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Cited by 25Barrier Structure and Function StudiesMesenchymal stem cell researchExtracellular vesicles in disease

Novel therapeutic opportunities for neurodegenerative diseases with mesenchymal stem cells: the focus on modulating the blood-brain barrier

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Vargas-Rodríguez, Pablo, Cuenca-Martagón, Alejandro, Castillo-González, Julia, Serrano-Martínez, Ignacio, Luque, Raúl M., Delgado, Mario, González-Rey, Elena·2023·International Journal of Molecular Sciences
DOI 10.3390/ijms241814117PMC PMC10531435
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Abstract

Neurodegenerative disorders encompass a broad spectrum of profoundly disabling situations that impact millions of individuals globally. While their underlying causes and pathophysiology display considerable diversity and remain incompletely understood, a mounting body of evidence indicates that the disruption of blood-brain barrier (BBB) permeability, resulting in brain damage and neuroinflammation, is a common feature among them. Consequently, targeting the BBB has emerged as an innovative therapeutic strategy for addressing neurological disorders. Within this review, we not only explore the neuroprotective, neurotrophic, and immunomodulatory benefits of mesenchymal stem cells (MSCs) in combating neurodegeneration but also delve into their recent role in modulating the BBB. We will investigate the cellular and molecular mechanisms through which MSC treatment impacts primary age-related neurological conditions like Alzheimer’s disease, Parkinson’s disease, and stroke, as well as immune-mediated diseases such as multiple sclerosis. Our focus will center on how MSCs participate in the modulation of cell transporters, matrix remodeling, stabilization of cell-junction components, and restoration of BBB network integrity in these pathological contexts.

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  • Aging and neurodegenerative diseases are associated with BBB impairment and NVU dysfunction.

    “This is particularly relevant to both aging and neurodegenerative diseases which are associated with BBB impairment and NVU dysfunction (Vargas-Rodriguez et al., 2023).”

    From APOE3-Christchurch variant enhances neurovascular support functions of iPSC-derived mesenchymal stromal cells (2026) · cites this paper as Vargas-Rodriguez et al., 2023

    The Introduction reports minor, variable BBB leakage in healthy aging and compromised BBB integrity in most neurological disorders, including those associated with aging. Section 4.1 describes BBB dysregulation affecting NVU components in Alzheimer’s disease. The copy does not establish NVU dysfunction as a general feature of healthy aging, and its account of age-related BBB impairment is more qualified than the claim. (LLM, conf=0.82)

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Authors
Vargas-Rodríguez, P., Cuenca-Martagón, A., Castillo-González, J., Serrano-Martínez, I., Luque, R. M., Delgado, M., & González-Rey, E.
Affiliations
  • Consejo Superior de Investigaciones Científicas (ES)
  • Instituto Maimónides de Investigación Biomédica de Córdoba (ES)
  • Maimonides Biomedical Research Institute of Cordoba (IMIBIC), 14004 Cordoba, Spain
  • Institute of Parasitology and Biomedicine Lopez-Neyra (IPBLN), CSIC, PT Salud, 18016 Granada, Spain
ORCID
Venue
International Journal of Molecular Sciences
Publisher
MDPI AG
Published
2023-09-14
Volume
24
Issue
18
Pages
14117
ISSN
1422-0067 (ISSN-L)
DOI
10.3390/ijms241814117
PMC
PMC10531435
OpenAlex
W4386784287
Cited by
25
References
18
Citations by year
2026: 13 · 2025: 7 · 2024: 4 · 2023: 1
FWCI
0.65
Type
journal article
Language
en
Open access
Licence
Locations
  • International Journal of Molecular Sciences (publishedVersion, cc-by)
  • Preprints.org (acceptedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • DIGITAL.CSIC (Spanish National Research Council (CSIC)) (submittedVersion, cc-by)
Funders
  • Spanish Ministry of Science and Innovation (PID2020-119638RB-I00, FPU17/02616, PRE2021-100172, E-14-2023-0079369)
  • PhD fellowship (PID2020-119638RB-I00, FPU17/02616, PRE2021-100172, E-14-2023-0079369)
  • Next Generation EU (PID2020-119638RB-I00, FPU17/02616, PRE2021-100172, E-14-2023-0079369)
Topics
  • Life Sciences › Neuroscience › Neurology › Barrier Structure and Function Studies
  • Health Sciences › Medicine › Genetics › Mesenchymal stem cell research
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Extracellular vesicles in disease
Keywords
mesenchymal stem cells, blood-brain barrier, neurodegenerative diseases, blood-brain barrier permeability, neuroinflammation, neuroprotection, neurotrophic factors, immunomodulation, Alzheimer's disease, Parkinson's disease, stroke, multiple sclerosis, extracellular matrix remodeling, tight junctions, cell junctions
MeSH terms
Alzheimer Disease, Blood-Brain Barrier, Humans, Parkinson Disease, Neurodegenerative Diseases, Mesenchymal Stem Cells

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