WIN 55,212-2 prevents mechanical allodynia but not alterations in feeding behaviour induced by chronic cisplatin in the rat
Abstract
Anorexia, nausea/emesis and peripheral sensorial neuropathy are frequent adverse effects associated with chemotherapy. Cannabinoids have been proposed to alleviate these effects, but their preventive properties in long-term experimental models have not been tested. This study was conducted to determine whether or not a cannabinoid agonist (WIN-55,212-2) can prevent anorexia, pica (an indirect marker of nausea in non-vomiting species, consisting of the ingestion of non-nutritive substances such as kaolin) and mechanical allodynia (a marker of peripheral neuropathy) induced by the antineoplastic drug cisplatin chronically administered. Isolated rats with free access to food and kaolin received either saline, cannabinoid vehicle, WIN-55,212-2 (1-2 mg kg(-1)), cisplatin (1-2 mg kg(-1)), or both drugs once per week for five consecutive weeks. Modifications in temperature, body weight gain, food and kaolin intake, and the threshold for mechanical allodynia were recorded. Additionally, the acute psychoactive effects of the cannabinoid (hypomotility, hypothermia, analgesia and catalepsia) were assayed by means of the cannabinoid tetrad. WIN 55,212-2 prevented the development of mechanical allodynia but not anorexia, pica and reduction in weight gain induced by chronic cisplatin. The effect of WIN 55,212-2 was evident even at a dose lacking activity in the cannabinoid tetrad. The preventive effect on cisplatin-induced mechanical allodynia exerted by the cannabinoid could be due to a neuroprotective role, as has been suggested for other conditions. The present results support the interest in the evaluation of cannabinoids for treatment of patients suffering or likely to suffer neuropathic pain.
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WIN55,212-2 prevented the development of mechanical allodynia induced by cisplatin, but failed to produce an anti-emetic benefit.
“WIN55,212-2 prevented the development of mechanical allodynia induced by cisplatin, but failed to produce an anti-emetic benefit in this study.116”
From Cannabinoids as Pharmacotherapies for Neuropathic Pain: From the Bench to the Bedside (2009) · cites this paper as [116]
Cites
A peripheral mononeuropathy in rat that produces disorders of pain sensation like those seen in man
Bennett, G. J., & Xie, Y.-K. (1988) · Pain · doi:10.1016/0304-3959(88)90209-6 · Cited by 5,376 · see citing works
The causes and consequences of cancer-associated malnutrition
Cutsem, E. V., & Arends, J. (2005) · European Journal of Oncology Nursing · doi:10.1016/j.ejon.2005.09.007 · Cited by 629 · see citing works
Cannabinoids for control of chemotherapy induced nausea and vomiting: quantitative systematic review
Tramèr, M. R., Carroll, D., Campbell, F. A., Reynolds, D. J. M., Moore, R. A., & McQuay, H. J. (2001) · BMJ · doi:10.1136/bmj.323.7303.16 · Cited by 610 · see citing works
Cannabinoids in medicine: A review of their therapeutic potential
Ben Amar, M. (2006) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2006.02.001 · Cited by 543 · see citing works
A Peripheral Mechanism for CB1 Cannabinoid Receptor-Dependent Modulation of Feeding
Gómez, R., Navarro, M., Ferrer, B., Trigo, J. M., Bilbao, A., del Arco, I., Cippitelli, A., Nava, F. A., Piomelli, D., & de Fonseca, F. R. (2002) · Journal of Neuroscience · doi:10.1523/jneurosci.22-21-09612.2002 · Cited by 486 · see citing works
A painful peripheral neuropathy in the rat produced by the chemotherapeutic drug, paclitaxel
Polomano, R. C., Mannes, A. J., Clark, U. S., & Bennett, G. J. (2001) · Pain · doi:10.1016/s0304-3959(01)00363-3 · Cited by 476 · see citing works
