Exercising our brains: how physical activity impacts synaptic plasticity in the dentate gyrus.

Journal of Clinical Psychiatry

(2018) · Journal of Clinical Psychiatry · doi:10.5505/kpd · Cited by 13,703 · see citing works

Long‐lasting potentiation of synaptic transmission in the dentate area of the unanaesthetized rabbit following stimulation of the perforant path

Bliss, T. V. P., & Gardner-Medwin, A. R. (1973) · The Journal of Physiology · doi:10.1113/jphysiol.1973.sp010274 · Cited by 7,460 · see citing works

Running enhances neurogenesis, learning, and long-term potentiation in mice

van Praag, H., Christie, B. R., Sejnowski, T. J., & Gage, F. H. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.23.13427 · Cited by 2,904 · see citing works

Functional neurogenesis in the adult hippocampus

van Praag, H., Schinder, A. F., Christie, B. R., Toni, N., Palmer, T. D., & Gage, F. H. (2002) · Nature · doi:10.1038/4151030a · Cited by 2,853 · see citing works

Brain corticosteroid receptor balance in health and disease

de Kloet, E. R., Vreugdenhil, E., Oitzl, M. S., & Joëls, M. (1998) · Endocrine Reviews · doi:10.1210/edrv.19.3.0331 · Cited by 2,614 · see citing works

Exercise enhances learning and hippocampal neurogenesis in aged mice

van Praag, H., Shubert, T., Zhao, C., & Gage, F. H. (2005) · The Journal of Neuroscience · doi:10.1523/jneurosci.1731-05.2005 · Cited by 2,078 · see citing works

The Role of the Hippocampus in Feedback Regulation of the Hypothalamic-Pituitary-Adrenocortical Axis*

JACOBSON, L., & SAPOLSKY, R. (1991) · Endocrine Reviews · doi:10.1210/edrv-12-2-118 · Cited by 1,739 · see citing works

Homosynaptic long-term depression in area CA1 of hippocampus and effects of N-methyl-D-aspartate receptor blockade.

Dudek, S. M., & Bear, M. F. (1992) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.89.10.4363 · Cited by 1,708 · see citing works

Regulation of Cell Survival by Secreted Proneurotrophins

Lee, R., Kermani, P., Teng, K. K., & Hempstead, B. L. (2001) · Science · doi:10.1126/science.1065057 · Cited by 1,670 · see citing works

Stress and glucocorticoids affect the expression of brain-derived neurotrophic factor and neurotrophin-3 mRNAs in the hippocampus

Smith, M., Makino, S., Květňanský, R., & Post, R. M. (1995) · Journal of Neuroscience · doi:10.1523/jneurosci.15-03-01768.1995 · Cited by 1,429 · see citing works

Hippocampal long-term potentiation is impaired in mice lacking brain-derived neurotrophic factor.

Korte, M., Carroll, P., Wolf, E., Brem, G., Thoenen, H., & Bonhoeffer, T. (1995) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.92.19.8856 · Cited by 1,426 · see citing works

Recombinant BDNF Rescues Deficits in Basal Synaptic Transmission and Hippocampal LTP in BDNF Knockout Mice

Patterson, S. L., Abel, T., Deuel, T. A. S., Martin, K. C., Rose, J. C., & Kandel, E. R. (1996) · Neuron · doi:10.1016/s0896-6273(00)80140-3 · Cited by 1,233 · see citing works

The Hippocampus Book

(2006) · doi:10.1093/acprof:oso/9780195100273.001.0001 · Cited by 1,186 · see citing works

Learning causes synaptogenesis, whereas motor activity causes angiogenesis, in cerebellar cortex of adult rats.

Black, J. E., Isaacs, K. R., Anderson, B. J., Alcantara, A. A., & Greenough, W. T. (1990) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.87.14.5568 · Cited by 1,161 · see citing works

Regulation of synaptic responses to high-frequency stimulation and LTP by neurotrophins in the hippocampus

Figurov, A., Pozzo-Miller, L. D., Olafsson, P., Wang, T., & Lu, B. (1996) · Nature · doi:10.1038/381706a0 · Cited by 1,106 · see citing works

Role of NMDA Receptor Subtypes in Governing the Direction of Hippocampal Synaptic Plasticity

Liu, L., Wong, T. P., Pozza, M. F., Lingenhoehl, K., Wang, Y., Sheng, M., Auberson, Y. P., & Wang, Y. T. (2004) · Science · doi:10.1126/science.1096615 · Cited by 1,106 · see citing works

Exercise and brain neurotrophins

Neeper, S. A., Góauctemez-Pinilla, F., Choi, J., & Cotman, C. (1995) · Nature · doi:10.1038/373109a0 · Cited by 1,066 · see citing works

Circulating Insulin-Like Growth Factor I Mediates Exercise-Induced Increases in the Number of New Neurons in the Adult Hippocampus

Trejo, J. L., Carro, E., & Torres-Alemán, I. (2001) · The Journal of Neuroscience · doi:10.1523/jneurosci.21-05-01628.2001 · Cited by 1,017 · see citing works

Physical activity increases mRNA for brain-derived neurotrophic factor and nerve growth factor in rat brain

Neeper, S. A., Gómez‐Pinilla, F., Choi, J., & Cotman, C. W. (1996) · Brain Research · doi:10.1016/0006-8993(96)00273-9 · Cited by 1,015 · see citing works

BDNF and 5-HT: a dynamic duo in age-related neuronal plasticity and neurodegenerative disorders

Mattson, M. P., Maudsley, S., & Martin, B. (2004) · Trends in Neurosciences · doi:10.1016/j.tins.2004.08.001 · Cited by 942 · see citing works

Effects of voluntary exercise on synaptic plasticity and gene expression in the dentate gyrus of adult male Sprague-Dawley rats in vivo

Farmer, J., Zhao, X., van Praag, H., Wodtke, K., Gage, F. H., & Christie, B. R. (2004) · Neuroscience · doi:10.1016/j.neuroscience.2003.09.029 · Cited by 836 · see citing works

Activation of p75NTR by proBDNF facilitates hippocampal long-term depression

Woo, N. H., Teng, H. K., Siao, C.-J., Chiaruttini, C., Pang, P. T., Milner, T. A., Hempstead, B. L., & Lu, B. (2005) · Nature Neuroscience · doi:10.1038/nn1510 · Cited by 815 · see citing works

Hippocampal LTP Is Accompanied by Enhanced F-Actin Content within the Dendritic Spine that Is Essential for Late LTP Maintenance In Vivo

Fukazawa, Y., Saitoh, Y., Ozawa, F., Ohta, Y., Mizuno, K., & Inokuchi, K. (2003) · Neuron · doi:10.1016/s0896-6273(03)00206-x · Cited by 695 · see citing works

Neurotrophin secretion: current facts and future prospects

Leßmann, V., Gottmann, K., & Malcangio, M. (2003) · Progress in Neurobiology · doi:10.1016/s0301-0082(03)00019-4 · Cited by 664 · see citing works

Synaptic plasticity in the hippocampus: LTP and LTD

Malenka, R. C. (1994) · Cell · doi:10.1016/0092-8674(94)90517-7 · Cited by 655 · see citing works

Prolonged exercise induces angiogenesis and increases cerebral blood volume in primary motor cortex of the rat

Swain, R. A., Harris, A. B., Wiener, E. C., Dutka, M. V., Morris, H. D., Theien, B. E., Konda, S., Engberg, K., Lauterbur, P. C., & Greenough, W. T. (2003) · Neuroscience · doi:10.1016/s0306-4522(02)00664-4 · Cited by 655 · see citing works

Synaptic enhancement in fascia dentata: Cooperativity among coactive afferents

McNaughton, B. L., Douglas, R. M., & Goddard, G. V. (1978) · Brain Research · doi:10.1016/0006-8993(78)90030-6 · Cited by 647 · see citing works

The neurotrophin receptor p75NTR: novel functions and implications for diseases of the nervous system

Dechant, G., & Barde, Y. (2002) · Nature Neuroscience · doi:10.1038/nn1102-1131 · Cited by 606 · see citing works

Circulating Insulin-Like Growth Factor I Mediates the Protective Effects of Physical Exercise against Brain Insults of Different Etiology and Anatomy

Carro, E., Trejo, J. L., Busiguina, S., & Torres-Aleman, I. (2001) · The Journal of Neuroscience · doi:10.1523/jneurosci.21-15-05678.2001 · Cited by 601 · see citing works

Biosynthesis and Post-translational Processing of the Precursor to Brain-derived Neurotrophic Factor

Mowla, S. J., Farhadi, H. F., Pareek, S., Atwal, J. K., Morris, S. J., Seidah, N. G., & Murphy, R. A. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m008104200 · Cited by 572 · see citing works

Cholesterol binds to synaptophysin and is required for biogenesis of synaptic vesicles

