489 · Cited by 80 · see citing works
The neural correlates of Childhood Trauma Questionnaire scores in adults: A meta-analysis and review of functional magnetic resonance imaging studies
Heany, S. J., Groenewold, N. A., Uhlmann, A., Dalvie, S., Stein, D. J., & Brooks, S. J. (2017) · Development and Psychopathology · doi:10.1017/s0954579417001717 · Cited by 80 · see citing works
Grey matter volume and thickness abnormalities in young people with a history of childhood abuse
Lim, L. L., Hart, H. C., Mehta, M. A., Worker, A., Simmons, A., Mirza, K., & Rubia, K. (2017) · Psychological Medicine · doi:10.1017/s0033291717002392 · Cited by 78 · see citing works
BDNFVal66Met genotype interacts with childhood adversity and influences the formation of hippocampal subfields
Frodl, T., Skokauskas, N., Frey, E.-M., Morris, D. W., Gill, M., & Carballedo, A. (2014) · Human Brain Mapping · doi:10.1002/hbm.22584 · Cited by 78 · see citing works
Interactive Effects of Childhood Maltreatment and Recent Stressful Life Events on Alcohol Consumption in Adulthood
Young‐Wolff, K. C., Kendler, K. S., & Prescott, C. A. (2012) · Journal of Studies on Alcohol and Drugs · doi:10.15288/jsad.2012.73.559 · Cited by 77 · see citing works
Genotype and Childhood Sexual Trauma Moderate Neurocognitive Performance: A Possible Role for Brain-Derived Neurotrophic Factor and Apolipoprotein E Variants
Savitz, J. B., van der Merwe, L., Stein, D. J., Solms, M., & Ramesar, R. (2007) · Biological Psychiatry · doi:10.1016/j.biopsych.2006.10.017 · Cited by 75 · see citing works
Hypothalamic-pituitary-adrenal axis genetic variation and early stress moderates amygdala function
Iorio, C., Carey, C. E., Michalski, L. J., Corral-Frías, N. S., Drabant, E. M., Hariri, A. R., & Bogdan, R. (2017) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2017.03.016 · Cited by 74 · see citing works
The Association Between Moderate Alcohol Use and Illness Severity in Bipolar Disorder
Goldstein, B. I., Velyvis, V., & Parikh, S. V. (2006) · The Journal of Clinical Psychiatry · doi:10.4088/jcp.v67n0114 · Cited by 74 · see citing works
Adverse childhood experiences influence white matter microstructure in patients with bipolar disorder
Benedetti, F., Bollettini, I., Radaelli, D., Poletti, S., Locatelli, C., Falini, A., Smeraldi, E., & Colombo, C. (2014) · Psychological Medicine · doi:10.1017/s0033291714000506 · Cited by 73 · see citing works
Childhood maltreatment preceding depressive disorder at age 18 years: A prospective Brazilian birth cohort study
Gallo, E. A. G., de Mola, C. L., Wehrmeister, F. C., Gonçalves, H., Kieling, C., & Murray, J. (2017) · Journal of Affective Disorders · doi:10.1016/j.jad.2017.03.065 · Cited by 73 · see citing works
Prenatal stress-immune programming of sex differences in comorbidity of depression and obesity/metabolic syndrome
Goldstein, J. M., Holsen, L. M., Huang, G. T.-W., Hammond, B. D., James-Todd, T. M., Cherkerzian, S., Hale, T. M., & Handa, R. J. (2016) · Dialogues in Clinical Neuroscience · doi:10.31887/dcns.2016.18.4/jgoldstein · Cited by 72 · see citing works
Childhood Emotional Maltreatment as a Robust Predictor of Suicidal Ideation: A 3-Year Multi-Wave, Prospective Investigation
Miller, A. B., Jenness, J. L., Oppenheimer, C. W., Barrocas, A. L., Young, J. F., & Hankin, B. L. (2016) · Research on Child and Adolescent Psychopathology · doi:10.1007/s10802-016-0150-z · Cited by 72 · see citing works
Childhood trauma and the limbic network: a multimodal MRI study in patients with bipolar disorder and controls
Queiroz, J. D. S., Boisgontier, J., Étain, B., Poupon, C., Duclap, D., d’Albis, M.-A., Daban, C., Hamdani, N., Corvoisier, P. L., Delavest, M., et al. (2016) · Journal of Affective Disorders · doi:10.1016/j.jad.2016.04.038 · Cited by 71 · see citing works
