Effects of Milk Products Fermented by Bifidobacterium longum on Blood Lipids in Rats and Healthy Adult Male Volunteers
Open accessAbstract
The effects of milk products fermented by Bifidobacterium longum strain BL1, a probiotic strain, on blood lipids in rats and humans were studied. Rats were fed a cholesterol-enriched experimental diet, supplemented with lyophilized powders of 1) acid milk (control), 2) milk fermented with a mixed culture of ordinary yogurt starters composed of Streptococcus thermophilus and Lactobacillus delbrueckii subsp. bulgaricus (SL), and 3) bifidobacterium milk fermented with the probiotic B. longum strain BL1, respectively. The bifidobacterium milk feeding brought about significant lowering of the serum concentrations of total cholesterol, low-density lipoprotein cholesterol, and triglycerides, in comparison with the control, while no change in high-density lipoprotein cholesterol concentration was observed. On the other hand, supplementation with SL milk resulted in only slight, nonsignificant decreases in serum lipid concentrations in comparison with the control. In the human study, 32 subjects with serum total cholesterol ranging from 220 to 280 mg/dl were randomly assigned to two treatments: 1) intake of a low-fat drinking yogurt prepared with ordinary yogurt starters composed of S. thermophilus and L. delbrueckii subsp. bulgaricus (P-group) and 2) intake of a low-fat drinking yogurt prepared with the two ordinary yogurt starters plus B. longum strain BL1 (B-group). After intake for 4 wk at 3 x 100 ml/day, reduction of serum total cholesterol was observed in approximately half of the B-group subjects; a particularly significant decrease in serum total cholesterol was found among subjects with moderate hypercholesterolemia (serum total cholesterol > 240 mg/dl). However, the serum lipid concentrations in the P-group subjects were almost stable during the experimental periods. The present results indicate the potential of the probiotic B. longum strain BL1 in serum lipid improvement.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
Friedewald, W. T., Levy, R. I., & Fredrickson, D. S. (1972) · Clinical Chemistry · doi:10.1093/clinchem/18.6.499 · Cited by 32,423 · see citing works
The pathogenesis of atherosclerosis: a perspective for the 1990s
Ross, R. (1993) · Nature · doi:10.1038/362801a0 · Cited by 10,618 · see citing works
Helsinki Heart Study: Primary-Prevention Trial with Gemfibrozil in Middle-Aged Men with Dyslipidemia
Frick, M. H., Elo, O., Haapa, K., Heinonen, O. P., Heinsalmi, P., Helo, P., Huttunen, J. K., Kaitaniemi, P., Koskinen, P., Manninen, V., et al. (1987) · New England Journal of Medicine · doi:10.1056/nejm198711123172001 · Cited by 3,881 · see citing works
Cholesterol and mortality. 30 years of follow-up from the Framingham study
Anderson, K. M. (1987) · JAMA · doi:10.1001/jama.257.16.2176 · Cited by 951 · see citing works
Assimilation of cholesterol by Lactobacillus acidophilus
Gilliland, S. E., Nelson, C. R., & Maxwell, C. V. (1985) · Applied and Environmental Microbiology · doi:10.1128/aem.49.2.377-381.1985 · Cited by 652 · see citing works
Salminen, S. (1993) · Medical Entomology and Zoology · Cited by 635 · see citing works
Anderson, K. M. (1987) · JAMA · doi:10.1001/jama.1987.03390160062027 · Cited by 627 · see citing works
Studies of a surfactant and cholesteremia in the Maasai
Mann, G. V., & Spoerry, A. (1974) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/27.5.464 · Cited by 386 · see citing works
Lees, A. M., Mok, H. Y. I., Lees, R. S., McCluskey, M. A., & Grundy, S. M. (1977) · Atherosclerosis · doi:10.1016/0021-9150(77)90180-0 · Cited by 345 · see citing works
Gilliland, S. E., & Walker, D. K. (1990) · Journal of Dairy Science · doi:10.3168/jds.s0022-0302(90)78747-4 · Cited by 307 · see citing works
Law, M. R., Wald, N., Wu, T., Hackshaw, A. K., & Bailey, A. (1994) · BMJ · doi:10.1136/bmj.308.6925.363 · Cited by 305 · see citing works
St‐Onge, M., Farnworth, E. R., & Jones, P. J. H. (2000) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/71.3.674 · Cited by 286 · see citing works
Long-term consumption of fermented dairy products over 6 months increases HDL cholesterol
Kiessling, G., Schneider, J., & Jahreis, G. (2002) · European Journal of Clinical Nutrition · doi:10.1038/sj.ejcn.1601399 · Cited by 256 · see citing works
Kawase, M., Hashimoto, H., Hosoda, M., Morita, H., & Hosono, A. (2000) · Journal of Dairy Science · doi:10.3168/jds.s0022-0302(00)74872-7 · Cited by 230 · see citing works
Self-citationHypocholesterolemic effect of yogurt and milk
Hepner, G., Fried, R., St Jeor, S., Fusetti, L., & Morin, R. (1979) · The American Journal of Clinical Nutrition · doi:10.1093/ajcn/32.1.19 · Cited by 202 · see citing works
Hypocholesterolaemic effect of a new fermented milk product in healthy middle-aged men.