Fox, A., Kesingland, A., Gentry, C., McNair, K., Patel, S., Urban, L., & James, I. (2001) · Pain · doi:10.1016/s0304-3959(00)00474-7 · Cited by 379 · see citing works
Endogenous cannabinoid system as a modulator of food intake
Cota, D., Marsicano, G., Lutz, B., Vicennati, V., Stalla, G. K., Pasquali, R., & Pagotto, U. (2003) · International Journal of Obesity · doi:10.1038/sj.ijo.0802250 · Cited by 313 · see citing works
Neuroprotective Effect of Vitamin E Supplementation in Patients Treated With Cisplatin Chemotherapy
Pace, A., Savarese, A., Picardo, M., Maresca, V., Pacetti, U., Monte, G. D., Biroccio, A., Leonetti, C., Jandolo, B., Cognetti, F., et al. (2003) · Journal of Clinical Oncology · doi:10.1200/jco.2003.05.139 · Cited by 308 · see citing works
Interventions for preventing neuropathy caused by cisplatin and related compounds
Albers, J. W., Chaudhry, V., Cavaletti, G., & Donehower, R. C. (2014) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd005228.pub4 · Cited by 302 · see citing works
Pica in rats is analogous to emesis: An animal model in emesis research
Takeda, N., Hasegawa, S., Morita, M., & Matsunaga, T. (1993) · Pharmacology Biochemistry and Behavior · doi:10.1016/0091-3057(93)90126-e · Cited by 272 · see citing works
Signals for nausea and emesis: Implications for models of upper gastrointestinal diseases
Andrews, P. L. R., & Horn, C. C. (2006) · Autonomic Neuroscience · doi:10.1016/j.autneu.2006.01.008 · Cited by 254 · see citing works
Prevention of chemotherapy and radiation toxicity with glutamine
Savarese, D. M. F., Savy, G. K., Vahdat, L. T., Wischmeyer, P. E., & Corey, B. (2003) · Cancer Treatment Reviews · doi:10.1016/s0305-7372(03)00133-6 · Cited by 238 · see citing works
Vitamin E for prophylaxis against chemotherapy-induced neuropathy
Argyriou, A. A., Chroni, E., Koutras, A. K., Ellul, J., Papapetropoulos, S., Katsoulas, G., Iconomou, G., & Kalofonos, H. P. (2005) · Neurology · doi:10.1212/01.wnl.0000148609.35718.7d · Cited by 210 · see citing works
Cannabinoid Receptors and Their Role in Neuroprotection
van der Stelt, M., & Marzo, V. D. (2005) · NeuroMolecular Medicine · doi:10.1385/nmm:7:1-2:037 · Cited by 189 · see citing works
The ring test: a quantitative method for assessing the ‘cataleptic’ effect of cannabis in mice
Pertwee, R. G. (1972) · British Journal of Pharmacology · doi:10.1111/j.1476-5381.1972.tb06900.x · Cited by 189 · see citing works
Toxic neuropathy in patients with pre-existing neuropathy
Chaudhry, V., Chaudhry, M. A., Crawford, T. O., Simmons-OʼBrien, E., & Griffin, J. W. (2003) · Neurology · doi:10.1212/01.wnl.0000043691.53710.53 · Cited by 173 · see citing works
An animal model of nociceptive peripheral neuropathy following repeated cisplatin injections
Authier, N. (2003) · Experimental Neurology · doi:10.1016/s0014-4886(03)00003-7 · Cited by 165 · see citing works
Mitchell, D., Wells, C., Hoch, N. E., Lind, K., Woods, S. C., & Mitchell, L. K. (1976) · Physiology & Behavior · doi:10.1016/0031-9384(76)90171-2 · Cited by 163 · see citing works
Chemotherapy-induced peripheral neuropathy: pathogenesis and emerging therapies
Ocean, A. J., & Vahdat, L. (2004) · Supportive Care in Cancer · doi:10.1007/s00520-004-0657-7 · Cited by 162 · see citing works
Pertwee, R. G., Stevenson, L. A., Elrick, D. B., Mechoulam, R., & Corbett, A. D. (1992) · British Journal of Pharmacology · doi:10.1111/j.1476-5381.1992.tb09088.x · Cited by 159 · see citing works
Bianchi, G., Vitali, G., Caraceni, A. T., Ravaglia, S., Capri, G., Cundari, S., Zanna, C., & Gianni, L. (2005) · European Journal of Cancer · doi:10.1016/j.ejca.2005.04.028 · Cited by 152 · see citing works
Reduction of paclitaxel-induced peripheral neuropathy with glutamine.