Altered brain network integrity after childhood maltreatment: A structural connectomic DTI-study
Puetz, V. B., Parker, D., Kohn, N., Dahmen, B., Verma, R., & Konrad, K. (2016) · Human Brain Mapping · doi:10.1002/hbm.23423 · Cited by 70 · see citing works
Childhood trauma, dimensions of psychopathology and the clinical expression of bipolar disorders: A pathway analysis
Étain, B., Lajnef, M., Henry, C., Aubin, V., Azorin, J., Bellivier, F., Bougerol, T., Courtet, P., Gard, S., Kahn, J. P., et al. (2017) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2017.07.013 · Cited by 68 · see citing works
Prevalence of child sexual abuse among adults and youths with bipolar disorder: A systematic review
Maniglio, R. (2013) · Clinical Psychology Review · doi:10.1016/j.cpr.2013.03.002 · Cited by 67 · see citing works
Childhood adversity associated with white matter alteration in the corpus callosum, corona radiata, and uncinate fasciculus of psychiatrically healthy adults
McCarthy‐Jones, S., Oestreich, L., Lyall, A. E., Kikinis, Z., Newell, D. T., Savadjiev, P., Shenton, M. E., Kubicki, M. R., Pasternak, O., & Whitford, T. J. (2017) · Brain Imaging and Behavior · doi:10.1007/s11682-017-9703-1 · Cited by 67 · see citing works
Heightened connectivity between the ventral striatum and medial prefrontal cortex as a biomarker for stress-related psychopathology: understanding interactive effects of early and more recent stress
Hanson, J. L., Knodt, A. R., Brigidi, B. D., & Hariri, A. R. (2017) · Psychological Medicine · doi:10.1017/s0033291717003348 · Cited by 64 · see citing works
Interaction between the MTHFR C677T polymorphism and traumatic childhood events predicts depression
Lok, A., Bockting, C., Koeter, M. W. J., Snieder, H., Assies, J., Mocking, R. J. T., Vinkers, C. H., Kahn, R. S., Boks, M. P., & Schene, A. H. (2013) · Translational Psychiatry · doi:10.1038/tp.2013.60 · Cited by 63 · see citing works
Childhood trauma moderates inhibitory control and anterior cingulate cortex activation during stress
Zhai, Z. W., Yip, S. W., Lacadie, C., Sinha, R., Mayes, L. C., & Potenza, M. N. (2018) · NeuroImage · doi:10.1016/j.neuroimage.2018.10.049 · Cited by 61 · see citing works
White matter microstructure in bipolar disorder is influenced by the serotonin transporter gene polymorphism 5‐ HTTLPR
Benedetti, F., Bollettini, I., Poletti, S., Locatelli, C., Lorenzi, C., Pirovano, A., Smeraldi, E., & Colombo, C. (2015) · Genes Brain & Behavior · doi:10.1111/gbb.12206 · Cited by 60 · see citing works
Combined Effect of TLR2 Gene Polymorphism and Early Life Stress on the Age at Onset of Bipolar Disorders
Oliveira, J., Étain, B., Lajnef, M., Hamdani, N., Bennabi, M., Bengoufa, D., Sundaresh, A., Chaabene, A. B., Bellivier, F., Henry, C., et al. (2015) · PLoS ONE · doi:10.1371/journal.pone.0119702 · Cited by 59 · see citing works
Adverse childhood experiences influence the detrimental effect of bipolar disorder and schizophrenia on cortico-limbic grey matter volumes
Poletti, S., Vai, B., Smeraldi, E., Cavallaro, R., Colombo, C., & Benedetti, F. (2015) · Journal of Affective Disorders · doi:10.1016/j.jad.2015.09.049 · Cited by 58 · see citing works
Effects of childhood trauma and clinical features on determining quality of life in patients with bipolar I disorder
Erten, E., Uney, A. F. K., Saatçioğlu, Ö., Özdemir, A., Fıstikçı, N., & Çakmak, D. (2014) · Journal of Affective Disorders · doi:10.1016/j.jad.2014.03.046 · Cited by 58 · see citing works
Maltreatment in Psychiatrically Hospitalized Children and Adolescents with Developmental Disabilities: Prevalence and Correlates
Ammerman, R. T., Hersen, M., Hasselt, V. B. V., et al. (1994) · Journal of the American Academy of Child & Adolescent Psychiatry · doi:10.1097/00004583-199405000-00015 · Cited by 58 · see citing works