Thiele, C., Hannah, M. J., Fahrenholz, F., & Huttner, W. Β. (1999) · Nature Cell Biology · doi:10.1038/71366 · Cited by 571 · see citing works

Neonatal Outcomes After Prenatal Exposure to Selective Serotonin Reuptake Inhibitor Antidepressants and Maternal Depression Using Population-Based Linked Health Data

Oberlander, T. F., Warburton, W., Misri, S., Aghajanian, J., & Hertzman, C. (2006) · Archives of General Psychiatry · doi:10.1001/archpsyc.63.8.898 · Cited by 551 · see citing works

BDNF Enhances Quantal Neurotransmitter Release and Increases the Number of Docked Vesicles at the Active Zones of Hippocampal Excitatory Synapses

Tyler, W. J., & Pozzo‐Miller, L. D. (2001) · Journal of Neuroscience · doi:10.1523/jneurosci.21-12-04249.2001 · Cited by 520 · see citing works

Behavioural stress facilitates the induction of long-term depression in the hippocampus

Xu, L., Anwyl, R., & Rowan, M. J. (1997) · Nature · doi:10.1038/387497a0 · Cited by 509 · see citing works

Long-term potentiation of the perforant path-granule cell synapse in the rat hippocampus

Douglas, R. M., & Goddard, G. V. (1975) · Brain Research · doi:10.1016/0006-8993(75)90697-6 · Cited by 507 · see citing works

Impairments in High-Frequency Transmission, Synaptic Vesicle Docking, and Synaptic Protein Distribution in the Hippocampus of BDNF Knockout Mice

Pozzo‐Miller, L. D., Gottschalk, W., Zhang, L., McDermott, K., Du, J., Gopalakrishnan, R., Oho, C., Sheng, Z., & Lu, B. (1999) · Journal of Neuroscience · doi:10.1523/jneurosci.19-12-04972.1999 · Cited by 471 · see citing works

Voluntary exercise alters the cytoarchitecture of the adult dentate gyrus by increasing cellular proliferation, dendritic complexity, and spine density

Eadie, B. D., Redila, V. A., & Christie, B. R. (2005) · Journal of Comparative Neurology · doi:10.1002/cne.20493 · Cited by 466 · see citing works

Postsynaptic induction of BDNF-mediated long-term potentiation

Kovalchuk, Y., Hanse, E., Kafitz, K. W., & Konnerth, A. (2002) · Science · doi:10.1126/science.1067766 · Cited by 456 · see citing works

Behavioral stress impairs long-term potentiation in rodent hippocampus

Foy, M. R., Stanton, M. E., Levine, S., & Thompson, R. F. (1987) · Behavioral and Neural Biology · doi:10.1016/s0163-1047(87)90664-9 · Cited by 436 · see citing works

Behavioral stress modifies hippocampal plasticity through N-methyl-D-aspartate receptor activation.

Kim, J. J., Foy, M. R., & Thompson, R. F. (1996) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.93.10.4750 · Cited by 435 · see citing works

Exercise and the Brain: Angiogenesis in the Adult Rat Cerebellum after Vigorous Physical Activity and Motor Skill Learning

Isaacs, K. R., Anderson, B. J., Alcantara, A. A., Black, J. E., & Greenough, W. T. (1992) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1038/jcbfm.1992.14 · Cited by 405 · see citing works

Downregulation of BDNF mRNA and protein in the rat hippocampus by corticosterone

Schaaf, M. J. M., de Jong, J., de Kloet, E. R., & Vreugdenhil, E. (1998) · Brain Research · doi:10.1016/s0006-8993(98)01010-5 · Cited by 360 · see citing works

Neuronal Circuit Regulation of the Hypothalamo-Pituitary-Adrenocortical Stress Axis

Herman, J. P., Prewitt, C. M.-F., & Cullinan, W. E. (1996) · Critical Reviews in Neurobiology · doi:10.1615/critrevneurobiol.v10.i3-4.50 · Cited by 357 · see citing works

Role for a cortical input to hippocampal area CA1 in the consolidation of a long-term memory

Remondes, M., & Schuman, E. M. (2004) · Nature · doi:10.1038/nature02965 · Cited by 352 · see citing works

Virus-mediated gene transfer into hippocampal CA1 region restores long-term potentiation in brain-derived neurotrophic factor mutant mice.

Korte, M., Griesbeck, O., Gravel, C., Carroll, P., Staiger, V, Thoenen, H., & Bonhoeffer, T. (1996) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.93.22.12547 · Cited by 351 · see citing works

Synaptic plasticity in the hippocampus

Bliss, T. (1979) · Trends in Neurosciences · doi:10.1016/0166-2236(79)90019-5 · Cited by 351 · see citing works

Differential Sorting of Nerve Growth Factor and Brain-Derived Neurotrophic Factor in Hippocampal Neurons

Mowla, S. J., Pareek, S., Farhadi, H. F., Petrecca, K., Fawcett, J. P., Seidah, N. G., Morris, S. J., Sossin, W. S., & Murphy, R. A. (1999) · Journal of Neuroscience · doi:10.1523/jneurosci.19-06-02069.1999 · Cited by 350 · see citing works

Induction and Experience-Dependent Consolidation of Stable Long-Term Potentiation Lasting Months in the Hippocampus

Abraham, W. C., Logan, B. J., Greenwood, J. M., & Dragunow, M. (2002) · Journal of Neuroscience · doi:10.1523/jneurosci.22-21-09626.2002 · Cited by 338 · see citing works

Localization and Regulation of Glucocorticoid and Mineralocorticoid Receptor Messenger RNAs in the Hippocampal Formation of the Rat

Herman, J. P., Patel, P. D., Akil, H., & Watson, S. J. (1989) · Molecular Endocrinology · doi:10.1210/mend-3-11-1886 · Cited by 328 · see citing works

Running induces widespread structural alterations in the hippocampus and entorhinal cortex

Stranahan, A. M., Khalil, D., & Gould, E. (2007) · Hippocampus · doi:10.1002/hipo.20348 · Cited by 327 · see citing works

Brain-Derived Neurotrophic Factor Promotes Long-Term Potentiation-Related Cytoskeletal Changes in Adult Hippocampus

Rex, C. S., Lin, C.-Y., Kramár, E. A., Chen, L. Y., Gall, C. M., & Lynch, G. (2007) · The Journal of Neuroscience · doi:10.1523/jneurosci.4037-06.2007 · Cited by 324 · see citing works

Effects of long-term voluntary exercise on the mouse hypothalamic–pituitary–adrenocortical axis

Droste, S. K., Gesing, A., Ulbricht, S., Müller, M. B., Linthorst, A. C. E., & Reul, J. M. H. M. (2003) · Endocrinology · doi:10.1210/en.2003-0097 · Cited by 324 · see citing works

Distribution of the mineralocorticoid and the glucocorticoid receptor mRNAs in the rat hippocampus

Eekelen, J. A. M. V., Jiang, W., de Kloet, E. R., & Bohn, M. C. (1988) · Journal of Neuroscience Research · doi:10.1002/jnr.490210113 · Cited by 316 · see citing works

Physical exercise induces FGF-2 and its mRNA in the hippocampus

Gómez‐Pinilla, F., Dao, L., & So, V. (1997) · Brain Research · doi:10.1016/s0006-8993(97)00375-2 · Cited by 292 · see citing works

BDNF acutely increases tyrosine phosphorylation of the NMDA receptor subunit 2B in cortical and hippocampal postsynaptic densities

Lin, S.-Y., Wu, K. M., Levine, E. S., Mount, H. T. J., Suen, P.-C., & Black, I. B. (1998) · Molecular Brain Research · doi:10.1016/s0169-328x(97)00349-5 · Cited by 278 · see citing works

Voluntary exercise protects against stress-induced decreases in brain-derived neurotrophic factor protein expression

Adlard, P. A., & Cotman, C. W. (2004) · Neuroscience · doi:10.1016/j.neuroscience.2003.12.039 · Cited by 265 · see citing works

Chronic unpredictable stress impairs long‐term potentiation in rat hippocampal CA1 area and dentate gyrus <i>in vitro</i>

Alfarez, D. N., Joëls, M., & Krugers, H. J. (2003) · European Journal of Neuroscience · doi:10.1046/j.1460-9568.2003.02622.x · Cited by 258 · see citing works

Brain-derived Neurotrophic Factor Regulates the Expression and Synaptic Delivery ofα-Amino-3-hydroxy-5-methyl-4-isoxazole Propionic Acid Receptor Subunits in Hippocampal Neurons

Caldeira, M. V., Melo, C. V., Pereira, D. B., Carvalho, R., Correia, S. S., Backos, D. S., Carvalho, A. L., Esteban, J. A., & Duarte, C. B. (2007) · Journal of Biological Chemistry · doi:10.1074/jbc.m700607200 · Cited by 251 · see citing works

Glucocorticoid receptor and protein/RNA synthesis-dependent mechanisms underlie the control of synaptic plasticity by stress.