Agerbæk, M., Gerdes, L. U., & Richelsen, B. (1995) · PubMed · Cited by 196 · see citing works
Cholesterol lowering in pigs through enhanced bacterial bile salt hydrolase activity
Smet, I. D., Boever, P. D., & Verstraete, W. (1998) · British Journal Of Nutrition · doi:10.1079/bjn19980030 · Cited by 182 · see citing works
Evidence for Hypocholesterolemic Effect of Lactobacillus reuteri in Hypercholesterolemic Mice
Taranto, M. P., Medici, M., Perdigón, G., Holgado, A. P. R., & de Valdez, G. F. (1998) · Journal of Dairy Science · doi:10.3168/jds.s0022-0302(98)70123-7 · Cited by 177 · see citing works
Hood, S. K., & ZOITOLA, E. A. (1988) · Journal of Food Science · doi:10.1111/j.1365-2621.1988.tb09312.x · Cited by 162 · see citing works
Hainer, J. W. (1987) · JAMA · doi:10.1001/jama.1987.03400120058022 · Cited by 153 · see citing works
Usman, U., & Hosono, A. (2000) · Journal of Dairy Science · doi:10.3168/jds.s0022-0302(00)75039-9 · Cited by 128 · see citing works
Self-citationThe effect of fermented and unfermented milks on serum cholesterol
Thompson, L., Jenkins, D., Amer, M., Reichert, R., Jenkins, A. L., & Kamulsky, J. (1982) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/36.6.1106 · Cited by 121 · see citing works
de Roos, N., Schouten, G. K., & Katan, M. (1999) · European Journal of Clinical Nutrition · doi:10.1038/sj.ejcn.1600722 · Cited by 112 · see citing works
Richelsen, B., Kristensen, K., & Pedersen, S. B. (1996) · PubMed · Cited by 104 · see citing works
Anticholesteremic Property of Lactobacillus Acidophilus Yogurt Fed to Mature Boars2
Danielson, A. D., Peo, E. R., SHAHANI, K. M., Lewis, A. J., Whalen, P. J., & Amer, M. A. (1989) · Journal of Animal Science · doi:10.2527/jas1989.674966x · Cited by 99 · see citing works
Influence of Yogurt and Acidophilus Yogurt on Serum Cholesterol Levels in Mice
Sibel Akalin, A., Gönç, S., & Düzel, S. (1997) · Journal of Dairy Science · doi:10.3168/jds.s0022-0302(97)76233-7 · Cited by 96 · see citing works
Effects of three strains of bifidobacteria on cholesterol
Tahri, K., Crociani, J., Ballongue, J., & Schneider, F. (1995) · Letters in Applied Microbiology · doi:10.1111/j.1472-765x.1995.tb01028.x · Cited by 83 · see citing works
Treatment of Hypercholesterolemia by Interference With Bile Acid Metabolism
Grundy, S. M. (1972) · Archives of Internal Medicine · doi:10.1001/archinte.1972.03650040162015 · Cited by 73 · see citing works
Beena, A. K., & PRASAD, V. (1997) · Journal of Dairy Research · doi:10.1017/s0022029997002252 · Cited by 73 · see citing works
Yamamoto, A., Horibe, H., Mabuchi, H., Kita, T., Matsuzawa, Y., Saitō, Y., Nakaya, N., FUJIOKA, T., Tenba, H., Kawaguchi, A., et al. (1999) · Atherosclerosis · doi:10.1016/s0021-9150(98)00275-5 · Cited by 43 · see citing works
Hashimoto, H., Yamazaki, K., He, F., Kawase, M., Hosoda, M., & Hosono, A. (1999) · Animal Science Journal · Cited by 24 · see citing works
Self-citationFunctional Benefits from Lactic Acid Bacteria used in Cultured Milk
Itoh, T. (1992) · Nihon Chikusan Gakkaiho · doi:10.2508/chikusan.63.1276 · Cited by 11 · see citing works
[Primary and secondary prevention of atherosclerotic disease by lipid-lowering therapies].
Mabuchi, H. (1999) · PubMed · Cited by 1 · see citing works
Flagged first, then by citations
3 of the 36 references couldn’t be matched to a known paper.
Research works printed but not linked: 2
- [15]15. Harvenaar, R. and M. Minekus. 1996. Stimulated assimilation. Dairy Ind. Int. 61(9):17-23.