The role of timing of maltreatment and child intelligence in pathways to low symptoms of depression and anxiety in adolescence
Harpur, L. J., Polek, E., & van Harmelen, A. (2015) · Child Abuse & Neglect · doi:10.1016/j.chiabu.2015.05.019 · Cited by 57 · see citing works
Longitudinal Effects of Early Childhood Maltreatment on Co-Occurring Substance Misuse and Mental Health Problems in Adulthood: The Role of Adolescent Alcohol Use and Depression
Skinner, M. L., Hong, S., Herrenkohl, T. I., Brown, E. C., Lee, J. O., & Jung, H. (2016) · Journal of Studies on Alcohol and Drugs · doi:10.15288/jsad.2016.77.464 · Cited by 56 · see citing works
Child maltreatment and age of alcohol and marijuana initiation in high-risk youth
Proctor, L. J., Lewis, T., Roesch, S. C., Thompson, R., Litrownik, A. J., English, D., Arria, A. M., Isbell, P., & Dubowitz, H. (2017) · Addictive Behaviors · doi:10.1016/j.addbeh.2017.06.021 · Cited by 56 · see citing works
Childhood maltreatment and the course of bipolar disorders among adults: Epidemiologic evidence of dose-response effects
Sala, R., Goldstein, B. I., Wang, S., & Blanco, C. (2014) · Journal of Affective Disorders · doi:10.1016/j.jad.2014.04.035 · Cited by 56 · see citing works
More stressors prior to and during the course of bipolar illness in patients from the United States compared with the Netherlands and Germany
Post, R. M., Altshuler, L. L., Leverich, G. S., Nolen, W. A., Kupka, R., Grunze, H., Frye, M. A., Suppes, T. M., McElroy, S., Keck, P. E., et al. (2013) · Psychiatry Research · doi:10.1016/j.psychres.2013.08.007 · Cited by 55 · see citing works
Modifiable predictors of depression following childhood maltreatment: a systematic review and meta-analysis
Braithwaite, E., O'Connor, R. M., Degli-Esposti, M., Luke, N., & Bowes, L. (2017) · Translational Psychiatry · doi:10.1038/tp.2017.140 · Cited by 54 · see citing works
A theoretical framework informing research about the role of stress in the pathophysiology of bipolar disorder
Brietzke, E. M., Mansur, R. B., Soczynska, J. K., Powell, A. M., & McIntyre, R. S. (2012) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2012.05.004 · Cited by 53 · see citing works
Genetic and childhood trauma interaction effect on age of onset in bipolar disorder: An exploratory analysis
Anand, A., Koller, D. L., Lawson, W. B., Gershon, E. S., & Nürnberger, J. I. (2015) · Journal of Affective Disorders · doi:10.1016/j.jad.2015.02.029 · Cited by 53 · see citing works
Is Depression With Atypical Features Associated With Trauma History?
Withers, A., Tarasoff, J. M., & Stewart, J. W. (2013) · The Journal of Clinical Psychiatry · doi:10.4088/jcp.12m07870 · Cited by 51 · see citing works
The Intergenerational Effects of Early Adversity
Galler, J. R., & Rabinowitz, D. G. (2014) · Progress in molecular biology and translational science · doi:10.1016/b978-0-12-800977-2.00007-3 · Cited by 51 · see citing works
Influence of childhood abuse and neglect subtypes on late-life suicide risk beyond depression
Behr Gomes Jardim, G., Novelo, M., Spanemberg, L., von Gunten, A., Engroff, P., Nogueira, E. L., & Cataldo Neto, A. (2018) · Child Abuse & Neglect · doi:10.1016/j.chiabu.2018.03.029 · Cited by 50 · see citing works
Multidimensional impulsivity as a mediator of early life stress and alcohol dependence
Kim, S. T., Hwang, S. S., Kim, H. W., Hwang, E. H., Cho, J., Kang, J. I., & Kim, S. J. (2018) · Scientific Reports · doi:10.1038/s41598-018-22474-8 · Cited by 50 · see citing works
Associations of monoamine oxidase A gene first exon methylation with sexual abuse and current depression in women
