Neurovascular Congruence during Cerebral Cortical Development
Open accessAbstract
There is evidence for interaction between the developing circulatory and nervous systems. Blood vessels provide a supporting niche in regions of adult neurogenesis. Here we present a systematic analysis of vascular development in the embryonic murine cortex and demonstrate that dividing cells, including Tbr2-positive intermediate progenitor cells, are closer to the vasculature than expected from a random distribution. To examine whether neurites of the newly generated embryonic neurons find blood vessels as an attractive and permissive substrate, we overlayed green fluorescent protein (GFP)-labeled dissociated cortical progenitors on embryonic organotypic cortical slice cultures with labeled vasculature. Our observations of neurites extending toward and along labeled blood vessels support the notion of vascular-neuronal interactions. The altered cortical layering had no obvious effect on the vascular patterns within the cortical plate (CP) in shaking rat Kawasaki (SRK) and the reeler mutant mouse at the ages studied (E19 and P3). It appears that similarly to other neurogenic regions in the adult, the embryonic "vascular niche" might influence neural progenitor cells during telencephalic neurogenesis, neuronal migration, and neurite extension, but the laminar phenotype of cell classes within the CP has limited influence on the developing vasculature.
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Brain organoids currently lack some cell types present in primary cortex, such as endothelial cells and microglia.
“Brain organoids currently lack some of the cell types present in primary cortex, such as endothelial cells (which have been shown to influence progenitor cell behaviour62,63) and microglia (which also have a role in early stages of cortical development64) (FIG. 2b).”
From The use of brain organoids to investigate neural development and disease (2017) · cites this paper as [63]
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- Authors
- Stubbs, D., DeProto, J., Nie, K., Englund, C., Mahmud, I., Hevner, R., & Molnár, Z.
- Affiliations
- University of Oxford (GB)
- Seattle Children's Hospital (US)
- Venue
- Cerebral Cortex
- Publisher
- Oxford University Press (OUP)
- Published
- 2009-04-22
- Volume
- 19
- Issue
- suppl_1
- Pages
- i32-i41
- ISSN
- 1047-3211 (ISSN-L)
- 1460-2199
- PMC
- PMC2693536
- OpenAlex
- W2121558276
- Cited by
- 133
- References
- 33
- Citations by year
- 2026: 3 · 2025: 2 · 2024: 4 · 2023: 7 · 2022: 5 · 2021: 3 · 2020: 12 · 2019: 8 · 2018: 6 · 2017: 11 · 2016: 9 · 2015: 6 · 2014: 12 · 2013: 9 · 2012: 9
- FWCI
- 3.75
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Cerebral Cortex (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- U.S. Public Health Service (R01 N5050248)
- Biotechnology and Biological Sciences Research Council (BB/F003285/1)
- Topics
- Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
- Life Sciences › Neuroscience › Neurology › Barrier Structure and Function Studies
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Angiogenesis and VEGF in Cancer
- Keywords
- neurovascular interactions, cortical development, embryonic vasculature, intermediate progenitor cells, Tbr2, neuronal migration, neurite outgrowth, vascular niche, cortical plate, cortical lamination, organotypic slice cultures, reeler mutant, Kawasaki disease, neural progenitor cells
- MeSH terms
- Animals, Cerebral Arteries, Cerebral Cortex, Cerebrovascular Circulation, Mice, Inbred C57BL, Mice
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