A novel small-molecule near-infrared II fluorescence probe for orthotopic osteosarcoma imaging
Open accessIntegrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Each methylene unit inserted between donor and acceptor typically induces a red-shift of ~100 nm.
“A general rule, as exemplified in cyanine dyes, is that each methylene unit inserted between donor and acceptor typically induces a red-shift of ~100 nm111–123.”
From Organic small-molecule NIR-II fluorophores for tumor phototheranostics (2026) · cites this paper as [117]
Higher molecular planarity, stronger donor strength, and increasing acceptor electron affinity in BBTD-based systems synergistically enhance conjugation, intramolecular charge transfer strength, and excited-state stability, resulting in narrowed bandgaps and superior NIR-II optical performance.
“Recent studies have demonstrated that higher molecular planarity, stronger donor strength, and increasing acceptor electron affinity in BBTD-based systems can synergistically enhance conjugation, ICT strength, and excited-state stability, which collectively result in narrowed bandgaps and superior NIR-II optical performance117–121.”
From Organic small-molecule NIR-II fluorophores for tumor phototheranostics (2026) · cites this paper as [117]
Cites
Near-infrared fluorophores for biomedical imaging
Hong, G., Antaris, A. L., & Dai, H. (2017) · Nature Biomedical Engineering · doi:10.1038/s41551-016-0010 · Cited by 3,013 · see citing works
A small-molecule dye for NIR-II imaging
Antaris, A. L., Chen, H., Cheng, K., Sun, Y., Hong, G., Qu, C., Diao, S., Deng, Z., Hu, X., Zhang, B., et al. (2016) · Nature Materials · doi:10.1038/nmat4476 · Cited by 1,778 · see citing works
Self-citationMultifunctional in vivo vascular imaging using near-infrared II fluorescence
Hong, G., Lee, J. C., Robinson, J. T., Raaz, U., Xie, L., Huang, N. F., Cooke, J. P., & Dai, H. (2012) · Nature Medicine · doi:10.1038/nm.2995 · Cited by 995 · see citing works
Current and future therapeutic approaches for osteosarcoma
Harrison, D. J., Geller, D. S., Gill, J. B., Lewis, V. O., & Gorlick, R. G. (2017) · Expert Review of Anticancer Therapy · doi:10.1080/14737140.2018.1413939 · Cited by 688 · see citing works
Near-Infrared Photoluminescent Ag 2 S Quantum Dots from a Single Source Precursor
Du, Y., Xu, B., Fu, T., Cai, M., Li, F., Zhang, Y., & Wang, Q. (2010) · Journal of the American Chemical Society · doi:10.1021/ja909490r · Cited by 645 · see citing works
Sun, C., Li, B., Zhao, M., Wang, S., Lei, Z., Lu, L., Zhang, H., Feng, L., Dou, C., Yin, D., et al. (2019) · Journal of the American Chemical Society · doi:10.1021/jacs.9b10043 · Cited by 582 · see citing works
Anti-quenching NIR-II molecular fluorophores for in vivo high-contrast imaging and pH sensing
Wang, S., Fan, Y., Li, D., Sun, C., Lei, Z., Lu, L., Wang, T., & Zhang, F. (2019) · Nature Communications · doi:10.1038/s41467-019-09043-x · Cited by 510 · see citing works
Sheng, Z., Guo, B., Hu, D., Xu, S., Wu, W., Liew, W. H., Yao, K., Jiang, J., Liu, C., Zheng, H., et al. (2018) · Advanced Materials · doi:10.1002/adma.201800766 · Cited by 445 · see citing works
Atomic‐Precision Gold Clusters for NIR‐II Imaging
Liu, H., Hong, G., Luo, Z., Chen, J., Chang, J., Gong, M., He, H., Jiang, Y., Yuan, X. F., Li, L., et al. (2019) · Advanced Materials · doi:10.1002/adma.201901015 · Cited by 441 · see citing works