- [29]29. Rasic, J. L., and J. A. Kurmann. 1979. Yogurt. Scientific Grounds Technology, Manufacture and Preparations. 2nd ed. Tech. Dairy Publ. House, Copenhagen, Denmark. Journal of Dairy Science Vol. 86, No. 7, 2003
Cited by
Sorted by citations
Functional cultures and health benefits
Shah, N. P. (2007) · International Dairy Journal · doi:10.1016/j.idairyj.2007.01.014 · Cited by 793 · see citing works
Cholesterol-Lowering Effects of Probiotics and Prebiotics: A Review of in Vivo and in Vitro Findings
Ooi, L.-G., & Liong, M. (2010) · International Journal of Molecular Sciences · doi:10.3390/ijms11062499 · Cited by 690 · see citing works
A top‐down systems biology view of microbiome‐mammalian metabolic interactions in a mouse model
Martin, F., Dumas, M., Wang, Y., Legido‐Quigley, C., Yap, I. K. S., Tang, H., Zirah, S., Murphy, G. M., Cloarec, O., Lindon, J. C., et al. (2007) · Molecular Systems Biology · doi:10.1038/msb4100153 · Cited by 471 · see citing works
Milk <i>kefir</i> : nutritional, microbiological and health benefits
Rosa, D. D., Dias, M. M. S., Grześkowiak, Ł. M., Reis, S. A., Conceição, L. L., & Peluzio, M. D. C. G. (2017) · Nutrition Research Reviews · doi:10.1017/s0954422416000275 · Cited by 463 · see citing works
The role of the gut microbiota in nonalcoholic fatty liver disease
Abu-Shanab, A., & Quigley, E. M. M. (2010) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/nrgastro.2010.172 · Cited by 457 · see citing works
The Microbiota and Health Promoting Characteristics of the Fermented Beverage Kefir
Bourrie, B. C. T., Willing, B. P., & Cotter, P. D. (2016) · Frontiers in Microbiology · doi:10.3389/fmicb.2016.00647 · Cited by 449 · see citing works
Cholesterol-Lowering Probiotics as Potential Biotherapeutics for Metabolic Diseases
Kumar, M., Nagpal, R., Kumar, R., Hemalatha, R., Verma, V., Kumar, A., Chakraborty, C., Singh, B., Marotta, F., Jain, S., et al. (2012) · Experimental Diabetes Research · doi:10.1155/2012/902917 · Cited by 439 · see citing works
Farnworth, E. R. (2005) · Food Science <html_ent glyph="@amp;" ascii="&amp;"/> Technology Bulletin: Functional Foods · doi:10.1616/1476-2137.13938 · Cited by 422 · see citing works
Ejtahed, H., Mohtadinia, J., Rad, A. H., Niafar, M., Jafarabadi, M. A., Mofid, V., & Akbarian-Moghari, A. (2011) · Journal of Dairy Science · doi:10.3168/jds.2010-4128 · Cited by 416 · see citing works
Probiotics in prevention and treatment of obesity: a critical view
Kobyliak, N. M., Conte, C., Cammarota, G., Haley, A. P., Štyriak, I., Gašpar, Ľ., Fusek, J., Rodrigo, L., & Kružliak, P. (2016) · Nutrition & Metabolism · doi:10.1186/s12986-016-0067-0 · Cited by 359 · see citing works
Probiotics, prebiotics, synbiotics and insulin sensitivity
Kim, Y. A., Keogh, J. B., & Clifton, P. M. (2017) · Nutrition Research Reviews · doi:10.1017/s095442241700018x · Cited by 341 · see citing works
Getting better with bifidobacteria
Leahy, S. C., Higgins, D. G., Fitzgerald, G. F., & van Sinderen, D. (2005) · Journal of Applied Microbiology · doi:10.1111/j.1365-2672.2005.02600.x · Cited by 331 · see citing works
Probiotics and Prebiotics: Present Status and Future Perspectives on Metabolic Disorders
Yoo, J. Y., & Kim, S. S. (2016) · Nutrients · doi:10.3390/nu8030173 · Cited by 330 · see citing works
Lee, S.-H., Cho, S.-Y., Yoon, Y., Park, C., Sohn, J., Jeong, J.-J., Jeon, B.-N., Jang, M., An, C., Lee, S., et al. (2021) · Nature Microbiology · doi:10.1038/s41564-020-00831-6 · Cited by 325 · see citing works
Antiobesity and lipid-lowering effects of Bifidobacterium spp. in high fat diet-induced obese rats
An, H. M., Park, S. Y., Lee, D. K., Kim, J. R., Cha, M. K., Lee, S. W., Lim, H. T., Kim, K. J., & Ha, N. J. (2011) · Lipids in Health and Disease · doi:10.1186/1476-511x-10-116 · Cited by 320 · see citing works
Rajkumar, H., Mahmood, N., Kumar, M., Varikuti, S. R., Challa, H. R., & Myakala, S. P. (2014) · Mediators of Inflammation · doi:10.1155/2014/348959 · Cited by 301 · see citing works
