Cited by 226Steroid Chemistry and BiochemistryAdrenal Hormones and DisordersHormonal Regulation and Hypertension

The DOI matches its Crossref record; 168 of the 176 references it cites were found in a registry or an index.

Integrated view on 17beta-hydroxysteroid dehydrogenases

Moeller, Gabriele, Adamski, Jerzy·2009·Molecular and Cellular Endocrinology

DOI 10.1016/j.mce.2008.10.040

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Abstract

17beta-Hydroxysteroid dehydrogenases (17beta-HSDs) are important enzymes in steroid metabolism. Long known members of the protein family seemed to be well characterised concerning their role in the regulation of the biological potency of steroid hormones, but today more and more evidence points to pivotal contributions of these enzymes in a variety of other metabolic pathways. Therefore, studies on 17beta-HSDs develop towards metabolomic survey. Latest research results give new insights into the complex metabolic interconnectivity of the 17beta-HSDs. In this paper metabolic activities of 17beta-HSDs will be compared, their interplay with endogenous substrates summarised, and interlacing pathways depicted. Strategies on deciphering the physiological role of 17beta-HSDs and the genetic predisposition for associated diseases will be presented.

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Background
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BackgroundInfluential
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BackgroundInfluential
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Background
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Background
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“37 – 39 Later, 17 α hydroxy pregnenolone is converted to 17 β OH-progesterone by Cyp21 and is further converted to cortisol by Cyp11b and to cortisone by Hsd11b2.”
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“There are at least 12 isoforms of 17βHSD present in organs including the liver, brain, and skin [6, 7].”
Background
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“The enzyme 17 β -hydroxysteroid dehydrogenase (17 β -HSD) mediates the conversion of DHEA into ADIOL [99].”
Background
Saccular Transcriptome Profiles of the Seasonal Breeding Plainfin Midshipman Fish (Porichthys notatus), a Teleost with Divergent Sexual Phenotypes
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“This very important steroidogenic enzyme catalyzes the last step in the biosynthesis of estradiol (E2), the most potent estrogen [2–4].”
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The dual sex hormone specificity for human reductive 17β-hydroxysteroid dehydrogenase type 7: Synergistic function in estrogen and androgen control
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“Although Hsd17b family genes, except for Hsd17b5 , which belongs to the AKR family, are part of the SDR superfamily, their amino acid similarity is relatively low, typically only 15% to 20% in vertebrates [25].”
Background
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Transcriptional regulation of type 11 17β-hydroxysteroid dehydrogenase expression in prostate cancer cells
Rotinen, M., Villar, J., Celay, J., Serrano-Mendioroz, I., Notario, V., & Encı́o, I. (2011) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2011.03.015 · Cited by 9
“17β-Hydroxysteroid dehydrogenases (HSD17Bs) are the enzymes responsible for reduction or oxidation of sex hormones, fatty acids and bile acids in vivo (Moeller and Adamski 2009).”
Background
Synthesis and characterization of targeted 17β-hydroxysteroid dehydrogenase type 7 inhibitors
Sancéau, J., Maltais, R., Zhou, M., Lin, S., & Poirier, D. (2024) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/j.jsbmb.2024.106544 · Cited by 7
HCC in metabolic syndrome: current concepts and future directions
Zampaglione, L., Ferrari, J., Pedica, F., & Goossens, N. (2021) · Hepatoma Research · doi:10.20517/2394-5079.2021.22 · Cited by 7
Evolution of Non-alcoholic Fatty Liver Disease to Liver Cancer: Insights from Genome-wide Association Studies
Mungamuri, S. K., Gupta, Y. K., Rao, P. N., & Ravishankar, B. (2023) · Gene Expression · doi:10.14218/ge.2022.00014 · Cited by 6
Severe Undervirilisation in a 46,XY Case Due to a Novel Mutation in HSD17B3 Gene