Xu, L., Hölscher, C., Anwyl, R., & Rowan, M. (1998) · Proceedings of the National Academy of Sciences of the United States of America · doi:10.1073/pnas.95.6.3204 · Cited by 248 · see citing works

Exercise differentially regulates synaptic proteins associated to the function of BDNF

Vaynman, S. S., Ying, Z., Yin, D., & Gomez-Pinilla, F. (2006) · Brain Research · doi:10.1016/j.brainres.2005.11.062 · Cited by 248 · see citing works

The effects of physical exercise on depressive symptoms among the aged: a systematic review

Sjösten, N., & Kivelä, S.-L. (2006) · International Journal of Geriatric Psychiatry · doi:10.1002/gps.1494 · Cited by 245 · see citing works

Tonic and phasic nitric oxide signals in hippocampal long-term potentiation

Hopper, R. A., & Garthwaite, J. (2006) · The Journal of Neuroscience · doi:10.1523/jneurosci.2259-06.2006 · Cited by 239 · see citing works

Exercise-induced changes in dendritic structure and complexity in the adult hippocampal dentate gyrus

Redila, V. A., & Christie, B. R. (2005) · Neuroscience · doi:10.1016/j.neuroscience.2005.10.050 · Cited by 235 · see citing works

Role of adrenal steroid mineralocorticoid and glucocorticoid receptors in long-term potentiation in the CA1 field of hippocampal slices

Pavlides, C., Ogawa, S., Kimura, A., & McEwen, B. S. (1996) · Brain Research · doi:10.1016/s0006-8993(96)00776-7 · Cited by 234 · see citing works

Circadian regulation of hippocampal long-term potentiation

Chaudhury, D., Wang, L. M., & Colwell, C. S. (2005) · Journal of Biological Rhythms · doi:10.1177/0748730405276352 · Cited by 231 · see citing works

Integrin-driven actin polymerization consolidates long-term potentiation

Kramár, E. A., Lin, B., Rex, C. S., Gall, C. M., & Lynch, G. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0601354103 · Cited by 221 · see citing works

Glucocorticoid and Mineralocorticoid Receptor mRNA Expression in Rat Brain

Chao, H. M., Choo, P. H., & McEwen, B. S. (2008) · Neuroendocrinology · doi:10.1159/000125250 · Cited by 217 · see citing works

Essential Psychopharmacology

Naussbaum, D. (2006) · Journal of Developmental & Behavioral Pediatrics · doi:10.1097/00004703-200602000-00014 · Cited by 215 · see citing works

Acute stress impairs spatial memory in male but not female rats: influence of estrous cycle

Conrad, C. D., Jackson, J. L., Wieczorek, L., Baran, S. E., Harman, J. S., Wright, R. L., & Korol, D. L. (2004) · Pharmacology Biochemistry and Behavior · doi:10.1016/j.pbb.2004.04.025 · Cited by 211 · see citing works

Effects of ageing and exercise training on endothelium‐dependent vasodilatation and structure of rat skeletal muscle arterioles

Spier, S. A., Delp, M. D., Meininger, C. J., Donato, A. J., Ramsey, M. W., & Muller‐Delp, J. M. (2004) · The Journal of Physiology · doi:10.1113/jphysiol.2003.060301 · Cited by 209 · see citing works

BDNF protects against stress‐induced impairments in spatial learning and memory and LTP

Radecki, D. T., Brown, L. M., Martinez, J., & Teyler, T. J. (2004) · Hippocampus · doi:10.1002/hipo.20048 · Cited by 209 · see citing works

Reduced mortality and brain damage after locomotor activity in gerbil forebrain ischemia.

Stummer, W., Weber, K., Tranmer, B. I., Baethmann, A. J., & Kempski, O. S. (1994) · Stroke · doi:10.1161/01.str.25.9.1862 · Cited by 205 · see citing works

Normal and reactive NG2+ glial cells are distinct from resting and activated microglia

Nishiyama, A., Yu, M., Drazba, J. A., & Tuohy, V. K. (1997) · Journal of Neuroscience Research · doi:10.1002/(sici)1097-4547(19970515)48:4 · Cited by 184 · see citing works

Intracellular Domains of NMDA Receptor Subtypes Are Determinants for Long-Term Potentiation Induction

Köhr, G., Jensen, V., Koester, H. J., Mihaljević, A. L., Utvik, J. K., Kvello, A., Ottersen, O. P., Seeburg, P. H., Sprengel, R., & Hvalby, Ø. (2003) · Journal of Neuroscience · doi:10.1523/jneurosci.23-34-10791.2003 · Cited by 181 · see citing works

Priming of associative long-term depression in the dentate gyrus by θ frequency synaptic activity

Christie, B. R., & Abraham, W. C. (1992) · Neuron · doi:10.1016/0896-6273(92)90222-y · Cited by 180 · see citing works

Dominance Hierarchy Influences Adult Neurogenesis in the Dentate Gyrus: Figure 1.

Kozorovitskiy, Y., & Gould, E. (2004) · Journal of Neuroscience · doi:10.1523/jneurosci.0345-04.2004 · Cited by 179 · see citing works

Regionally specific and rapid increases in brain-derived neurotrophic factor messenger RNA in the adult rat brain following seizures induced by systemic administration of kainic acid

Dugich‐Djordjevic, M. M., Tocco, G., Lapchak, P. A., Pasinetti, G. M., Najm, I., Baudry, M., & Hefti, F. F. (1992) · Neuroscience · doi:10.1016/0306-4522(92)90246-x · Cited by 171 · see citing works

Daily Rhythm of Tryptophan Hydroxylase-2 Messenger Ribonucleic Acid within Raphe Neurons Is Induced by Corticoid Daily Surge and Modulated by Enhanced Locomotor Activity

Malek, Z. S., Ciocca, D., Pévet, P., & Raison, S. (2007) · Endocrinology · doi:10.1210/en.2007-0526 · Cited by 169 · see citing works

Evidence for Mineralocorticoid Receptor Facilitation of Glucocorticoid Receptor-Dependent Regulation of Hypothalamic-Pituitary-Adrenal Axis Activity

Spencer, R. L., Kim, P. J., Kalman, B. A., & Cole, M. A. (1998) · Endocrinology · doi:10.1210/endo.139.6.6029 · Cited by 169 · see citing works

Physiology and Pathophysiology of the Serotonergic System and its Implications on Mental and Physical Performance. Part II

Strüder, H. K., & Weicker, H. (2001) · International Journal of Sports Medicine · doi:10.1055/s-2001-17606 · Cited by 167 · see citing works

Noradrenergic and serotonergic blockade inhibits BDNF mRNA activation following exercise and antidepressant

Ivy, A. S., Rodriguez, F. G., Garcia, C., Chen, M. J., & Russo‐Neustadt, A. A. (2003) · Pharmacology Biochemistry and Behavior · doi:10.1016/s0091-3057(03)00044-3 · Cited by 164 · see citing works

Gender-dependent alterations in corticosteroid receptor status and spatial performance following 21 days of restraint stress

Kitraki, E., Kremmyda, O., Youlatos, D., Alexis, Μ. N., & Kittas, C. N. (2004) · Neuroscience · doi:10.1016/j.neuroscience.2003.12.024 · Cited by 156 · see citing works

Stress-Related Modulation of Hippocampal Long-Term Potentiation in Rats: Involvement of Adrenal Steroid Receptors

Korz, V., & Frey, J. U. (2003) · The Journal of Neuroscience · doi:10.1523/jneurosci.23-19-07281.2003 · Cited by 155 · see citing works

Voluntary exercise rescues deficits in spatial memory and long‐term potentiation in prenatal ethanol‐exposed male rats

Christie, B. R., Swann, S. E., Fox, C. J., Froc, D. J., Lieblich, S. E., Redila, V. A., & Webber, A. J. (2005) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2005.04004.x · Cited by 154 · see citing works

Effect of voluntary wheel running on circadian corticosterone release and on HPA axis responsiveness to restraint stress in Sprague-Dawley rats

Fediuc, S., Campbell, J. E., & Riddell, M. C. (2006) · Journal of Applied Physiology · doi:10.1152/japplphysiol.01416.2005 · Cited by 148 · see citing works

Corticosterone regulates expression of BDNF and trkB but not NT-3 and trkC mRNA in the rat hippocampus.