Vahdat, L. T., Papadopoulos, K. P., Lange, D., Leuin, S. C., Kaufman, E. A., Donovan, D., Frederick, D., Bagiella, E., Tiersten, A., NICHOLS, G. L., et al. (2001) · PubMed · Cited by 149 · see citing works
de Wit, R., Herrstedt, J., Rapoport, B. L., Carides, A. D., Guoguang-Ma, J., Elmer, M. E., Schmidt, C., Evans, J. K., & Horgan, K. J. (2004) · PubMed · Cited by 144 · see citing works
Sepers, M. D., Oland, L. D., Mackie, K., Davison, J. S., & Sharkey, K. A. (2003) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00113.2003 · Cited by 141 · see citing works
Toxicities of the platinum antineoplastic agents
Markman, M. M. (2003) · Expert Opinion on Drug Safety · doi:10.1517/14740338.2.6.597 · Cited by 137 · see citing works
Jordan, K., Kasper, C., & Schmoll, H. (2004) · European Journal of Cancer · doi:10.1016/j.ejca.2004.09.026 · Cited by 132 · see citing works
Kwiatkowska, M., Parker, L., Burton, P., & Mechoulam, R. (2004) · Psychopharmacology · doi:10.1007/s00213-003-1739-9 · Cited by 131 · see citing works
A cannabinoid agonist, WIN 55,212-2, reduces neuropathic nociception induced by paclitaxel in rats
Pascual, D., Goicoechea, C., Suardíaz, M., & Martín, M. I. (2005) · Pain · doi:10.1016/j.pain.2005.07.008 · Cited by 117 · see citing works
Self-citationToxicity and Carcinogenicity of Δ9-Tetrahydrocannabinol in Fischer Rats and B6C3F1 Mice
Chan, P. C. (1996) · Fundamental and Applied Toxicology · doi:10.1006/faat.1996.0048 · Cited by 113 · see citing works
A New Animal Model of Vincristine-Induced Nociceptive Peripheral Neuropathy
Authier, N., Gillet, J.-P., Fialip, J., Eschalier, A., & Coudoré, F. (2003) · NeuroToxicology · doi:10.1016/s0161-813x(03)00043-3 · Cited by 110 · see citing works
Darmani, N. A. (2001) · Pharmacology Biochemistry and Behavior · doi:10.1016/s0091-3057(01)00531-7 · Cited by 103 · see citing works
Costa, B., Siniscalco, D., Trovato, A. E., Comelli, F., Sotgiu, M. L., Colleoni, M., Maione, S., Rossi, F., & Giagnoni, G. (2006) · British Journal of Pharmacology · doi:10.1038/sj.bjp.0706798 · Cited by 99 · see citing works
La Rana, G., Russo, R., Campolongo, P., Bortolato, M., Mangieri, R. A., Cuomo, V., Iacono, A., Raso, G. M., Meli, R., Piomelli, D., et al. (2006) · The Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.105.100792 · Cited by 97 · see citing works
Review: The Management of Nausea and Vomiting in Clinical Oncology
Craig, J. B., & Powell, B. L. (1987) · The American Journal of the Medical Sciences · doi:10.1097/00000441-198701000-00008 · Cited by 97 · see citing works
Costa, B., Colleoni, M., Conti, S., Trovato, A. E., Bianchi, M., Sotgiu, M. L., & Giagnoni, G. (2004) · British Journal of Pharmacology · doi:10.1038/sj.bjp.0705587 · Cited by 89 · see citing works
Cannabinoids and the Digestive Tract
Izzo, A. A., & Coutts, A. A. (2005) · Springer eBooks · doi:10.1007/3-540-26573-2_19 · Cited by 87 · see citing works
Palazzo, E., De Novellis, V., Petrosino, S., Marabese, I., Vita, D., Giordano, C., Di Marzo, V., Mangoni, G. S., Rossi, F., & Maione, S. (2006) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2006.05086.x · Cited by 86 · see citing works
Darmani, N. A. (2001) · European Journal of Pharmacology · doi:10.1016/s0014-2999(01)01355-3 · Cited by 84 · see citing works
Management of chemotherapy-induced peripheral neuropathy
Stillman, M. J., & Cata, J. P. (2006) · Current Pain and Headache Reports · doi:10.1007/s11916-006-0033-z · Cited by 83 · see citing works
Obesity drugs in clinical development.
Halford, J. C. G. (2006) · PubMed · Cited by 79 · see citing works
Neurophysiological Study of Peripheral Neuropathy after High-Dose Paclitaxel
Openshaw, H., Beamon, K., Synold, T. W., Longmate, J., Slatkin, N. E., Doroshow, J. H., Forman, S. J., Margolin, K. A., Morgan, R. J., Shibata, S., et al. (2004) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-0772-03 · Cited by 78 · see citing works
Cannabinoids of diverse structure inhibit two DOI-induced 5-HT2A receptor-mediated behaviors in mice
Darmani, N. A. (2001) · Pharmacology Biochemistry and Behavior · doi:10.1016/s0091-3057(00)00477-9 · Cited by 77 · see citing works
Pica in mice as a new model for the study of emesis
Yamamoto, K., Matsunaga, S., Matsui, M., Takeda, N., & Yamatodani, A. (2002) · Methods and Findings in Experimental and Clinical Pharmacology · doi:10.1358/mf.2002.24.3.802297 · Cited by 75 · see citing works
Cannabinoids and the Regulation of Ingestive Behaviour
Vickers, S. P., & Kennett, G. A. (2005) · Current Drug Targets · doi:10.2174/1389450053174514 · Cited by 74 · see citing works
The Changeable Nature of Patients' Fears Regarding Chemotherapy
Passik, S. D., Kirsh, K. L., Rosenfeld, B. D., McDonald, M. V., & Theobald, D. (2001) · Journal of Pain and Symptom Management · doi:10.1016/s0885-3924(00)00249-9 · Cited by 73 · see citing works
Anemia in cancer: update on studies of erythropoiesis-stimulating agents.
