Licorice flavonoid oil enhances muscle mass in KK-A mice
Abstract
Aims Muscle mass is regulated by the balance between the synthesis and degradation of muscle proteins. Loss of skeletal muscle mass is associated with an increased risk of developing metabolic diseases such as obesity and type 2 diabetes mellitus. The aim of this study was to clarify the effects of licorice flavonoid oil on muscle mass in KK-A y/Ta mice.Main methods Male genetically type II diabetic KK-A y/Ta mice received 0, 1, or 1.5 g/kg BW of licorice flavonoid oil by mouth once daily for 4 weeks. After 4 weeks, the femoral and soleus muscles were collected for western blotting for evaluation of the mTOR/p70 S6K, p38/FoxO3a, and Akt/FoxO3a signaling pathways.Key findings Ingestion of licorice flavonoid oil significantly enhanced femoral muscle mass without affecting body weight in KK-A y/Ta mice. Licorice flavonoid oil also decreased expression of MuRF1 and atrogin-1, which are both markers of muscle atrophy. The mechanisms by which licorice flavonoid oil enhances muscle mass include activation of mTOR and p70 S6K, and regulation of phosphorylation of FoxO3a.Significance Ingestion of licorice flavonoids may help to prevent muscle atrophy.
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Oral administration of licorice flavonoid oil decreases the expression of MuRF1 and MAFbx in KK-Ay mice, related to activation of mTOR, p70S6K, and FoxO3a.
“Oral administration of licorice flavonoid oil significantly enhances femoral muscle mass in KK-Ay mice and decreases the expression of MuRF1 and MAFbx, which is related to the activation of mTOR, p70S6K, and FoxO3a [104].”
From Nutraceuticals in the Prevention and Treatment of the Muscle Atrophy (2021) · cites this paper as [104]
Oral administration of licorice flavonoid oil significantly enhances femoral muscle mass in KK-Ay mice.
“Oral administration of licorice flavonoid oil significantly enhances femoral muscle mass in KK-Ay mice and decreases the expression of MuRF1 and MAFbx, which is related to the activation of mTOR, p70S6K, and FoxO3a [104].”
From Nutraceuticals in the Prevention and Treatment of the Muscle Atrophy (2021) · cites this paper as [104]
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- Authors
- Yoshioka, Y., Yamashita, Y., Kishida, H., Nakagawa, K., & Ashida, H.
- Affiliations
- Kobe University (JP)
- Kaneka (Japan) (JP)
- Corresponding author
- Yoshioka, Yasukiyo
- Venue
- Life Sciences
- Publisher
- Elsevier BV
- Published
- 2018-07
- Volume
- 205
- Pages
- 91-96
- ISSN
- 0024-3205 (ISSN-L)
- OpenAlex
- W2804138248
- Cited by
- 39
- References
- 37
- Citations by year
- 2026: 1 · 2025: 3 · 2024: 2 · 2023: 3 · 2022: 8 · 2021: 9 · 2020: 7 · 2019: 6
- FWCI
- 1.96
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Life Sciences (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Ministry of Education, Culture, Sports, Science and Technology
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Muscle Physiology and Disorders
- Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmacology › Pharmacological Effects of Natural Compounds
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Muscle metabolism and nutrition
- Keywords
- muscle mass, muscle atrophy, type 2 diabetes, FOXO3, p38 MAPK, Akt signaling, MuRF1, atrogin-1, skeletal muscle, obesity
- MeSH terms
- Tripartite Motif Proteins, Forkhead Box Protein O3, Animals, Carrier Proteins, Diabetes Mellitus, Experimental, Diabetes Mellitus, Type 2, Flavonoids, Glycyrrhiza, Male, Muscle Proteins, Organ Size, Plant Oils, Signal Transduction, Muscle, Skeletal, SKP Cullin F-Box Protein Ligases, Intracellular Signaling Peptides and Proteins, p38 Mitogen-Activated Protein Kinases, Mice, TOR Serine-Threonine Kinases
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