Cited by 226Steroid Chemistry and BiochemistryAdrenal Hormones and DisordersHormonal Regulation and Hypertension

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Integrated view on 17beta-hydroxysteroid dehydrogenases

Moeller, Gabriele, Adamski, Jerzy·2009·Molecular and Cellular Endocrinology

DOI 10.1016/j.mce.2008.10.040

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Abstract

17beta-Hydroxysteroid dehydrogenases (17beta-HSDs) are important enzymes in steroid metabolism. Long known members of the protein family seemed to be well characterised concerning their role in the regulation of the biological potency of steroid hormones, but today more and more evidence points to pivotal contributions of these enzymes in a variety of other metabolic pathways. Therefore, studies on 17beta-HSDs develop towards metabolomic survey. Latest research results give new insights into the complex metabolic interconnectivity of the 17beta-HSDs. In this paper metabolic activities of 17beta-HSDs will be compared, their interplay with endogenous substrates summarised, and interlacing pathways depicted. Strategies on deciphering the physiological role of 17beta-HSDs and the genetic predisposition for associated diseases will be presented.

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“However, there are at least 14 different members of the 17β-HSD family identified in humans and mice, and some of them could also potentially convert DHEA to ADIOL (Moeller and Adamski, 2009).”

See all 226

Authors: Moeller, G., & Adamski, J.
Affiliations: Helmholtz Munich (DE)
ORCID: Adamski, Jerzy
Venue: Molecular and Cellular Endocrinology
Publisher: Elsevier BV
Published: 2009-03
Volume: 301
Issue: 1-2
Pages: 7-19
ISSN: 0303-7207 (ISSN-L)
DOI: 10.1016/j.mce.2008.10.040
OpenAlex: W2048714965
Cited by: 214
References: 176
Citations by year: 2026: 5 · 2025: 6 · 2024: 12 · 2023: 8 · 2022: 6 · 2021: 8 · 2020: 11 · 2019: 8 · 2018: 17 · 2017: 12 · 2016: 14 · 2015: 12 · 2014: 11 · 2013: 16 · 2012: 11
FWCI: 1.52
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Molecular and Cellular Endocrinology (publishedVersion)
PubMed (publishedVersion)
Site cant be reached (submittedVersion)
Topics: Physical Sciences › Chemistry › Organic Chemistry › Steroid Chemistry and Biochemistry
Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adrenal Hormones and Disorders
Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Hormonal Regulation and Hypertension
Keywords: 17β-hydroxysteroid dehydrogenase, steroid metabolism, steroid hormone regulation, metabolomics, endogenous substrates, genetic susceptibility, disease
MeSH terms: Animals, Disease, Humans, Polymorphism, Genetic, 17-Hydroxysteroid Dehydrogenases, Crystallography, X-Ray, Models, Animal

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Integrated view on 17beta-hydroxysteroid dehydrogenases

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