Schaaf, M. J. M., Hoetelmans, R. W. M., de Kloet, E. R., & Vreugdenhil, E. (1997) · PubMed · Cited by 143 · see citing works

Effects of tryptophan and/or acute running on extracellular 5-HT and 5-HIAA levels in the hippocampus of food-deprived rats

MEEUSEN, R. R., Thorré, K., Chaouloff, F., Sarre, S., Meirleir, K. D., Ebinger, G., & Michotte, Y. M. (1996) · Brain Research · doi:10.1016/s0006-8993(96)00872-4 · Cited by 141 · see citing works

Exercise training: Significance of regional alterations in serotonin metabolism of rat brain in relation to antidepressant effect of exercise

Dey, S., Singh, R. H., & Dey, P. K. (1992) · Physiology &amp; Behavior · doi:10.1016/0031-9384(92)90465-e · Cited by 140 · see citing works

Flip side of synaptic plasticity: Long‐term depression mechanisms in the hippocampus

Christie, B. R., Kerr, D. S., & Abraham, W. C. (1994) · Hippocampus · doi:10.1002/hipo.450040203 · Cited by 140 · see citing works

Site-dependent effects of an acute intensive exercise on extracellular 5-HT and 5-HIAA levels in rat brain

Gomez-Mérino, D., Bequet, F., Berthelot, M., Chennaoui, M., & Guézennec, C. Y. (2001) · Neuroscience Letters · doi:10.1016/s0304-3940(01)01626-3 · Cited by 139 · see citing works

Chronic corticosterone decreases brain-derived neurotrophic factor (BDNF) mRNA and protein in the hippocampus, but not in the frontal cortex, of the rat

Jacobsen, J. P. R., & Mørk, A. (2006) · Brain Research · doi:10.1016/j.brainres.2006.06.077 · Cited by 139 · see citing works

Distinct Roles of Synapsin I and Synapsin II during Neuronal Development

Ferreira, A., Chin, L.-S., Li, L., Lanier, L. M., Kosik, K. S., & Greengard, P. (1998) · Molecular Medicine · doi:10.1007/bf03401726 · Cited by 131 · see citing works

NMDA receptor–independent long-term depression correlates with successful aging in rats

Lee, H., Min, S. S., Gallagher, M., & Kirkwood, A. (2005) · Nature Neuroscience · doi:10.1038/nn1586 · Cited by 126 · see citing works

Selectivity of antidepressants: from the monoamine hypothesis of depression to the SSRI revolution and beyond.

Owens, M. J. (2004) · PubMed · Cited by 123 · see citing works

Protective effects of brain-derived neurotrophic factor on the development of hippocampal kindling in the rat

Larmet, Y., Reibel, S., Carnahan, J. F., Nawa, H., Marescaux, C., & Depaulis, A. (1995) · Neuroreport · doi:10.1097/00001756-199510020-00027 · Cited by 116 · see citing works

Functional trkB neurotrophin receptors are intrinsic components of the adult brain postsynaptic density

Wu, K. M., Xu, J., Suen, P.-C., Levine, E. S., Huang, Y.-Y., Mount, H. T. J., Lin, S.-Y., & Black, I. B. (1996) · Molecular Brain Research · doi:10.1016/s0169-328x(96)00211-2 · Cited by 109 · see citing works

Contrasting Roles of Corticosteroid Receptors in Hippocampal Plasticity

Avital, A., Segal, M., & Richter‐Levin, G. (2006) · Journal of Neuroscience · doi:10.1523/jneurosci.1628-06.2006 · Cited by 109 · see citing works

Adrenal Steroid Regulation of Neurotrophic Factor Expression in the Rat Hippocampus

Chao, H. M., Sakai, R. R., Li, Y., & McEwen, B. S. (1998) · Endocrinology · doi:10.1210/endo.139.7.6114 · Cited by 107 · see citing works

Decreased BDNF signalling in transgenic mice reduces epileptogenesis

Lähteinen, S., Pitkänen, A., Saarelainen, T., Nissinen, J., Koponen, E., & Ċastrén, E. (2002) · European Journal of Neuroscience · doi:10.1046/j.1460-9568.2002.01897.x · Cited by 107 · see citing works

Effects of exercise on NMDA receptor subunit contributions to bidirectional synaptic plasticity in the mouse dentate gyrus

Vasuta, C., Caunt, C., James, R., Samadi, S., Schibuk, E., Kannangara, T., Titterness, A. K., & Christie, B. R. (2007) · Hippocampus · doi:10.1002/hipo.20349 · Cited by 105 · see citing works

The effects of brain-derived neurotrophic factor (BDNF) administration on kindling induction, Trk expression and seizure-related morphological changes

Xu, B., Michalski, B., Racine, R. J., & Fahnestock, M. L. (2004) · Neuroscience · doi:10.1016/j.neuroscience.2004.03.044 · Cited by 100 · see citing works

Exercise increases metabolic capacity in the motor cortex and striatum, but not in the hippocampus

McCloskey, D. P., Adamo, D. S., & Anderson, B. J. (2001) · Brain Research · doi:10.1016/s0006-8993(00)03200-5 · Cited by 100 · see citing works

Pronounced individual variation in the response to the stimulatory action of exercise on immature hippocampal neurons

Llorens-Martı́n, M., Torres‐Alemán, I., & Trejo, J. L. (2006) · Hippocampus · doi:10.1002/hipo.20175 · Cited by 98 · see citing works

Differential Effects of BDNF, ADNF9, and TNFα on Levels of NMDA Receptor Subunits, Calcium Homeostasis, and Neuronal Vulnerability to Excitotoxicity

Glazner, G. W., & Mattson, M. P. (2000) · Experimental Neurology · doi:10.1006/exnr.1999.7242 · Cited by 97 · see citing works

NMDA‐dependent heterosynaptic long‐term depression in the dentate gyrus of anaesthetized rats

Christie, B. R., & Abraham, W. C. (1992) · Synapse · doi:10.1002/syn.890100102 · Cited by 89 · see citing works

Wheel running following spinal cord injury improves locomotor recovery and stimulates serotonergic fiber growth

Engesser‐Cesar, C., Ichiyama, R. M., Nefas, A. L., Hill, M. A., Edgerton, V. R., Cotman, C. W., & Anderson, A. J. (2007) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2007.05469.x · Cited by 88 · see citing works

Acute stress impairs (or induces) synaptic long‐term potentiation (LTP) but does not affect paired‐pulse facilitation in the stratum radiatum of rat hippocampus

Shors, T. J., & Thompson, R. F. (1992) · Synapse · doi:10.1002/syn.890110311 · Cited by 88 · see citing works

Brain-derived neurotrophic factor delays hippocampal kindling in the rat

Reibel, S., Larmet, Y., Lê, B.-T., Carnahan, J. F., Marescaux, C., & Depaulis, A. (2000) · Neuroscience · doi:10.1016/s0306-4522(00)00351-1 · Cited by 83 · see citing works

Circadian variation in BDNF mRNA expression in the rat hippocampus

Schaaf, M. J. M., Duurland, R., de Kloet, E. R., & Vreugdenhil, E. (2000) · Molecular Brain Research · doi:10.1016/s0169-328x(99)00314-9 · Cited by 76 · see citing works

p75NTR immunoreactivity in the rat dentate gyrus is mostly within presynaptic profiles but is also found in some astrocytic and postsynaptic profiles

Dougherty, K. D., & Milner, T. A. (1999) · The Journal of Comparative Neurology · doi:10.1002/(sici)1096-9861(19990428)407:1 · Cited by 76 · see citing works

BDNF attenuates hippocampal LTD via activation of phospholipase C: implications for a vertical shift in the frequency–response curve of synaptic plasticity

Ikegaya, Y., Ishizaka, Y., & Matsuki, N. (2002) · European Journal of Neuroscience · doi:10.1046/j.1460-9568.2002.02051.x · Cited by 75 · see citing works

Cognitive Status, Stroke Symptom Reports, and Modifiable Risk Factors Among Individuals With No Diagnosis of Stroke or Transient Ischemic Attack in the RE asons for G eographic and R acial D ifferences in S troke (REGARDS) Study

Wadley, V. G., McClure, L. A., Howard, V. J., Unverzagt, F. W., Go, R. C. P., Moy, C. S., Crowther, M. R., Gomez, C. R., & Howard, G. (2007) · Stroke · doi:10.1161/01.str.0000259676.75552.38 · Cited by 68 · see citing works

Cardiovascular responses to voluntary and treadmill exercise in rats

Yancey, S. L., & Overton, J. M. (1993) · Journal of Applied Physiology · doi:10.1152/jappl.1993.75.3.1334 · Cited by 66 · see citing works

Corticosterone inhibits generation of long-term potentiation in rat hippocampal slice: involvement of brain-derived neurotrophic factor

Zhou, J., Zhang, F., & Zhang, Y. (2000) · Brain Research · doi:10.1016/s0006-8993(00)02934-6 · Cited by 64 · see citing works

Nitric oxide synthesis is required for exercise-induced increases in hippocampal BDNF and phosphatidylinositol 3′ kinase expression

Chen, M. J., Ivy, A. S., & Russo‐Neustadt, A. A. (2005) · Brain Research Bulletin · doi:10.1016/j.brainresbull.2005.08.013 · Cited by 61 · see citing works

In vivo measurement of extracellular serotonin in the ventral hippocampus during treadmill running.