Alikaşifoğlu, A., Vurallı, D., Hiort, O., Gonc, N. E., Özön, A., & Kandemir, N. (2015) · Journal of Clinical Research in Pediatric Endocrinology · doi:10.4274/jcrpe.2069 · Cited by 7
“The 17β-HSD3 enzyme family includes at least 14 isoenzymes identified thus far and these isoenzymes contribute to reproductive organ development by playing a role in the final steps of androgen and estrogen syntheses (2).”
Background
The mouse as a model to investigate sex steroid metabolism in the normal and pathological prostate
McNamara, K. M., Handelsman, D. J., & Simanainen, U. (2011) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/j.jsbmb.2011.10.009 · Cited by 7
Crystal structure of human 17beta-HSD type 1 in ternary complex with PBRM and NADP+
Li, T., & Lin, S. X. (2018) · Worldwide Protein Data Bank · doi:10.2210/pdb6cge/pdb · Cited by 7
Three types of 17β-hydroxysteroid dehydrogenases involved in Japanese eel ovarian steroidogenesis
Suzuki, H., Ito, R., Ozaki, Y., & Kazeto, Y. (2025) · General and Comparative Endocrinology · doi:10.1016/j.ygcen.2025.114697 · Cited by 6
17β-Hydroxysteroid Dehydrogenase Type 3 Deficiency: Diagnosis, Phenotypic Variability and Molecular Findings
Felicia, M., & Cavallo, L. (2012) · InTech eBooks · doi:10.5772/27190 · Cited by 6
Exploiting whole genome sequence data to fine map and characterize candidate genes within a quantitative trait loci region affecting androstenone on porcine chromosome 5
van Son, M., Agarwal, R., Kent, M., Grove, H., Grindflek, E. H., & Lien, S. (2017) · Animal Genetics · doi:10.1111/age.12615 · Cited by 6
Di-isononyl Phthalate (DINP) Impairs Reproduction in the Freshwater Fish, Oreochromis mossambicus (Peters 1852)
Revathy, V. S. (2018) · Asian Fisheries Science · doi:10.33997/j.afs.2018.31.04.004 · Cited by 6
High Expression of 17β-hydroxysteroid Dehydrogenase Type 2 is Associated with a Better Prognosis in Urothelial Carcinoma of the Urinary Tract
Wang, C.-T., Li, C., Wu, W., Huang, C., Li, C., Li, W., Chan, T., Liang, P., Hsing, C., & Liao, K. (2016) · Journal of Cancer · doi:10.7150/jca.16777 · Cited by 6
“These processes involve NAD+/NADH or NADP+/NADPH-dependent biological reactions [2].”
Background
Synthesis of substituted 15β-alkoxy estrone derivatives and their cofactor-dependent inhibitory effect on 17β-HSD1
Herman, B. E., Kiss, A., Woelfling, J., Mernyák, E., Szécsi, M., & Schneider, G. (2019) · Journal of Enzyme Inhibition and Medicinal Chemistry · doi:10.1080/14756366.2019.1634064 · Cited by 5
“one (15) Compound 11 (435mg, 1mmol) was dissolved in acetone (10ml) and Jones reagent (1ml) was added while cooling with ice.”
Method
17β-Hydroxysteroid dehydrogenases types 1 and 2: Enzymatic assays based on radiometric and mass-spectrometric detection
Sinreih, M., Gjorgoska, M., Möller, G., Adamski, J., & Rižner, T. L. (2023) · Methods in enzymology on CD-ROM/Methods in enzymology · doi:10.1016/bs.mie.2023.04.015 · Cited by 5
RNA deep sequencing reveals novel transcripts and pathways involved in the unsaturated fatty acid metabolism in chicken
Gunawan, A., Listyarini, K., Furqon, A., Jakaria, J., Sumantri, C., Akter, S., & Uddin, M. J. (2019) · Gene Reports · doi:10.1016/j.genrep.2019.100370 · Cited by 5
46,XY Sex Development Defect due to a Novel Homozygous (Splice Site) c.673_1G>C Variation in the HSD17B3 Gene: Case Report
Çiftçi, N., Kayaş, L., Çamtosun, E., & Akıncı, A. (2020) · Journal of Clinical Research in Pediatric Endocrinology · doi:10.4274/jcrpe.galenos.2020.2020.0249 · Cited by 5
“biologically active form testosterone (T) (1).”
Mitochondrial RNase P Complex in Animals: Mitochondrial tRNA Processing and Links to Disease
Saoji, M. M., & Cox, R. T. (2018) · Nucleic acids and molecular biology · doi:10.1007/978-3-319-78190-7_3 · Cited by 5
Unraveling the anti-androgenic mechanism of tris(2,3-dibromopropyl) isocyanurate (TBC) via the non-classical testosterone pathway and steroidogenesis: Potential human reproductive health implications
Tabęcka-Łonczyńska, A., Koszła, O., & Sołek, P. (2024) · Chemosphere · doi:10.1016/j.chemosphere.2024.142802 · Cited by 4
A supergene affects androgen concentrations during early development in a bird with alternative reproductive morphs
Giraldo‐Deck, L. M., Loveland, J. L., Goymann, W., Lank, D. B., & Küpper, C. (2024) · Hormones and Behavior · doi:10.1016/j.yhbeh.2024.105645 · Cited by 6