Checknita, D., Ekström, T. J., Comasco, E., Nilsson, K. W., Tiihonen, J., & Hodgins, S. (2018) · Journal of Neural Transmission · doi:10.1007/s00702-018-1875-3 · Cited by 50 · see citing works
Bipolar Disorder and Early Emotional Trauma: A Critical Literature Review on Indicators of Prevalence Rates and Clinical Outcomes
Dualibe, A. L., & Osório, F. D. L. (2017) · Harvard Review of Psychiatry · doi:10.1097/hrp.0000000000000154 · Cited by 50 · see citing works
Gender and the associated impairments of childhood sexual abuse: A national study of Icelandic youth
Gault-Sherman, M., Silver, E., & Sigfúsdóttir, I. D. (2009) · Social Science & Medicine · doi:10.1016/j.socscimed.2009.08.037 · Cited by 49 · see citing works
Negative and positive childhood experiences across developmental periods in psychiatric patients with different diagnoses – an explorative study
Saleptsi, E., Bichescu, D., Rockstroh, B. S., Neuner, F., Schauer, M., Studer, K., Hoffmann, K. K. P., & Elbert, T. R. (2004) · BMC Psychiatry · doi:10.1186/1471-244x-4-40 · Cited by 49 · see citing works
Developmental Timing of Childhood Physical and Sexual Maltreatment Predicts Adult Depression and Post-Traumatic Stress Symptoms
Capretto, J. J. (2017) · Journal of Interpersonal Violence · doi:10.1177/0886260517704963 · Cited by 48 · see citing works
Gender Differences in the Physical and Psychological Manifestation of Childhood Trauma and/or Adversity in People with Psychosis
Sweeney, S., Air, T., Zannettino, L., & Galletly, C. A. (2015) · Frontiers in Psychology · doi:10.3389/fpsyg.2015.01768 · Cited by 48 · see citing works
Gray matter brain volumes in childhood-maltreated patients with bipolar disorder type I: A voxel-based morphometric study
Duarte, D. G. G., das Neves, M. D. C. L., Albuquerque, M. R., Duran, F., Busatto, G. F., & Corrêa, H. (2016) · Journal of Affective Disorders · doi:10.1016/j.jad.2016.02.068 · Cited by 47 · see citing works
Associations of 5HTTLPR polymorphism with major depressive disorder and alcohol dependence: A systematic review and meta-analysis
Oo, K. Z., Aung, Y. K., Jenkins, M. A., & Win, A. K. (2016) · Australian & New Zealand Journal of Psychiatry · doi:10.1177/0004867416637920 · Cited by 45 · see citing works
The differential relation of childhood maltreatment to stress sensitization in adolescent and young adult depression
La Rocque, C. L., Harkness, K. L., & Bagby, R. M. (2014) · Journal of Adolescence · doi:10.1016/j.adolescence.2014.05.012 · Cited by 44 · see citing works
Effects of childhood trauma on working memory in affective and non-affective psychotic disorders
Quidé, Y., O’Reilly, N., Rowland, J. E., Carr, V. J., Elzinga, B. M., & Green, M. J. (2016) · Brain Imaging and Behavior · doi:10.1007/s11682-016-9548-z · Cited by 41 · see citing works
Interaction between childhood maltreatment on immunogenetic risk in depression: Discovery and replication in clinical case-control samples
Cohen‐Woods, S., Fisher, H. L., Ahmetspahic, D., Douroudis, K., Stacey, D., Hosang, G. M., Korszun, A., Owen, M. J., Craddock, N. J., Arolt, V., et al. (2017) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2017.08.023 · Cited by 40 · see citing works
The contribution of emotional maltreatment to alcohol dependence in a treatment-seeking sample
Potthast, N., Neuner, F., & Catani, C. (2014) · Addictive Behaviors · doi:10.1016/j.addbeh.2014.01.015 · Cited by 40 · see citing works
Bridging Basic and Clinical Research in Early Life Adversity, DNA Methylation, and Major Depressive Disorder
Brown, A., Fiori, L. M., & Turecki, G. (2019) · Frontiers in Genetics · doi:10.3389/fgene.2019.00229 · Cited by 39 · see citing works
Cyberbullying and LGBTQ Youth: A Deadly Combination
Wiederhold, B. K. (2014) · Cyberpsychology Behavior and Social Networking · doi:10.1089/cyber.2014.1521 · Cited by 39 · see citing works