Flavylium Polymethine Fluorophores for Near‐ and Shortwave Infrared Imaging
Cosco, E. D., Caram, J. R., Bruns, O. T., Franke, D., Day, R. A., Farr, E. P., Bawendi, M. G., & Sletten, E. M. (2017) · Angewandte Chemie International Edition · doi:10.1002/anie.201706974 · Cited by 415 · see citing works
Wang, Q., Dai, Y.-N., Xu, J.-Z., Cai, J., Niu, X., Zhang, L., Chen, R.-F., Shen, Q.-M., Huang, W., & Fan, Q.-L. (2019) · Advanced Functional Materials · doi:10.1002/adfm.201901480 · Cited by 313 · see citing works
Common Musculoskeletal Tumors of Childhood and Adolescence
Arndt, C. A. S., Rose, P. S., Folpe, A. L., & Laack, N. N. (2012) · Mayo Clinic Proceedings · doi:10.1016/j.mayocp.2012.01.015 · Cited by 298 · see citing works
Tm3+‐Sensitized NIR‐II Fluorescent Nanocrystals for In Vivo Information Storage and Decoding
Zhang, H., Fan, Y., Pei, P., Sun, C., Lu, L., & Zhang, F. (2019) · Angewandte Chemie International Edition · doi:10.1002/anie.201903536 · Cited by 287 · see citing works
Huang, J., Xie, C., Zhang, X., Jiang, Y., Li, J., Fan, Q., & Pu, K. (2019) · Angewandte Chemie International Edition · doi:10.1002/anie.201909560 · Cited by 258 · see citing works
Novel near-infrared II aggregation-induced emission dots for in vivo bioimaging
Lin, J., Zeng, X., Xiao, Y., Tang, L., Nong, J., Liu, Y., Zhou, H., Ding, B., Xu, F., Tong, H., et al. (2018) · Chemical Science · doi:10.1039/c8sc04363a · Cited by 243 · see citing works
Self-citationMeng, X., Zhang, J., Sun, Z., Zhou, L., Deng, G., Li, S., Li, W., Gong, P., & Cai, L. (2018) · Theranostics · doi:10.7150/thno.26607 · Cited by 231 · see citing works
Self-citationDing, B., Xiao, Y., Zhou, H., Zhang, X., Qu, C., Xu, F., Deng, Z., Cheng, Z., & Hong, X. (2019) · Journal of Medicinal Chemistry · doi:10.1021/acs.jmedchem.8b01682 · Cited by 215 · see citing works
Self-citationOsteosarcoma: The COSS Experience
Bielack, S., Jürgens, H., Jundt, G., Kevric, M., Kühne, T., Reichardt, P., Zoubek, A., Werner, M., Winkelmann, W., & Kotz, R. I. (2009) · Cancer treatment and research · doi:10.1007/978-1-4419-0284-9_15 · Cited by 212 · see citing works
Lei, Z., Sun, C., Pei, P., Wang, S., Li, D., Zhang, X., & Zhang, F. (2019) · Angewandte Chemie · doi:10.1002/ange.201904182 · Cited by 209 · see citing works
Tang, Y., Li, Y., Hu, X., Zhao, H., Ji, Y., Chen, L., Hu, W., Zhang, W., Li, X., Lü, X., et al. (2018) · Advanced Materials · doi:10.1002/adma.201801140 · Cited by 204 · see citing works
Self-citationHao, X., Li, C., Zhang, Y., Wang, H., Chen, G., Wang, M., & Wang, Q. (2018) · Advanced Materials · doi:10.1002/adma.201804437 · Cited by 143 · see citing works
Li, C., Zhang, Y., Chen, G., Hu, F., Zhao, K., & Wang, Q. (2017) · Advanced Materials · doi:10.1002/adma.201605754 · Cited by 134 · see citing works
Development of Polyene-Bridged Hybrid Rhodamine Fluorophores for High-Resolution NIR-II Imaging
Shi, Y., Yuan, W., Liu, Q., Kong, M., Li, Z., Feng, W., Hu, K., & Li, F. (2019) · ACS Materials Letters · doi:10.1021/acsmaterialslett.9b00265 · Cited by 80 · see citing works
Guo, Z., Ma, Y., Liu, Y., Yan, C., Shi, P., Tian, H., & Zhu, W. (2018) · Science China Chemistry · doi:10.1007/s11426-018-9240-6 · Cited by 72 · see citing works
Fluorescence Imaging for Cancer Screening and Surveillance