Schwartzberg, L. S. (2007) · PubMed · Cited by 70 · see citing works
Altered feeding behaviour induced by long-term cisplatin in rats
Vera, G., Chiarlone, A., Martin, M., & Abalo, R. (2006) · Autonomic Neuroscience · doi:10.1016/j.autneu.2006.02.011 · Cited by 58 · see citing works
Umapathi, T., & Chaudhry, V. (2005) · Current Opinion in Neurology · doi:10.1097/01.wco.0000180158.34713.aa · Cited by 57 · see citing works
Takeda, N., Hasegawa, S., Morita, M., Horii, A., Uno, A., Yamatodani, A., & Matsunaga, T. (1995) · PubMed · Cited by 54 · see citing works
Interventions for preventing neuropathy caused by cisplatin and related compounds
Albers, J. W., Chaudhry, V., Cavaletti, G., & Donehower, R. C. (2007) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd005228.pub2 · Cited by 54 · see citing works
Prevention of Emesis from Multiple-Day and High-Dose Chemotherapy Regimens
Navari, R. M. (2007) · Journal of the National Comprehensive Cancer Network · doi:10.6004/jnccn.2007.0007 · Cited by 51 · see citing works
Yamamoto, K., Ngan, M. P., Takeda, N., Yamatodani, A., & Rudd, J. A. (2004) · Physiology & Behavior · doi:10.1016/j.physbeh.2004.08.006 · Cited by 50 · see citing works
(1995) · PubMed · Cited by 47 · see citing works
Darmani, N. A., Sim‐Selley, L. J., Martin, B. R., Janoyan, J. J., Crim, J. L., Parekh, B., & Breivogel, C. S. (2003) · European Journal of Pharmacology · doi:10.1016/s0014-2999(02)02815-7 · Cited by 47 · see citing works
Weekly cisplatin ± glutathione in relapsed ovarian carcinoma
Colombo, N., BINI, S., Miceli, D. D., Bogliun, G., Marzorati, L., Cavaletti, G., Parmigiani, F., Venturino, P., Tedeschi, M., Frattola, L., et al. (1995) · International Journal of Gynecological Cancer · doi:10.1046/j.1525-1438.1995.05020081.x · Cited by 44 · see citing works
The emerging role of cannabinoid neuromodulators in symptom management
Davis, M. P., Maida, V., Daeninck, P. J., & Pergolizzi, J. V. (2006) · Supportive Care in Cancer · doi:10.1007/s00520-006-0180-0 · Cited by 37 · see citing works
Higgs, S., Barber, D. J., Cooper, A. J., & Terry, P. (2005) · Behavioural Pharmacology · doi:10.1097/00008877-200509000-00011 · Cited by 36 · see citing works
Chemotherapy-induced peripheral neuropathy: Underreported and underappreciated
Markman, M. M. (2006) · Current Pain and Headache Reports · doi:10.1007/s11916-006-0032-0 · Cited by 34 · see citing works
Neurotoxicity of cisplatin and taxol
Warner, E. (1995) · International Journal of Gynecological Cancer · doi:10.1046/j.1525-1438.1995.05030161.x · Cited by 32 · see citing works
A model of peripheral mononeuropathy in the rat
Bennett, G. J., & Hargreaves, K. (1990) · Pain · doi:10.1016/0304-3959(90)91170-n · Cited by 15 · see citing works
deWit, R., Herrstedt, J., Rapoport, B. L., Carides, A. D., Guoguang-Ma, J., Elmer, M. E., SCHMIDT, C., Evans, J. K., & Horgan, K. J. (2004) · European Journal of Cancer · doi:10.1016/s0959-8049(03)00931-6 · Cited by 14 · see citing works
Martı́n, M. I., Vera, G., Chiarlone, A., Cabezos, P. A., & Abalo, R. (2006) · European Journal of Pain · doi:10.1016/s1090-3801(06)60216-4 · Cited by 3 · see citing works
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1 of the 64 references couldn’t be matched to a known paper.