Current status of probiotic and related health benefits
Das, T. K., Pradhan, S., Chakrabarti, S., Mondal, K. C., & Ghosh, K. (2022) · Applied Food Research · doi:10.1016/j.afres.2022.100185 · Cited by 294 · see citing works
Cholesterol-Lowering Nutraceuticals and Functional Foods
Chen, Z., Jiao, R., & Ma, K. Y. (2008) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf801566r · Cited by 275 · see citing works
Review: Functional Properties of Kefir
Güzel‐Seydim, Z. B., Taş, T. K., Greene, A. K., & Seydim, A. C. (2011) · Critical Reviews in Food Science and Nutrition · doi:10.1080/10408390903579029 · Cited by 272 · see citing works
Metabolic activities and probiotic potential of bifidobacteria
Russell, D. A., Ross, R. P., Fitzgerald, G. F., & Stanton, C. (2011) · International Journal of Food Microbiology · doi:10.1016/j.ijfoodmicro.2011.06.003 · Cited by 265 · see citing works
Gao, R., Zhu, C., Li, H., Yin, M., Pan, C., Huang, L., Kong, C., Wang, X., Zhang, Y., Qu, S., et al. (2017) · Obesity · doi:10.1002/oby.22088 · Cited by 264 · see citing works
Probiotics, Prebiotics, and Synbiotics: Gut and Beyond
Vyas, U., & Ranganathan, N. (2012) · Gastroenterology Research and Practice · doi:10.1155/2012/872716 · Cited by 258 · see citing works
Moroti, C., Magri, L. F. S., Costa, M. D. R., Cavallini, D., & Sivieri, K. (2012) · Lipids in Health and Disease · doi:10.1186/1476-511x-11-29 · Cited by 254 · see citing works
Lye, H., Ali, G. R. R., & Liong, M. (2009) · International Dairy Journal · doi:10.1016/j.idairyj.2009.10.003 · Cited by 253 · see citing works
Lasker, S., Rahman, M. M., Parvez, F., Zamila, M., Miah, P., Nahar, K., Kabir, F., Mohona, S. B. S., Subhan, N., Ahsan, G. U., et al. (2019) · Scientific Reports · doi:10.1038/s41598-019-56538-0 · Cited by 253 · see citing works
Guo, Z., Liu, X. M., Zhang, Q. X., Shen, Z., Tian, F., Zhang, H., Sun, Z., Zhang, H. P., & Chen, W. (2011) · Nutrition Metabolism and Cardiovascular Diseases · doi:10.1016/j.numecd.2011.04.008 · Cited by 249 · see citing works
Effects of fourBifidobacteriaon obesity in high-fat diet induced rats
Yin, Y. (2010) · World Journal of Gastroenterology · doi:10.3748/wjg.v16.i27.3394 · Cited by 259 · see citing works
Kefir and Health: A Contemporary Perspective
Ahmed, Z., Wang, Y., Ahmad, A., Khan, S. T., Nisa, M., Ahmad, H., & Afreen, A. (2013) · Critical Reviews in Food Science and Nutrition · doi:10.1080/10408398.2010.540360 · Cited by 242 · see citing works
Nabavi, S., Rafraf, M., Somi, M. H., Rad, A. H., & Jafarabadi, M. A. (2014) · Journal of Dairy Science · doi:10.3168/jds.2014-8500 · Cited by 235 · see citing works
Gut microbiota in patients with obesity and metabolic disorders — a systematic review
Xu, Z., Jiang, W., Huang, W., Lin, Y., Chan, F. K. L., & Ng, S. C. (2022) · Genes & Nutrition · doi:10.1186/s12263-021-00703-6 · Cited by 248 · see citing works
Yasmin, I., Saeed, M., Khan, W. A., Khaliq, A., Chughtai, M. F. J., Iqbal, R., Tehseen, S., Naz, S., Liaqat, A., Mehmood, T., et al. (2020) · Microorganisms · doi:10.3390/microorganisms8030354 · Cited by 233 · see citing works
Ryan, P. M., Ross, R. P., Fitzgerald, G. F., Caplice, N. M., & Stanton, C. (2015) · Food & Function · doi:10.1039/c4fo00529e · Cited by 221 · see citing works
The perspective on cholesterol‐lowering mechanisms of probiotics
Ishimwe, N., Daliri, E. B., Lee, B. H., Fang, F., & Du, G. (2014) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.201400548 · Cited by 216 · see citing works
Xie, N., Cui, Y., Yin, Y.-N., Zhao, X., Yang, J.-W., Wang, Z.-G., Fu, N., Tang, Y., Wang, X.-H., Liu, X.-W., et al. (2011) · BMC Complementary and Alternative Medicine · doi:10.1186/1472-6882-11-53 · Cited by 211 · see citing works
Gioia, D. D., Aloisio, I., Mazzola, G., & Biavati, B. (2013) · Applied Microbiology and Biotechnology · doi:10.1007/s00253-013-5405-9 · Cited by 208 · see citing works
Ataie‐Jafari, A., Larijani, B. A., Majd, H. A., & Tahbaz, F. (2009) · Annals of Nutrition and Metabolism · doi:10.1159/000203284 · Cited by 194 · see citing works