Tipirneni, K. E., Rosenthal, E. L., Moore, L. S., Haskins, A. D., Udayakumar, N., Jani, A. H., Carroll, W. R., Morlandt, A. B., Bogyo, M. S., Rao, J., et al. (2017) · Molecular Imaging and Biology · doi:10.1007/s11307-017-1050-5 · Cited by 68 · see citing works
Wu, X., Shao, A., Zhu, S., Guo, Z., & Zhu, W. (2015) · Science China Chemistry · doi:10.1007/s11426-015-5490-y · Cited by 49 · see citing works
A bright NIR-II fluorescent probe for breast carcinoma imaging and image-guided surgery
Zeng, X., Xie, L., Chen, D., Li, S., Nong, J., Wang, B., Tang, L., Li, Q., Li, Y., Deng, Z., et al. (2019) · Chemical Communications · doi:10.1039/c9cc07694h · Cited by 48 · see citing works
Self-citationNew NIR-II dyes without a benzobisthiadiazole core
Zhou, H., Xiao, Y., & Hong, X. (2018) · Chinese Chemical Letters · doi:10.1016/j.cclet.2018.08.009 · Cited by 40 · see citing works
Self-citationRousseau, J., Escriou, V., Perrot, P., Picarda, G. G. A., Charrier, C., Scherman, D., Heymann, D., Rédiní, F., & Trichet, V. (2010) · Cancer Gene Therapy · doi:10.1038/cgt.2009.89 · Cited by 29 · see citing works
Jia, Q., Liu, Y. L., Duan, Y., & Zhou, J. (2019) · Analytical Chemistry · doi:10.1021/acs.analchem.9b02855 · Cited by 29 · see citing works
Tang, Y., Shao, A., Cao, J., Li, H., Li, Q., Zeng, M., Liu, M., Cheng, Y.-S., & Zhu, W. (2017) · Science China Chemistry · doi:10.1007/s11426-017-9092-9 · Cited by 25 · see citing works
Self-citationNew glowing dyes in vivo imaging with wavelengths beyond 1500 nm
Yang, J., & Hong, X. (2018) · Science China Chemistry · doi:10.1007/s11426-018-9341-7 · Cited by 13 · see citing works
Self-citationUlaner, G. A., Hwang, S., Landa, J., Lefkowitz, R. A., & Panicek, D. M. (2013) · International Orthopaedics · doi:10.1007/s00264-013-1824-6 · Cited by 13 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Molecular Engineering of NIR‐II Fluorophores for Improved Biomedical Detection
Lei, Z., & Zhang, F. (2020) · Angewandte Chemie International Edition · doi:10.1002/anie.202007040 · Cited by 689 · see citing works
Liu, Y., Li, Y., Koo, S., Sun, Y., Liu, Y., Liu, X., Pan, Y., Zhang, Z., Du, M., Lu, S., et al. (2021) · Chemical Reviews · doi:10.1021/acs.chemrev.1c00553 · Cited by 544 · see citing works
Self-citationUpconversion NIR-II fluorophores for mitochondria-targeted cancer imaging and photothermal therapy
Zhou, H., Zeng, X., Li, A., Zhou, W., Tang, L., Hu, W., Fan, Q., Meng, X., Deng, H., Duan, L., et al. (2020) · Nature Communications · doi:10.1038/s41467-020-19945-w · Cited by 289 · see citing works
Self-citationCheng, H., Cao, X., Zhang, S., Zhang, K., Cheng, Y., Wang, J., Zhao, J., Zhou, L., Liang, X., & Yoon, J. (2022) · Advanced Materials · doi:10.1002/adma.202207546 · Cited by 264 · see citing works
NIR-II bioimaging of small organic molecule
Su, Y., Yu, B., Wang, S., Cong, H., & Shen, Y. (2021) · Biomaterials · doi:10.1016/j.biomaterials.2021.120717 · Cited by 251 · see citing works
Novel NIR-II organic fluorophores for bioimaging beyond 1550 nm
Li, Y., Liu, Y., Li, Q., Zeng, X., Tian, T., Zhou, W., Cui, Y., Wang, X., Cheng, X., Ding, Q., et al. (2020) · Chemical Science · doi:10.1039/c9sc06567a · Cited by 177 · see citing works
Self-citationXu, Y., Li, C., An, J., Ma, X., Yang, J., Luo, L., Deng, Y., Kim, J. S., & Sun, Y. (2022) · Science China Chemistry · doi:10.1007/s11426-022-1440-2 · Cited by 159 · see citing works