“Conversely, for androstenedione a precursor of testosterone and less potent androgen (Moeller and Adamski, 2009), Satellites and Faeders have higher levels than In-dependents (Küpper et al., 2016; Loveland et al., 2022, Loveland et al., 2021a).”
Background
Molecular Marker–Assisted Selective Breeding of Largemouth Bass
Junjie, B., & Li, S. (2019) · Elsevier eBooks · doi:10.1016/b978-0-12-816473-0.00005-0 · Cited by 4
Chemical synthesis of fluorinated and iodinated 17β-HSD3 inhibitors and evaluation for imaging prostate cancer tumors and tissue biodistribution
Poirier, D., Maltais, R., Rousseau, J. A., Roy, J., Phoenix, S., Cortés‐Benítez, F., & Lecomte, R. (2022) · Bioorganic Chemistry · doi:10.1016/j.bioorg.2022.106145 · Cited by 4
Transgenerational expression profiles of a sex related and an epigenetic control gene in the rotifer Brachionus plicatilis in relation to environmental predictability
Colinas, N., Montero‐Pau, J., Carmona, M. J., Sabatino, R., Cesare, A. D., Eckert, E. M., & García-Roger, E. M. (2023) · Hydrobiologia · doi:10.1007/s10750-023-05316-1 · Cited by 4
“Since edh encodes for 17 -β- dehydrogenase 12 enzyme, which is required to catalyse the interconversion of estrogenic hormones estrone and 17-β -estradiol (Mind-nich et al., 2004; Moeller & Adamski, 2009), the low expression of the gene would be expected to result in a reduced level of estradiol.”
Involvement of estrogen receptor alpha (ERα) and impairment of steroidogenesis after exposure to tris(2,3-dibromopropyl) isocyanurate (TBC) in mouse spermatogenic (GC-1 spg) cells in vitro
Tabęcka-Łonczyńska, A., Kaczka, P., & Kaleniuk, E. (2023) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/j.jsbmb.2023.106398 · Cited by 4
Synthesis and preliminary evaluation of a modified estradiol-core bearing a fused γ-lactone as non-estrogenic inhibitor of 17β-hydroxysteroid dehydrogenase type 1
Ouellet, É., Ayan, D. P., & Poirier, D. (2011) · Bioorganic & Medicinal Chemistry Letters · doi:10.1016/j.bmcl.2011.06.110 · Cited by 4
Cysteine-10 on 17β-Hydroxysteroid Dehydrogenase 1 Has Stabilizing Interactions in the Cofactor Binding Region and Renders Sensitivity to Sulfhydryl Modifying Chemicals
Nashev, L. G., Atanasov, A. G., Baker, M. E., & Odermatt, A. (2013) · International Journal of Cell Biology · doi:10.1155/2013/769536 · Cited by 4
“Hindawi Publishing Corporation International Journal of Cell Biology Volume 2013, Article ID 769536, 8 pages http://dx.doi.org/10.1155/2013/769536”
BackgroundInfluential
SOME ASPECTS OF STEROID REGULATION IN TELEOSTS
Львович, Р. Н. (2018) · Proceedings of the Karelian Research Centre of the Russian Academy of Sciences · doi:10.17076/eb777 · Cited by 4
Integration of steroid research: Perspectives on environment factors, homeostasis in health, and disease treatment
Penning, T. M., & Adamski, J. (2011) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/j.jsbmb.2011.04.011 · Cited by 4
The steroid hormone ADIOL promotes learning by reducing neural kynurenic acid levelsPreprint
Lemieux, G. A., Yoo, S., Lin, L., Vohra, M., & Ashrafi, K. (2023) · Genes & Development · doi:10.1101/gad.350745.123 · Cited by 5
Female Adipose Tissue Sex Steroid Biosynthesis
Hetemäki, N., Mikkola, T. S., & Savolainen-Peltonen, H. M. (2025) · Seminars in Reproductive Medicine · doi:10.1055/s-0045-1811952 · Cited by 5
Localization of Five Steroidogenic Enzyme mRNAs in Japanese Black Bear (Ursus thibetanus japonicus) Testes During the Mating Season by In Situ Hybridization
Iibuchi, R., Shimozuru, M., Kamine, A., Nio‐Kobayashi, J., Iwanaga, T., & Tsubota, T. (2010) · Journal of Reproduction and Development · doi:10.1262/jrd.09-188n · Cited by 3
“The 17βHSD family controls the last step in the formation of androgens and estrogens, and at least 14 isoenzymes are known in vertebrates [23].”
Background
Identification of a First Enzymatic Activator of a 17β-Hydroxysteroid Dehydrogenase
Trottier, A., Maltais, R., & Poirier, D. (2014) · ACS Chemical Biology · doi:10.1021/cb500109e · Cited by 3
A supergene affects steroid metabolism during early ontogeny in a bird with alternative reproductive morphsPreprint
Giraldo‐Deck, L. M., Loveland, J. L., Goymann, W., Lank, D. B., & Küpper, C. (2022) · doi:10.22541/au.166913241.14402024/v1 · Cited by 3