Flagged first, then by citations

Research works printed but not linked: 8

[6]Green JG,, Childhood adversities and adult psychiatric disorders in the national comorbidity survey replication I: associations with first onset of DSM-IV disorders. Arch Gen Psychiatry, 2010 67(2): p. 113– 23. 20124111 PMC2822662
[43]Short AT and Nemeroff CB, Early life trauma and suicide In Suicide: Phenomenology and Neurobiology, Cannon KE and Hudzik TJ, eds. (Springer), pp 187– 205. 2014.
[48]Dube SR,, Childhood abuse, household dysfunction, and the risk of attempted suicide throughout the life span: findings from the Adverse Childhood Experiences Study. JAMA, 2001 286(24): p. 3089– 96. 11754674
[51]Peyre H,, Contributing Factors and Mental Health Outcomes of First Suicide Attempt During Childhood and Adolescence: Results From a Nationally Representative Study. J Clin Psychiatry, 2017 78(6): p. e622– e630. 28355042
[70]Carr CP,, The role of early life stress in adult psychiatric disorders: a systematic review according to childhood trauma subtypes. J Nerv Ment Dis, 2013 201(12): p. 1007– 20. 24284634
[93]Miller AH and Raison CL, Are Anti-inflammatory Therapies Viable Treatments for Psychiatric Disorders?: Where the Rubber Meets the Road. JAMA Psychiatry, 2015 72(6): p. 527– 8. 25853989 PMC5542670
[113]Bradley RG,, Influence of child abuse on adult depression: moderation by the corticotropin-releasing hormone receptor gene. Arch Gen Psychiatry, 2008 65(2): p. 190– 200. 18250257 PMC2443704
[235]Rodgers SM, Transitional Age Lesbian, Gay, Bisexual, Transgender, and Questioning Youth: Issues of Diversity, Integrated Identities, and Mental Health. Child Adolesc Psychiatr Clin N Am, 2017 26(2): p. 297– 309. 28314457

