Current and potential imaging applications of ferumoxytol for magnetic resonance imaging
Open accessAbstract
Contrast-enhanced magnetic resonance imaging is a commonly used diagnostic tool. Compared with standard gadolinium-based contrast agents, ferumoxytol (Feraheme, AMAG Pharmaceuticals, Waltham, MA), used as an alternative contrast medium, is feasible in patients with impaired renal function. Other attractive imaging features of i.v. ferumoxytol include a prolonged blood pool phase and delayed intracellular uptake. With its unique pharmacologic, metabolic, and imaging properties, ferumoxytol may play a crucial role in future magnetic resonance imaging of the central nervous system, various organs outside the central nervous system, and the cardiovascular system. Preclinical and clinical studies have demonstrated the overall safety and effectiveness of this novel contrast agent, with rarely occurring anaphylactoid reactions. The purpose of this review is to describe the general and organ-specific properties of ferumoxytol, as well as the advantages and potential pitfalls associated with its use in magnetic resonance imaging. To more fully demonstrate the applications of ferumoxytol throughout the body, an imaging atlas was created and is available online as supplementary material.
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Studies investigating the toxicity profile of ferumoxytol and ferumoxtran reported less than 1% serious side effects and 10-20% moderate adverse events.
“Studies investigating the toxicity profile of ferumoxytol and ferumoxtran reported less than 1% of serious side effects (including anaphylatic shock, chest pain, dyspnea and hypotension) and 10-20% of moderate adverse events (such as back pain, headache and urticaria) [135, 136].”
From Iron oxide nanoparticles: Diagnostic, therapeutic and theranostic applications (2019) · cites this paper as [136]
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Self-citationNing, P., Zucker, E. J., Wong, P., & Vasanawala, S. S. (2015) · Magnetic Resonance Imaging · doi:10.1016/j.mri.2015.10.019 · Cited by 39 · see citing works
Self-citationNeuro-oncology dilemma: Tumour or tumefactive demyelinating lesion
Abdoli, M., & Freedman, M. S. (2015) · Multiple Sclerosis and Related Disorders · doi:10.1016/j.msard.2015.07.013 · Cited by 35 · see citing works
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Self-citationQuantitative Evaluation of the Reticuloendothelial System Function with Dynamic MRI
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Gadolinium Deposition in the Brain: Do We Know Enough to Change Practice?
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Speeding up PET/MR for cancer staging of children and young adults
Aghighi, M., Pisani, L. J., Sun, Z., Klenk, C., Madnawat, H., Luna‐Fineman, S., Advani, R. H., von Eyben, R., Owen, D. R., Quon, A. S. W., et al. (2016) · European Radiology · doi:10.1007/s00330-016-4332-4 · Cited by 26 · see citing works
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MRI with Magnetic Nanoparticles Monitors Downstream Anti-Angiogenic Effects of mTOR Inhibition
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The impact of chronic renal insufficiency on vascular surgery patient outcomes
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Therapies Targeting Inflammation After Stent Implantation
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Self-citationSystemic inflammation as a predictor of clinical outcomes after lower extremity angioplasty/stenting
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Assessment of vessel size by MRI in an orthotopic model of human pancreatic cancer
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Nanoparticle-based Diagnostic Imaging of Inflammation in Rheumatic Disease
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Ferumoxytol negatively enhances T2‐weighted MRI of pedal osteomyelitis in vivo
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Self-citationMR imaging of pelvic lymph nodes
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Flagged first, then by citations
Research works printed but not linked: 1
- [110]Neuwelt EA Varallyay CG Manninger S Solymosi D Haluska M Hunt MA The potential of ferumoxytol nanoparticle magnetic resonance imaging, perfusion, and angiography in central nervous system malignancy: a pilot study Neurosurgery 2007 60 4 601 11 discussion 11–2 17415196
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Sorted by citations
Iron oxide nanoparticles: Diagnostic, therapeutic and theranostic applications
Dadfar, S. M., Roemhild, K., Drude, N. I., von Stillfried, S., Knüchel, R., Kiessling, F., & Lammers, T. (2019) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2019.01.005 · Cited by 1,181 · see citing works
- Authors
- Toth, G. B., Varallyay, C. G., Horvath, A., Bashir, M. R., Choyke, P. L., Daldrup-Link, H. E., Dosa, E., Finn, J. P., Gahramanov, S., Harisinghani, M., Macdougall, I., Neuwelt, A., Vasanawala, S. S., Ambady, P., Barajas, R., Cetas, J. S., Ciporen, J., DeLoughery, T. J., Doolittle, N. D., Fu, R., Grinstead, J., Guimaraes, A. R., Hamilton, B. E., Li, X., McConnell, H. L., Muldoon, L. L., Nesbit, G., Netto, J. P., Petterson, D., Rooney, W. D., Schwartz, D., Szidonya, L., & Neuwelt, E. A.