Wilson, W. M., & Marsden, C. A. (1996) · PubMed · Cited by 58 · see citing works

Brain‐derived neurotrophic factor enhances fast excitatory synaptic transmission in human epileptic dentate gyrus

Zhu, W. J., & Roper, S. N. (2001) · Annals of Neurology · doi:10.1002/ana.1074 · Cited by 56 · see citing works

Tyrosine phosphorylation of the GluR2 subunit is required for long-term depression of synaptic efficacy in young animals in vivo

Fox, C. J., Russell, K., Titterness, A. K., Wang, Y. T., & Christie, B. R. (2007) · Hippocampus · doi:10.1002/hipo.20302 · Cited by 56 · see citing works

6.3 Co-localization of brain corticosteroid receptors in the rat hippocampus

Eekelen, J. A. M. V., & de Kloet, E. R. (1992) · Progress in Histochemistry and Cytochemistry · doi:10.1016/s0079-6336(11)80102-6 · Cited by 51 · see citing works

In vivo measurement of extracellular serotonin in the ventral hippocampus during treadmill running

Wilson, W. M., & Marsden, C. A. (1996) · Behavioural Pharmacology · doi:10.1097/00008877-199601000-00011 · Cited by 47 · see citing works

The effect of acute stress on LTP and LTD induction in the hippocampal CA1 region of anesthetized rats at three different ages

Xiong, W., Wei, H., Xiang, X., Cao, J., Dong, Z., Wang, Y., Xu, T., & Xu, L. (2004) · Brain Research · doi:10.1016/j.brainres.2004.01.051 · Cited by 44 · see citing works

Study of 5-HT release with a chronically implanted microdialysis probe in the ventral horn of the spinal cord of unrestrained rats during exercise on a treadmill

Gerin, C. G., Legrand, A., & Privat, A. (1994) · Journal of Neuroscience Methods · doi:10.1016/0165-0270(94)90121-x · Cited by 42 · see citing works

The stress experience dependent long-term depression disassociated with stress effect on spatial memory task

Xiong, W., Yang, Y., Cao, J., Wei, H., Liang, C., Yang, S., & Xu, L. (2003) · Neuroscience Research · doi:10.1016/s0168-0102(03)00120-2 · Cited by 33 · see citing works

Chronic ethanol treatment reduces the magnitude of hippocampal LTD in the adult rat

Thinschmidt, J. S., Walker, D. W., & King, M. A. (2003) · Synapse · doi:10.1002/syn.10203 · Cited by 33 · see citing works

Sex-specific effects of corticosterone on hippocampally mediated learning in young rats

Claflin, D. I., Hennessy, M. B., & JENSEN, S. (2005) · Physiology & Behavior · doi:10.1016/j.physbeh.2005.03.015 · Cited by 21 · see citing works

Neurochemical basis of disruption of hippocampal long term potentiation by chronic alcohol exposure

Peris, J. (1997) · Frontiers in bioscience · doi:10.2741/a193 · Cited by 20 · see citing works

The management of fatigue in depressed patients.

Marín, H., & Menza, M. A. (2005) · PubMed · Cited by 19 · see citing works

THE EFFECT OF CERTAIN ANALGESIC DRUGS ON SYNAPTIC TRANSMISSION AS OBSERVED IN THE PERFUSED SUPERIOR CERVICAL GANGLION OF THE CAT

Hebb, C. O., & Konzett, H. (1949) · Quarterly Journal of Experimental Physiology and Cognate Medical Sciences · doi:10.1113/expphysiol.1949.sp000950 · Cited by 15 · see citing works

Bridging animal and human models of exercise-induced brain plasticity

Voss, M. W., Vivar, C., Kramer, A. F., & van Praag, H. (2013) · Trends in Cognitive Sciences · doi:10.1016/j.tics.2013.08.001 · Cited by 1,030 · see citing works

Aerobic fitness is associated with hippocampal volume in elderly humans

Erickson, K. I., Prakash, R. S., Voss, M. W., Chaddock, L., Hu, L., Morris, K. S., White, S. M., Wójcicki, T. R., McAuley, E., & Kramer, A. F. (2009) · Hippocampus · doi:10.1002/hipo.20547 · Cited by 1,007 · see citing works

A meta-analytic review of the effects of exercise on brain-derived neurotrophic factor

Szuhany, K. L., Bugatti, M., & Otto, M. W. (2015) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2014.10.003 · Cited by 909 · see citing works

Sex differences in exercise efficacy to improve cognition: a systematic review and meta-analysis of randomized controlled trials in older humans

Barha, C. K., Davis, J. C., Falck, R. S., Nagamatsu, L. S., & Liu-Ambrose, T. (2017) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2017.04.002 · Cited by 432 · see citing works

Neurobiological markers of exercise-related brain plasticity in older adults

Voss, M. W., Erickson, K. I., Prakash, R. S., Chaddock, L., Kim, J. S., Alves, H., Szabo, A., Phillips, S. M., Wójcicki, T. R., Mailey, E. L., et al. (2013) · Brain, Behavior, and Immunity · doi:10.1016/j.bbi.2012.10.021 · Cited by 418 · see citing works

Functional connectivity: A source of variance in the association between cardiorespiratory fitness and cognition?

Voss, M. W., Erickson, K. I., Prakash, R. S., Chaddock, L., Malkowski, E., Alves, H., Kim, J., Morris, K. S., White, S. M., Wójcicki, T. R., et al. (2010) · Neuropsychologia · doi:10.1016/j.neuropsychologia.2010.01.005 · Cited by 261 · see citing works

Voluntary exercise induces anxiety‐like behavior in adult C57BL/6J mice correlating with hippocampal neurogenesis

Fuss, J., Ben Abdallah, N. M. ‐., Vogt, M. A., Touma, C., Pacifici, P. G., Palme, R., Witzemann, V., Hellweg, R., & Gass, P. (2010) · Hippocampus · doi:10.1002/hipo.20634 · Cited by 240 · see citing works

Active rehabilitation for children who are slow to recover following sport-related concussion

Gagnon, I. J., Galli, C., Friedman, D., Grilli, L., & Iverson, G. L. (2009) · Brain Injury · doi:10.3109/02699050903373477 · Cited by 227 · see citing works

AMPK and the Adaptation to Exercise

Spaulding, H. R., & Yan, Z. (2022) · Annual Review of Physiology · doi:10.1146/annurev-physiol-060721-095517 · Cited by 231 · see citing works

Aerobic fitness is associated with gray matter volume and white matter integrity in multiple sclerosis

Prakash, R. S., Snook, E. M., Motl, R. W., & Kramer, A. F. (2009) · Brain Research · doi:10.1016/j.brainres.2009.06.063 · Cited by 212 · see citing works

The effects of exercise and stress on the survival and maturation of adult‐generated granule cells

Snyder, J. S., Glover, L. R., Sanzone, K. M., Kamhi, J. F., & Cameron, H. A. (2009) · Hippocampus · doi:10.1002/hipo.20552 · Cited by 181 · see citing works

Exercise for cognitive brain health in aging

Gomes‐Osman, J., Cabral, D. F., Morris, T. P., McInerney, K., Cahalin, L. P., Rundek, T., Oliveira, A., & Pascual‐Leone, Á. (2018) · Neurology Clinical Practice · doi:10.1212/cpj.0000000000000460 · Cited by 179 · see citing works

Revenge of the “sit” II: does lifestyle impact neuronal and cognitive health through distinct mechanisms associated with sedentary behavior and physical activity?

Voss, M. W., Carr, L. J., Clark, R., & Weng, T. (2014) · Mental health and physical activity · doi:10.1016/j.mhpa.2014.01.001 · Cited by 164 · see citing works

Long-term exercise training improves memory in middle-aged men and modulates peripheral levels of BDNF and Cathepsin B

la Rosa, A. D., Solana, E., Corpas, R., David Bartrés-faz, A., Pallàs, M., Viña, J., Sanfeliu, C., & Gómez‐Cabrera, M. C. (2019) · Scientific Reports · doi:10.1038/s41598-019-40040-8 · Cited by 161 · see citing works

An umbrella review of randomized control trials on the effects of physical exercise on cognition

Ciria, L. F., Román-Caballero, R., Vadillo, M. A., Holgado, D., Luque-Casado, A., Perakakis, P., & Sanabria, D. (2023) · Nature Human Behaviour · doi:10.1038/s41562-023-01554-4 · Cited by 157 · see citing works

Aerobic Exercise as a Tool to Improve Hippocampal Plasticity and Function in Humans: Practical Implications for Mental Health Treatment

Kandola, A., Hendrikse, J., Lucassen, P. J., & Yücel, M. (2016) · Frontiers in Human Neuroscience · doi:10.3389/fnhum.2016.00373 · Cited by 155 · see citing works

Exercise for Brain Health: An Investigation into the Underlying Mechanisms Guided by Dose

Cabral, D. F., Rice, J., Morris, T. P., Rundek, T., Pascual‐Leone, Á., & Gomes‐Osman, J. (2019) · Neurotherapeutics · doi:10.1007/s13311-019-00749-w · Cited by 158 · see citing works

Cardiorespiratory Fitness and Attentional Control in the Aging Brain

Prakash, R. S., Voss, M. W., Erickson, K. I., Lewis, J. M., Chaddock, L., Malkowski, E., Alves, H., Kim, J., Szabo‐Reed, A. N., White, S. M., et al. (2011) · Frontiers in Human Neuroscience · doi:10.3389/fnhum.2010.00229 · Cited by 146 · see citing works

Functional analysis of neurovascular adaptations to exercise in the dentate gyrus of young adult mice associated with cognitive gain.