Functional characterization of two 20β-hydroxysteroid dehydrogenase type 2 homeologs from Xenopus laevis reveals multispecificity
Tokarz, J., Schmitt, S. M., Möller, G., Brändli, A. W., & Adamski, J. (2021) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/j.jsbmb.2021.105874 · Cited by 2
Formation of 5α-dihydrotestosterone from 5α-androstane-3α,17β-diol in prostate cancer LAPC-4 cells – Identifying inhibitors of non-classical pathways producing the most potent androgen
Boutin, S., Roy, J., Maltais, R., & Poirier, D. (2019) · Bioorganic & Medicinal Chemistry Letters · doi:10.1016/j.bmcl.2019.126783 · Cited by 2
Clinical, hormonal, and molecular-genetic characteristics of two cases of abnormal sex formation (ASF) in 46XY subjects caused by type 3 17-beta hydroxysteroid dehydrogenase deficiency
Kolodkina, A. A., Калинченко, Н. Ю., Nizhnik, A. N., Nokel', M. A., & Tiulpakov, A. N. (2011) · Problems of Endocrinology · doi:10.14341/probl201157325-30 · Cited by 2
Chemical synthesis, characterisation and biological evaluation of lactonic-estradiol derivatives as inhibitors of 17β-hydroxysteroid dehydrogenase type 1
Farhane, S., Fournier, M.-A., & Poirier, D. (2013) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/j.jsbmb.2013.05.002 · Cited by 2
Serum hydroxysteroid (17beta) dehydrogenase 1 concentration in pregnant women correlates with pregnancy-associated plasma protein A but does not serve as an independent marker for preeclampsia
Heinosalo, T., Saarinen, N., Biehl, A., Rytkönen, K. T., Villa, P., Juhila, J., Koskimies, P., Laiho, A., Hämäläinen, E. K., Kajantie, E., et al. (2024) · Biology of Reproduction · doi:10.1093/biolre/ioae078 · Cited by 1
Identification of Hydroxysteroid Dehydrogenase Type 1 As a Potential Bladder Tumor Marker
Albadawy, A., Alqudaimi, M., Cui, H., Yan, X., Sun, J., & Shi, P. (2024) · ̒Ulūm va funūn-i bastah/bandī · doi:10.61186/ibj.4068 · Cited by 1
“These processes involve biological reactions that rely on either NAD + /NADH or NADP + /NADPH [5] .”
Background
Molecular characterization and expression profiling of 3 beta-hydroxysteroid dehydrogenase and hydroxysteroid 17-beta dehydrogenase in response to HCG stimulation in striped murrel, Channa striata (Bloch, 1793)
Rasal, K. D., Davu, S., Asgolkar, P., Shinde, S., Kumar, P. V., Dhere, S., Acharya, A., Kumar, R., Sonwane, A., Brahmane, M. P., et al. (2024) · Gene Reports · doi:10.1016/j.genrep.2024.102018 · Cited by 1
Breakdown and clearance of steroids
Honour, J. W. (2023) · Elsevier eBooks · doi:10.1016/b978-0-12-818124-9.00001-2 · Cited by 1
Single cell resolution of neurosteroidogenesis in the murine brain: intermediary biosynthesis
Koganti, P. P., & Selvaraj, V. (2025) · Journal of Endocrinology · doi:10.1530/joe-24-0333 · Cited by 1
Estrogens in Prostate Cancer
Carruba, G. (2012) · Springer eBooks · doi:10.1007/978-1-4471-2864-9_30 · Cited by 1
Steroid Sulfatase Inhibitor Reduces Proliferation of Ishikawa Endometrial Cancer Cells in Co-Culture Systems
Nishimoto, M., Toyoshima, M., Shiga, N., Utsunomiya, H., Suzuki, F., Nagase, S., Nishigori, H., Suzuki, T., Sasano, H., Ito, K., et al. (2016) · Open Journal of Endocrine and Metabolic Diseases · doi:10.4236/ojemd.2016.69025 · Cited by 1
“There are two subtypes of 17β-HSD: type 1 catalyzes E1 to E2, and type 2 preferentially catalyzes the oxidation of E2 to E1 [3] [4] [14].”
Background
Molecular Modelling of Estrogen-Producing Enzymes CYP450 Aromatase and 17beta-Hydroxysteroid Dehydrogenase Type 1
Karkola, S. (2009) · Työväentutkimus Vuosikirja · Cited by 1
Molecular profiling of human endometrium and endometriosis
Huhtinen, K. (2010) · UTUPub (University of Turku) · Cited by 1
Personalized Treatment of Prostate Cancer Based on Inherited Variations of Steroid Pathway–Related Genes
Todenhöfer, T., Schwentner, C., & Stenzl, A. (2012) · European Urology · doi:10.1016/j.eururo.2011.12.052 · Cited by 1
“Variants of these enzymes have been linked to a broad spectrum of diseases, including sexual disorders, breast cancer, and polycystic kidney disease, and have been shown to correlate with sex hormone levels [6].”
Background
Development of potent and selective inhibitors of 17β-hydroxysteroid dehydrogenase type 2 : a new target for the treatment of osteoporosis
Wetzel, M. (2011) · Publications of the UdS (Saarland University) · doi:10.22028/d291-22814