Cited by
Sorted by citations
Animal models of neuropathic pain
Jaggi, A. S., Jain, V., & Singh, N. (2010) · Fundamental and Clinical Pharmacology · doi:10.1111/j.1472-8206.2009.00801.x · Cited by 391 · see citing works
Cannabinoids as Pharmacotherapies for Neuropathic Pain: From the Bench to the Bedside
Rahn, E. J., & Hohmann, A. G. (2009) · Neurotherapeutics · doi:10.1016/j.nurt.2009.08.002 · Cited by 305 · see citing works
Mechanisms of Chemotherapy-Induced Neurotoxicity
Waś, H., Borkowska, A., Bagüés, A., Tu, L., Liu, J. Y. H., Lu, Z., Rudd, J. A., Nurgali, K., & Abalo, R. (2022) · Frontiers in Pharmacology · doi:10.3389/fphar.2022.750507 · Cited by 289 · see citing works
Lynch, M. E., Cesar-Rittenberg, P., & Hohmann, A. G. (2014) · Journal of Pain and Symptom Management · doi:10.1016/j.jpainsymman.2013.02.018 · Cited by 266 · see citing works
High Fat/High Glucose Diet Induces Metabolic Syndrome in an Experimental Rat Model
Moreno-Fernández, S., Garcés‐Rimón, M., Vera, G., Astier, J., Landrier, J., & Miguel, M. (2018) · Nutrients · doi:10.3390/nu10101502 · Cited by 237 · see citing works
Regulation of nausea and vomiting by cannabinoids and the endocannabinoid system
Sharkey, K. A., Darmani, N. A., & Parker, L. A. (2013) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2013.09.068 · Cited by 195 · see citing works
Ta, L. E., Bieber, A. J., Carlton, S. M., Loprinzi, C. L., Low, P. A., & Windebank, A. J. (2010) · Molecular Pain · doi:10.1186/1744-8069-6-15 · Cited by 193 · see citing works
Guindon, J., Lai, Y., Takacs, S. M., Bradshaw, H. B., & Hohmann, A. G. (2013) · Pharmacological Research · doi:10.1016/j.phrs.2012.10.013 · Cited by 160 · see citing works
The analgesic potential of cannabinoids.
Elikottil, M., Gupta, M., & Gupta, P. (2018) · Journal of Opioid Management · doi:10.5055/jom.2009.0034 · Cited by 141 · see citing works
Chemotherapy-induced neuropathic pain
Farquhar-Smith, P. W. (2010) · Current Opinion in Supportive and Palliative Care · doi:10.1097/spc.0b013e328342f9cc · Cited by 124 · see citing works
Animal Models of Chemotherapy-Evoked Painful Peripheral Neuropathies
Authier, N., Balayssac, D., Marchand, F., Ling, B., Zangarelli, A., Descoeur, J., Coudoré, F., Bourinet, E., & Eschalier, A. (2009) · Neurotherapeutics · doi:10.1016/j.nurt.2009.07.003 · Cited by 120 · see citing works
Enteric neuropathy evoked by repeated cisplatin in the rat
Vera, G., Castillo, M. I., Cabezos, P. A., Chiarlone, A., Martín, M. I., Gori, A., Pasquinelli, G., Barbara, G., Stanghellini, V., Corinaldesi, R., et al. (2011) · Neurogastroenterology & Motility · doi:10.1111/j.1365-2982.2011.01674.x · Cited by 86 · see citing works
Cabezos, P. A., Vera, G., Martín‐Fontelles, M. I., Fernández‐pujol, R., & Abalo, R. (2010) · Neurogastroenterology & Motility · doi:10.1111/j.1365-2982.2010.01483.x · Cited by 70 · see citing works
Cannabinoids: Current and Future Options to Treat Chronic and Chemotherapy-Induced Neuropathic Pain
Blanton, H. L., Brelsfoard, J., Deturk, N., Pruitt, K., Narasimhan, M., Morgan, D. J., & Guindon, J. (2019) · Drugs · doi:10.1007/s40265-019-01132-x · Cited by 70 · see citing works
Rahn, E. J., Deng, L., Thakur, G. A., Vemuri, K. V., Zvonok, A. M., Lai, Y. Y., Makriyannis, A., & Hohmann, A. G. (2014) · Molecular Pain · doi:10.1186/1744-8069-10-27 · Cited by 65 · see citing works
The Gastrointestinal Pharmacology of Cannabinoids: Focus on Motility
Abalo, R., Vera, G., López-Pérez, A. E., Martínez-Villaluenga, M., & Martı́n, M. I. (2012) · Pharmacology · doi:10.1159/000339072 · Cited by 63 · see citing works
Guindon, J., Deng, L., Fan, B., Wager‐Miller, J., & Hohmann, A. G. (2014) · Molecular Pain · doi:10.1186/1744-8069-10-56 · Cited by 62 · see citing works
Xu, J. J., Diaz, P., Astruc‐Diaz, F., Craig, S. L., Muñoz, E., & Naguib, M. (2010) · Anesthesia & Analgesia · doi:10.1213/ane.0b013e3181e0cdaf · Cited by 51 · see citing works