Clark, P. J., Brzezinska, W. J., Puchalski, E. K., Krone, D. A., & Rhodes, J. S. (2009) · Hippocampus · doi:10.1002/hipo.20543 · Cited by 138 · see citing works

Exercise modulates insulin-like growth factor 1-dependent and -independent effects on adult hippocampal neurogenesis and behaviour.

LLorens-Martín, M., Torres-Alemán, I., & Trejo, J. L. (2010) · Molecular and Cellular Neuroscience · doi:10.1016/j.mcn.2010.02.006 · Cited by 135 · see citing works

Cardiovascular and cognitive fitness at age 18 and risk of early-onset dementia

Nyberg, J., Åberg, M., Schiöler, L., Nilsson, M., Wallin, A., Torén, K., & Kuhn, H. G. (2014) · Brain · doi:10.1093/brain/awu041 · Cited by 109 · see citing works

Long-term exercise is needed to enhance synaptic plasticity in the hippocampus

Patten, A. R., Sickmann, H., Hryciw, B. N., Kucharsky, T., Parton, R., Kernick, A., & Christie, B. R. (2013) · Learning &amp; Memory · doi:10.1101/lm.030635.113 · Cited by 101 · see citing works

A behavioral analysis of the impact of voluntary physical activity on hippocampus‐dependent contextual conditioning

Greenwood, B. N., Strong, P. V., Foley, T. E., & Fleshner, M. (2008) · Hippocampus · doi:10.1002/hipo.20534 · Cited by 106 · see citing works

Angiogenesis but not neurogenesis is critical for normal learning and memory acquisition.

Kerr, A. L., Steuer, E. L., Pochtarev, V., & Swain, R. A. (2010) · Neuroscience · doi:10.1016/j.neuroscience.2010.08.008 · Cited by 103 · see citing works

Brain-Derived Neurotrophic Factor Val66Met Human Polymorphism Impairs the Beneficial Exercise-Induced Neurobiological Changes in Mice

Ieraci, A., Madaio, A. I., Mallei, A., Lee, F. S., & Popoli, M. (2016) · Neuropsychopharmacology · doi:10.1038/npp.2016.120 · Cited by 103 · see citing works

Exercise in multiple sclerosis -- an integral component of disease management

Döring, A., Pfueller, C. F., Paul, F., & Dörr, J. (2011) · The EPMA Journal · doi:10.1007/s13167-011-0136-4 · Cited by 98 · see citing works

Exercise in a Pill: The Latest on Exercise-Mimetics

Guerrieri, D., Moon, H. Y., & van Praag, H. (2016) · Brain Plasticity · doi:10.3233/bpl-160043 · Cited by 77 · see citing works

Sex differences in aerobic exercise efficacy to improve cognition: A systematic review and meta-analysis of studies in older rodents

Barha, C. K., Falck, R. S., Davis, J. C., Nagamatsu, L. S., & Liu-Ambrose, T. Y. L. (2017) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2017.06.001 · Cited by 74 · see citing works

Voluntary Wheel Running Reverses Age-Induced Changes in Hippocampal Gene Expression

Kohman, R. A., Rodriguez‐Zas, S. L., Southey, B. R., Kelley, K. W., Dantzer, R., & Rhodes, J. S. (2011) · PLoS ONE · doi:10.1371/journal.pone.0022654 · Cited by 73 · see citing works

Obesity is associated with reduced cerebral blood flow – modified by physical activity

Knight, S., Laird, E., Williamson, W., O’Connor, J., Newman, L., Carey, D., Looze, C. D., Fagan, A., Chappell, M., Meaney, J., et al. (2021) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2021.04.008 · Cited by 58 · see citing works

Physical Activity Modulates Common Neuroplasticity Substrates in Major Depressive and Bipolar Disorder

Phillips, C. (2017) · Neural Plasticity · doi:10.1155/2017/7014146 · Cited by 65 · see citing works

Neurobiological effects of aerobic exercise, with a focus on patients with schizophrenia

Maurus, I., Hasan, A., Röh, A., Takahashi, S., Rauchmann, B., Keeser, D., Malchow, B., Schmitt, A., & Falkai, P. (2019) · European Archives of Psychiatry and Clinical Neuroscience · doi:10.1007/s00406-019-01025-w · Cited by 62 · see citing works

The benefits of exercise on structural and functional plasticity in the rodent hippocampus of different disease models.

Patten, A. R., Yau, S. Y., Fontaine, C. J., Meconi, A., Wortman, R. C., & Christie, B. R. (2015) · Brain Plasticity · doi:10.3233/bpl-150016 · Cited by 64 · see citing works

The antidepressant effects of running and escitalopram are associated with levels of hippocampal NPY and Y1 receptor but not cell proliferation in a rat model of depression.

Bjørnebekk, A., Mathé, A. A., & Brené, S. (2010) · Hippocampus · doi:10.1002/hipo.20683 · Cited by 61 · see citing works

Physical Activity Attenuates Intermittent Hypoxia-induced Spatial Learning Deficits and Oxidative Stress

Gozal, D., Nair, D., & Goldbart, A. D. (2010) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.201001-0108oc · Cited by 60 · see citing works

Improving fitness increases dentate gyrus/CA3 volume in the hippocampal head and enhances memory in young adults

Nauer, R. K., Dunne, M. F., Stern, C. E., Storer, T. W., & Schön, K. (2019) · Hippocampus · doi:10.1002/hipo.23166 · Cited by 56 · see citing works

Effect of combined physical training on cognitive function in people with epilepsy: Results from a randomized controlled trial

Feter, N., Alt, R., Häfele, C. A., da Silva, M. C., & Rombaldi, A. J. (2020) · Epilepsia · doi:10.1111/epi.16588 · Cited by 56 · see citing works

Exercising during learning improves vocabulary acquisition: Behavioral and ERP evidence

Schmidt‐Kassow, M., Kulka, A., Gunter, T. C., Rothermich, K., & Kotz, S. A. (2010) · Neuroscience Letters · doi:10.1016/j.neulet.2010.06.089 · Cited by 51 · see citing works

Long-Term Exercise Modulates Hippocampal Gene Expression in Senescent Female Mice

Álvarez‐López, M. J., Castro, M., Cosín‐Tomás, M., Sanchez‐Roige, S., Lalanza, J. F., del Valle, J., Párrizas, M., Camins, A., Pallàs, M., Escorihuela, R. M., et al. (2013) · Journal of Alzheimer s Disease · doi:10.3233/jad-121264 · Cited by 50 · see citing works

On Aerobic Exercise and Behavioral and Neural Plasticity

Swain, R., Berggren, K. L., Kerr, A. L., Patel, A. U., Peplinski, C., & Sikorski, A. M. (2012) · Brain Sciences · doi:10.3390/brainsci2040709 · Cited by 44 · see citing works

Sex differences in exercise efficacy: Is midlife a critical window for promoting healthy cognitive aging?

Barha, C. K., & Liu-Ambrose, T. Y. L. (2020) · The FASEB Journal · doi:10.1096/fj.202000857r · Cited by 45 · see citing works

Voluntary wheel running enhances contextual but not trace fear conditioning

Kohman, R. A., Clark, P., DeYoung, E. K., Bhattacharya, T. K., Venghaus, C. E., & Rhodes, J. S. (2011) · Behavioural Brain Research · doi:10.1016/j.bbr.2011.08.031 · Cited by 40 · see citing works

Restored presynaptic synaptophysin and cholinergic inputs contribute to the protective effects of physical running on spatial memory in aged mice

Xu, L., Long, J., Su, Z., Xu, B., Lin, M. L., Chen, Y., & Long, D. (2019) · Neurobiology of Disease · doi:10.1016/j.nbd.2019.104586 · Cited by 40 · see citing works

It takes biking to learn: Physical activity improves learning a second language.