Authors: Moeller, G., & Adamski, J.
Affiliations: Helmholtz Munich (DE)
ORCID: Adamski, Jerzy
Venue: Molecular and Cellular Endocrinology
Publisher: Elsevier BV
Published: 2009-03
Volume: 301
Issue: 1-2
Pages: 7-19
ISSN: 0303-7207 (ISSN-L)
DOI: 10.1016/j.mce.2008.10.040
OpenAlex: W2048714965
Cited by: 214
References: 176
Citations by year: 2026: 5 · 2025: 6 · 2024: 12 · 2023: 8 · 2022: 6 · 2021: 8 · 2020: 11 · 2019: 8 · 2018: 17 · 2017: 12 · 2016: 14 · 2015: 12 · 2014: 11 · 2013: 16 · 2012: 11
FWCI: 1.52
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Molecular and Cellular Endocrinology (publishedVersion)
PubMed (publishedVersion)
Site cant be reached (submittedVersion)
Topics: Physical Sciences › Chemistry › Organic Chemistry › Steroid Chemistry and Biochemistry
Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adrenal Hormones and Disorders
Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Hormonal Regulation and Hypertension
Keywords: 17β-hydroxysteroid dehydrogenase, steroid metabolism, steroid hormone regulation, metabolomics, endogenous substrates, genetic susceptibility, disease
MeSH terms: Animals, Disease, Humans, Polymorphism, Genetic, 17-Hydroxysteroid Dehydrogenases, Crystallography, X-Ray, Models, Animal

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Integrated view on 17beta-hydroxysteroid dehydrogenases

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