Sorted by citations

Time for united action on depression: a Lancet–World Psychiatric Association Commission
Herrman, H., Patel, V., Kieling, C., Berk, M., Buchweitz, C., Cuijpers, P., Furukawa, T. A., Kessler, R. C., Kohrt, B. A., Maj, M., et al. (2022) · The Lancet · doi:10.1016/s0140-6736(21)02141-3 · Cited by 1,104 · see citing works
The clinical characterization of the adult patient with depression aimed at personalization of management
Maj, M., Stein, D. J., Parker, G., Zimmerman, M., Fava, G. A., De Hert, M., Demyttenaere, K., McIntyre, R. S., Widiger, T., & Wittchen, H. (2020) · World Psychiatry · doi:10.1002/wps.20771 · Cited by 435 · see citing works
Compassion: From Its Evolution to a Psychotherapy
Gilbert, P. (2020) · Frontiers in Psychology · doi:10.3389/fpsyg.2020.586161 · Cited by 365 · see citing works
“Various forms of abuse (Lippard and Nemeroff, 2020) and other common histories for people with mental health problems (Van der Kolk, 2015) indicate that either they did not experience feeling a sense of security or safeness and “loving” empathic engagement with developmental needs being met, and/or as they move throug…”
Background
Recognizing the importance of childhood maltreatment as a critical factor in psychiatric diagnoses, treatment, research, prevention, and education
Teicher, M. H., Gordon, J. B., & Nemeroff, C. B. (2022) · Molecular Psychiatry · doi:10.1038/s41380-021-01367-9 · Cited by 325 · see citing works
Self-citation
Comorbidity between major depressive disorder and physical diseases: a comprehensive review of epidemiology, mechanisms and management
Berk, M., Köhler‐Forsberg, O., Turner, M., Penninx, B. W. J. H., Wrobel, A., Firth, J., Loughman, A., Reavley, N. J., McGrath, J. J., Momen, N. C., et al. (2023) · World Psychiatry · doi:10.1002/wps.21110 · Cited by 336 · see citing works
Elevated C-Reactive Protein in Patients With Depression, Independent of Genetic, Health, and Psychosocial Factors: Results From the UK Biobank
Pitharouli, M. C., Hagenaars, S. P., Glanville, K. P., Coleman, J. R. I., Hotopf, M., Lewis, C. M., & Pariante, C. M. (2021) · American Journal of Psychiatry · doi:10.1176/appi.ajp.2020.20060947 · Cited by 218 · see citing works
Childhood Trauma, the HPA Axis and Psychiatric Illnesses: A Targeted Literature Synthesis
Murphy, F., Nasa, A., Cullinane, D., Raajakesary, K., Gazzaz, A., Sooknarine, V., Haines, M., Roman, E., Kelly, L., O'Neill, A., et al. (2022) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2022.748372 · Cited by 181 · see citing works
“Early life stress (ELS) due to childhood abuse and/or neglect has been linked to increased risk of psychiatric illness onset and recurrence, increased disease severity and poor treatment response (pharmacotherapy and psychotherapy) (148, 149).”
Background
Creating a compassionate world: addressing the conflicts between sharing and caring versus controlling and holding evolved strategies
Gilbert, P. (2021) · Frontiers in Psychology · doi:10.3389/fpsyg.2020.582090 · Cited by 77 · see citing works
Childhood sexual abuse and pervasive problems across multiple life domains: Findings from a five-decade study
Guiney, H., Caspi, A., Ambler, A., Belsky, J., Kokaua, J., Broadbent, J., Cheyne, K., Dickson, N., Hancox, R. J., Harrington, H., et al. (2024) · Development and Psychopathology · doi:10.1017/s0954579422001146 · Cited by 64 · see citing works
Identification of biopsychological trait markers in functional neurological disorders
Weber, S., Bühler, J., Vanini, G., Loukas, S., Bruckmaier, R., & Aybek, S. (2023) · Brain · doi:10.1093/brain/awac442 · Cited by 63 · see citing works
Associations between childhood trauma and childhood psychiatric disorders in Brazil: a population-based, prospective birth cohort study
Bauer, A., Fairchild, G., Hammerton, G., Murray, J., Santos, I. S., Tovo Rodrigues, L., Munhoz, T. N., Barros, A. J. D., Matijasevich, A., & Halligan, S. L. (2022) · The Lancet Psychiatry · doi:10.1016/s2215-0366(22)00337-6 · Cited by 41 · see citing works
Social media use and body image issues among adolescents in a vulnerable Louisiana community
Sagrera, C. E., Magner, J., Temple, J., Lawrence, R., Magner, T. J., Avila-Quintero, V. J., McPherson, P., Alderman, L. L., Bhuiyan, M. A. N., Patterson, J. C., et al. (2022) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2022.1001336 · Cited by 42 · see citing works
Factors associated with onset-age in major affective disorders
Miola, A., Tondo, L., Salvatore, P., & Baldessarini, R. J. (2022) · Acta Psychiatrica Scandinavica · doi:10.1111/acps.13497 · Cited by 27 · see citing works
Pathological Dissociation in The National Comorbidity Survey Replication (NCS-R): Prevalence, Morbidity, Comorbidity, and Childhood Maltreatment
Simeon, D., & Putnam, F. (2022) · Journal of Trauma & Dissociation · doi:10.1080/15299732.2022.2064580 · Cited by 24 · see citing works
Early adversity as the prototype gene × environment interaction in mental disorders?
Martins, J., Yusupov, N., Binder, E. B., Brückl, T. M., & Czamara, D. (2022) · Pharmacology Biochemistry and Behavior · doi:10.1016/j.pbb.2022.173371 · Cited by 22 · see citing works
Modular-based psychotherapy (MoBa) versus cognitive–behavioural therapy (CBT) for patients with depression, comorbidities and a history of childhood maltreatment: study protocol for a randomised controlled feasibility trial.
Elsaesser, M., Herpertz, S., Piosczyk, H., Jenkner, C., Hautzinger, M., & Schramm, E. (2022) · BMJ Open · doi:10.1136/bmjopen-2021-057672 · Cited by 19 · see citing works
Genetic analyses of the endocannabinoid pathway in association with affective phenotypic variants
Lazary, J., Eszlari, N., Kriko, E., Tozser, D., Dome, P., Deakin, J. F. W., Juhasz, G., & Bagdy, G. (2021) · Neuroscience Letters · doi:10.1016/j.neulet.2020.135600 · Cited by 16 · see citing works
Early sexual or physical abuse in female and male mood disorder patients
Visioli, C., Tondo, L., Miola, A., Pinna, M., Contu, M., & Baldessarini, R. J. (2023) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2023.10.015 · Cited by 10 · see citing works
Homotypical and Heterotypical Intergenerational Continuity of Child Maltreatment: Evidence from a Cohort of Families Involved with Child Protection Services
Langevin, R., Kern, A., Esposito, T., & Hélie, S. (2023) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph20054151 · Cited by 10 · see citing works
“These longlasting consequences may be due to the well-documented association between child abuse and alterations in the brain structure and function and their related poorer treatment responses [6,7].”
Background
Self-Compassion: An Evolutionary, Biopsychosocial, and Social Mentality Approach
Gilbert, P. (2023) · Mindfulness in Behavioral Health · doi:10.1007/978-3-031-22348-8_4 · Cited by 8 · see citing works
Theorie und Praxis der Trauma-fokussierten Mentalisierungsbasierten Therapie: Ist eine Traumabehandlung in der Gruppe möglich?
Rüfenacht, E. N., Shaverin, L., Bateman, A., Fonagy, P., & Taubner, S. (2023) · Die Psychotherapie · doi:10.1007/s00278-023-00686-2 · Cited by 6 · see citing works
Early maladaptive schemas from child maltreatment in depression and psychotherapeutic remediation: a predictive coding framework
Ramamurthy, G., & Chen, A. (2025) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2025.1548601 · Cited by 5 · see citing works