Liu, F., Sulpizio, S., Kornpetpanee, S., & Job, R. (2017) · PLoS ONE · doi:10.1371/journal.pone.0177624 · Cited by 31 · see citing works

Poorer physical fitness is associated with reduced structural brain integrity in heart failure

Alosco, M. L., Brickman, A. M., Spitznagel, M. B., Griffith, E. Y., Narkhede, A., Raz, N., Cohen, R. A., Sweet, L. H., Colbert, L. H., Josephson, R., et al. (2013) · Journal of the Neurological Sciences · doi:10.1016/j.jns.2013.02.015 · Cited by 31 · see citing works

Influence of Physical Activity on Human Sensory Long-Term Potentiation

Smallwood, N., Spriggs, M. J., Thompson, C. S., Wu, C. W. ‐., Hamm, J. P., Moreau, D., & Kirk, I. J. (2015) · Journal of the International Neuropsychological Society · doi:10.1017/s1355617715001095 · Cited by 28 · see citing works

Different durations of cognitive stimulation therapy for Alzheimer’s disease: a systematic review and meta-analysis

Chen, J., Duan, Y., Li, H., Lu, L., Liu, J., & Tang, C. (2019) · Clinical Interventions in Aging · doi:10.2147/cia.s210062 · Cited by 29 · see citing works

Antidepressant and Proneurogenic Influence of Environmental Enrichment in Mice: Protective Effects vs Recovery

Llorens-Martı́n, M., Tejeda, G. S., & Trejo, J. L. (2011) · Neuropsychopharmacology · doi:10.1038/npp.2011.134 · Cited by 29 · see citing works

Physical Activity and Fitness Effects on Cognition and Brain Health in Children and Older Adults

Chaddock, L., Voss, M. W., & Kramer, A. F. (2012) · Kinesiology Review · doi:10.1123/krj.1.1.37 · Cited by 27 · see citing works

Delayed atomoxetine or fluoxetine treatment coupled with limited voluntary running promotes motor recovery in mice after ischemic stroke

Karamyan, V. T., Alamri, F. F., Shoyaib, A. A., Syeara, N., Paul, A., Jayaraman, S., Karamyan, S. T., & Arumugam, T. V. (2020) · Neural Regeneration Research · doi:10.4103/1673-5374.301031 · Cited by 26 · see citing works

Exercise and the Brain: Neurogenesis, Synaptic Plasticity, Spine Density, and Angiogenesis

Wang, Z., & van Praag, H. (2012) · Springer eBooks · doi:10.1007/978-1-4614-3293-7_1 · Cited by 26 · see citing works

FAST Club: The Impact of a Physical Activity Intervention on Executive Function in Children With Fetal Alcohol Spectrum Disorder

Pritchard Orr, A. B., Keiver, K., Bertram, C. P., & Clarren, S. (2018) · Adapted Physical Activity Quarterly · doi:10.1123/apaq.2017-0137 · Cited by 24 · see citing works

Active body, healthy brain: Exercise for healthy cognitive aging

Liu-Ambrose, T. Y. L., Barha, C. K., & Falck, R. S. (2019) · International review of neurobiology · doi:10.1016/bs.irn.2019.07.004 · Cited by 25 · see citing works

Individual Stress Prevention through Qigong

van Dam, K. (2020) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph17197342 · Cited by 24 · see citing works

Running-induced memory enhancement correlates with the preservation of thin spines in the hippocampal area CA1 of old C57BL/6 mice

Xu, B., Sun, A., He, Y., Qian, F., Liu, L., Chen, Y., & Luo, H. (2017) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2017.01.002 · Cited by 21 · see citing works

Delayed Exercise-induced Upregulation of Angiogenic Proteins and Recovery of Motor Function after Photothrombotic Stroke in Mice

Shoyaib, A. A., Alamri, F. F., Biggers, A., Karamyan, S. T., Arumugam, T. V., Ahsan, F., Mikelis, C. M., Al-Hilal, T. A., & Karamyan, V. T. (2021) · Neuroscience · doi:10.1016/j.neuroscience.2021.02.023 · Cited by 19 · see citing works

Relationship of regular physical activity with neuroelectric indices of interference processing in young adults

Aly, M., & Kojima, H. (2020) · Psychophysiology · doi:10.1111/psyp.13674 · Cited by 20 · see citing works

Daily activities are associated with non-invasive measures of neuroplasticity in older adults

Smith, A. E., Dumuid, D., Goldsworthy, M. R., Graetz, L. J., Hodyl, N. A., Thornton, N. L. R., & Ridding, M. C. (2021) · Clinical Neurophysiology · doi:10.1016/j.clinph.2021.01.016 · Cited by 19 · see citing works

Cardiovascular fitness in late adolescent males and later risk of serious non-affective mental disorders: a prospective, population-based study

Nyberg, J., Henriksson, M., Åberg, M., Rosengren, A., Söderberg, M., Åberg, N. D., Kuhn, H. G., & Wærn, M. (2017) · Psychological Medicine · doi:10.1017/s0033291717001763 · Cited by 17 · see citing works

体育锻炼促进认知功能的脑机制

Xia, H., Qingwen, D. I. N. G., Zhuang, Y., & Chen, A. (2018) · Advances in Psychological Science · doi:10.3724/sp.j.1042.2018.01857 · Cited by 15 · see citing works

The Effect of Histone Deacetylase Inhibitors Panobinostat or Entinostat on Motor Recovery in Mice After Ischemic Stroke

Shoyaib, A. A., Alamri, F. F., Syeara, N., Jayaraman, S., Karamyan, S. T., Arumugam, T. V., & Karamyan, V. T. (2021) · NeuroMolecular Medicine · doi:10.1007/s12017-021-08647-1 · Cited by 15 · see citing works

The effects of exercise during pregnancy on the newborn’s brain: study protocol for a randomized controlled trial

Labonté-LeMoyne, É., Curnier, D. Y., St-Jacques, S., & Dave Ellemberg, A. (2012) · Trials · doi:10.1186/1745-6215-13-68 · Cited by 15 · see citing works

Potential Biomarkers for Physical Exercise-Induced Brain Health

Yau, S. Y., Li, A., Sun, X., Fontaine, C. J., Christie, B. R., & So, K. (2016) · InTech eBooks · doi:10.5772/62458 · Cited by 16 · see citing works

Role of Biomarkers in Medicine

Wang, M., & Witzmann, F. A. (2016) · InTech eBooks · doi:10.5772/61449 · Cited by 15 · see citing works

Physical Activity and Intelligence: A Causal Exploration

O’Callaghan, F., O'Callaghan, M. J., Williams, G. M., Bor, W., & Najman, J. M. (2012) · Journal of Physical Activity and Health · doi:10.1123/jpah.9.2.218 · Cited by 14 · see citing works

Effects of exercise on proactive interference in memory: potential neuroplasticity and neurochemical mechanisms

Li, C., Liu, T., Li, R., & Zhou, C. (2020) · Psychopharmacology · doi:10.1007/s00213-020-05554-4 · Cited by 14 · see citing works

The association between the health-related physical fitness and inhibitory control in preschool children

Li, Y., Zhou, T., Lü, Y., Sang, M., Liu, J., He, X., & Quan, M. (2022) · BMC Pediatrics · doi:10.1186/s12887-022-03163-y · Cited by 14 · see citing works

Postexercise serum from humans influences the biological tug of war of APP processing in human neuronal cells

Marko, D. M., Finch, M. S., Mohammad, A., MacNeil, A. J., Klentrou, P., & MacPherson, R. E. K. (2022) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00418.2021 · Cited by 13 · see citing works

High-velocity resistance training improves executive function in mobility-limited older adults

Feter, N., Schaun, G. Z., Smith, E. C., Cassuriaga, J., Alt, R., Redig, L., Alberton, C. L., Coombes, J. S., & Rombaldi, A. J. (2023) · Archives of Gerontology and Geriatrics · doi:10.1016/j.archger.2023.105081 · Cited by 11 · see citing works

Exercise ameliorates aberrant synaptic plasticity without enhancing adult-born cell survival in the hippocampus of serotonin transporter knockout mice

Wilson, C., Rogers, J., Chen, F., Li, S., Adlard, P. A., Hannan, A. J., & Renoir, T. (2021) · Brain Structure and Function · doi:10.1007/s00429-021-02283-y · Cited by 11 · see citing works

The Influence of Moderate Physical Activity on Brain Monoaminergic Responses to Binge-Patterned Alcohol Ingestion in Female Mice

Buhr, T. J., Reed, C. H., Shoeman, A., Bauer, E. E., Valentine, R. J., & Clark, P. (2021) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2021.639790 · Cited by 11 · see citing works

The fitness versus body fat hypothesis in relation to hippocampal structure

Aghjayan, S. L., Jakicic, J. M., Rogers, R. J., Esteban‐Cornejo, I., Peven, J. C., Stillman, C. M., Watt, J. C., & Erickson, K. I. (2020) · Psychophysiology · doi:10.1111/psyp.13591 · Cited by 10 · see citing works

