Experimental validation of the nerve conduction velocity selective recording technique using a multi-contact cuff electrode
Abstract
The earthworm (Lumbricus terrestris) is presented as an in vitro model of a peripheral nerve containing only two fibers each with distinctly different conduction velocities, the median and lateral giant fibers (MGF and LGF). The worm model is used with a multi-contact cuff electrode to validate the spatial-temporal filtering effect of different electrode contact configurations and the effect of applying a delay adder and matched filter tuned to either the MGF or LGF action potential (AP) to extract conduction direction and velocity from the recording. The results confirmed the known effect of inter-electrode spacing and bipolar and tripolar recording configuration on the AP amplitude. It also demonstrates a crossover point where the amplitude of the tripolar recording is larger than the monopolar recording, an effect of the slower action potential conduction velocities in the worm. The delay adder was found to be an effective velocity sensitive filter, able to discriminate units based on conduction velocity. The matched filter to be an effective means to eliminate artifact and increase signal to noise ratios, however was not found to improve selectivity.
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The ability of velocity selection recording to discriminate recorded activity by fiber type has been validated in several acute in vivo studies.
“The ability of VSR to discriminate recorded activity based on fiber type has been validated in several acute in vivo studies [123, 124, 153]; demonstrating this technique in a chronically implanted model would represent a major advancement.”
From Implantable neurotechnologies: a review of integrated circuit neural amplifiers (2016) · cites this paper as [153]
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Implantable neurotechnologies: a review of integrated circuit neural amplifiers
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- Authors
- Yoshida, K., Kurstjens, G. A. M., & Hennings, K.
- Affiliations
- Indiana University – Purdue University Indianapolis (US)
- Aalborg University (DK)
- Aalborg University Hospital (DK)
- Corresponding author
- Yoshida, K.
- Venue
- Medical Engineering & Physics
- Publisher
- IOP Publishing
- Published
- 2009-09-16
- Volume
- 31
- Issue
- 10
- Pages
- 1261-1270
- ISSN
- 1350-4533 (ISSN-L)
- 1873-4030
- OpenAlex
- W2075344214
- Cited by
- 43
- References
- 28
- Citations by year
- 2026: 1 · 2025: 1 · 2024: 4 · 2022: 3 · 2021: 2 · 2020: 4 · 2019: 3 · 2018: 2 · 2017: 1 · 2016: 3 · 2015: 2 · 2014: 3 · 2013: 4 · 2012: 5
- FWCI
- 1.38
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- Locations
- Medical Engineering & Physics (publishedVersion)
- PubMed (publishedVersion)
- VBN Forskningsportal (Aalborg Universitet) (submittedVersion)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neural Engineering
- Physical Sciences › Engineering › Biomedical Engineering › Muscle activation and electromyography studies
- Physical Sciences › Engineering › Biomedical Engineering › Analog and Mixed-Signal Circuit Design
- Keywords
- nerve conduction velocity, earthworms, Lumbricus terrestris, giant fiber, matched filter, electrode spacing, bipolar recording, action potential amplitude, peripheral nerves, signal-to-noise ratio
- MeSH terms
- Action Potentials, Algorithms, Amplifiers, Electronic, Animals, Electric Conductivity, Electrodes, Electrodes, Implanted, Equipment Design, Models, Neurological, Neural Conduction, Neurons, Oligochaeta, Peripheral Nerves, Signal Processing, Computer-Assisted, Time Factors
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