Pascual, D., Goicoechea, C., Burgos, E., & Martín, M. I. (2010) · Pharmacology Biochemistry and Behavior · doi:10.1016/j.pbb.2010.02.009 · Cited by 52 · see citing works
The flavonoid 6-methoxyflavone allays cisplatin-induced neuropathic allodynia and hypoalgesia
Shahid, M. M., Subhan, F., Ahmad, N., & Sewell, R. D. E. (2017) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2017.09.108 · Cited by 52 · see citing works
Characterization of Cardiovascular Alterations Induced by Different Chronic Cisplatin Treatments
Herradón, E., González, C., Uranga, J. A., Abalo, R., Martin, M., & López‐Miranda, V. (2017) · Frontiers in Pharmacology · doi:10.3389/fphar.2017.00196 · Cited by 51 · see citing works
Chemotherapy-induced painful neuropathy
Hopkins, H. L., Duggett, N. A., & Flatters, S. J. L. (2016) · Current Opinion in Supportive and Palliative Care · doi:10.1097/spc.0000000000000204 · Cited by 47 · see citing works
Cannabinoid pharmacology and therapy in gut disorders
Uranga, J. A., Vera, G., & Abalo, R. (2018) · Biochemical Pharmacology · doi:10.1016/j.bcp.2018.07.048 · Cited by 46 · see citing works
Song, M. Y., Ku, S., Kim, H. J., & Han, J. S. (2012) · Food and Chemical Toxicology · doi:10.1016/j.fct.2012.09.020 · Cited by 43 · see citing works
Vera, G., López‐Miranda, V., Herradón, E., Martı́n, M. I., & Abalo, R. (2012) · Pharmacology Biochemistry and Behavior · doi:10.1016/j.pbb.2012.05.008 · Cited by 41 · see citing works
Animal Models of Peripheral Pain: Biology Review and Application for Drug Discovery
Kaliyaperumal, S., Wilson, K. L., Aeffner, F., & Dean, C. (2019) · Toxicologic Pathology · doi:10.1177/0192623319857051 · Cited by 40 · see citing works
Abalo, R., Cabezos, P. A., López‐Miranda, V., Vera, G., González, C., Castillo, M. I., Fernández‐pujol, R., & Martı́n, M. I. (2009) · Neurogastroenterology & Motility · doi:10.1111/j.1365-2982.2009.01315.x · Cited by 39 · see citing works
Masocha, W. (2018) · Pain Research and Management · doi:10.1155/2018/5234943 · Cited by 37 · see citing works
Abalo, R., Cabezos, P. A., Vera, G., López‐Miranda, V., Herradón, E., & Martı́n, M. I. (2011) · Neurogastroenterology & Motility · doi:10.1111/j.1365-2982.2011.01677.x · Cited by 35 · see citing works
Shahid, F., Farooqui, Z., Khan, A. A., & Khan, F. (2018) · Naunyn-Schmiedeberg s Archives of Pharmacology · doi:10.1007/s00210-017-1444-6 · Cited by 34 · see citing works
Ahmad, N., Subhan, F., Islam, N. U., Shahid, M. M., Rahman, F., & Sewell, R. D. E. (2017) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2017.08.040 · Cited by 33 · see citing works
Łuszczki, J. J., & Florek-Łuszczki, M. (2012) · Pharmacological Reports · doi:10.1016/s1734-1140(12)70867-8 · Cited by 28 · see citing works
López‐Gómez, L., Díaz-Ruano, S., Girón, R., López-Pérez, A. E., Vera, G., Herradón, E., López‐Miranda, V., Nurgali, K., Martı́n, M. I., Uranga, J. A., et al. (2018) · Neurogastroenterology & Motility · doi:10.1111/nmo.13399 · Cited by 28 · see citing works
Cannabinoids may worsen gastric dysmotility induced by chronic cisplatin in the rat
Abalo, R., Cabezos, P. A., Vera, G., López-Pérez, A. E., & Martı́n, M. I. (2013) · Neurogastroenterology & Motility · doi:10.1111/nmo.12073 · Cited by 28 · see citing works
Abalo, R., Cabezos, P. A., Vera, G., Fernández‐pujol, R., & Martı́n, M. I. (2010) · Neurogastroenterology & Motility · doi:10.1111/j.1365-2982.2009.01466.x · Cited by 26 · see citing works
Alterations in the small intestinal wall and motor function after repeated cisplatin in rat
Uranga, J. A., García-Martínez, J. M., García‐Jiménez, C., Vera, G., Martı́n, M. I., & Abalo, R. (2017) · Neurogastroenterology & Motility · doi:10.1111/nmo.13047 · Cited by 25 · see citing works
Rizzetti, D. A., Fernández, F., Moreno-Fernández, S., Uranga, J. A., Peçanha, F. M., Vera, G., Vassallo, D. V., Miguel, M., & Wiggers, G. A. (2016) · Brain Research · doi:10.1016/j.brainres.2016.06.037 · Cited by 23 · see citing works
Update on cannabis and cannabinoids for cancer pain
