Cited by 226Steroid Chemistry and BiochemistryAdrenal Hormones and DisordersHormonal Regulation and Hypertension

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Integrated view on 17beta-hydroxysteroid dehydrogenases

Moeller, Gabriele, Adamski, Jerzy·2009·Molecular and Cellular Endocrinology

DOI 10.1016/j.mce.2008.10.040

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Abstract

17beta-Hydroxysteroid dehydrogenases (17beta-HSDs) are important enzymes in steroid metabolism. Long known members of the protein family seemed to be well characterised concerning their role in the regulation of the biological potency of steroid hormones, but today more and more evidence points to pivotal contributions of these enzymes in a variety of other metabolic pathways. Therefore, studies on 17beta-HSDs develop towards metabolomic survey. Latest research results give new insights into the complex metabolic interconnectivity of the 17beta-HSDs. In this paper metabolic activities of 17beta-HSDs will be compared, their interplay with endogenous substrates summarised, and interlacing pathways depicted. Strategies on deciphering the physiological role of 17beta-HSDs and the genetic predisposition for associated diseases will be presented.

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“Finally, AKRs (that also include HSD17B5) are enzymes that posses various 3, 17, 20 steroid keto-reductase/hydroxyl-dehydrogenase activities and can use various substrates like androgens, progesterone (and other 21carbon derivatives), thus making the intracrine network extremely flexible (Konings et al., 2018a; Moelle…”
Human dehydrogenase/reductase (SDR family) member 11 is a novel type of 17β-hydroxysteroid dehydrogenase
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“Since more than half of all known types of 17β-HSDs have been found in the liver (Moeller and Adamski, 2009), it is reasonable to speculate that the liver can also generate intracrine sex steroid signaling.”
Background
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“Of the isozymes of 17BHSD, type 5 was chosen because of its confirmed expression in the brain and its primary direction of action, namely the conversion of androstenedione to testosterone (Labrie et al., 2000; Luu-The and Labrie, 2010; Moeller and Adamski, 2009).”
Background
Multiple lines of evidence on the genetic relatedness of the parthenogenetic and bisexual Haemaphysalis longicornis (Acari: Ixodidae)
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“…gene 82 (hsp82), which are usually used for phylogenetic analysis in insects and mites, and 17-beta-hydroxysteroid dehydrogenase (17b-HSD), which is hypothetically responsible for catalyzing the sex hormone and involved in fatty acid elongation (Moeller and Adamski, 2009), were also amplified.”
BackgroundMethod
Increased levels of enzymes involved in local estradiol synthesis in chronic obstructive pulmonary disease
Konings, G. F. J., Reynaert, N. L., Delvoux, B., Verhamme, F. M., Bracke, K. R., Brusselle, G., Romano, A., & Vernooy, J. H. J. (2016) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2016.12.001 · Cited by 35
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“DHEA may be converted to D(5)-androstenediol (A5diol) by a member of the 17b-hydroxysteroid dehydrogenase (17bHSD) family [45,46].”
Background
Potent and Selective Steroidal Inhibitors of 17β-Hydroxysteroid Dehydrogenase Type 7, an Enzyme That Catalyzes the Reduction of the Key Hormones Estrone and Dihydrotestosterone
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“…different isoenzymes of the 17 - HSD fulfill specific roles in sex steroid metabolism by catalyzing the conversion of low-activity 17-ketosteroids, such as androstenedione and estrone to their more potent 17 -hydroxysteroid forms, testosterone or estradiol and reverse [Moeller and Adamski, 2009].”
BackgroundInfluential
Characteristics of 17β-hydroxysteroid dehydrogenase 8 and its potential role in gonad of Zhikong scallop Chlamys farreri
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Sex hormone levels in the brain of d-aspartate-treated rats
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HSD17B1 expression enhances estrogen signaling stimulated by the low active estrone, evidenced by an estrogen responsive element-driven reporter gene in vivo
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Combined Biophysical Chemistry Reveals a New Covalent Inhibitor with a Low-Reactivity Alkyl Halide
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Genetic polymorphisms and obesity influence estradiol decline during the menopause
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Species Used for Drug Testing Reveal Different Inhibition Susceptibility for 17beta-Hydroxysteroid Dehydrogenase Type 1
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“Several druggable targets were defined in humans [1,2] including steroid metabolizing enzymes like 17b-hydroxysteroid dehydrogenases (17b-HSDs) controlling the biological potency of steroid hormones by redox reactions at position 17 of the steroid scaffold [3,4,5,6,7].”
Background
Crucial Role of 3-Bromoethyl in Removing the Estrogenic Activity of 17β-HSD1 Inhibitor 16β-(m-Carbamoylbenzyl)estradiol
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Synthesis of novel 13α-estrone derivatives by Sonogashira coupling as potential 17β-HSD1 inhibitors
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Deacetylation of HSD17B10 by SIRT3 regulates cell growth and cell resistance under oxidative and starvation stresses
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“…of androgens and estrogens to more inactive or active forms, and thus might have influence local availability of active ligands for androgen and estrogen receptors in the Pn. 17β-HSDs also have numerous other functions, however, including fatty acid/lipid metabolism (Moeller and Adamski 2009).”
17β-Estradiol (E2) may be involved in the mode of crustacean female sex hormone (CFSH) action in the blue crab, Callinectes sapidus
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Identification of Hydroxysteroid (17β) dehydrogenase type 12 (HSD17B12) as a CD8+ T-cell-defined human tumor antigen of human carcinomas
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Authors: Moeller, G., & Adamski, J.
Affiliations: Helmholtz Munich (DE)
ORCID: Adamski, Jerzy
Venue: Molecular and Cellular Endocrinology
Publisher: Elsevier BV
Published: 2009-03
Volume: 301
Issue: 1-2
Pages: 7-19
ISSN: 0303-7207 (ISSN-L)
DOI: 10.1016/j.mce.2008.10.040
OpenAlex: W2048714965
Cited by: 214
References: 176
Citations by year: 2026: 5 · 2025: 6 · 2024: 12 · 2023: 8 · 2022: 6 · 2021: 8 · 2020: 11 · 2019: 8 · 2018: 17 · 2017: 12 · 2016: 14 · 2015: 12 · 2014: 11 · 2013: 16 · 2012: 11
FWCI: 1.52
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Molecular and Cellular Endocrinology (publishedVersion)
PubMed (publishedVersion)
Site cant be reached (submittedVersion)
Topics: Physical Sciences › Chemistry › Organic Chemistry › Steroid Chemistry and Biochemistry
Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adrenal Hormones and Disorders
Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Hormonal Regulation and Hypertension
Keywords: 17β-hydroxysteroid dehydrogenase, steroid metabolism, steroid hormone regulation, metabolomics, endogenous substrates, genetic susceptibility, disease
MeSH terms: Animals, Disease, Humans, Polymorphism, Genetic, 17-Hydroxysteroid Dehydrogenases, Crystallography, X-Ray, Models, Animal

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Integrated view on 17beta-hydroxysteroid dehydrogenases

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