Liu, X., Yu, B., Shen, Y., & Cong, H. (2022) · Coordination Chemistry Reviews · doi:10.1016/j.ccr.2022.214609 · Cited by 151 · see citing works
Smart Self‐Assembly Amphiphilic Cyclopeptide‐Dye for Near‐Infrared Window‐II Imaging
Chen, H., Shou, K., Chen, S., Qu, C., Wang, Z., Jiang, L., Zhu, M., Ding, B., Qian, K., Ji, A., et al. (2021) · Advanced Materials · doi:10.1002/adma.202006902 · Cited by 87 · see citing works
Sun, P., Jiang, X., Sun, B., Wang, H., Li, J., Fan, Q., & Huang, W. (2021) · Biomaterials · doi:10.1016/j.biomaterials.2021.121319 · Cited by 82 · see citing works
All-in-one mitochondria-targeted NIR-II fluorophores for cancer therapy and imaging
Zheng, Y., Li, Q., Wu, J., Luo, Z., Zhou, W., Li, A., Chen, Y., Rouzi, T., Tian, T., Zhou, H., et al. (2020) · Chemical Science · doi:10.1039/d0sc04727a · Cited by 79 · see citing works
Self-citationMolecular Engineering of NIR‐II Fluorophores for Improved Biomedical Detection
Lei, Z., & Zhang, F. (2020) · Angewandte Chemie · doi:10.1002/ange.202007040 · Cited by 63 · see citing works
Li, Y., Gao, J., Wang, S., Du, M., Hou, X., Tian, T., Qiao, X., Tian, Z., Stang, P. J., Li, S., et al. (2021) · Journal of Medicinal Chemistry · doi:10.1021/acs.jmedchem.1c01615 · Cited by 58 · see citing works
Self-citationA Small-Molecule Based Organic Nanoparticle for Photothermal Therapy and Near-Infrared-IIb Imaging
Lou, H., Ji, A., Qu, C., Liu, H., Jiang, L., Chen, H., & Cheng, Z. (2022) · ACS Applied Materials & Interfaces · doi:10.1021/acsami.2c11706 · Cited by 47 · see citing works
Tumor-homing peptide-based NIR-II probes for targeted spontaneous breast tumor imaging
Zhou, H., Li, S., Zeng, X., Zhang, M., Tang, L., Li, Q., Chen, D., Meng, X., & Hong, X. (2020) · Chinese Chemical Letters · doi:10.1016/j.cclet.2020.04.030 · Cited by 48 · see citing works
Self-citationNovel CD-MOF NIR-II fluorophores for gastric ulcer imaging
Liu, Y., Yuzhen, Y., Tian, T., Wang, W., Nong, J., Qiao, X., Xu, F., Gao, J., & Hong, X. (2021) · Chinese Chemical Letters · doi:10.1016/j.cclet.2021.03.075 · Cited by 46 · see citing works
Self-citationLi, Z., Zhao, C., Fu, Q., Ye, J., Su, L., Ge, X., Chen, L., Song, J., & Yang, H. (2021) · Small · doi:10.1002/smll.202105160 · Cited by 33 · see citing works
Near-infrared-II triggered inorganic photodynamic nanomedicines for deep-tissue therapy
Tang, Y., Feng, J., Li, S., Yang, G., Tao, Z., Xiao, T., Lu, F., Xie, B., Fan, Q., & Wang, Q. (2024) · Journal of Material Science and Technology · doi:10.1016/j.jmst.2024.07.002 · Cited by 23 · see citing works
Ren, F., Li, Z., Li, K., Zheng, X., Shi, J., Zhang, C., Guo, H., Tong, B., Xi, L., Cai, Z., et al. (2021) · Science China Chemistry · doi:10.1007/s11426-021-1055-0 · Cited by 21 · see citing works
Xie, Y., Qin, Z., Qian, M., Ren, T., & Yuan, L. (2024) · Chemical Research in Chinese Universities · doi:10.1007/s40242-024-3264-9 · Cited by 19 · see citing works
Organic small-molecule NIR-II fluorophores for tumor phototheranostics
Xiang, D., Wang, Z., Zheng, H., Tang, Y., & Li, Q. (2026) · Light: Science & Applications · doi:10.1038/s41377-026-02212-w · Cited by 22 · see citing works
“…molecular planarity, stronger donor strength, and increasing acceptor electron af fi nity in BBTD-based systems can synergistically enhance conjugation, ICT strength, and excited-state stability, which collectively result in narrowed bandgaps and superior NIR-II optical performance 117 – 121 .”