Authors: Lippard, E. T. C., & Nemeroff, C. B.
Affiliations: The University of Texas at Austin (US)
ORCID: Lippard, Elizabeth T.C.
Nemeroff, Charles B.
Venue: American Journal of Psychiatry
Publisher: American Psychiatric Association Publishing
Published: 2020-01-01
Volume: 177
Issue: 1
Pages: 20-36
ISSN: 0002-953X (ISSN-L)
1535-7228
DOI: 10.1176/appi.ajp.2019.19010020
PMC: PMC6939135
OpenAlex: W2973818823
Cited by: 527
References: 230
Citations by year: 2026: 60 · 2025: 88 · 2024: 91 · 2023: 96 · 2022: 104 · 2021: 58 · 2020: 25 · 2019: 1
FWCI: 7.44
Type: journal article
Language: en
Open access: bronze
doi.org
Locations: American Journal of Psychiatry (publishedVersion)
PubMed (publishedVersion)
PubMed Central (acceptedVersion)
Funders: Brain and Behavior Research Foundation
American Foundation for Suicide Prevention
American Psychiatric Publishing
Celgene
Sunovion
OPKO Health
National Institutes of Health (AA024933)
Department of Mechanical Engineering, University of Texas at Austin
Waggoner Center for Alcohol and Addiction Research, University of Texas at Austin
Dell Medical School, University of Texas at Austin
Laureate Institute for Brain Research, University of Tulsa
National Institute on Alcohol Abuse and Alcoholism (K01AA027573, R01AA024933)
National Institute of Mental Health (R01MH117293)
Janssen Research and Development
Topics: Social Sciences › Psychology › Clinical Psychology › Child Abuse and Trauma
Social Sciences › Safety Research › Child Welfare and Adoption
Social Sciences › Psychology › Clinical Psychology › Child and Adolescent Psychosocial and Emotional Development
Keywords: child abuse, mood disorders, bipolar disorder, depression, disease susceptibility, treatment response, suicidal ideation, suicide attempts, episode recurrence, comorbidities, hypothalamic-pituitary-adrenal axis, inflammatory cytokines, candidate genes, substance use, neurobiology of depression, prevention
MeSH terms: Child, Child Abuse, Disease Susceptibility, Humans, Risk Factors, Comorbidity, Mood Disorders

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

The Devastating Clinical Consequences of Child Abuse and Neglect: Increased Disease Vulnerability and Poor Treatment Response in Mood Disorders

Abstract

Integrity signals

Claims the paper makes

Claims other papers make about this one

Self-check

Cites

Cited by

Record

About these checks