Effect of probiotics on lipid profiles in hypercholesterolaemic adults: A meta-analysis of randomized controlled trials
Abstract
Background Recent clinical studies have yielded controversial results regarding the effect of probiotics on lipid profiles. To assess the efficacy of probiotics in lowering serum lipid concentrations, we conducted a meta-analysis of randomized controlled trials (RCTs).Methods Literature from the PubMed, Embase and Cochrane databases were searched and screened. The effects of probiotics on lipid profiles were assessed by mean difference (MD) and 95% confidence interval (CI). All included studies were analyzed using Review Manager 5.3 (Cochrane Collaboration, 2014).Results A total of 19 RCTs, including 967 participants, met the inclusion criteria. Probiotic interventions reduced total cholesterol (TC) and low-density lipoprotein cholesterol (LDL-C) compared to controls (placebo or no treatment) by -0.25mmol/L (95% CI: -0.39, -0.12) and -0.17mmol/L (95% CI: -0.25, -0.09), respectively. No significant effects of probiotics on triglyceride (TG) and high-density lipoprotein cholesterol (HDL-C) levels were found. The effects of probiotics on decreasing TC and LDL-C levels were greater for longer intervention times, certain probiotic strains, and in younger mildly hypercholesterolaemic subjects.Conclusion This meta-analysis revealed that the use of probiotics can significantly lower TC and LDL-C levels in hypercholesterolaemic adults, which brings hope for reducing the risk factors for developing cardiovascular disease.
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Administration of probiotics can improve markers of cardiovascular diseases, including hypertension and dyslipidemia.
“On the other hand, it has been shown that the administration of probiotic markers of cardiovascular diseases can be improved, including hypertension [148] and dyslipidemia [149,150].”
From The Potential Impact of Probiotics on Human Health: An Update on Their Health-Promoting Properties (2024) · cites this paper as [149]
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- Authors
- Mo, R., Zhang, X., & Yang, Y.
- Affiliations
- Nankai University (CN)
- Corresponding author
- Yang, Yunsheng
- Venue
- Medicina Clínica
- Publisher
- Elsevier BV
- Published
- 2019-06
- Volume
- 152
- Issue
- 12
- Pages
- 473-481
- ISSN
- 0025-7753 (ISSN-L)
- OpenAlex
- W2901833353
- Cited by
- 52
- References
- 39
- Citations by year
- 2026: 4 · 2025: 5 · 2024: 8 · 2023: 4 · 2022: 13 · 2021: 11 · 2020: 7
- FWCI
- 0.45
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Medicina Clínica (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National High Technology Research and Development Program of China (2015AA020701)
- Topics
- Life Sciences › Agricultural and Biological Sciences › Food Science › Probiotics and Fermented Foods
- Health Sciences › Medicine › Surgery › Lipoproteins and Cardiovascular Health
- Health Sciences › Medicine › Surgery › Natural Products and Biological Research
- Keywords
- probiotics, hypercholesterolemia, lipid profile, total cholesterol, LDL cholesterol, triglycerides, HDL cholesterol, cardiovascular risk, intervention duration, probiotic strains, adults, dietary supplementation, effect size heterogeneity, publication bias, risk of bias assessment
- MeSH terms
- Adult, Age Factors, Cardiovascular Diseases, Cholesterol, Humans, Hypercholesterolemia, Lipids, Lipoproteins, HDL, Cholesterol, LDL, Triglycerides, Randomized Controlled Trials as Topic, Probiotics
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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