Exercise engagement drives changes in cognition and cardiorespiratory fitness after 8 weeks of aerobic training in sedentary aging adults at risk of cognitive decline

Hinchman, C. A., Cabral, D. F., Ciesla, M. R., Flothmann, M., Nunez, C., Rice, J., Loewenstein, D., Kitaigorodsky, M., Cahalin, L. P., Rundek, T., et al. (2022) · Frontiers in Rehabilitation Sciences · doi:10.3389/fresc.2022.923141 · Cited by 9 · see citing works

Neuroprotective synergy of vitamin D and exercise: a narrative review of preclinical and clinical evidence on aging-related neuroplasticity and cognitive health

Chen, J., Yang, L., Wang, L., Liu, Q., & Qiu, B. (2025) · Frontiers in Nutrition · doi:10.3389/fnut.2025.1642363 · Cited by 7 · see citing works

Determinants of exercise adherence in sedentary middle‐aged and older adults

Cabral, D. F., Fried, P. J., Bigliassi, M., Cahalin, L. P., & Gomes‐Osman, J. (2024) · Psychophysiology · doi:10.1111/psyp.14591 · Cited by 9 · see citing works

Effects of a High-Intensity Interval Physical Exercise Program on Cognition, Physical Performance, and Electroencephalogram Patterns in Korean Elderly People: A Pilot Study

Lee, S. M., Choi, M., Chun, B., Sun, K., Kim, K. S., Kang, S. W., Song, H., & Moon, S. Y. (2022) · Dementia and Neurocognitive Disorders · doi:10.12779/dnd.2022.21.3.93 · Cited by 6 · see citing works

Activating the Right Hemisphere Through Left-Hand Muscle Contraction Improves Novel Metaphor Comprehension

Noufi, T., & Zeev‐Wolf, M. (2021) · Frontiers in Psychology · doi:10.3389/fpsyg.2021.729814 · Cited by 6 · see citing works

Exercise in Multiple Sclerosis – An Integral Component of Disease Management

Döring, A., Pfueller, C. F., Paul, F., & Dörr, J. (2012) · Advances in predictive, preventive and personalised medicine · doi:10.1007/978-94-007-5866-7_12 · Cited by 5 · see citing works

Aging and exercise effects on motor learning and spatial memory

Kennard, J., & Woodruff‐Pak, D. S. (2011) · Ageing Research · doi:10.4081/ar.2011.e2 · Cited by 5 · see citing works

Harnessing Neuroplasticity to Promote Brain Health in Aging Adults: Protocol for the MOVE-Cog Intervention Study

Cabral, D. F., Hinchman, C. A., Nunez, C., Rice, J., Loewenstein, D., Cahalin, L. P., Rundek, T., Pascual‐Leone, Á., & Gomes‐Osman, J. (2021) · JMIR Research Protocols · doi:10.2196/33589 · Cited by 4 · see citing works

The role of physical exercise on hippocampal volume in depressive symptoms: a systematic review and multi-level meta-analysis

Javelle, F., Suhrkamp, J., Wählen, L., Donath, L., & Bloch, W. (2025) · NeuroImage · doi:10.1016/j.neuroimage.2025.121386 · Cited by 3 · see citing works

Hippocampal long-term potentiation is modulated by exercise-induced alterations in dopaminergic synaptic transmission in mice selectively bred for high voluntary wheel running

Phan, J. M.-P., Yi, J., Foote, J. H. A., Ayabe, A. R. K., Guan, K., Garland, T., & Parfitt, K. D. (2024) · Restorative Neurology and Neuroscience · doi:10.1177/09226028241290400 · Cited by 3 · see citing works

Effects of exercise mimetics as putative therapeutics on brain health, aging, and neurodegenerative diseases

Rad, R. S. (2024) · Sport Sciences for Health · doi:10.1007/s11332-024-01187-8 · Cited by 2 · see citing works

Diabetes Associated Cognitive Decline, is there a Role for Exercise?

Tonoli, C. (2013) · Journal of Diabetes & Metabolism · doi:10.4172/2155-6156.s10-006 · Cited by 2 · see citing works

Protective Role of Regular Physical Activity on Mental Health During the COVID-19 Pandemic

de Sá, V. R., & Padovan‐Neto, F. E. (2025) · Psychiatric Quarterly · doi:10.1007/s11126-025-10148-4 · Cited by 1 · see citing works

Exploring the Association Between Physical Fitness Components and Cognitive Function in Older Korean Adults: The SUPERBRAIN Exploratory Sub-study

Kim, D. A., Chun, B., Choi, M., Sun, K., Jeong, J. H., Park, Y. K., Hong, C. H., Na, H. R., Choi, S. H., Moon, S. Y., et al. (2026) · Dementia and Neurocognitive Disorders · doi:10.12779/dnd.2026.25.1.13 · Cited by 1 · see citing works

The Value of Exercise Training for Prevention and Complementary Treatment of Brain Aging and Neurodegeneration

Kaliman, P. (2014) · Journal of Yoga & Physical Therapy · doi:10.4172/2157-7595.1000152

Changes in Cerebral Blood Flow During Steady-State Exercise

Hiura, M., & Nariai, T. (2017) · Elsevier eBooks · doi:10.1016/b978-0-12-805094-1.00008-3 · Cited by 1 · see citing works

Examining the Impact of Light and Vigorous Acute Aerobic Exercise on Pattern Separation and Sustained Attention in Young AdultsPreprint

Melville, M. A., Stark, J. H., Hiersche, K. J., Esterman, M. S., & Hayes, S. M. (2024) · doi:10.31219/osf.io/9aenu · Cited by 1 · see citing works

Group exercise program using large amplitude movements and functional activity training in older adults with Parkinson's disease.

Gallagher, K. (2014) · UVic’s Research and Learning Repository (University of Victoria)

THE EFFICACY OF HIPPOCAMPAL STIMULATION IN PREVENTING DEPRESSIVE SYMPTOMS

Patrick, T. B. (2011) · EngagedScholarship @ Cleveland State University (Cleveland State University)

PET imaging for altered brain function evoked by exercise: measurements of changes in cerebral blood flow and neurotransmitters

Hiura, M., Nariai, T., Muta, A., Inaji, M., Toyohara, J., Ishii, K., Ishibahi, K., Wagatsuma, K., Sakata, M., Oda, K., et al. (2017) · Cerebral Blood Flow and Metabolism (Japanese journal of cerebral blood flow and metabolism) · doi:10.16977/cbfm.28.2_297

Internal versus External Predictors of Physical Activity in Youth

Ryan, P. M. (2019) · doi:10.31390/gradschool_dissertations.4906

Physical Exercise

Yau, S., Patten, A. R., Sharp, Z., & Christie, B. R. (2016) · Elsevier eBooks · doi:10.1016/b978-0-12-801977-1.00005-2

Biochemical correlates of synaptic plasticity in exercise

Basnet, R. M. (2012) · BIBSYS Brage (BIBSYS (Norway))

Faculty Opinions recommendation of Aerobic fitness is associated with gray matter volume and white matter integrity in multiple sclerosis.

BOURDETTE, D. N., & Cameron, M. H. (2009) · Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature · doi:10.3410/f.1161809.623417

Additional file 2 of The association between the health-related physical fitness and inhibitory control in preschool children

Li, Y., Zhou, T., Lu, Y., Sang, M., Liu, J., He, X., & Quan, M. (2022) · Figshare · doi:10.6084/m9.figshare.19234310

Additional file 1 of The association between the health-related physical fitness and inhibitory control in preschool children

Li, Y., Zhou, T., Lu, Y., Sang, M., Liu, J., He, X., & Quan, M. (2022) · Figshare · doi:10.6084/m9.figshare.19234307

Diabetes-associated cognitive decline, is there a role for exercice? : a study on the effects of physical activity and exercise on neurotrophic markers and cognitive function in type 1 diabetes

Tonoli, C. (2014) · doi:10.70675/66d53edbzb14ez4de5zad9bz41d74d2113b6

The Brain And Exercise: In Sickness And In Health

Reslan, M. A., Tabet, M., Yehya, Y., Shaito, A. A., & Kobeissy, F. H. (2022) · Frontiers for Young Minds · doi:10.3389/frym.2022.632277 · Cited by 1 · see citing works

Physical exercise and the brain

Firth, J., & Carney, R. (2019)

Exercising the brain: Molecular pathways linking exercise, neuronal mitochondria, and synaptic plasticity

Mao, X., Rygalski, E., & Yan, Z. (2026) · Sports Medicine and Health Science · doi:10.1016/j.smhs.2026.07.001 · Cited by 1 · see citing works

Exercise and the brain

Robinson, A. M. (2014) · doi:10.1349/ddlp.1250

Physical Exercise Can Induce Brain Plasticity and Regulate Mental Function

Ichiro, K. (2014) · Advances in exercise and sports physiology · Cited by 4 · see citing works