Chung, M. J., Kim, H. K., & Abdi, S. (2020) · Current Opinion in Anaesthesiology · doi:10.1097/aco.0000000000000934 · Cited by 24 · see citing works
Martinez, C. S., Vera, G., Uranga, J. A., Peçanha, F. M., Vassallo, D. V., Miguel, M., & Wiggers, G. A. (2017) · Journal of Inorganic Biochemistry · doi:10.1016/j.jinorgbio.2017.08.011 · Cited by 22 · see citing works
Ostadhadi, S., Rahmatollahi, M., Dehpour, A. R., & Rahimian, R. (2014) · Phytotherapy Research · doi:10.1002/ptr.5265 · Cited by 19 · see citing works
Chronic pain and cannabinoids. Great expectations or a christmas carol
Pascual, D., Sánchez-Robles, E., García, M. M., & Goicoechea, C. (2018) · Biochemical Pharmacology · doi:10.1016/j.bcp.2018.07.033 · Cited by 22 · see citing works
Endocannabinoid Mechanisms Influencing Nausea
Sticht, M. A., Rock, E. M., Limebeer, C. L., & Parker, L. A. (2015) · International review of neurobiology · doi:10.1016/bs.irn.2015.09.001 · Cited by 20 · see citing works
Bagüés, A., López‐Tofiño, Y., Llorente‐Berzal, A., & Abalo, R. (2022) · Behavioural Pharmacology · doi:10.1097/fbp.0000000000000667 · Cited by 18 · see citing works
Alterations of colonic sensitivity and gastric dysmotility after acute cisplatin and granisetron
Martín‐Ruíz, M., Uranga, J. A., Mosińska, P., Fichna, J., Nurgali, K., Martín‐Fontelles, M. I., & Abalo, R. (2018) · Neurogastroenterology & Motility · doi:10.1111/nmo.13499 · Cited by 18 · see citing works
Vera, G., López-Pérez, A. E., Martínez-Villaluenga, M., Cabezos, P. A., & Abalo, R. (2014) · Experimental Brain Research · doi:10.1007/s00221-014-3954-5 · Cited by 17 · see citing works
López‐Gómez, L., Szymaszkiewicz, A., Zielińska, M., & Abalo, R. (2022) · Molecules · doi:10.3390/molecules27196773 · Cited by 16 · see citing works
Guindon, J., & Hohmann, A. G. (2013) · Neuroscience Letters · doi:10.1016/j.neulet.2013.03.033 · Cited by 14 · see citing works
Dönertaş, B., Ünel, Ç. Ç., & Erol, K. (2018) · Journal of Experimental Pharmacology · doi:10.2147/jep.s162059 · Cited by 14 · see citing works
Evaluating the various phases of cisplatin-induced emesis in rats
SHI, J. (2014) · Oncology Letters · doi:10.3892/ol.2014.2506 · Cited by 13 · see citing works
Pretreatment with Oxygen Protects Rat Kidney from Cisplatin Nephrotoxicity
Rasoulian, B., Jafari, M., Mahbod, M., Esmailidehaj, M., Nowrozi, M., Wahhabaghai, H., Mofid, M., Ghasemi, A., Bigdeli, M. R., & Khoshbaten, A. (2010) · Renal Failure · doi:10.3109/08860221003592838 · Cited by 13 · see citing works
Vera, G., Girón, R., Martı́n, M. I., & Abalo, R. (2019) · Neurogastroenterology & Motility · doi:10.1111/nmo.13621 · Cited by 13 · see citing works
Emerging Roles of Cannabinoids and Synthetic Cannabinoids in Clinical Experimental Models
Morales, P., & Reggio, P. H. (2020) · Advances in experimental medicine and biology · doi:10.1007/978-3-030-57369-0_4 · Cited by 13 · see citing works
Gong, Y., Liu, Y., Liu, F., Wang, S., Jin, H. Y., Guo, F., & Xu, L. (2017) · Brain Research · doi:10.1016/j.brainres.2017.01.004 · Cited by 11 · see citing works
López‐Tofiño, Y., Vera, G., López‐Gómez, L., Girón, R., Nurgali, K., Uranga, J. A., & Abalo, R. (2020) · Neurogastroenterology & Motility · doi:10.1111/nmo.14020 · Cited by 11 · see citing works
Cannabinoids and Effects on the Gastrointestinal Tract: A Focus on Motility
Vera, G., Fichna, J., & Abalo, R. (2017) · Elsevier eBooks · doi:10.1016/b978-0-12-800756-3.00114-9 · Cited by 9 · see citing works
Chemotherapy‐Induced Neuropathy Affecting the Gastrointestinal Tract
Vera, G., Nurgali, K., & Abalo, R. (2024) · Neurogastroenterology & Motility · doi:10.1111/nmo.14976 · Cited by 8 · see citing works
Díaz-Ruano, S., López-Pérez, A. E., Girón, R., Pérez-García, I., Martı́n, M. I., & Abalo, R. (2019) · Journal of Neurogastroenterology and Motility · doi:10.5056/jnm18202 · Cited by 7 · see citing works
May a sigma‐1 antagonist improve neuropathic signs induced by cisplatin and vincristine in rats?
