Student or educator? Sign up with your school email and get 6 months of Pro free.
CoChat
Sign Up
Cited by 9

The DOI matches its Crossref record; 10 of the 10 references it cites were found in a registry or an index.

Creatine supplementation protects against diet-induced non-alcoholic fatty liver but exacerbates alcoholic fatty liver

Marinello, Poliana C., Cella, Paola S., Testa, Mayra T.J., Guirro, Phillipe B., da Silva Brito, Walison Augusto, Padilha, Camila S., Cecchini, Alessandra L., da Silva, Robin P., Duarte, José Alberto R., Deminice, Rafael·2022·Life Sciences
DOI 10.1016/j.lfs.2022.121064
Open this paper in CoChat — free account

Overview

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Integrity signals

Registry

Crossref · 10.1016/j.lfs.2022.121064

Cites

10 of 10 references verified0 citation errors · 0 not checkable

Statistics

Verification

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Citations

Cites

Show all 10 references

Research works printed but not linked: 37

  1. Younossi, 2018, Global burden of NAFLD and NASH: trends, predictions, risk factors and prevention, Nat Rev Gastroenterol Hepatol, 15, 11, 10.1038/nrgastro.2017.109 · DOI · Paper page
  2. Asrani, 2019, Burden of liver diseases in the world, J. Hepatol., 70, 151, 10.1016/j.jhep.2018.09.014 · DOI · Paper page
  3. Andronescu, 2018, Nonalcoholic fatty liver disease: epidemiology, pathogenesis and therapeutic implications, J. Med. Life, 11, 20
  4. Toshikuni, 2014, Clinical differences between alcoholic liver disease and nonalcoholic fatty liver disease, World J. Gastroenterol., 20, 8393, 10.3748/wjg.v20.i26.8393 · DOI
  5. Hardy, 2015, Nonalcoholic fatty liver disease: new treatments, Curr. Opin. Gastroenterol., 31, 175, 10.1097/MOG.0000000000000175 · DOI
  6. Gualano, 2010, Exploring the therapeutic role of creatine supplementation, Amino Acids, 38, 31, 10.1007/s00726-009-0263-6 · DOI · Paper page
  7. Harmon, 2021, The application of creatine supplementation in medical rehabilitation, Nutrients, 13, 1825, 10.3390/nu13061825 · DOI
  8. Deminice, 2011, Creatine supplementation prevents the accumulation of fat in the livers of rats fed a high-fat diet, J. Nutr., 141, 1799, 10.3945/jn.111.144857 · DOI · Paper page
  9. da Silva, 2014, Creatine reduces hepatic TG accumulation in hepatocytes by stimulating fatty acid oxidation, Biochim. Biophys. Acta, 1841, 1639, 10.1016/j.bbalip.2014.09.001 · DOI · Paper page
  10. Deminice, 2015, Creatine supplementation prevents fatty liver in rats fed choline-deficient diet: a burden of one-carbon and fatty acid metabolism, J. Nutr. Biochem., 26, 391, 10.1016/j.jnutbio.2014.11.014 · DOI · Paper page
  11. Deminice, 2016, Creatine supplementation as a possible new therapeutic approach for fatty liver disease: early findings, Amino Acids, 48, 1983, 10.1007/s00726-016-2183-6 · DOI · Paper page
  12. da Silva, 2020, One-carbon metabolism in fatty liver disease and fibrosis: one-carbon to rule them all, J. Nutr., 150, 994, 10.1093/jn/nxaa032 · DOI
  13. Ganesan, 2016, Creatine supplementation does not prevent the development of alcoholic steatosis, Alcohol. Clin. Exp. Res., 40, 2312, 10.1111/acer.13214 · DOI
  14. Marinello, 2019, Creatine supplementation exacerbates ethanol-induced hepatic damage in mice, Nutrition, 66, 122, 10.1016/j.nut.2019.05.004 · DOI
  15. Duarte, 2005, Strenuous exercise aggravates MDMA-induced skeletal muscle damage in mice, Toxicology, 206, 349, 10.1016/j.tox.2004.07.012 · DOI
  16. Deminice, 2009, Effects of creatine supplementation on homocysteine levels and lipid peroxidation in rats, Br. J. Nutr., 102, 110, 10.1017/S0007114508162985 · DOI
  17. Gonzalez Flecha, 1991, Hydroperoxide-initiated chemiluminescence: an assay for oxidative stress in biopsies of heart, liver, and muscle, Free Radic. Biol. Med., 10, 93, 10.1016/0891-5849(91)90002-K · DOI · Paper page
  18. Hu, 1994, Measurement of protein thiol groups and glutathione in plasma, Methods Enzymol., 233, 380, 10.1016/S0076-6879(94)33044-1 · DOI · Paper page
  19. Reznick, 1994, Oxidative damage to proteins: spectrophotometric method for carbonyl assay, Methods Enzymol., 233, 357, 10.1016/S0076-6879(94)33041-7 · DOI · Paper page
  20. Prakash, 2002, Alcohol and liver disease, Ochsner J., 4, 241
  21. Khan, 2017, Crosstalk of liver immune cells and cell death mechanisms in different murine models of liver injury and its clinical relevance, Hepatobiliary Pancreat. Dis. Int., 16, 245, 10.1016/S1499-3872(17)60014-6 · DOI
  22. Peter Guengerich, 2018, Roles of cytochrome P450 in metabolism of ethanol and carcinogens, Adv. Exp. Med. Biol., 1032, 15, 10.1007/978-3-319-98788-0_2 · DOI
  23. Zhao, 2019, Mitochondrial electron transport chain, ROS generation and uncoupling (Review), Int. J. Mol. Med., 44, 3
  24. Murphy, 2009, How mitochondria produce reactive oxygen species, Biochem. J., 417, 1, 10.1042/BJ20081386 · DOI · Paper page
  25. Berge, 2020, Hepatic steatosis induced in C57BL/6 mice by a non-ß oxidizable fatty acid analogue is associated with reduced plasma kynurenine metabolites and a modified hepatic NAD+/NADH ratio, Lipids Health Dis., 19, 94, 10.1186/s12944-020-01271-1 · DOI
  26. Masia, 2018, Live cell imaging of cytosolic NADH/NAD+ ratio in hepatocytes and liver slices, Am. J. Physiol. Gastrointest. Liver Physiol., 314, G97, 10.1152/ajpgi.00093.2017 · DOI
  27. Lu, 2008, Cytochrome P450 2E1 contributes to ethanol-induced fatty liver in mice, Hepatology, 47, 1483, 10.1002/hep.22222 · DOI · Paper page
  28. Doody, 2017, Ethanol metabolism by alcohol dehydrogenase or cytochrome P450 2E1 differentially impairs hepatic protein trafficking and growth hormone signaling, Am. J. Physiol. Gastrointest. Liver Physiol., 313, G558, 10.1152/ajpgi.00027.2017 · DOI
  29. Järveläinen, 2000, Kupffer cell inactivation alleviates ethanol-induced steatosis and CYP2E1 induction but not inflammatory responses in rat liver, J. Hepatol., 32, 900, 10.1016/S0168-8278(00)80094-X · DOI
  30. Gouillon, 2000, Inhibition of ethanol-induced liver disease in the intragastric feeding rat model by chlormethiazole, Proc. Soc. Exp. Biol. Med., 224, 302
  31. Gao, 2019, Inflammatory pathways in alcoholic steatohepatitis, J. Hepatol., 70, 249, 10.1016/j.jhep.2018.10.023 · DOI · Paper page
  32. Gilles, 2003, Release of TNF-alpha during myocardial reperfusion depends on oxidative stress and is prevented by mast cell stabilizers, Cardiovasc. Res., 60, 608, 10.1016/j.cardiores.2003.08.016 · DOI
  33. Vieira, 2007, Creatine supplementation exacerbates allergic lung inflammation and airway remodeling in mice, Am. J. Respir. Cell Mol. Biol., 37, 660, 10.1165/rcmb.2007-0108OC · DOI
  34. Nomura, 2003, Anti-inflammatory activity of creatine supplementation in endothelial cells in vitro, Br. J. Pharmacol., 139, 715, 10.1038/sj.bjp.0705316 · DOI
  35. Lenz, 2005, The creatine kinase system in human skin: protective effects of creatine against oxidative and UV damage in vitro and in vivo, J. Invest. Dermatol., 124, 443, 10.1111/j.0022-202X.2004.23522.x · DOI · Paper page
  36. Bassit, 2010, Effect of short-term creatine supplementation on markers of skeletal muscle damage after strenuous contractile activity, Eur. J. Appl. Physiol., 108, 945, 10.1007/s00421-009-1305-1 · DOI
  37. Deminice, 2013, Effects of creatine supplementation on oxidative stress and inflammatory markers after repeated-sprint exercise in humans, Nutrition, 29, 1127, 10.1016/j.nut.2013.03.003 · DOI · Paper page