Shimizu, M., Hashiguchi, M., Shiga, T., Tamura, H.-O., & Mochizuki, M. (2015) · PLoS ONE · doi:10.1371/journal.pone.0139795 · Cited by 182 · see citing works
Hsieh, M., Tsai, W.-H., Jheng, Y.-P., Su, S., Wang, S., Lin, C., Chen, Y.-H., & Chang, W. (2018) · Scientific Reports · doi:10.1038/s41598-018-35014-1 · Cited by 182 · see citing works
The effects of probiotic and conventional yoghurt on lipid profile in women
Sadrzadeh-Yeganeh, H., Elmadfa, I., Djazayery, A., Jalali, M., Heshmat, R., & Chamary, M. (2010) · British Journal Of Nutrition · doi:10.1017/s0007114509993801 · Cited by 179 · see citing works
Milk and the metabolic syndrome
Pfeuffer, M., & Schrezenmeir, J. (2006) · Obesity Reviews · doi:10.1111/j.1467-789x.2006.00265.x · Cited by 173 · see citing works
Nazir, Y., Hussain, S. A., Hamid, A. A., & Song, Y. (2018) · BioMed Research International · doi:10.1155/2018/3428437 · Cited by 156 · see citing works
Effect of Probiotics on Blood Lipid Concentrations: A Meta-Analysis of Randomized Controlled Trials
Cho, Y. A., & Kim, J. (2015) · Medicine · doi:10.1097/md.0000000000001714 · Cited by 143 · see citing works
Complete Genome Sequence of Bifidobacterium longum subsp. longum KACC 91563
Ham, J.-S., Lee, T., Byun, M.-J., Lee, K., Kim, M., Han, G.-S., Jeong, S.-G., Oh, M., Kim, D., & Kim, H. (2011) · Journal of Bacteriology · doi:10.1128/jb.05620-11 · Cited by 143 · see citing works
Effectiveness of probiotics in type 2 diabetes: a meta-analysis
Kasińska, M., & Drzewoski, J. (2015) · Polskie Archiwum Medycyny Wewnętrznej · doi:10.20452/pamw.3156 · Cited by 144 · see citing works
Kefiran, a branched polysaccharide: Preparation, properties and applications: A review
Moradi, Z., & Kalanpour, N. (2019) · Carbohydrate Polymers · doi:10.1016/j.carbpol.2019.115100 · Cited by 140 · see citing works
Klein, A., Friedrich, U., Vogelsang, H., & Jahreis, G. (2007) · European Journal of Clinical Nutrition · doi:10.1038/sj.ejcn.1602761 · Cited by 136 · see citing works
Prasanna, P. H. P., Grandison, A. S., & Charalampopoulos, D. (2014) · Food Research International · doi:10.1016/j.foodres.2013.11.013 · Cited by 135 · see citing works
Lee, D. K., Jang, S., Baek, E. H., Kim, M. J., Lee, K. S., Shin, H. S., Chung, M. J., Kim, J. E., Lee, K. O., & Ha, N. J. (2009) · Lipids in Health and Disease · doi:10.1186/1476-511x-8-21 · Cited by 131 · see citing works
Ali, A., Velasquez, M. T., Hansen, C. T., Mohamed, A. I., & Bhathena, S. J. (2004) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2004.04.005 · Cited by 128 · see citing works
Larsen, C. N., Nielsen, S., Kæstel, P., Brockmann, E., Bennedsen, M., Christensen, H. R., Eskesen, D. C., Jacobsen, B. L., & Michaelsen, K. F. (2006) · European Journal of Clinical Nutrition · doi:10.1038/sj.ejcn.1602450 · Cited by 124 · see citing works
Recent Trends in Development of Fermented Milks
Khurana, H., & Kanawjia, S. K. (2007) · Current Nutrition & Food Science · doi:10.2174/1573401310703010091 · Cited by 123 · see citing works
Effect of probiotics on biomarkers of cardiovascular disease: implications for heart-healthy diets
DiRienzo, D. B. (2013) · Nutrition Reviews · doi:10.1111/nure.12084 · Cited by 119 · see citing works
Safavi, S. M., Farajian, S., Kelishadi, R., Mirlohi, M., & Hashemipour, M. (2013) · International Journal of Food Sciences and Nutrition · doi:10.3109/09637486.2013.775224 · Cited by 117 · see citing works
Shin, H. S., Park, S.-Y., Lee, D. K., Kim, S. A., An, H. M., Kim, J. R., Kim, M. J., Gyeong, M., Lee, S. W., Kim, K., et al. (2010) · Archives of Pharmacal Research · doi:10.1007/s12272-010-0917-7 · Cited by 116 · see citing works
Hypocholesterolaemic effects of milk-kefir and soyamilk-kefir in cholesterol-fed hamsters
Liu, J.-R., Wang, S.-Y., Chen, M.-J., Chen, H.-L., Yueh, P.-Y., & Lin, C.-W. (2006) · British Journal of Nutrition · doi:10.1079/bjn20061752 · Cited by 115 · see citing works
The Gut Microbiota and Human Health with an Emphasis on the Use of Microencapsulated Bacterial Cells