Self-citationDevi, A., Seksaria, H., Bain, D., Kolay, S., Rashi, R., Sarkar, A. D., & Patra, A. (2023) · Physical Chemistry Chemical Physics · doi:10.1039/d2cp05120f · Cited by 15 · see citing works
Cao, M., Wang, C., Wang, F., Zou, W., Yu, B., Cong, H., & Shen, Y. (2024) · Advanced Healthcare Materials · doi:10.1002/adhm.202304564 · Cited by 14 · see citing works
Li, Z., Song, J., & Yang, H. (2022) · Science China Chemistry · doi:10.1007/s11426-022-1355-6 · Cited by 9 · see citing works
A near-infrared IIb fluorophore for in vivo imaging and image-guided therapy of ischemic stroke
Qiao, X., Yang, L., Wang, W., Xiao, Y., Tian, T., Wang, X., Luo, H.-B., Chen, D., Meng, X., Zeng, X., et al. (2023) · Dyes and Pigments · doi:10.1016/j.dyepig.2023.111123 · Cited by 7 · see citing works
Self-citationOrganic Molecules: Desirable Candidates for NIR-II Window Bioimaging
Liu, Z., Xiao, W., & Wang, R. (2021) · Journal of Physics Conference Series · doi:10.1088/1742-6596/1885/3/032070 · Cited by 6 · see citing works
Wen, X., Chen, X.-Y., Jin, Y.-L., Sun, Z., Zhang, A.-G., & Wang, K. (2024) · TrAC Trends in Analytical Chemistry · doi:10.1016/j.trac.2024.118030 · Cited by 2 · see citing works
Qian, J., Gu, Y., Wang, Z., Pan, M., Li, D., & Ding, J. (2025) · Journal of Molecular Structure · doi:10.1016/j.molstruc.2025.144222 · Cited by 1 · see citing works
Gu, Y., Ding, J., Li, D., qian, J., & Song, X. (2023) · SSRN Electronic Journal · doi:10.2139/ssrn.4561314
- Authors
- Lin, J., Li, Q., Zeng, X., Chen, Z., Ding, Q., Li, Y., Zhou, H., Meng, X., Chen, D., Deng, Z., Hong, X., & Xiao, Y.
- Affiliations
- University of Cambridge (GB)
- Wuhan University (CN)
- Chengdu University of Traditional Chinese Medicine (CN)
- Gannan Normal University (CN)
- Corresponding author
- Xiao, Yuling
- ORCID
- Venue
- Science China Chemistry
- Published
- 2020-04-15
- Volume
- 63
- Issue
- 6
- Pages
- 766-770
- ISSN
- 1001-652X (ISSN-L)
- 1674-7291
- 1869-1870
- OpenAlex
- W3016829586
- Cited by
- 29
- References
- 33
- Citations by year
- 2026: 2 · 2025: 1 · 2024: 4 · 2023: 2 · 2022: 5 · 2021: 9 · 2020: 6
- FWCI
- 2.08
- Type
- journal article
- Language
- en
- Open access
- green
- doi.org
- Locations
- Science China Chemistry (publishedVersion)
- Apollo (University of Cambridge) (submittedVersion)
- Apollo
- Topics
- Physical Sciences › Chemistry › Spectroscopy › Molecular Sensors and Ion Detection
- Physical Sciences › Engineering › Biomedical Engineering › Nanoplatforms for cancer theranostics
- Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Optical Imaging and Spectroscopy Techniques
- Keywords
- osteosarcoma, small-molecule fluorescent probes, orthotopic tumor model, xenograft mouse model, postoperative monitoring, early diagnosis, second near-infrared window
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