- Affiliations
- Duke University (US)
- National Institutes of Health (US)
- Lucile Packard Children's Hospital (US)
- University of California, Los Angeles (US)
- University of New Mexico Health Sciences Center (US)
- Harvard University (US)
- King's College Hospital (GB)
- University of Colorado Denver (US)
- Stanford Medicine (US)
- Oregon Health & Science University (US)
- Corresponding author
- Neuwelt, Edward A.
- ORCID
- Bashir, Mustafa R.
- Choyke, Peter L.
- Daldrup-Link, Heike E.
- Finn, John Paul
- Gahramanov, Seymur
- Harisinghani, Mukesh
- Macdougall, Iain
- Neuwelt, Alexander
- Vasanawala, Shreyas S.
- Ambady, Prakash
- Barajas, Ramon
- Cetas, Justin S.
- Ciporen, Jeremy
- Fu, Rongwei
- Hamilton, Bronwyn E.
- Li, Xin
- McConnell, Heather L.
- Muldoon, Leslie L.
- Rooney, William D.
- Szidonya, Laszlo
- Neuwelt, Edward A.
- Venue
- Kidney International
- Publisher
- Elsevier BV
- Published
- 2017-07
- Volume
- 92
- Issue
- 1
- Pages
- 47-66
- ISSN
- 0085-2538 (ISSN-L)
- PMC
- PMC5505659
- OpenAlex
- W2607015440
- Cited by
- 317
- References
- 108
- Citations by year
- 2026: 25 · 2025: 37 · 2024: 26 · 2023: 31 · 2022: 27 · 2021: 52 · 2020: 49 · 2019: 42 · 2018: 23 · 2017: 5
- FWCI
- 4.92
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Kidney International (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- eScholarship (California Digital Library) (submittedVersion)
- Funders
- National Institutes of Health (5r01hd081123-05, HHSN261200800001C)
- National Heart, Lung, and Blood Institute (R01HL127153)
- National Cancer Institute (R21CA176519, HHSN261200800001E), R21CA190196, R01CA137488)
- National Institute of Neurological Disorders and Stroke (R01NS053468)
- National Institute of Arthritis and Musculoskeletal and Skin Diseases (R21AR066302, R01AR054458)
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (R01-HD081123)
- Topics
- Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Advanced MRI Techniques and Applications
- Physical Sciences › Materials Science › Materials Chemistry › Lanthanide and Transition Metal Complexes
- Physical Sciences › Engineering › Biomedical Engineering › Characterization and Applications of Magnetic Nanoparticles
- Keywords
- ferumoxytol, MRI contrast agents, iron-based contrast agents, gadolinium alternatives, renal dysfunction, cellular uptake, central nervous system imaging, cardiovascular imaging, anaphylactoid reactions, contrast media safety
- MeSH terms
- Adolescent, Adult, Animals, Atlases as Topic, Child, Preschool, Contrast Media, Female, Hematinics, Humans, Kidney, Magnetic Resonance Imaging, Male, Middle Aged, Predictive Value of Tests, Reproducibility of Results, Renal Insufficiency, Chronic, Ferrosoferric Oxide, Renal Elimination
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
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