Prakash, S., Tomaro-Duchesneau, C., Saha, S., & Cantor, A. (2011) · BioMed Research International · doi:10.1155/2011/981214 · Cited by 115 · see citing works
Probiotic fermented foods for health benefits
Divya, J. B., Varsha, K. K., Nampoothiri, K. M., Ismail, B., & Pandey, A. (2012) · Engineering in Life Sciences · doi:10.1002/elsc.201100179 · Cited by 110 · see citing works
Liong, M. (2008) · Nutrition Reviews · doi:10.1111/j.1753-4887.2007.tb00309.x · Cited by 106 · see citing works
Hypocholesterolemic Effects of Probiotic Mixture on Diet-Induced Hypercholesterolemic Rats
Kim, S., Park, S. W., Sin, H., Jang, S., Lee, S.-W., Kim, S., Kwon, B., Yu, K.-Y., Kim, S. Y., & Yang, D. K. (2017) · Nutrients · doi:10.3390/nu9030293 · Cited by 104 · see citing works
Antagonistic activity against pathogenic bacteria by human vaginal lactobacilli
Voravuthikunchai, S. P., Bilasoi, S., & Supamala, O. (2006) · Anaerobe · doi:10.1016/j.anaerobe.2006.06.003 · Cited by 104 · see citing works
Higashikawa, F., Noda, M., Awaya, T., Nomura, K., Oku, H., & Sugiyama, M. (2009) · Nutrition · doi:10.1016/j.nut.2009.05.008 · Cited by 104 · see citing works
Cole‐Jeffrey, C. T., Liu, M., Katovich, M. J., Raizada, M. K., & Shenoy, V. (2015) · Journal of Cardiovascular Pharmacology · doi:10.1097/fjc.0000000000000307 · Cited by 103 · see citing works
Karimi, G., Sabran, M. R., Jamaluddin, R., Parvaneh, K., Mohtarrudin, N., Ahmad, Z., Khaza’ai, H., & Khodavandi, A. (2015) · Food & Nutrition Research · doi:10.3402/fnr.v59.29273 · Cited by 102 · see citing works
Milk, Milk Products, and Disease Free Health: An Updated Overview
Nagpal, R., Behare, P. V., Kumar, M., Mohania, D., Yadav, M., Jain, S., Menon, S., Parkash, O., Marotta, F., Minelli, E., et al. (2011) · Critical Reviews in Food Science and Nutrition · doi:10.1080/10408398.2010.500231 · Cited by 101 · see citing works
Impact of Functional Foods on Prevention of Cardiovascular Disease and Diabetes
Sikand, G., Kris‐Etherton, P. M., & Boulos, N. M. (2015) · Current Cardiology Reports · doi:10.1007/s11886-015-0593-9 · Cited by 101 · see citing works
Probiotics in Clinical Practice: An Overview
Zuccotti, G., Meneghin, F., Raimondi, C., Dilillo, D., Agostoni, C. V., Riva, E., & Giovannini, M. (2008) · Journal of International Medical Research · doi:10.1177/14732300080360s101 · Cited by 99 · see citing works
Impact of Probiotics on Risk Factors for Cardiovascular Diseases. A Review
Ebel, B., Lemetais, G., Beney, L., Cachon, R., Sokol, H., Langella, P., & Gervais, P. (2014) · Critical Reviews in Food Science and Nutrition · doi:10.1080/10408398.2011.579361 · Cited by 97 · see citing works
Gut-liver axis and fibrosis in nonalcoholic fatty liver disease: An input for novel therapies
Frăsinariu, O. E., Ceccarelli, S., Alisi, A., Moraru, E., & Nobili, V. (2012) · Digestive and Liver Disease · doi:10.1016/j.dld.2012.11.010 · Cited by 97 · see citing works
Kumar, M., Rakesh, S., Nagpal, R., Hemalatha, R., Ramakrishna, A. V. S., Sudarshan, V., Ramagoni, R., Shujauddin, M., Verma, V., Kumar, A., et al. (2013) · Nutrition · doi:10.1016/j.nut.2012.09.006 · Cited by 97 · see citing works
Antiviral activity of Bifidobacterium adolescentisSPM1005-A on human papillomavirus type 16
Cha, M.-K., Lee, D., An, H.-M., Lee, S., Shin, S. H., Kwon, J.-H., Kim, K.-J., & Ha, N. (2012) · BMC Medicine · doi:10.1186/1741-7015-10-72 · Cited by 95 · see citing works
Effects of Probiotics, Prebiotics, and Synbiotics on Hypercholesterolemia: A Review
Anandharaj, M., Sivasankari, B., & Rani, R. P. (2014) · Chinese Journal of Biology · doi:10.1155/2014/572754 · Cited by 92 · see citing works
Ebrahimi, Z., Nasli‐Esfahani, E., Nadjarzade, A., & Mozaffari–Khosravi, H. (2017) · Journal of Diabetes & Metabolic Disorders · doi:10.1186/s40200-017-0304-8 · Cited by 91 · see citing works
Chen, D., Yang, Z., Chen, X., Huang, Y., Yin, B., Guo, F., Zhao, H., Zhao, T., Qu, H., Huang, J., et al. (2014) · BMC Complementary and Alternative Medicine · doi:10.1186/1472-6882-14-386 · Cited by 90 · see citing works
