The DOI matches its Crossref record; 9 of the 9 references it cites were found in a registry or an index.
Adaptive homeostasis
Open accessAbstract
Homeostasis is a central pillar of modern Physiology. The term homeostasis was invented by Walter Bradford Cannon in an attempt to extend and codify the principle of 'milieu intérieur,' or a constant interior bodily environment, that had previously been postulated by Claude Bernard. Clearly, 'milieu intérieur' and homeostasis have served us well for over a century. Nevertheless, research on signal transduction systems that regulate gene expression, or that cause biochemical alterations to existing enzymes, in response to external and internal stimuli, makes it clear that biological systems are continuously making short-term adaptations both to set-points, and to the range of 'normal' capacity. These transient adaptations typically occur in response to relatively mild changes in conditions, to programs of exercise training, or to sub-toxic, non-damaging levels of chemical agents; thus, the terms hormesis, heterostasis, and allostasis are not accurate descriptors. Therefore, an operational adjustment to our understanding of homeostasis suggests that the modified term, Adaptive Homeostasis, may be useful especially in studies of stress, toxicology, disease, and aging. Adaptive Homeostasis may be defined as follows: 'The transient expansion or contraction of the homeostatic range in response to exposure to sub-toxic, non-damaging, signaling molecules or events, or the removal or cessation of such molecules or events.'
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Cites
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Cited by
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Defining roles of specific reactive oxygen species (ROS) in cell biology and physiology
Sies, H., Belousov, V. V., Chandel, N. S., Davies, M. J., Jones, D. P., Mann, G. E., Murphy, M. P., Yamamoto, M., & Winterbourn, C. (2022) · Nature Reviews Molecular Cell Biology · doi:10.1038/s41580-022-00456-z · Cited by 1,735
Functions of ROS in Macrophages and Antimicrobial Immunity
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“Thankfully, we can nowmechanistically explain this particular ostensible paradox as the phenomenon of BAdaptive Homeostasis^ (Eisenberg et al. 2016; Davies 2016; Pomatto et al. 2017a; Lomeli et al. 2017; Pomatto and Davies 2017),;the non-damaging process by which an apparent toxicant can activate…”
BackgroundSelf-citationIs free-energy minimisation the mark of the cognitive?
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Dai, L., Schurgers, L., Shiels, P. G., & Stenvinkel, P. (2021) · Clinical Science · doi:10.1042/cs20201452 · Cited by 11
Metadata
- Authors
- Davies, K. J. A.
- Venue
- Molecular Aspects of Medicine
- Publisher
- Elsevier BV
- Published
- 2016-06
- Volume
- 49
- Pages
- 1-7
- ISSN
- 0098-2997 (ISSN-L)
- OpenAlex
- W4229958714
- Cited by
- 315
- References
- 9
- FWCI
- 22.34
- Type
- journal article
- Language
- en
- Open access
- hybrid
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