Vaspin suppresses cytokine-induced inflammation in 3T3-L1 adipocytes via inhibition of NFκB pathway
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Vaspin expression is increased in white adipose tissue (WAT) of diet-induced obese mice and rats and is supposed to compensate HFD-induced inflammatory processes and insulin resistance in adipose tissue by counteracting pro-inflammatory gene expression in obesity. Multiple studies have also demonstrated strong anti-inflammatory effects in vascular and skin cells. Here, we used vaspin treated 3T3-L1 murine adipocytes as well as 3T3-L1 cells with stable vaspin expression to investigate the effect of exogenous and endogenous vaspin on inflammatory processes and insulin signaling in adipocytes. Our stably transfected cells secreted significant amounts of vaspin which was in the physiological range of ∼0.5 ng/ml in cell supernatants. Adipocyte differentiation was not affected by vaspin as expression of adipogenic marker genes as well as lipid accumulation after full differentiation was similar to control cells. We found that IL-1β induced expression and secretion of pro-inflammatory cytokines, such as IL-6, MCP1 and TNFα was significantly blunted in vaspin expressing 3T3-L1 cells. Treatment of 3T3-L1 cells with exogenous vaspin resulted in reduced cytokine-induced activation of the intracellular and pro-inflammatory NFκB signaling cascades (IKKα/β, IκB and NFκB). Moreover, endogenous vaspin positively affected insulin signaling by increasing insulin-stimulated phosphorylation of the key mediator protein kinase B (AKT). Together, we demonstrate anti-inflammatory effects of vaspin in 3T3-L1 adipocytes as well as increased insulin signaling by endogenous expression or exogenous treatment. The results provide evidence for potent anti-inflammatory action of vaspin not only in vascular cells but also in adipose tissue.
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Vaspin protects vascular tissues from fatty acid-induced apoptosis via PI3K/Akt/eNOS signaling pathway.
“Studies show that vaspin protects vascular tissues from fatty acid-induced apoptosis via the signaling pathway PI3K/Akt/eNOS [25].”
From Adipokines, Myokines, and Hepatokines: Crosstalk and Metabolic Repercussions (2021) · cites this paper as [25]
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- Authors
- Zieger, K., Weiner, J., Krause, K., Schwarz, M., Kohn, M., Stumvoll, M., Blüher, M., & Heiker, J. T.
- Affiliations
- Leipzig University (DE)
- IFB Adiposity Diseases (DE)
- Corresponding author
- Heiker, John T.
- Venue
- Molecular and Cellular Endocrinology
- Publisher
- Elsevier BV
- Published
- 2018-01
- Volume
- 460
- Pages
- 181-188
- ISSN
- 0303-7207 (ISSN-L)
- OpenAlex
- W2736863141
- Cited by
- 65
- References
- 48
- Citations by year
- 2026: 4 · 2025: 10 · 2024: 9 · 2023: 7 · 2022: 5 · 2021: 9 · 2020: 9 · 2019: 6 · 2018: 5 · 2017: 1
- FWCI
- 4.50
- Type
- journal article
- Language
- en
- Open access
- green
- ul.qucosa.de
- Licence
- Locations
- Molecular and Cellular Endocrinology (publishedVersion)
- PubMed (publishedVersion)
- Qucosa (Saxon State and University Library Dresden) (submittedVersion, other-oa)
- Funders
- European Union and the Free State of Saxony
- Formel1 Nachwuchsförderung of the Medical Faculty of the University of Leipzig
- Deutsche Forschungsgemeinschaft (SFB1052, KR 4258/1-1)
- DDG/German Diabetes Association
- German Federal Ministry of Education and Research (01EO1501)
- Topics
- Health Sciences › Medicine › Epidemiology › Adipokines, Inflammation, and Metabolic Diseases
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › NF-κB Signaling Pathways
- Health Sciences › Medicine › Physiology › Adipose Tissue and Metabolism
- Keywords
- vaspin, adipocytes, adipose tissue inflammation, NF-κB signaling, insulin signaling, Akt phosphorylation, IL-1β, inflammatory cytokines, obesity, insulin resistance, adipogenesis, white adipose tissue
- MeSH terms
- Animals, Cell Differentiation, Humans, Inflammation, Insulin, Phosphorylation, Signal Transduction, Serpins, Cytokines, NF-kappa B, Adipocytes, Chemokines, 3T3-L1 Cells, Proto-Oncogene Proteins c-akt, Mice
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