Ooi, L.-G., Ahmad, R., Yuen, K. H., & Liong, M. (2010) · Journal of Dairy Science · doi:10.3168/jds.2010-3311 · Cited by 85 · see citing works
Probiotics and blood pressure: current insights
Sudha, R., & Upadrasta, A. (2016) · Integrated Blood Pressure Control · doi:10.2147/ibpc.s73246 · Cited by 83 · see citing works
Probiotics for Preventive Health
Minocha, A. (2009) · Nutrition in Clinical Practice · doi:10.1177/0884533608331177 · Cited by 80 · see citing works
Rabot, S., Rafter, J. J., Rijkers, G. T., Watzl, B., & Antoine, J. (2010) · Journal of Nutrition · doi:10.3945/jn.109.113738 · Cited by 79 · see citing works
Selecting, testing and understanding probiotic microorganisms
Reid, G., Kim, S. O., & Koehler, G. (2005) · FEMS Immunology & Medical Microbiology · doi:10.1111/j.1574-695x.2005.00026.x · Cited by 78 · see citing works
Probiotic capsules do not lower plasma lipids in young women and men
Greany, K. A., Bonorden, M. J. L., Hamilton‐Reeves, J. M., McMullen, M. H., Wangen, K. E., Phipps, W. R., Feirtag, J. M., Thomas, W. T. B., & Kurzer, M. S. (2007) · European Journal of Clinical Nutrition · doi:10.1038/sj.ejcn.1602719 · Cited by 77 · see citing works
Effect of functional yogurt NY-YP901 in improving the trait of metabolic syndrome
Chang, B. J., Park, S.-H., Jang, Y. S., Ko, S. H., Joo, N., Kim, S.-I., Kim, C.-H., & Chang, D. K. (2011) · European Journal of Clinical Nutrition · doi:10.1038/ejcn.2011.115 · Cited by 77 · see citing works
Takeda, S., Yamasaki, K., Takeshita, M., Kikuchi, Y., Tsend‐Ayush, C., Dashnyam, B., Ahhmed, A. M., Kawahara, S., & Muguruma, M. (2011) · Animal Science Journal · doi:10.1111/j.1740-0929.2011.00874.x · Cited by 76 · see citing works
Bifidobacteria supplementation: Effects on plasma lipid profiles in dyslipidemic children
Guardamagna, O., Amaretti, A., Puddu, P. E., Raimondi, S., Abello, F., Cagliero, P., & Rossi, M. (2014) · Nutrition · doi:10.1016/j.nut.2014.01.014 · Cited by 74 · see citing works
Larkin, T., Astheimer, L. B., & Price, W. E. (2007) · European Journal of Clinical Nutrition · doi:10.1038/sj.ejcn.1602910 · Cited by 74 · see citing works
Greany, K. A., Nettleton, J. A., Wangen, K. E., Kurzer, M. S., & Thomas, W. J. (2004) · Journal of Nutrition · doi:10.1093/jn/134.12.3277 · Cited by 73 · see citing works
Hatakka, K., Mutanen, M. L., Holma, R., Saxelin, M., & Korpela, R. (2008) · Journal of the American College of Nutrition · doi:10.1080/07315724.2008.10719723 · Cited by 71 · see citing works
Pourrajab, B., Fatahi, S., Dehnad, A., Kord‐Varkaneh, H., & Shidfar, F. (2019) · Nutrition Metabolism and Cardiovascular Diseases · doi:10.1016/j.numecd.2019.10.001 · Cited by 70 · see citing works
Prasanna, P. H. P., & Charalampopoulos, D. (2017) · Food Bioscience · doi:10.1016/j.fbio.2017.12.002 · Cited by 69 · see citing works
Zhang, J., Wang, S., Zeng, Z., Qin, Y., Shen, Q., & Li, P. (2020) · Journal of Functional Foods · doi:10.1016/j.jff.2020.103843 · Cited by 68 · see citing works
Hypolipidaemic effects of synbiotic yoghurt in rabbits
Sarfraz, F., Farooq, U., Shafi, A., Hayat, Z., Akram, K., & Rehman, H. U. (2019) · International Journal of Dairy Technology · doi:10.1111/1471-0307.12618 · Cited by 66 · see citing works
Ahn, H. Y., Kim, M., Chae, J. S., Ahn, Y., Sim, J.-H., Choi, I.-D., Lee, S., & Lee, J. H. (2015) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2015.06.030 · Cited by 66 · see citing works
Effects of NS lactobacillus strains on lipid metabolism of rats fed a high-cholesterol diet
Hu, X., Wang, T., Li, W., Jin, F., & Wang, L. (2013) · Lipids in Health and Disease · doi:10.1186/1476-511x-12-67 · Cited by 66 · see citing works
Cavallini, D., Suzuki, J. Y., Abdalla, D. S. P., Vendramini, R. C., Pauly-Silveira, N. D., Roselino, M. N., Pinto, R. A., & Rossi, E. A. (2011) · Lipids in Health and Disease · doi:10.1186/1476-511x-10-126 · Cited by 66 · see citing works
Do probiotics act more efficiently in foods than in supplements?
