Comparison of Mono-, Bi-, and Tripolar Configurations for Stimulation and Recording With an Interfascicular Interface
Abstract
Previous studies have indicated that electrodes placed between fascicles can provide nerve recruitment with high topological selectivity if the areas of interest in the nerve are separated with passive elements. In this study, we investigated if this separation of fascicles also can provide topologically selective nerve recordings and compared the performance of mono-, bi-, and tripolar configurations for stimulation and recording with an intra-neural interface. The interface was implanted in the sciatic nerve of 10 rabbits and achieved a median selectivity of Ŝ=0.98-0.99 for all stimulation configurations, while recording selectivity configurations was in the range of Ŝ=0.70-0.80 with the monopolar configuration providing the lowest and the average reference configuration the highest recording selectivity. Interfascicular electrodes could provide an interesting addition to the bulk of peripheral nerve interfaces available for neural prosthetic devices. The separation of the nerve into chambers by the passive elements of the electrode could ensure a higher selectivity than comparable cuff electrodes and the intra-neural location could provide an option of targeting mainly central fascicles. Further studies are, however, still required to develop biocompatible electrodes and test their stability and safety in chronic experiments.
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Two interfascicular electrode designs tested in rabbit experiments confirmed the capability of interfascicular electrodes in interfacing with subpopulations of nerve fibers.
“These studies also confirmed the capability of interfascicular electrodes in interfacing with subpopulations of nerve fibers.”
From Interfaces with the peripheral nervous system for the control of a neuroprosthetic limb: a review (2020) · cites this paper as [83]
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“Electrode configuration may be used to focus extracellular fields and improve stimulation selectivity and efficacy [121], [122].”
- Authors
- Nielsen, T. N., Sevcencu, C., & Struijk, J. J.
- Affiliations
- Aalborg University (DK)
- Venue
- IEEE Transactions on Neural Systems and Rehabilitation Engineering
- Published
- 2014-01
- Volume
- 22
- Issue
- 1
- Pages
- 88-95
- ISSN
- 1534-4320 (ISSN-L)
- 1558-0210
- OpenAlex
- W1980086968
- Cited by
- 15
- References
- 39
- Citations by year
- 2026: 1 · 2025: 1 · 2024: 1 · 2022: 1 · 2021: 1 · 2020: 1 · 2019: 2 · 2018: 2 · 2016: 1 · 2015: 3 · 2014: 1
- FWCI
- 0.81
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- IEEE Transactions on Neural Systems and Rehabilitation Engineering (publishedVersion)
- PubMed (publishedVersion)
- VBN Forskningsportal (Aalborg Universitet) (submittedVersion)
- Funders
- Danish National Advanced Technology Foundation
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neural Engineering
- Physical Sciences › Engineering › Biomedical Engineering › Muscle activation and electromyography studies
- Life Sciences › Neuroscience › Neurology › Vagus Nerve Stimulation Research
- Keywords
- sciatic nerve, neurostimulation, neural recording, bipolar configuration, peripheral nerve interfaces, neuroprosthetics, cuff electrodes, rabbit model
- MeSH terms
- Action Potentials, Animals, Electric Stimulation, Electrodes, Implanted, Equipment Design, Peripheral Nerves, Rabbits, Sensitivity and Specificity, Reproducibility of Results, Equipment Failure Analysis
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