Paniagua, N., Goicoechea, C., Abalo, R., López‐Miranda, V., Vela, J. M., Merlos, M., Fontelles, M. I. M., & Girón, R. (2018) · European Journal of Pain · doi:10.1002/ejp.1333 · Cited by 7 · see citing works
Modulation of Pain by Endocannabinoids in the Periphery
Uhelski, M. L., Khasabova, I. A., & Simone, D. A. (2019) · IntechOpen eBooks · doi:10.5772/intechopen.79673 · Cited by 5 · see citing works
MODELS FOR NEUROPATHIC PAIN: A REVIEW
Tyagi, N., & Goel, R. (2014) · International Journal of Pharmacy and Pharmaceutical Sciences · Cited by 3 · see citing works
Medical marijuana in cancer: harmful or harm reduction?
Thielmann, A., & Daeninck, P. J. (2013) · Clinical Practice · doi:10.2217/cpr.13.15 · Cited by 3 · see citing works
Animal models of cisplatin‐induced neuropathic pain
Li, N., Li, M., Jin, S., Yu, J., Wei, H., Wang, W., Ma, S., Jiang, Y., Liu, Q., & Yao, H. (2025) · Animal Models and Experimental Medicine · doi:10.1002/ame2.12548 · Cited by 2 · see citing works
Fotinos, A., Zhu, Y., Mao, L. L. J., Atassi, N., Zhou, E., Ahmad, S., Guan, Y., Berry, J. D., Cudkowicz, M., & Wang, X. (2016) · Springer eBooks · doi:10.1007/978-81-322-2803-5_51 · Cited by 2 · see citing works
Cannabinoids to Fight Chemotherapy-Induced Adverse Effects
Bagüés, A., Benítez, D., & Abalo, R. (2023) · Springer eBooks · doi:10.1007/978-3-030-80962-1_350-2 · Cited by 1 · see citing works
The Management of Neuropathic Pain
Toth, C., & Moulin, D. E. (2013) · Cambridge University Press eBooks · doi:10.1017/cbo9781139152211.019 · Cited by 1 · see citing works
M’Dahoma, S., Bourgoin, S., & Hamon, M. (2014) · Methods and principles in medicinal chemistry · doi:10.1002/9783527679348.ch14 · Cited by 1 · see citing works
Ware, M. A. (2013) · Cambridge University Press eBooks · doi:10.1017/cbo9781139152211.022
Cannabinoids to Fight Chemotherapy-Induced Adverse Effects
Bagüés, A., Benítez, D., & Abalo, R. (2023) · Springer eBooks · doi:10.1007/978-3-030-80962-1_350-1
Cannabinoids to Fight Chemotherapy-Induced Adverse Effects
Bagüés, A., Benítez, D., & Abalo, R. (2025) · Springer eBooks · doi:10.1007/978-3-032-00775-9_350
Vera, G., Cabezos, P. A., Martín, M. I., & Abalo, R. (2013) · Pharmacology Biochemistry and Behavior · doi:10.1016/j.pbb.2013.02.008 · Cited by 68 · see citing works
- Authors
- Vera, G., Chiarlone, A., Cabezos, P. A., Pascual, D., Martín, M. I., & Abalo, R.
- Affiliations
- Universidad Rey Juan Carlos (ES)
- Corresponding author
- Abalo, Raquel
- Venue
- Life Sciences
- Publisher
- Elsevier BV
- Published
- 2007-07
- Volume
- 81
- Issue
- 6
- Pages
- 468-479
- ISSN
- 0024-3205 (ISSN-L)
- OpenAlex
- W2076898181
- Cited by
- 73
- References
- 64
- Citations by year
- 2025: 2 · 2024: 1 · 2023: 2 · 2022: 3 · 2020: 3 · 2019: 5 · 2018: 11 · 2017: 7 · 2016: 3 · 2015: 1 · 2014: 7 · 2013: 9 · 2012: 5
- FWCI
- 2.66
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Life Sciences (publishedVersion)
- PubMed (publishedVersion)
- Funders
- European Commission
- Universidad Rey Juan Carlos
- Topics
- Health Sciences › Medicine › Pharmacology › Cannabis and Cannabinoid Research
- Health Sciences › Medicine › Oncology › Cancer Treatment and Pharmacology
- Health Sciences › Medicine › Surgery › Nausea and vomiting management
- Keywords
- WIN 55,212-2, cannabinoids, cisplatin, chemotherapy-induced peripheral neuropathy, mechanical allodynia, anorexia, pica, nausea, feeding behaviour, neuroprotection, neuropathic pain, antineoplastic drug adverse effects
- MeSH terms
- Analgesics, Animals, Antidiarrheals, Antineoplastic Agents, Body Temperature, Body Weight, Cisplatin, Feeding Behavior, Kaolin, Male, Morpholines, Naphthalenes, Pain, Peripheral Nervous System Diseases, Pica, Rats, Wistar, Benzoxazines, Rats
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