Use of proteomic analysis of endometriosis to identify different protein expression in patients with endometriosis versus normal controls
Open accessAbstract
Objective To use proteomic techniques, including two-dimensional electrophoresis (2-DE), Western blot, and mass spectrometry, to screen and identify proteins that were expressed differently in patients with endometriosis versus normal controls.Design First, we aimed to find a difference in the way serum and eutopic endometrial proteins were expressed in women with and without endometriosis. Second, we were interested in searching for endometriotic proteins, which were specifically recognized by sera from patients with endometriosis.Setting Collaborative investigation in an academic research environment.Patient(s) Consenting women of reproductive age taking no medications and with laparoscopically proven endometriosis.Intervention(s) Surgical excision of eutopic and ectopic endometrial biopsy and phlebotomization of patients with endometriosis and controls.Main outcome measure(s) Protein expression.Result(s) Thirteen protein spots from serum correlated with 11 known proteins and 11 protein spots from endometrium correlated with 11 known proteins were found differently expressed between women with and without endometriosis. Some proteins may be cytoskeletons, and some may be involved in the regulation of cell cycle, signal transduction, or immunological function. Three proteins, which were identified as vimentin, beta-actin, and ATP synthase beta subunit, hybridized significantly differently between endometriosis sera and normal sera.Conclusion(s) The data help to establish a human endometriosis proteome database and broaden our understanding of the pathogenesis of endometriosis. Further study of the proteins identified herein will assist in the eventual development of new diagnoses and treatments for endometriosis.
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IGSF21, along with other members of the IGSF superfamily, has functions linked to endometriosis.
“The IGSF21, along with other members of the IGSF superfamily, has functions linked to endometriosis.”
From Altered genome-wide methylation in endometriosis (2014) · cites this paper as [51]
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- Authors
- Zhang, H., Niu, Y., Feng, J., Guo, H., Ye, X., & Cui, H.
- Affiliations
- Peking University People's Hospital (CN)
- Corresponding author
- Feng, Jie
- Venue
- Fertility and Sterility
- Publisher
- Elsevier BV
- Published
- 2006-08
- Volume
- 86
- Issue
- 2
- Pages
- 274-282
- ISSN
- 0015-0282 (ISSN-L)
- OpenAlex
- W1998255094
- Cited by
- 101
- References
- 39
- Citations by year
- 2026: 1 · 2025: 1 · 2024: 2 · 2023: 4 · 2022: 1 · 2021: 1 · 2020: 3 · 2019: 5 · 2018: 3 · 2017: 2 · 2016: 5 · 2015: 8 · 2014: 10 · 2013: 12 · 2012: 4
- FWCI
- 6.35
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Fertility and Sterility (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Chinese Academy of Sciences
- Peking University
- Fok Ying Tong Education Foundation
- Topics
- Health Sciences › Medicine › Reproductive Medicine › Endometriosis Research and Treatment
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Ectopic Pregnancy Diagnosis and Management
- Physical Sciences › Chemistry › Spectroscopy › Advanced Proteomics Techniques and Applications
- Keywords
- endometriosis, proteomics, serum proteins, eutopic endometrium, differentially expressed proteins, vimentin, beta-actin, ATP synthase beta subunit, endometriosis pathogenesis, biomarkers
- MeSH terms
- Actins, Endometriosis, Endometrium, Female, Humans, Mass Spectrometry, Vimentin, Blotting, Western, Electrophoresis, Gel, Two-Dimensional, Case-Control Studies, Mitochondrial Proton-Translocating ATPases, Proteomics
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