The DOI matches its Crossref record; 165 of the 166 references it cites were found in a registry or an index.
The role of nitric oxide in cardiovascular diseases
Abstract
Nitric oxide (NO) is a gaseous lipophilic free radical cellular messenger generated by three distinct isoforms of nitric oxide synthases (NOS), neuronal (nNOS), inducible (iNOS) and endothelial NOS (eNOS). NO plays an important role in the protection against the onset and progression of cardiovascular disease. Cardiovascular disease is associated with a number of different disorders including hypercholesterolaemia, hypertension and diabetes. The underlying pathology for most cardiovascular diseases is atherosclerosis, which is in turn associated with endothelial dysfunctional. The cardioprotective roles of NO include regulation of blood pressure and vascular tone, inhibition of platelet aggregation and leukocyte adhesion, and prevention smooth muscle cell proliferation. Reduced bioavailability of NO is thought to be one of the central factors common to cardiovascular disease, although it is unclear whether this is a cause of, or result of, endothelial dysfunction. Disturbances in NO bioavailability leads to a loss of the cardio protective actions and in some case may even increase disease progression. In this chapter the cellular and biochemical mechanisms leading to reduced NO bioavailability are discussed and evidence for the prevalence of these mechanisms in cardiovascular disease evaluated.
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Schwedhelm, E., Maas, R., Freese, R., Jung, D., Lukacs, Z., Jambrecina, A., Spickler, W., Schulze, F., & Böger, R. H. (2008) · British Journal of Clinical Pharmacology · doi:10.1111/j.1365-2125.2007.02990.x · Cited by 494
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Leptin and Cardiovascular Disease
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Rochette, L., Lorin, J., Zeller, M., Guilland, J.-C., Lorgis, L., Cottin, Y., & Vergely, C. (2013) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2013.07.004 · Cited by 456
Janaszak-Jasiecka, A., Płoska, A., Wierońska, J. M., Dobrucki, L. W., & Kalinowski, L. (2023) · Cellular & Molecular Biology Letters · doi:10.1186/s11658-023-00423-2 · Cited by 358
Metadata
- Authors
- NASEEM, K.
- Affiliations
- University of Bradford (GB)
- Corresponding author
- NASEEM, K
- ORCID
- NASEEM, K
- Venue
- Molecular Aspects of Medicine
- Publisher
- Elsevier BV
- Published
- 2005-04
- Volume
- 26
- Issue
- 1-2
- Pages
- 33-65
- ISSN
- 0098-2997 (ISSN-L)
- OpenAlex
- W1974081986
- Cited by
- 557
- References
- 166
- Citations by year
- 2026: 20 · 2025: 28 · 2024: 32 · 2023: 35 · 2022: 19 · 2021: 34 · 2020: 32 · 2019: 23 · 2018: 34 · 2017: 20 · 2016: 24 · 2015: 22 · 2014: 24 · 2013: 29 · 2012: 31
- FWCI
- 15.85
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Molecular Aspects of Medicine (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Physiology (medical) › Nitric Oxide and Endothelin Effects
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Health and Disease Prevention
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Biochemistry › Eicosanoids and Hypertension Pharmacology
- Keywords
- nitric oxide, cardiovascular disease, nitric oxide synthase, endothelial dysfunction, NO bioavailability, atherosclerosis, hypertension, hypercholesterolemia, diabetes mellitus, platelet aggregation, leukocyte adhesion, vascular tone, smooth muscle cell proliferation, cardioprotection
- MeSH terms
- Arteriosclerosis, Blood Platelets, Cardiovascular Diseases, Diabetes Mellitus, Humans, Hypercholesterolemia, Hypertension, Lipoproteins, LDL, Nitric Oxide, Oxidation-Reduction, Shock, Septic, Reactive Oxygen Species
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