Cited by

See all 9

Metadata

Authors
Marinello, P. C., Cella, P. S., Testa, M. T. J., Guirro, P. B., da Silva Brito, W. A., Padilha, C. S., Cecchini, A. L., da Silva, R. P., Duarte, J. A. R., & Deminice, R.
Venue
Life Sciences
Publisher
Elsevier BV
Published
2022-12
Volume
310
Pages
121064
ISSN
0024-3205
DOI
10.1016/j.lfs.2022.121064
Cited by
9
References
10
Language
en
Update notices
erratum (2023-02-01)
Licence
Funders
  • Coordenação de Aperfeiçoamento de Pessoal de Nível Superior
  • Conselho Nacional de Desenvolvimento Científico e Tecnológico (315131/2018-4)

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

How to cite

Cite CoChat for the checks on this page, and the paper for its own findings.

This page
CoChat. (2026). Citation check: Creatine supplementation protects against diet-induced non-alcoholic fatty liver but exacerbates alcoholic fatty liver. https://app.cochat.ai/papers/10.1016/j.lfs.2022.121064
The paper
Marinello, P. C., Cella, P. S., Testa, M. T. J., Guirro, P. B., da Silva Brito, W. A., Padilha, C. S., Cecchini, A. L., da Silva, R. P., Duarte, J. A. R., & Deminice, R. (2022). Creatine supplementation protects against diet-induced non-alcoholic fatty liver but exacerbates alcoholic fatty liver. Life Sciences. https://doi.org/10.1016/j.lfs.2022.121064

Data sources

Bibliographic data: Semantic Scholar, OpenAlex, Crossref.

Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.