Cited by 557Nitric Oxide and Endothelin EffectsCardiovascular Health and Disease PreventionEicosanoids and Hypertension Pharmacology

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The role of nitric oxide in cardiovascular diseases

NASEEM, K·2005·Molecular Aspects of Medicine

DOI 10.1016/j.mam.2004.09.003

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Abstract

Nitric oxide (NO) is a gaseous lipophilic free radical cellular messenger generated by three distinct isoforms of nitric oxide synthases (NOS), neuronal (nNOS), inducible (iNOS) and endothelial NOS (eNOS). NO plays an important role in the protection against the onset and progression of cardiovascular disease. Cardiovascular disease is associated with a number of different disorders including hypercholesterolaemia, hypertension and diabetes. The underlying pathology for most cardiovascular diseases is atherosclerosis, which is in turn associated with endothelial dysfunctional. The cardioprotective roles of NO include regulation of blood pressure and vascular tone, inhibition of platelet aggregation and leukocyte adhesion, and prevention smooth muscle cell proliferation. Reduced bioavailability of NO is thought to be one of the central factors common to cardiovascular disease, although it is unclear whether this is a cause of, or result of, endothelial dysfunction. Disturbances in NO bioavailability leads to a loss of the cardio protective actions and in some case may even increase disease progression. In this chapter the cellular and biochemical mechanisms leading to reduced NO bioavailability are discussed and evidence for the prevalence of these mechanisms in cardiovascular disease evaluated.

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“Research has suggested that reduced bioavailability of NO is one of the central and critical factors common to cardiovascular diseases, although it is unclear whether this is a cause or results due to endothelial dysfunction (37).”
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Authors: NASEEM, K.
Affiliations: University of Bradford (GB)
Corresponding author: NASEEM, K
ORCID: NASEEM, K
Venue: Molecular Aspects of Medicine
Publisher: Elsevier BV
Published: 2005-04
Volume: 26
Issue: 1-2
Pages: 33-65
ISSN: 0098-2997 (ISSN-L)
DOI: 10.1016/j.mam.2004.09.003
OpenAlex: W1974081986
Cited by: 557
References: 166
Citations by year: 2026: 20 · 2025: 28 · 2024: 32 · 2023: 35 · 2022: 19 · 2021: 34 · 2020: 32 · 2019: 23 · 2018: 34 · 2017: 20 · 2016: 24 · 2015: 22 · 2014: 24 · 2013: 29 · 2012: 31
FWCI: 15.85
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Molecular Aspects of Medicine (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Medicine › Physiology (medical) › Nitric Oxide and Endothelin Effects
Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Health and Disease Prevention
Life Sciences › Biochemistry, Genetics and Molecular Biology › Biochemistry › Eicosanoids and Hypertension Pharmacology
Keywords: nitric oxide, cardiovascular disease, nitric oxide synthase, endothelial dysfunction, NO bioavailability, atherosclerosis, hypertension, hypercholesterolemia, diabetes mellitus, platelet aggregation, leukocyte adhesion, vascular tone, smooth muscle cell proliferation, cardioprotection
MeSH terms: Arteriosclerosis, Blood Platelets, Cardiovascular Diseases, Diabetes Mellitus, Humans, Hypercholesterolemia, Hypertension, Lipoproteins, LDL, Nitric Oxide, Oxidation-Reduction, Shock, Septic, Reactive Oxygen Species

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