Radiotherapy-related fatigue
Abstract
Radiotherapy-induced fatigue is a common early and chronic side-effect of irradiation, reported in up to 80 and 30% of patients during radiation therapy and at follow-up visits, respectively. It is frequently underestimated by medical and nursing staff, only about 50% of patients discuss it with a physician and in one fourth of cases any intervention is proposed to the patient. The patients rarely expect fatigue to be a side-effect of treatment. The etiology of this common symptom, its correlates and prevalence are poorly understood. In numerous studies the level and time course of fatigue was demonstrated to depend on the site of tumor and treatment modalities. For example, psychological mechanisms have been proposed to explain fatigue in women receiving irradiation for early breast cancer, whereas decline in neuromuscular efficiency rather than psychological reasons can lead to the fatigue observed in patients undergoing radiotherapy for prostate cancer. Fatigue can affect global quality of life more than pain, sexual dysfunction and other cancer- or treatment-related symptoms. Several interventions have been tested in the management of radiotherapy-related fatigue and some randomized studies have been recently published. Although an optimal method has not yet been established, some promising results have been reported with relaxation therapy, group psychotherapy, physical exercise and sleep. Further methodologically correct studies are warranted to define better the causes, optimal prevention and management of this symptom.
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Fatigue is one of the most common, debilitating, and distressing side effects of RT reported by cancer patients.
“Fatigue is one of the most common, debilitating, and distressing side effects of RT reported by cancer patients,2-4”
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“radiosensitive healthy tissues (like the skin) and often resolve in a few days/weeks after interruption.(44,51) On the contrary, the”
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“Some of the most concerning toxicities that older adults may have a higher vulnerability of experiencing are fatigue [83, 84], mucositis, xerostomia, dehydration, infections [78], and cognitive defects [85–88].”
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“However, fatigue also has been documented in patients receiving conventional chemotherapy(32) and radiation.(33) Inclusion of this type of information, if it had been available, may have allowed us to identify important subgroups for further analysis.”
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“”(1) It is the most frequently reported side effect resulting from surgical, chemotherapeutic, and hormonal treatment for many cancers and is a common and burdensome side effect of radiation therapy.(2) Reports suggest that between 60% and 96% of all cancer patients experience CRF.”
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Effect of aerobic exercise on cancer-related fatiguecommentary
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“Consistent with previous reports of mean fatigue severity scores (Hickok et al., 2005; Irvine et al., 1998; Jereczek-Fossa et al., 2002; Wratten et al., 2004), this fatigue trajectory was quadratic with a slight increase during RT followed by a slight decrease after RT.”
ResultPsychosocial interventions for reducing fatigue during cancer treatment in adults
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“724 Integrative Cancer Therapies 17(3)”
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“This conflicts with another literature review of the same year (Jereczek-Fossa et al 2002), which found that fatigue was dependent on the type of malignancy, with patients with lung, breast and prostate cancer having the highest levels of early and chronic fatigue.”
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“Fatigue is a common, highly disruptive complaint of patients undergoing external RT (Ahsberg and Fürst 2001), and its prevalence rates among patients receiving RT can reach 70% or more (Danjoux et al. 2007; Janaki et al. 2010; Jereczek-Fossa et al. 2002).”
Background
- Authors
- Jereczek-Fossa, B. A., Marsiglia, H. R., & Orecchia, R.
- Affiliations
- European Institute of Oncology (IT)
- University of Milan (IT)
- ORCID
- Orecchia, Roberto
- Venue
- Critical Reviews in Oncology/Hematology
- Publisher
- Elsevier BV
- Published
- 2002-03
- Volume
- 41
- Issue
- 3
- Pages
- 317-325
- ISSN
- 1040-8428 (ISSN-L)
- OpenAlex
- W1968760806
- Cited by
- 240
- References
- 64
- Citations by year
- 2026: 8 · 2025: 11 · 2024: 4 · 2023: 11 · 2022: 7 · 2021: 13 · 2020: 8 · 2019: 10 · 2018: 7 · 2017: 11 · 2016: 11 · 2015: 8 · 2014: 16 · 2013: 16 · 2012: 17
- FWCI
- 0.50
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Critical Reviews in Oncology/Hematology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Oncology › Cancer survivorship and care
- Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Cancer-related cognitive impairment studies
- Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Childhood Cancer Survivors' Quality of Life
- Keywords
- radiation side effects, chronic fatigue, breast cancer radiotherapy, prostate cancer radiotherapy, quality of life, fatigue management, relaxation training, group therapy, physical activity, sleep, neuromuscular efficiency, psychological mechanisms
- MeSH terms
- Fatigue, Humans, Neoplasms, Radiotherapy, Disease Management
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