Rad, A. H., Mehrabany, E. V., Alipour, B., Vaghef‐Mehrabany, L., & Javadi, M. (2012) · Nutrition · doi:10.1016/j.nut.2012.01.012 · Cited by 65 · see citing works
Divya, J. B., Varsha, K. K., & Nampoothiri, K. M. (2012) · Applied Biochemistry and Biotechnology · doi:10.1007/s12010-012-9561-7 · Cited by 65 · see citing works
Effect of Lactobacillus plantarum P‐8 on lipid metabolism in hyperlipidemic rat model
Bao, Y., Wang, Z., Zhang, Y., Zhang, J., Wang, L., Dong, X., Su, F., Yao, G., Wang, S., & Zhang, H. (2012) · European Journal of Lipid Science and Technology · doi:10.1002/ejlt.201100393 · Cited by 64 · see citing works
The therapeutic value of bifidobacteria in cardiovascular disease
Tang, J., Wei, Y., Pi, C., Zheng, W., Zuo, Y., Shi, P., Chen, J., Xiong, L., Chen, T., Liu, H., et al. (2023) · npj Biofilms and Microbiomes · doi:10.1038/s41522-023-00448-7 · Cited by 68 · see citing works
Mechanisms of Action of Kefir in Chronic Cardiovascular and Metabolic Diseases
Pimenta, F. S., Luaces-Regueira, M., Ton, A. M. M., Campagnaro, B. P., Campos‐Toimil, M., Pereira, T. M., & Vasquez, E. C. (2018) · Cellular Physiology and Biochemistry · doi:10.1159/000492511 · Cited by 68 · see citing works
Probiotics Used in Human Studies
Montrose, D. C., & Floch, M. H. (2005) · Journal of Clinical Gastroenterology · doi:10.1097/01.mcg.0000165649.32371.71 · Cited by 60 · see citing works
Rerksuppaphol, S. (2015) · JOURNAL OF CLINICAL AND DIAGNOSTIC RESEARCH · doi:10.7860/jcdr/2015/11867.5728 · Cited by 62 · see citing works
Maehata, H., Arai, S., Iwabuchi, N., & Abe, F. (2021) · International Journal of Immunopathology and Pharmacology · doi:10.1177/20587384211008291 · Cited by 59 · see citing works
- Authors
- Xiao, J. Z., Kondo, S., Takahashi, N., Miyaji, K., Oshida, K., Hiramatsu, A., Iwatsuki, K., Kokubo, S., & Hosono, A.
- Affiliations
- Morinaga (Japan) (JP)
- Morinaga Milk Industry Co., Ltd. (Japan) (JP)
- Shinshu University (JP)
- Corresponding author
- Xiao, J.Z.
- Venue
- Journal of Dairy Science
- Publisher
- American Dairy Science Association
- Published
- 2003-07
- Volume
- 86
- Issue
- 7
- Pages
- 2452-2461
- ISSN
- 0022-0302 (ISSN-L)
- OpenAlex
- W2163491850
- Cited by
- 322
- References
- 36
- Citations by year
- 2026: 4 · 2025: 3 · 2024: 12 · 2023: 11 · 2022: 14 · 2021: 22 · 2020: 16 · 2019: 18 · 2018: 16 · 2017: 16 · 2016: 13 · 2015: 22 · 2014: 17 · 2013: 25 · 2012: 23
- FWCI
- 11.43
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Journal of Dairy Science (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Agricultural and Biological Sciences › Food Science › Probiotics and Fermented Foods
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Health Sciences › Nursing › Nutrition and Dietetics › Microbial Metabolites in Food Biotechnology
- Keywords
- Bifidobacterium longum, probiotics, fermented milk, serum lipids, serum cholesterol, LDL cholesterol, triglycerides, hypercholesterolemia, yogurt, Streptococcus thermophilus, Lactobacillus bulgaricus, dietary cholesterol
- MeSH terms
- Adult, Animals, Bifidobacterium, Bile, Cholesterol, Dairy Products, Fermentation, Gastric Juice, Humans, Hypercholesterolemia, Lipids, Cholesterol, LDL, Male, Middle Aged, Milk, Placebos, Triglycerides, Yogurt, Rats, Sprague-Dawley, Probiotics, Rats
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
